​Nanomedicine, micro-nano bionic drug delivery, tumor immunity, gene therapy 

Ø  2017/09—2020/06   University of Chinese Academy of Sciences   Ph.D in Biochemistry and Molecular Biology

​

 2012/07—2019/12   Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences.  Assistant professor

​ 2020/01—now     Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences.  Associate professor

Ø  2020 Teaching of biotechnology frontier courses for Undergraduate;

Ø  2017-2020 Guiding the writing of graduation thesis for Graduate and Undergraduate.

1)        Huaqing Chen#, Lanlan Liu#, Aiqing Ma#,*, Ting Yin, Ze Chen, Ruijing Liang, Yuzhi Qiu, Mingbin Zheng, and Lintao Cai*. Noninvasively Immunogenic Sonodynamic Therapy with Manganese Protoporphyrin Liposomes against Triple-Negative Breast Cancer. Biomaterials 2021, 269, 120639. (IF=12.479, co-first author)

2)        Haimei Zhou#, Huamei He#, Ruijing Liang#, Hong Pan, Ze Chen, Guanjun Deng, Shengping Zhang, Yifan Ma***, Lanlan Liu**, Lintao Cai*. In situ poly I:C released from living cell drug nanocarriers for macrophage-mediated antitumor immunotherapy. Biomaterials 2021,269,120670. (IF=12.479, Corresponding author)

3)        Lanlan Liu#, Huamei He#, Zhenyu Luo, Haimei Zhou, Ruijing Liang, Hong Pan,Yifan Ma, and Lintao Cai. In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple-Negative Breast Cancer. Advanced Functional Materials 2020, 30(10): 1910176. (IF=18.808, first author)

4)        Huamei He #, Lanlan Liu#, Shengping Zhang#, Mingbing Zheng, Aiqing Ma, Ze Chen, Hong Pan, Haimei Zhou, Ruijing Liang, and Lintao Cai. Smart Gold Nanocages for Mild Heat-Triggered Drug Release and Breaking Chemoresistance. Journal of Controlled Release 2020, 323: 387-397. (IF=9.776, co-first author)

5)        Huamei He#, Lanlan Liu#, Ruijing Liang#, Haimei Zhou, Hong Pan ,Shengping Zhang, Lintao Cai. Tumor-targeted nanoplatform for in situ oxygenation-boosted immunogenic phototherapy of colorectal cancer. Acta Biomaterialia 2020, 104, 188-197. (IF=8.947, co-first author)

6)        Lanlan Liu#, Huamei He#, Ruijing Liang#, Huqiang Yi, Xiaoqing Meng, Zhikuan Chen, Hong Pan, Yifan Ma, and Lintao Cai. ROS-Inducing Micelles Sensitize Tumor-Associated Macrophages to TLR3 Stimulation for Potent Immunotherapy. Biomacromolecules 2018, 19, 2146-2155. (IF=6.988, first author)

7)        Ruijing Liang#, Lanlan Liu#, Huamei He, Zhikuan Chen, Zhiqun Han, Zhenyu Luo, Zhihao Wu, Mingbing Zheng, Yifan Ma, Lintao Cai. Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases. Biomaterials 2018, 177, 149-160. (IF=12.479, co-first author)

8)        Zhikuan Chen#, Lanlan Liu#, Ruijing Liang#, Zhenyu Luo, Huamei He, Zhihao Wu, Hao Tian, Mingbin Zheng, Yifan Ma, and Lintao Cai. Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect. ACS Nano 2018, 12(8): 8633. (IF=15.881, co-first author)

9)        Zhenyu Luo#, Hao Tian#, Lanlan Liu#, Zhikuan Chen, Ruijing Liang, Ze Chen, Zhihao Wu, Aiqing Ma, Mingbin Zheng, and Lintao Cai. Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose. Theranostics 2018, 8(13): 3584-3596. (IF=11.556, co-first author)

10)     Hao Tian#, Zhenyu Luo#, Lanlan Liu#, Mingbin Zheng*, Ze Chen, Aiqing Ma, Ruijing Liang, Zhiqun Han, Chengyu Lu, and Lintao Cai*. Cancer Cell Membrane-biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance. Advanced Functional Materials. 2017 (IF=18.808, co-first author)

11)     Lanlan Liu#, Huqiang Yi#, Huamei He, Hong Pan, Lintao Cai*, and Yifan Ma*. Tumor associated macrophage-targeted microRNA delivery with dual-responsive polypeptide nanovectors for anti-cancer therapy. Biomaterials. 2017,134,166-179. (IF=12.479, first author)

12)     Lanlan Liu, Huqiang Yi, Ce Wang, Huamei He, Ping Li, Hong Pan, Nan Sheng, Manyi Ji, Lintao Cai, and Yifan Ma*. Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis. Journal of Immunology. 2016. (IF=5.422, first author)

