神经胶质细胞

   

071006-神经生物学

神经胶质细胞

1982-04--1987-09   海德堡大学   Habilitation
1980-09--1982-03   海德堡大学   博士研究生

   

[1] Logiacco, Francesca, Grzegorzek, Laura Cathleen, Cordell, Elizabeth C, Popp, Oliver, Mertins, Philipp, Gutmann, David H, Kettenmann, Helmut, Semtner, Marcus. Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic. ACTA NEUROPATHOLOGICA COMMUNICATIONS[J]. 2023, 11(1): http://dx.doi.org/10.1186/s40478-023-01525-w.
[2] Dilansu Guneykaya, Bilge Ugursu, Francesca Logiacco, Oliver Popp, Maria Almut Feiks, Niklas Meyer, Stefan Wendt, Marcus Semtner, Fatma Cherif, Christian Gauthier, Charlotte Madore, Zhuoran Yin, zcan nar, Taner Arslan, Zoltan Gerevich, Philipp Mertins, Oleg Butovsky, Helmut Kettenmann, Susanne A Wolf. Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder. BRAIN, BEHAVIOR, AND IMMUNITY. 2023, 111: 61-75, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330133/.
[3] Thomas Wallach, Martin Raden, Lukas Hinkelmann, Mariam Brehm, Dominik Rabsch, Hannah Weidling, Christina Krger, Helmut Kettenmann, Rolf Backofen, Seija Lehnardt. Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia. FRONTIERS IN IMMUNOLOGY. 2023, 13: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880480/.
[4] Neuschulz, Anika, Bakina, Olga, BadilloLisakowski, Victor, OlivaresChauvet, Pedro, Conrad, Thomas, Gotthardt, Michael, Kettenmann, Helmut, Junker, Jan Philipp. A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation. MOLECULAR SYSTEMS BIOLOGY[J]. 2023, 19(2): http://dx.doi.org/10.15252/msb.202211147.
[5] Philipp Jordan, Amanda Costa, Edgar Specker, Oliver Popp, Andrea Volkamer, Regina Piske, Tessa Obrusnik, Sabrina Kleissle, Kevin Stuke, Andre Rex, Martin Neuenschwander, Jens Peter von Kries, Marc Nazare, Phillip Mertins, Helmut Kettenmann, Susanne A Wolf, Alexander A Mongin. Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation. PLOS ONE[J]. 2023, 18(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901772/.
[6] Bakina, Olga, Kettenmann, Helmut, Nolte, Christiane. Microglia form satellites with different neuronal subtypes in the adult murine central nervous system. JOURNAL OF NEUROSCIENCE RESEARCH[J]. 2022, 100(4): 1105-1122, http://dx.doi.org/10.1002/jnr.25026.
[7] Yimin Huang, Edyta Motta, Cynthia Nanvuma, Leonard D Kuhrt, Yang Yuan, Pengfei Xia, Malgorzata Lubas, Shuai Zhu, Marina Schnauss, Niyeti Qazi, Feng Hu, Huaqiu Zhang, Ting Lei, Michael Synowitz, Charlotte Flh, Helmut Kettenmann. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model. CELL REPORTS. 2022, 39(2): http://dx.doi.org/10.1016/j.celrep.2022.110670.
[8] Rosa C Paolicelli, Amanda Sierra, Beth Stevens, MarieEve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew BlurtonJones, Erik Boddeke, Dora Brites, Bert Brne, Guy C Brown, Oleg Butovsky, Monica J Carson, Bernardo Castellano, Marco Colonna, Sally A Cowley, Colm Cunningham, Dimitrios Davalos, Philip L De Jager, Bart de Strooper, Adam Denes, Bart JL Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K Glass, Ozgun Gokce, Diego GomezNicola, Berta Gonzlez, Siamon Gordon, Manuel B Graeber, Andrew D Greenhalgh, Pierre Gressens, Melanie Greter, David H Gutmann, Christian Haass, Michael T Heneka, Frank L Heppner, Soyon Hong, David A Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W McColl, Veronique E Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V Hugh Perry, Phillip G Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M Ransohoff, Michael W Salter, Anne Schaefer, Dorothy P Schafer, Michal Schwartz, Mikael Simons, Cody J Smith, Wolfgang J Streit, Tuan Leng Tay, LiHuei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valrie Wittamer, Susanne A Wolf, LongJun Wu, Tony WyssCoray. Microglia states and nomenclature: A field at its crossroads. NEURON. 2022, 110(21): 3458-3483, http://dx.doi.org/10.1016/j.neuron.2022.10.020.
