曹琦琛，博士，中国科学院天津工业生物技术研究所，系统生物学中心, 副研究员。2004年至2014年于辽宁中医药大学附属医院国家药物临床试验机构从事Ⅰ期临床试验药动学研究。主要开展基于质谱MRM/SRM方法的血浆药物及其代谢物的检测工作。 2011-2014年于北京蛋白质组学研究中心攻读博士学位。主要期间主要开展“核心岩藻糖化修饰蛋白质组的大规模鉴定”及“酵母2-羟基异丁酰化修饰蛋白质组”等研究。2014年加入中科院天津工生所，主要开展基于质谱SWATH/DIA技术的工业微生物蛋白质组大规模定量研究。利用蛋白质组学手段解析工业菌株发酵过程。

   

071010-生物化学与分子生物学
100704-药物分析学
086000-生物与医药

分子生物学
系统生物学
合成生物学

2011-09--2014-06   沈阳药科大学   博士
2004-09--2007-06   辽宁中医药大学   硕士

   

2018-07~现在, 中国科学院天津工业生物技术研究所, 副研究员
2014-08~2018-06,中国科学院天津工业生物技术研究所, 助理研究员
2007-08~2014-06,辽宁中医药大学附属医院, 国家药物临床试验机构 I期临床试验研究员

   

（1） 中药药效物质药动学特征及其与中药复方配伍规律相关性的研究, 二等奖, 省级, 2010
（2） 典方剂的配伍研究与开发, 三等奖, 省级, 2007

（ 1 ） 一种鉴别山羊绒与细羊毛的方法, 发明专利, 2019, 第 1 作者, 专利号: 201710382317.X

（ 2 ） 纺织品中羊绒的检测方法, 发明专利, 2018, 第 2 作者, 专利号: 201510716825.8

   