13)     Huqiang Yi#, Lanlan Liu#, Nan Sheng#, Ping Li, Hong Pan, Lintao Cai, Yifan Ma*. Synergistic Therapy of Doxorubicin and miR-129-5p with Self-cross-linked Bioreducible Polypeptide Nanoparticles Reverses Multidrug Resistance in Cancer Cells. Biomacromolecules 2016, 17, 5, 1737-1747. (IF=6.988, co-first author)

14)     Lanlan Liu^#, Zhaojuan Yang^#, Yinqian Xu, Dongxu Xu, Li Zhang, Jiabin Sun, Suhua Xia, Feiyan Zou, Yongzhong Liu*. Inhibition of Oxidative Stress-Elicited AKT Activation Facilitates PPARγ Agonist-Mediated Inhibition of Stem Cell Character and Tumor Growth of Liver Cancer Cells. PLoS ONE 2013, 8(8): e73038. (IF=3.24, first author)

15)        Hong Pan, Mingbin Zheng, Aiqing Ma, Lanlan Liu, and Lintao Cai*. Cell/Bacteria-Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy. Adv. Mater. 2021, 2100241.

16)        Zhihong Sun, Guanjun Deng, Xinghua Peng, Xiuli Xu, Lanlan Liu, Jiaofeng Peng, Yifan Ma, Pengfei Zhang, Austin Wen, Yifan Wang, Zhaogang Yang, Ping Gong***, Wen Jiang**, Lintao Cai*. Intelligent photothermal dendritic cells restart the cancer immunity cycle through enhanced immunogenic cell death. Biomaterials 2021,279, 121228.

17)        Ping Li, Xinyu Yang, Yang Yang, Huamei He, Chon-Kit Chou, Fengyang Chen, Hong Pan, Lanlan Liu, Lintao Cai, Yifan Ma, Xin Chen. Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice. Journal of Controlled Release 2020,319, 87-103. 

18)        Hong Pan, Wenjun Li, Ze Chen, Yingmei Luo, Wei He, Mengmeng Wang, Xiaofan Tang, Huamei He, Lanlan Liu, Mingbin Zheng, Xin Jiang, Ting Yin, Ruijing Liang, Yifan Ma, Lintao Cai. Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor. Bioactive Materials 2021, 6, 951-962. 

19)        Fangfang Wang, Hong Pan, Xiangjie Yao, Huamei He, Lanlan Liu, Yingmei Luo, Haimei Zhou, Mingbin Zheng, Renli Zhang, Yifan Ma, and Lintao Cai. Bioorthogonal Metabolic Labeling Utilizing Protein Biosynthesis for Dynamic Visualization of Nonenveloped Enterovirus 71 Infection. ACS Appl. Mater. Interfaces 2020, 12, 3363-3370. 

20)        Ying Luo, Jun Yang, Chi Zhang, Yan Jin, Hong Pan, Lanlan Liu, Yifeng Gong, Yu Xia, Guobing Wang, Jiaosheng Zhang, Chengrong Li, Qiu Li. Up-regulation of miR-27a promotes monocyte-mediated inflammatory responses in Kawasaki disease by inhibiting function of B10 cells. J Leukoc Biol. 2019.  

21)        Wenjun Li, Hong Pan, Huamei He, Xiaoqing Meng, Qian Ren, Ping Gong, Xin Jiang, Zhenguo Liang, Lanlan Liu, Mingbin Zheng, Ximing Shao, Yifan Ma, Lintao Cai. Bio-Orthogonal T Cell Targeting Strategy for Robustly Enhancing Cytotoxicity against Tumor Cells.Small.2019. 

22)        Hong Pan, Ping Li, Guifei Li, Wenjun Li, Bian Hu, Huamei He, Ze Chen, Fangfang Wang, Lanlan Liu, Yifeng Gong, Yutong Han, Yingmei Luo, Mingbin Zheng,Yifan Ma, Lintao Cai, and Yan Jin. Glycometabolic Bioorthogonal Chemistry-Guided Viral Transduction for Robust Human T Cell Engineering. Advanced Functional Materials. 2019.

23)        Hong Pan#, Xiangjie Yao#, Weihua Chen, Fangfang Wang, Huamei He, Lanlan Liu, Yaqing He, Jinquan Chen, Puzi Jiang, Renli Zhang∗∗∗, Yifan Ma∗∗, Lintao Cai∗. Dissecting complicated viral spreading of enterovirus 71 using in situ bioorthogonal fluorescent labeling. Biomaterials. 2018.

24)     Hong Pan, Wenjun Li, Xiangjie Yao, Yayun Wu, Lanlan Liu, Huamei He, Renli Zhang, Yifan Ma*, and Lintao Cai*. In Situ Bioorthogonal Metabolic Labeling for Fluorescence Imaging of Virus Infection In Vivo. Small. 2017. 