[9] Huang, Y, Motta, E, Nanvuma, C, Yuan, Y, Kuhrt, L, Xia, P, Lubas, M, Zhu, S, Schnauss, M, Hu, F, Zhang, H, Lei, T, Synowitz, M, Fluh, C, Kettenmann, H. ACTIVATION OF THE CCR8-ACP5 AXIS BY HUMAN MICROGLIA/MACROPHAGE DERIVED CCL18 PROMOTES GLIOMA GROWTH. NEURO-ONCOLOGY. 2022, 24: [10] Philippot, Camille, Griemsmann, Stephanie, Jabs, Ronald, Seifert, Gerald, Kettenmann, Helmut, Steinhaeuser, Christian. Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites. CELL REPORTS[J]. 2021, 34(3): http://dx.doi.org/10.1016/j.celrep.2020.108642.
[11] Huang, Yimin, Zhang, Baole, Haneke, Hannah, Haage, Verena, Lubas, Malgorzata, Yuan, Yang, Xia, Pengfei, Motta, Edyta, Nanvuma, Cynthia, Dzaye, Omar, Hu, Feng, Kettenmann, Helmut. Glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression. JOURNAL OF NEUROSCIENCE RESEARCH[J]. 2021, 99(4): 1048-1063, http://dx.doi.org/10.1002/jnr.24768.
[12] Costa, Amanda, Haage, Verena, Yang, Seulkee, Wegner, Stephanie, Ersoy, Burcu, Ugursu, Bilge, Rex, Andre, Kronenberg, Golo, Gertz, Karen, Endres, Matthias, Wolf, Susanne A, Kettenmann, Helmut. Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury. BRAIN BEHAVIOR AND IMMUNITY[J]. 2021, 91: 89-104, http://dx.doi.org/10.1016/j.bbi.2020.09.008.
[13] Escartin, Carole, Galea, Elena, Lakatos, Andras, OCallaghan, James P, Petzold, Gabor C, SerranoPozo, Alberto, Steinhauser, Christian, Volterra, Andrea, Carmignoto, Giorgio, Agarwal, Amit, Allen, Nicola J, Araque, Alfonso, Barbeito, Luis, Barzilai, Ari, Bergles, Dwight E, Bonvento, Gilles, Butt, Arthur M, Chen, WeiTing, CohenSalmon, Martine, Cunningham, Colm, Deneen, Benjamin, De Strooper, Bart, DiazCastro, Blanca, Farina, Cinthia, Freeman, Marc, Gallo, Vittorio, Goldman, James E, Goldman, Steven A, Gotz, Magdalena, Gutierrez, Antonia, Haydon, Philip G, Heiland, Dieter H, Hol, Elly M, Holt, Matthew G, Iino, Masamitsu, Kastanenka, Ksenia V, Kettenmann, Helmut, Khakh, Baljit S, Koizumi, Schuichi, Lee, C Justin, Liddelow, Shane A, MacVicar, Brian A, Magistretti, Pierre, Messing, Albee, Mishra, Anusha, Molofsky, Anna V, Murai, Keith K, Norris, Christopher M, Okada, Seiji, Oliet, Stephane H R, Oliveira, Joao F, Panatier, Aude, Parpura, Vladimir, Pekna, Marcela, Pekny, Milos, Pellerin, Luc, Perea, Gertrudis, PerezNievas, Beatriz G, Pfrieger, Frank W, Poskanzer, Kira E, Quintana, Francisco J, Ransohoff, Richard M, RiquelmePerez, Miriam, Robel, Stefanie, Rose, Christine R, Rothstein, Jeffrey D, Rouach, Nathalie, Rowitch, David H, Semyanov, Alexey, Sirko, Swetlana, Sontheimer, Harald, Swanson, Raymond A, Vitorica, Javier, Wanner, InaBeate, Wood, Levi B, Wu, Jiaqian, Zheng, Binhai, Zimmer, Eduardo R, Zorec, Robert, Sofroniew, Michael V, Verkhratsky, Alexei. Reactive astrocyte nomenclature, definitions, and future directions. NATURE NEUROSCIENCEnull. 2021, 24(3): 312-325, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007081/.
[14] Xia, Pengfei, Logiacco, Francesca, Huang, Yimin, Kettenmann, Helmut, Semtner, Marcus. Histamine triggers microglial responses indirectly via astrocytes and purinergic signaling. GLIA[J]. 2021, 69(9): 2291-2304, http://dx.doi.org/10.1002/glia.24039.
[15] Rooney, Sinead, Sah, Anupam, Unger, Michael S, Kharitonova, Maria, Sartori, Simone B, Schwarzer, Christoph, Aigner, Ludwig, Kettenmann, Helmut, Wolf, Susanne A, Singewald, Nicolas. Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline. TRANSLATIONAL PSYCHIATRY[J]. 2020, 10(1): http://dx.doi.org/10.1038/s41398-020-00942-y.
