基本信息
徐凤萍 女 硕导 深圳华大生命科学研究院
电子邮件： xufengping@genomics.cn
通信地址： 深圳市盐田区华大基因研究院综合楼
邮政编码：
电子邮件： xufengping@genomics.cn
通信地址： 深圳市盐田区华大基因研究院综合楼
邮政编码：
招生信息
招生专业
0710J3-生物信息学
0710Z1-基因组学
0710Z1-基因组学
招生方向
干细胞治疗
再生医学
生物信息学
再生医学
生物信息学
教育背景
2015-03--2019-02 哥本哈根大学 博士研究生学位
2006-09--2009-01 大连理工大学 硕士研究生学位
2001-09--2005-07 湖北师范大学 学士学位
2006-09--2009-01 大连理工大学 硕士研究生学位
2001-09--2005-07 湖北师范大学 学士学位
工作经历
工作简历
2021-06~现在, 深圳华大基因细胞科技有限责任公司, 副经理
2019-02~2021-06,深圳华大生命科学研究院, 副所长
2012-03~2015-02,华大基因研究院, 项目主管
2009-12~2012-02,华大基因科技事业部, 项目主管
2019-02~2021-06,深圳华大生命科学研究院, 副所长
2012-03~2015-02,华大基因研究院, 项目主管
2009-12~2012-02,华大基因科技事业部, 项目主管
专利与奖励
奖励信息
（1） 深圳市海外高层次人才, 三等奖, 市地级, 2019
（2） 深圳市盐田区“梧桐人才”, 三等奖, 市地级, 2019
（3） 深圳市盐田区生物产业高层次人才, 一等奖, 市地级, 2015
（2） 深圳市盐田区“梧桐人才”, 三等奖, 市地级, 2019
（3） 深圳市盐田区生物产业高层次人才, 一等奖, 市地级, 2015
专利成果
（ 1 ） 长链非编码RNA NONHSAT005760.2作为骨质疏松诊断标志物的应用, 发明专利, 2019, 第 3 作者, 专利号: CN110157794A
（ 2 ） 长链非编码RNA NONHSAG039951.2作为骨质疏松诊断标志物的应用, 发明专利, 2019, 第 3 作者, 专利号: CN110106249A
（ 3 ） 确定个体染色体结构异常的方法和系统, 发明专利, 2019, 第 1 作者, 专利号: CN 109280702 A
（ 4 ） 原发性免疫缺陷病的致病突变及其应用, 发明专利, 2018, 第 2 作者, 专利号: CN 108977449 A
（ 5 ） 基因突变体及其应用, 发明专利, 2017, 第 2 作者, 专利号: CN 106987593 A
（ 2 ） 长链非编码RNA NONHSAG039951.2作为骨质疏松诊断标志物的应用, 发明专利, 2019, 第 3 作者, 专利号: CN110106249A
（ 3 ） 确定个体染色体结构异常的方法和系统, 发明专利, 2019, 第 1 作者, 专利号: CN 109280702 A
（ 4 ） 原发性免疫缺陷病的致病突变及其应用, 发明专利, 2018, 第 2 作者, 专利号: CN 108977449 A
（ 5 ） 基因突变体及其应用, 发明专利, 2017, 第 2 作者, 专利号: CN 106987593 A
出版信息
发表论文
[1] Clin Transl Med.. 2024, 通讯作者
[2] Heliyon. 2024, 通讯作者
[3] Yong,Zhang, Qinghua,Wang, Zhongyi,Zhu, Shujuan,Wang, Shuyang,Tu, Yongqiang,Zhang, Yanli,Zou, Yutian,Liu, Chunju,Liu, Weijie,Ren, Dongxia,Zheng, Yunling,Zhao, Yongxin,Hu, Lin,Li, Chuan,Shi, Shengqiang,Ge, Peng,Lin, Fengping,Xu, Jinmin,Ma, Xiaodong,Wu, Hongchao,Ma, Zhiliang,Wang, Jingyue,Bao, Jordi,Casal. Tracing the Origin of Genotype II African Swine Fever Virus in China by Genomic Epidemiology Analysis. Transboundary and Emerging Diseases. 2023, 第 18 作者2023: https://dx.doi.org/10.1155/2023/4820809.
[4] Jingyue Bao, Yong Zhang, Chuan Shi, Qinghua Wang, Shujuan Wang, Xiaodong Wu, Shengbo Cao, Fengping Xu, Zhiliang Wang, Katja Schulz, Anette Boklund. Genome-Wide Diversity Analysis of African Swine Fever Virus Based on a Curated Dataset. ANIMALS : AN OPEN ACCESS JOURNAL FROM MDPI. 2022, 第 8 作者12(18): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495133/.