25)     Ce Wang#, Ping Li#, Lanlan Liu, Hong Pan, Hongchang Li, Lintao Cai, Yifan Ma. Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation. Biomaterials. 2016. 

26)     Yijuan Zhang#, Ping Li#, Hong Pan#, Lanlan Liu, Manyi Ji, Nan Sheng, Ce Wang, Lintao Cai, Yifan Ma*. Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy. Biomaterials. 2016. 

27)     Manyi Ji#, Ping Li#, Nan Sheng#, Lanlan Liu, Hong Pan, Ce Wang, Lintao Cai, Yifan Ma*. Sialic acid-targeted nanovectors with phenylboronic acid-grafted polyethylenimine robustly enhance siRNA-based cancer therapy. ACS Appl. Mater. Interfaces. 2016. 

28)     Ze Chen#, Pengfei Zhao#, Zhenyu Luo#, Mingbin Zheng*, Hao Tian, Ping Gong, Guanhui Gao, Hong Pan, Lanlan Liu, Aiqing Ma, Haodong Cui, Yifan Ma, and Lintao Cai*. Cancer Cell Membrane–Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy. ACS nano. 2016.

29)     Zichao Luo#, Ce Wang#, Huqiang Yi, Ping Li, Hong Pan, Lanlan Liu, Lintao Cai, Yifan Ma. Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo. Biomaterials 2015. 

30)     Hong Pan#, Pengfei Zhang#, Duyang Gao, Yijuan Zhang, Ping Li, Lanlan Liu, Ce Wang, Hanzhong Wang, Yifan Ma*, Lintao Cai*. Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal conjugated Near-Infrared Emitting Quantum Dots. ACS Nano. 8(6):5468-77. 2014. 

31)     Ce Wang, Peng Liu, Yan Zhuang, Ping Li, Boling Jiang, Hong Pan, Lanlan Liu, Lintao Cai, Yifan Ma*. Lymphatic-targeted cationic liposomes: a robust vaccine adjuvant for promoting long-term immunological memory. Vaccine. 32(42):5475-83. 2014. 

32)     Hong Pan, Yijuan Zhang, Zichao Luo, Ping Li, Lanlan Liu, Ce Wang, Hanzhong Wang, Hongchang Li, Yifan Ma*. Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-κB and p38 MAPK signaling pathways. Am J Physiol Lung Cell Mol Physiol. 306(2):L183-95, 2014. 

33)     Zichao Luo#, Ping Li#, Jizhe Deng, Ningning Gao, Yijuan Zhang, Hong Pan, Lanlan Liu, Ce Wang, Lintao Cai*, Yifan Ma*. Cationic polypeptide micelle-based antigen delivery system: A simple and robust adjuvant to improve vaccine efficacy. J. Control. Release. 170(2):259-67. 2013. 

34)     Yijuan Zhang, Hong Pan, Pengfei Zhang, Ningning Gao, Yi Lin, Zichao Luo, Ping Li, Ce Wang, Lanlan Liu, Daiwen Pang, Lintao Cai*, Yifan Ma*. Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways. Nanoscale, 5(13):5919-29. 2013.

35)     Ping Li#, Zichao Luo#, Peng Liu, Ningning Gao, Yijuan Zhang, Hong Pan, Lanlan Liu, Ce Wang, Lintao Cai*, Yifan Ma*. Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune. J. Control. Release. 168(3), 271–279, 2013. 

36)     Zhaojuan Yang, Li Zhang, Aihui Ma, Lanlan Liu, Jinjun Li, Jianren Gu, Yongzhong Liu*. Transient mTOR Inhibition Facilitates Continuous Growth of Liver Tumors by Modulating the Maintenance of CD133+ Cell Populations. PLoS ONE. 6(12):e28405, 2011.

1)        Lanlan Liu; Ce Wang; Yifan Ma. Nanovaccine-based gene-immune therapy robustly elicits anti-tumor immune response in vivo. ChinaNANO2015.

2)        Yifan Ma ; Ce Wang ; Lanlan Liu ; Huqiang Yi ; Lintao Cai. Nanovaccine-based immuno-gene therapy robustly elicits anti-tumor immune response in vivo. ChinaNANO2015.

3)        Lanlan Liu, Lintao Cai, Yifan Ma*：Integrated nanovaccine with microRNA-148a inhibition reprograms tumor-associated dendritic cells by modulating miR-148a/DNMT1/SOCS1 axis. The 14th International Symposium on Dendritic Cells, 2016.