[16] Ransom, Bruce R, Kettenmann, Helmut. Studying Human Glial Cells: Where Are We Today?. GLIAnull. 2020, 68(4): 683-684, https://www.webofscience.com/wos/woscc/full-record/WOS:000513283700001.
[17] Huang, Yimin, Zhang, Quan, Lubas, Malgorzata, Yuan, Yang, Yalcin, Fatih, Efe, Ibrahim E, Xia, Pengfei, Motta, Edyta, Buonfiglioli, Alice, Lehnardt, Seija, Dzaye, Omar, Flueh, Charlotte, Synowitz, Michael, Hu, Feng, Kettenmann, Helmut. Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia. JOURNAL OF NEUROSCIENCE[J]. 2020, 40(33): 6428-6443, http://dx.doi.org/10.1523/JNEUROSCI.0666-20.2020.
[18] Triller, Paul, Bachorz, Julia, Synowitz, Michael, Kettenmann, Helmut, Markovic, Darko. O-Vanillin Attenuates the TLR2 Mediated Tumor-Promoting Phenotype of Microglia. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000535565300301.
[19] Sielska, Malgorzata, Przanowski, Piotr, Pasierbinska, Maria, Wojnicki, Kamil, Poleszak, Katarzyna, Wojtas, Bartosz, Grzeganek, Dominika, EllertMiklaszewska, Aleksandra, Ku MinChi, Kettenmann, Helmut, Kaminska, Bozena. Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas. BRITISH JOURNAL OF CANCER[J]. 2020, 123(3): 438-448, https://www.webofscience.com/wos/woscc/full-record/WOS:000531456900004.
[20] Ifuku, Masataka, Hinkelmann, Lukas, Kuhrt, Leonard D, Efe, Ibrahim E, Kumbol, Victor, Buonfiglioli, Alice, Krueger, Christina, Jordan, Philipp, Fulde, Marcus, Noda, Mami, Kettenmann, Helmut, Lehnardt, Seija. Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury. ACTA NEUROPATHOLOGICA COMMUNICATIONS[J]. 2020, 8(1): http://dx.doi.org/10.1186/s40478-020-01031-3.
[21] Hu, Feng, Huang, Yimin, Semtner, Marcus, Zhao, Kai, Tan, Zhoubin, Dzaye, Omar, Kettenmann, Helmut, Shu, Kai, Lei, Ting. Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth. EXPERIMENTAL CELL RESEARCH[J]. 2020, 396(2): http://dx.doi.org/10.1016/j.yexcr.2020.112323.
[22] Nirmeen Elmadany, Felipe de Almeida Sassi, Stefan Wendt, Francesca Logiacco, Josien Visser, Verena Haage, Daniel Perez Hernandez, Philipp Mertins, Dolores Hambardzumyan, Susanne Wolf, Helmut Kettenmann, Marcus Semtner. The VGF-derived Peptide TLQP21 Impairs Purinergic Control of Chemotaxis and Phagocytosis in Mouse Microglia. THE JOURNAL OF NEUROSCIENCE. 2020, 40(17): 3320-3331, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178903/.
[23] Kaffes, Ioannis, Szulzewsky, Frank, Chen, Zhihong, Herting, Cameron J, Gabanic, Ben, Vega, Jose E Velazquez, Shelton, Jennifer, Switchenko, Jeffrey M, Ross, James L, McSwain, Leon F, Huse, Jason T, Westermark, Bengt, Nelander, Sven, ForsbergNilsson, Karin, Uhrbom, Lene, Maturi, Naga Prathyusha, Cimino, Patrick J, Holland, Eric C, Kettenmann, Helmut, Brennan, Cameron W, Brat, Daniel J, Hambardzumyan, Dolores. Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. ONCOIMMUNOLOGY[J]. 2019, 8(11): https://doaj.org/article/99915def14e347129ecc08b39b7bf014.
[24] Elmadany, N N, Sassi, F de Almeida, Wendt, S, Visser, J, Hambardyumzan, D, Wolf, S, Kettenmann, H, Semtner, M. The VGF-derived peptide TLQP-21 impairs purinergic control of chemotaxis and phagocytosis in cultured microglia. GLIAnull. 2019, 67: E172-E173, [25] Gutmann, David H, Kettenmann, Helmut. Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology. NEURONnull. 2019, 104(3): 442-449, https://www.webofscience.com/wos/woscc/full-record/WOS:000495107500007.