[5] Jovic, Dragomirka, Liang, Xue, Zeng, Hua, Lin, Lin, Xu, Fengping, Luo, Yonglun. Single-cell RNA sequencing technologies and applications: A brief overview. CLINICAL AND TRANSLATIONAL MEDICINE. 2022, 第 5 作者12(3): http://dx.doi.org/10.1002/ctm2.694.
[6] Li, Conghui, Zhang, Yue, Leng, Lizhi, Pan, Xiaoguang, Zhao, Depeng, Li, Xuemei, Huang, Jinrong, Bolund, Lars, Lin, Ge, Luo, Yonglun, Xu, Fengping. The single-cell expression profile of transposable elements and transcription factors in human early biparental and uniparental embryonic development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 第 11 作者 通讯作者 10: http://dx.doi.org/10.3389/fcell.2022.1020490.
[7] Bao, Jingyue, Zhang, Yong, Shi, Chuan, Wang, Qinghua, Wang, Shujuan, Wu, Xiaodong, Cao, Shengbo, Xu, Fengping, Wang, Zhiliang. Genome-Wide Diversity Analysis of African Swine Fever Virus Based on a Curated Dataset. ANIMALS[J]. 2022, 第 8 作者 通讯作者 12(18): http://dx.doi.org/10.3390/ani12182446.
[8] Xiang, Xi, Corsi, Giulia, I, Anthon, Christian, Qu, Kunli, Pan, Xiaoguang, Liang, Xue, Han, Peng, Dong, Zhanying, Liu, Lijun, Zhong, Jiayan, Ma, Tao, Wang, Jinbao, Zhang, Xiuqing, Jiang, Hui, Xu, Fengping, Liu, Xin, Xu, Xun, Wang, Jian, Yang, Huanming, Bolund, Lars, Church, George M, Lin, Lin, Gorodkin, Jan, Luo, Yonglun. Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. NATURE COMMUNICATIONS[J]. 2021, 第 15 作者12(1): 1-9, http://dx.doi.org/10.1038/s41467-021-23576-0.
[9] Zhang, Chenxi, Li, Conghui, Yang, Ling, Leng, Lizhi, Jovic, Dragomirka, Wang, Jun, Fang, Fang, Li, Guibo, Zhao, Depeng, Li, Xuemei, Lin, Lin, Luo, Yonglun, Bolund, Lars, Huang, Jinrong, Lin, Ge, Xu, Fengping. The Dynamic Changes of Transcription Factors During the Development Processes of Human Biparental and Uniparental Embryos. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 第 16 作者 通讯作者 9: http://dx.doi.org/10.3389/fcell.2021.709498.
[10] Yu, Jiaying, Xiang, Xi, Huang, Jinrong, Liang, Xue, Pan, Xiaoguang, Dong, Zhanying, Petersen, Trine Skov, Qu, Kunli, Yang, Ling, Zhao, Xiaoying, Li, Siyuan, Zheng, Tianyu, Xu, Zhe, Liu, Chengxun, Han, Peng, Xu, Fengping, Yang, Huanming, Liu, Xin, Zhang, Xiuqing, Bolund, Lars, Luo, Yonglun, Lin, Lin. Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 16 作者48(5): e25-e25, https://www.webofscience.com/wos/woscc/full-record/WOS:000525957100001.
[11] Luo, Lidan, Zhou, Yan, Zhang, Chenxi, Huang, Jinrong, Du, Jie, Liao, Jinqi, Bergholt, Natasja Leth, Bunger, Cody, Xu, Fengping, Lin, Lin, Tong, Guangdong, Zhou, Guangqian, Luo, Yonglun. Feeder-free generation and transcriptome characterization of functional mesenchymal stromal cells from human pluripotent stem cells. STEM CELL RESEARCH[J]. 2020, 第 9 作者48: http://dx.doi.org/10.1016/j.scr.2020.101990.