[1] Cao, Qichen, Han, Manman, Zhang, Zuoqing, Yu, Chang, Xu, Lida, Shi, Tuo, zheng, Ping, Sun, Jibin. Novel 15N Metabolic Labeling-Based Large-Scale Absolute Quantitative Proteomics Method for Corynebacterium glutamicum. Analytical Chemistry[J]. 2023, 95(11): 4829-4833, https://pubs.acs.org/doi/10.1021/acs.analchem.2c05524.
[2] Sun, Xi, Mao, Yufeng, Luo, Jiahao, Liu, Pi, Jiang, Meiru, He, Guimei, Zhang, Zhidan, Cao, Qichen, Shen, Jie, Ma, Hongwu, Chen, Tao, Wang, Zhiwen. Global Cellular Metabolic Rewiring Adapts Corynebacterium glutamicum to Efficient Nonnatural Xylose Utilization. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2022, 88(23): http://dx.doi.org/10.1128/aem.01518-22.
[3] Miao, Chen, Yang, Yunfei, Li, Shanshan, Guo, Yufeng, Shui, Wenqing, Cao, Qichen. Discrimination and quantification of homologous keratins from goat and sheep with dual protease digestion and PRM assays. JOURNALOFPROTEOMICS[J]. 2018, 186: 38-46, http://dx.doi.org/10.1016/j.jprot.2018.07.010.
[4] Xiao, Weidi, Duan, Xiaoxiao, Lin, Yuping, Cao, Qichen, Li, Shanshan, Guo, Yufeng, Gan, Yuman, Qi, Xianni, Zhou, Yue, Guo, Lihai, Qin, Peibin, Wang, Qinhong, Shui, Wenqing. Distinct Proteome Remodeling of Industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock. JOURNAL OF PROTEOME RESEARCH[J]. 2018, 17(5): 1812-1825, https://www.webofscience.com/wos/woscc/full-record/WOS:000431726700007.
[5] Zhao, Qing, Jia, Tian Zhu, Cao, Qi Chen, Tian, Fang, Ying, Wan Tao. A Crude 1-DNJ Extract from Home Made Bombyx Batryticatus Inhibits Diabetic Cardiomyopathy-Associated Fibrosis in db/db Mice and Reduces Protein N-Glycosylation Levels. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2018, 19(6): https://doaj.org/article/0d3c17b2eb27413188cc480f5821de25.
[6] Li, Zhucui, Li, Yujin, Chen, Wujiu, Cao, Qichen, Guo, Yufeng, Wan, Ni, Jiang, Xiaolong, Tang, Yinjie J, Wang, Qinhong, Shui, Wenqing. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic C-13-Labeling Metabolism Analysis (vol 89, pg 877, 2017). ANALYTICAL CHEMISTRYnull. 2018, 90(8): 5509-5509, https://www.webofscience.com/wos/woscc/full-record/WOS:000430512200078.
[7] Cao Qichen. Optimization of acquisition and data-processing parameters for improved proteomic quantification by SWATH mass spectrometry. Journal of Proteome Research. 2017, [8] Li, Zhucui, Li, Yujing, Chen, Wujiu, Cao, Qichen, Guo, Yufeng, Wan, Ni, Jiang, Xiaolong, Tang, Yinjie J, Wang, Qinhong, Shui, Wenqing. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic C-13-Labeling Metabolism Analysis. ANALYTICAL CHEMISTRY[J]. 2017, 89(1): 877-885, http://www.irgrid.ac.cn/handle/1471x/1180897.
[9] Huang, Jing, Luo, Zhouqing, Ying, Wantao, Cao, Qichen, Huang, He, Dong, Junkai, Wu, Qingyu, Zhao, Yingming, Qian, Xiaohong, Dai, Junbiao. 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(33): 8782-8787, https://www.webofscience.com/wos/woscc/full-record/WOS:000407610400062.
[10] 王钦宏.  Li Z, Li Y, Chen W, Cao Q, Guo Y, Wan N, Jiang X, Tang YJ, Wang Q, Shui W. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis.. Analytical Chemistry. 2017, [11] Li, Shanshan, Cao, Qichen, Xiao, Weidi, Guo, Yufeng, Yang, Yunfei, Duan, Xiaoxiao, Shui, Wenqing. Optimization of Acquisition and Data-Processing Parameters for Improved Proteomic Quantification by Sequential Window Acquisition of All Theoretical Fragment Ion Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH[J]. 2017, 16(2): 738-747, https://www.webofscience.com/wos/woscc/full-record/WOS:000393539600035.
[12] Zhao, Yan, Chang, Cheng, Qin, Peibin, Cao, Qichen, Tian, Fang, Jiang, Jing, Li, Xianyu, Yu, Wenfeng, Zhu, Yunping, He, Fuchu, Ying, Wantao, Qian, Xiaohong. Mining the human plasma proteome with three-dimensional strategies by high-resolution Quadrupole Orbitrap Mass Spectrometry. ANALYTICA CHIMICA ACTA[J]. 2016, 904: 65-75, http://dx.doi.org/10.1016/j.aca.2015.11.001.
[13] 杨阿芳, 李珊珊, 张勇, 曹琦琛, 水雯箐. 基于发展靶向蛋白质组技术的羊绒纤维组成鉴定及含量分析. 中国科技论文[J]. 2016, 11(6): 663-669, http://lib.cqvip.com/Qikan/Article/Detail?id=669296486.
[14] Xiong, Yun, Guo, Yufeng, Xiao, Weidi, Cao, Qichen, Li, Shanshan, Qi, Xianni, Zhang, Zhidan, Wang, Qinhong, Shui, Wenqing. An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2016, 88(5): 2784-2791, http://124.16.173.210/handle/834782/1526.
[15] Shanshan Li, Yong Zhang, Jihua Wang, Yunfei Yang, Chen Miao, Yufeng Guo, Zhidan Zhang, Qichen Cao, Wenqing Shui. Combining Untargeted and Targeted Proteomic Strategies for Discrimination and Quantification of Cashmere Fibers.. PLOS ONE[J]. 2016, 11(1): https://doaj.org/article/2ad630909ca24c458c6ae6249831fdd1.
[16] Cao, Qichen, Ma, Cheng, Bai, Haihong, Li, Xianyu, Yan, Hui, Zhao, Yan, Ying, Wantao, Qian, Xiaohong. Multivalent hydrazide-functionalized magnetic nanoparticles for glycopeptide enrichment and identification. ANALYST[J]. 2014, 139(3): 603-609, https://www.webofscience.com/wos/woscc/full-record/WOS:000328912000011.
[17] Cao, Qichen, Zhao, Xinyuan, Zhao, Qing, Lv, Xiaodong, Ma, Cheng, Li, Xianyu, Zhao, Yan, Peng, Bo, Ying, Wantao, Qian, Xiaohong. Strategy Integrating Stepped Fragmentation and Glycan Diagnostic Ion-Based Spectrum Refinement for the Identification of Core Fucosylated Glycoproteome Using Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2014, 86(14): 6804-6811, https://www.webofscience.com/wos/woscc/full-record/WOS:000339227400013.

（1） Identification of Core-Fucosylated Glycoproteome in Human Plasma, Methods in Molecular Biology, 2017-06, 第 1 作者

   

（ 1 ） 有机碳一原料生物利用关键元件的开发与表征, 负责人, 国家任务, 2019-07--2024-06
（ 2 ） 系统生物学平台, 参与, 地方任务, 2020-12--2023-11