[26] Yalcin, Fatih, Buonfiglioli, Alice, Efe, Ibrahim Efecan, Haneke, Hannah, Kuhrt, Leonard D, Synowitz, Michael, Nickl, Bernadette, Bader, Michael, Kettenmann, Helmut, Dzaye, Omar. MICROGLIA/BRAIN MACROPHAGES PROMOTE GLIOMA GROWTH BY EXPRESSING GLYCOPROTEIN NMB. NEURO-ONCOLOGYnull. 2019, 21: 254-254, [27] Haage, V C, Semtner, M, Vidal, R Oliveira, Hernandez, D Perez, Pong, W W, Chen, Z, Hambardzumyan, D, Magrini, V, Li, A, Walker, J, Mardis, E, Mertins, P, Sauer, S, Kettenmann, H, Gutmann, D H. Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma. GLIAnull. 2019, 67: E528-E528, https://www.webofscience.com/wos/woscc/full-record/WOS:000502867403007.
[28] Sierra, Amanda, Paolicelli, Rosa C, Kettenmann, Helmut. Cien Anos de Microglia: Milestones in a Century of Microglial Research. TRENDS IN NEUROSCIENCESnull. 2019, 42(11): 778-792, http://dx.doi.org/10.1016/j.tins.2019.09.004.
[29] Haage, Verena, Elmadany, Nirmeen, Roll, Lars, Faissner, Andreas, Gutmann, David H, Semtner, Marcus, Kettenmann, Helmut. Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1. BRAIN BEHAVIOR AND IMMUNITY[J]. 2019, 81: 470-483, http://dx.doi.org/10.1016/j.bbi.2019.06.047.
[30] Haage, Verena, Semtner, Marcus, Vidal, Ramon Oliveira, Hernandez, Daniel Perez, Pong, Winnie W, Chen, Zhihong, Hambardzumyan, Dolores, Magrini, Vincent, Ly, Amy, Walker, Jason, Mardis, Elaine, Mertins, Philipp, Sauer, Sascha, Kettenmann, Helmut, Gutmann, David H. Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma. ACTA NEUROPATHOLOGICA COMMUNICATIONS[J]. 2019, 7: https://doaj.org/article/986b937012e84a5e90276262cfb94f49.
[31] Buonfiglioli, Alice, Efe, Ibrahim E, Guneykaya, Dilansu, Ivanov, Andranik, Huang, Yimin, Orlowski, Elisabeth, Krueger, Christina, Deisz, Rudolf A, Markovic, Darko, Flueh, Charlotte, Newman, Andrew G, Schneider, Ulf C, Beule, Dieter, Wolf, Susanne A, Dzaye, Omar, Gutmann, David H, Semtner, Marcus, Kettenmann, Helmut, Lehnardt, Seija. let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7. CELL REPORTS[J]. 2019, 29(11): 3460-+, http://dx.doi.org/10.1016/j.celrep.2019.11.029.
[32] Meyer, Niklas, Richter, Nadine, Fan, Zoya, Siemonsmeier, Gabrielle, Pivneva, Tatyana, Jordan, Philipp, Steinhaeuser, Christian, Semtner, Marcus, Nolte, Christiane, Kettenmann, Helmut. Oligodendrocytes in the Mouse Corpus Callosum Maintain Axonal Function by Delivery of Glucose. CELL REPORTS[J]. 2018, 22(9): 2383-2394, http://dx.doi.org/10.1016/j.celrep.2018.02.022.
[33] Guneykaya, Dilansu, Ivanov, Andranik, Hernandez, Daniel Perez, Haage, Verena, Wojtas, Bartosz, Meyer, Niklas, Maricos, Meron, Jordan, Philipp, Buonfiglioli, Alice, Gielniewski, Bartlomiej, Ochocka, Natalia, Coemert, Cagla, Friedrich, Corinna, Artiles, Lorena Suarez, Kaminska, Bozena, Mertins, Philipp, Beule, Dieter, Kettenmann, Helmut, Wolf, Susanne A. Transcriptional and Translational Differences of Microglia from Male and Female Brains. CELL REPORTS[J]. 2018, 24(10): 2773-+, http://dx.doi.org/10.1016/j.celrep.2018.08.001.
[34] Wendt, Stefan, Wogram, Emile, Korvers, Laura, Kettenmann, Helmut. Experimental Cortical Spreading Depression Induces NMDA Receptor Dependent Potassium Currents in Microglia. JOURNAL OF NEUROSCIENCE[J]. 2016, 36(23): 6165-6174, https://www.webofscience.com/wos/woscc/full-record/WOS:000379007700005.
[35] Hambardzumyan, Dolores, Gutmann, David H, Kettenmann, Helmut. The role of microglia and macrophages in glioma maintenance and progression. NATURE NEUROSCIENCEnull. 2016, 19(1): 20-27, http://dx.doi.org/10.1038/nn.4185.

（1） Neuroglia, Neuroglia, Oxford University Press, 2013-02, 第 1 作者

   

（ 1 ） 国际大科学培育专项, 参与, 研究所（学校）, 2017-01--2021-12