[12] Leng, Lizhi, Sun, Jiya, Huang, Jinrong, Gong, Fei, Yang, Ling, Zhang, Shuoping, Yuan, Xuye, Fang, Fang, Xu, Xun, Luo, Yonglun, Bolund, Lars, Peters, Brock A, Lu, Guangxiu, Jiang, Taijiao, Xu, Fengping, Lin, Ge. Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development. CELL STEM CELL[J]. 2019, 第 15 作者 通讯作者 25(5): 697-+,
[13] Zirui Dong, Junhao Yan, Fengping Xu, Jianying Yuan, Hui Jiang, Huilin Wang, Haixiao Chen, Lei Zhang, Lingfei Ye, Jinjin Xu, Yuhua Shi, Zhenjun Yang, Ye Cao, Lingyun Chen, Qiaoling Li, Xia Zhao, Jiguang Li, Ao Chen, Wenwei Zhang, Hoi Gin Wong, Yingying Qin, Han Zhao, Yuan Chen, Pei Li, Tao Ma, WenJing Wang, Yvonne K Kwok, Yuan Jiang, Amber N Pursley, Jacqueline PW Chung, Yan Hong, Karsten Kristiansen, Huanming Yang, Raul E PiaAguilar, Tak Yeung Leung, Sau Wai Cheung, Cynthia C Morton, Kwong Wai Choy, ZiJiang Chen. Genome Sequencing Explores Complexity of Chromosomal Abnormalities in Recurrent Miscarriage. THE AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2019, 第 3 作者105(6): 1102-1111, http://dx.doi.org/10.1016/j.ajhg.2019.10.003.
[14] Chen, Muwan, Laursen, Sofie H, Habekost, Mette, Knudsen, Camilla H, Buchholdt, Susanne H, Huang, Jinrong, Xu, Fengping, Liu, Xin, Bolund, Lars, Luo, Yonglun, Nissen, Poul, Febbraro, Fabia, Denham, Mark. Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2018, 第 7 作者6: https://doaj.org/article/75706b549ff94d05b1824beb2b089326.
[15] Lin, Lin, Liu, Yong, Xu, Fengping, Huang, Jinrong, Daugaard, Tina Fuglsang, Petersen, Trine Skov, Hansen, Bettina, Ye, Lingfei, Zhou, Qing, Fang, Fang, Yang, Ling, Li, Shengting, Floe, Lasse, Jensen, Kristopher Torp, Shrock, Ellen, Chen, Fang, Yang, Huanming, wang, Jian, Liu, Xin, Xu, Xun, Bolund, Lars, Nielsen, Anders Lade, Luo, Yonglun. Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases. GIGASCIENCE[J]. 2018, 第 3 作者7(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000429091600001.
[16] Liu, Bin, Palmfeldt, Johan, Lin, Lin, Colaco, Alexandria, Clemmensen, Knut K B, Huang, Jinrong, Xu, Fengping, Liu, Xin, Maeda, Kenji, Luo, Yonglun, Jaattela, Marja. STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH. CELL RESEARCH[J]. 2018, 第 7 作者28(10): 996-1012, http://dx.doi.org/10.1038/s41422-018-0080-0.
[2] Heliyon. 2024, 通讯作者
[3] Yong,Zhang, Qinghua,Wang, Zhongyi,Zhu, Shujuan,Wang, Shuyang,Tu, Yongqiang,Zhang, Yanli,Zou, Yutian,Liu, Chunju,Liu, Weijie,Ren, Dongxia,Zheng, Yunling,Zhao, Yongxin,Hu, Lin,Li, Chuan,Shi, Shengqiang,Ge, Peng,Lin, Fengping,Xu, Jinmin,Ma, Xiaodong,Wu, Hongchao,Ma, Zhiliang,Wang, Jingyue,Bao, Jordi,Casal. Tracing the Origin of Genotype II African Swine Fever Virus in China by Genomic Epidemiology Analysis. Transboundary and Emerging Diseases. 2023, 第 18 作者2023: https://dx.doi.org/10.1155/2023/4820809.
[4] Jingyue Bao, Yong Zhang, Chuan Shi, Qinghua Wang, Shujuan Wang, Xiaodong Wu, Shengbo Cao, Fengping Xu, Zhiliang Wang, Katja Schulz, Anette Boklund. Genome-Wide Diversity Analysis of African Swine Fever Virus Based on a Curated Dataset. ANIMALS : AN OPEN ACCESS JOURNAL FROM MDPI. 2022, 第 8 作者12(18): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495133/.
[5] Jovic, Dragomirka, Liang, Xue, Zeng, Hua, Lin, Lin, Xu, Fengping, Luo, Yonglun. Single-cell RNA sequencing technologies and applications: A brief overview. CLINICAL AND TRANSLATIONAL MEDICINE. 2022, 第 5 作者12(3): http://dx.doi.org/10.1002/ctm2.694.