4)        Yifan Ma*, Lanlan Liu, Huqiang Yi. Nanovaccine-based immuno-gene therapy: Targeting microRNA-148a for reprogramming tumor-associated dendritic cells in vivo. IMMUNOLOGY 2016TM, Seattle, Washington, May 13-17, 2016. (oral)

5)        Lanlan Liu, Zhikuan Chen, Ruijing Liang, Huamei He, Haimei Zhou, Mingbin Zheng and Lintao Cai*. Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect. The 3rd International Conference on Nanomedicine. 2018.

6)        Huamei He, Lanlan Liu, Ruijing Liang, Haimei Zhou, Zhikuan Chen and Lintao Cai*. Targeted Co-Delivery of Zinc Protoporphyrin IX and Adjuvant to Reprogramme Tumor-Associated Macrophages for Effective Cancer Immunotherapy. The 3rd International Conference on Nanomedicine. 2018.

7)        Lanlan Liu and Lintao Cai*. Bioinspired hybrid protein oxygen nanocarrier amplified photodynamic therapy for eliciting anti-tumor immunity and abscopal effect. ChinaNANO2019.

8)        Lanlan Liu, Ruijing Liang, Huamei He, Haimei Zhou and Lintao Cai*. Targeted oxygen-enhanced photodynamic therapy for inducing anti-tumor immunity. CASNN2019.

9)        Huamei He, Lanlan Liu, Ruijing Liang, Haimei Zhou and Lintao Cai*, Tumor microenvironment responsive nanoparticle for targeted oxygen-elevated phototherapy and ehhanced anti-cancer immunity via immunogenic cancer cell death. CASNN2019.

10)    Ruijing Liang, Lanlan Liu, Huamei He, shengping zhang and Lintao Cai*, Smart gold nanocages for oxygen-boosted and immune-stimulative photodynamic therapy. CASNN2019.

11)    Lanlan Liu, Lintao Cai*. Photosynthetic Bacteria Engineered Biohybrid System for Robust Photodynamic Therapy and Chemotherapy of Cancer. 2020 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 

Ø  Shenzhen Science and Technology Program

Directional synthesis and therapeutic application of novel photosynthesizing micro-nano biorobot. RMB 2500,000. 2021/08-2024/08. Project leader.

Photosynthetic bacteria combined with photodynamic nanoparticles for antitumor immunotherapy and mechanism studies. RMB 300,000. 2019/04-2021/03. Project leader.

Ø  National Natural Science Foundation of China

The study of engineered cyanobacteria micro/nano-biomimetic robot in regulation of tumor microenvironment and precision therapy. RMB 660,800. 2021/01-2024/12. Project leader.

Photosynthetic bacteria carrying photosensitizer-encapsulated nanoparticles for anti-cancer immunogenic photodynamic therapy and mechanism studies. RMB 250,000. 2019/01-2021/12. Project leader.

The study of live CAR T cell nanodrug in regulation of immunomicroenvironment and antitumor immunotherapy. RMB 550,000. 2020/01-2023/12.

Ø  Natural Science Foundation of Guangdong Province

Research on hybrid protein oxygen nanocarrier amplified photodynamic therapy and antitumor immunological mechanism. RMB 100,000. 2018/05-2021/04. Project leader.

现指导学生

蔡佳璇  硕士研究生  086000-生物与医药  

Honors and awards:

Ø  2020, The First Prize of Science and Technology of Shenzhen City;

Ø  2020, Beijing Ordinary Institutions of higher learning. Excellent Graduate;

Ø  2020, University of Chinese Academy of Sciences. Excellent Graduate;

Ø  2019, University of Chinese Academy of Sciences. Three good student;

Ø  2019, University of Chinese Academy of Sciences. Zhu Li Yue Hua Outstanding Doctoral Scholarship;

Ø  2019, University of Chinese Academy of Sciences. National Scholarship for Doctoral Students;

Ø  2019, Dean Prize of Chinese Academy of Sciences for Excellent Doctoral Students;

Ø  2019, University of Chinese Academy of Sciences. Academic Scholarship;

Ø  2019, the 7th Liyan Forum "New Era of Liyan, Big future of Bay Area" Academic Forum Competition. Second Prize;

Ø  2018, University of Chinese Academy of Sciences. Academic Scholarship;

Ø  2018, Chinananomedicine. Excellent Poster Award;

Ø  2018, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. Excellent staff;

Ø  2017, University of Chinese Academy of Sciences. Academic Scholarship;

Ø  2017, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. Excellent staff;

Ø  2016, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. Excellent staff.

Activities in the scientific community/memberships

Ø  Member of the Chinese Chemical Society;

Ø  Reviewer of ACS NANO Journal;

Ø  Reviewer of ACS Applied Materials & Interfaces Journal;

Ø  Evaluation Expert of National Natural Science Foundation of China;

Ø  Evaluation Expert of Natural Science Foundation of Guangdong Province.