[6] Li, Conghui, Zhang, Yue, Leng, Lizhi, Pan, Xiaoguang, Zhao, Depeng, Li, Xuemei, Huang, Jinrong, Bolund, Lars, Lin, Ge, Luo, Yonglun, Xu, Fengping. The single-cell expression profile of transposable elements and transcription factors in human early biparental and uniparental embryonic development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 第 11 作者 通讯作者 10: http://dx.doi.org/10.3389/fcell.2022.1020490.
[7] Bao, Jingyue, Zhang, Yong, Shi, Chuan, Wang, Qinghua, Wang, Shujuan, Wu, Xiaodong, Cao, Shengbo, Xu, Fengping, Wang, Zhiliang. Genome-Wide Diversity Analysis of African Swine Fever Virus Based on a Curated Dataset. ANIMALS[J]. 2022, 第 8 作者 通讯作者 12(18): http://dx.doi.org/10.3390/ani12182446.
[8] Xiang, Xi, Corsi, Giulia, I, Anthon, Christian, Qu, Kunli, Pan, Xiaoguang, Liang, Xue, Han, Peng, Dong, Zhanying, Liu, Lijun, Zhong, Jiayan, Ma, Tao, Wang, Jinbao, Zhang, Xiuqing, Jiang, Hui, Xu, Fengping, Liu, Xin, Xu, Xun, Wang, Jian, Yang, Huanming, Bolund, Lars, Church, George M, Lin, Lin, Gorodkin, Jan, Luo, Yonglun. Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. NATURE COMMUNICATIONS[J]. 2021, 第 15 作者12(1): 1-9, http://dx.doi.org/10.1038/s41467-021-23576-0.
[9] Zhang, Chenxi, Li, Conghui, Yang, Ling, Leng, Lizhi, Jovic, Dragomirka, Wang, Jun, Fang, Fang, Li, Guibo, Zhao, Depeng, Li, Xuemei, Lin, Lin, Luo, Yonglun, Bolund, Lars, Huang, Jinrong, Lin, Ge, Xu, Fengping. The Dynamic Changes of Transcription Factors During the Development Processes of Human Biparental and Uniparental Embryos. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 第 16 作者 通讯作者 9: http://dx.doi.org/10.3389/fcell.2021.709498.
[10] Yu, Jiaying, Xiang, Xi, Huang, Jinrong, Liang, Xue, Pan, Xiaoguang, Dong, Zhanying, Petersen, Trine Skov, Qu, Kunli, Yang, Ling, Zhao, Xiaoying, Li, Siyuan, Zheng, Tianyu, Xu, Zhe, Liu, Chengxun, Han, Peng, Xu, Fengping, Yang, Huanming, Liu, Xin, Zhang, Xiuqing, Bolund, Lars, Luo, Yonglun, Lin, Lin. Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 16 作者48(5): e25-e25, https://www.webofscience.com/wos/woscc/full-record/WOS:000525957100001.
[11] Luo, Lidan, Zhou, Yan, Zhang, Chenxi, Huang, Jinrong, Du, Jie, Liao, Jinqi, Bergholt, Natasja Leth, Bunger, Cody, Xu, Fengping, Lin, Lin, Tong, Guangdong, Zhou, Guangqian, Luo, Yonglun. Feeder-free generation and transcriptome characterization of functional mesenchymal stromal cells from human pluripotent stem cells. STEM CELL RESEARCH[J]. 2020, 第 9 作者48: http://dx.doi.org/10.1016/j.scr.2020.101990.
[12] Leng, Lizhi, Sun, Jiya, Huang, Jinrong, Gong, Fei, Yang, Ling, Zhang, Shuoping, Yuan, Xuye, Fang, Fang, Xu, Xun, Luo, Yonglun, Bolund, Lars, Peters, Brock A, Lu, Guangxiu, Jiang, Taijiao, Xu, Fengping, Lin, Ge. Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development. CELL STEM CELL[J]. 2019, 第 15 作者 通讯作者 25(5): 697-+,
[13] Zirui Dong, Junhao Yan, Fengping Xu, Jianying Yuan, Hui Jiang, Huilin Wang, Haixiao Chen, Lei Zhang, Lingfei Ye, Jinjin Xu, Yuhua Shi, Zhenjun Yang, Ye Cao, Lingyun Chen, Qiaoling Li, Xia Zhao, Jiguang Li, Ao Chen, Wenwei Zhang, Hoi Gin Wong, Yingying Qin, Han Zhao, Yuan Chen, Pei Li, Tao Ma, WenJing Wang, Yvonne K Kwok, Yuan Jiang, Amber N Pursley, Jacqueline PW Chung, Yan Hong, Karsten Kristiansen, Huanming Yang, Raul E PiaAguilar, Tak Yeung Leung, Sau Wai Cheung, Cynthia C Morton, Kwong Wai Choy, ZiJiang Chen. Genome Sequencing Explores Complexity of Chromosomal Abnormalities in Recurrent Miscarriage. THE AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2019, 第 3 作者105(6): 1102-1111, http://dx.doi.org/10.1016/j.ajhg.2019.10.003.
[14] Chen, Muwan, Laursen, Sofie H, Habekost, Mette, Knudsen, Camilla H, Buchholdt, Susanne H, Huang, Jinrong, Xu, Fengping, Liu, Xin, Bolund, Lars, Luo, Yonglun, Nissen, Poul, Febbraro, Fabia, Denham, Mark. Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2018, 第 7 作者6: https://doaj.org/article/75706b549ff94d05b1824beb2b089326.
[15] Lin, Lin, Liu, Yong, Xu, Fengping, Huang, Jinrong, Daugaard, Tina Fuglsang, Petersen, Trine Skov, Hansen, Bettina, Ye, Lingfei, Zhou, Qing, Fang, Fang, Yang, Ling, Li, Shengting, Floe, Lasse, Jensen, Kristopher Torp, Shrock, Ellen, Chen, Fang, Yang, Huanming, wang, Jian, Liu, Xin, Xu, Xun, Bolund, Lars, Nielsen, Anders Lade, Luo, Yonglun. Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases. GIGASCIENCE[J]. 2018, 第 3 作者7(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000429091600001.
[16] Liu, Bin, Palmfeldt, Johan, Lin, Lin, Colaco, Alexandria, Clemmensen, Knut K B, Huang, Jinrong, Xu, Fengping, Liu, Xin, Maeda, Kenji, Luo, Yonglun, Jaattela, Marja. STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH. CELL RESEARCH[J]. 2018, 第 7 作者28(10): 996-1012, http://dx.doi.org/10.1038/s41422-018-0080-0.
科研活动
科研项目
（ 1 ） 基于多组学技术的抗乙肝肝硬化的“益气活血化 积”复方中药研究, 参与, 地方任务, 2020-01--2022-12
（ 2 ） 舒肝消脂方对于NAFLD患者基因表达调控及肠道微生物菌群的影响, 负责人, 地方任务, 2018-04--2021-12
（ 3 ） 子宫内膜容受性的无创评估体系建立和应用研究, 参与, 地方任务, 2020-11--2023-11
（ 4 ） 胚胎发育微环境转录组10x genomics研究, 负责人, 研究所自选, 2019-05--2021-06
（ 5 ） 基 20220185 间充质干细胞（MSC）改善卵巢衰老的作用机制研究, 参与, 地方任务, 2023-02--2026-02
（ 2 ） 舒肝消脂方对于NAFLD患者基因表达调控及肠道微生物菌群的影响, 负责人, 地方任务, 2018-04--2021-12
（ 3 ） 子宫内膜容受性的无创评估体系建立和应用研究, 参与, 地方任务, 2020-11--2023-11
（ 4 ） 胚胎发育微环境转录组10x genomics研究, 负责人, 研究所自选, 2019-05--2021-06
（ 5 ） 基 20220185 间充质干细胞（MSC）改善卵巢衰老的作用机制研究, 参与, 地方任务, 2023-02--2026-02
参与会议
（1）基因表达调控对非酒精性脂肪肝发生的影响 2020年广东省中医药学会肝病专业委员会学术年会 2020-09-04
（2）The Dynamic Changes of Transcription Factors During Development Processes of Uniparental Embryos ICG-14国际基因组大会 2019-10-24
（3）非酒精性脂肪肝基因组学研究进展 2019年广东省中医药学会肝病专业委员会学术年会 2019-06-21
（4）高通量测序在再生医学中的应用 深圳市医疗卫生“三名工程”丹麦奥胡斯大学Lars Bolund教授肝脏疾病基因医学-再生医学团队国际肝病会议 2018-08-17
（2）The Dynamic Changes of Transcription Factors During Development Processes of Uniparental Embryos ICG-14国际基因组大会 2019-10-24
（3）非酒精性脂肪肝基因组学研究进展 2019年广东省中医药学会肝病专业委员会学术年会 2019-06-21
（4）高通量测序在再生医学中的应用 深圳市医疗卫生“三名工程”丹麦奥胡斯大学Lars Bolund教授肝脏疾病基因医学-再生医学团队国际肝病会议 2018-08-17
指导学生
现指导学生
王丹 硕士研究生 086000-生物与医药
王憬元 硕士研究生 071007-遗传学