100104-病理学与病理生理学

病理学与病理生理学-核酸RNA药物；肿瘤病理中的RNA可变剪接调控

2002-09--2007-07   中国科学院华南植物研究所   博士研究生
1998-09--2002-07   四川大学   本科/学士

   

2016-03~现在, 中国科学院上海营养与健康研究所, 副研究员
2007-07~2016-03,复旦大学, 青年骨干教师
2002-09~2007-07,中国科学院华南植物研究所, 博士研究生
1998-09~2002-07,四川大学, 本科/学士

2023-01-01-今,期刊编辑, Guest Editor

   

（1） 第一届全国系统生物学大会, 二等奖, 专项, 2019

   

（1） RNA therapeutics: new vaccination and beyond, Fundamental Research, 2023, 通讯作者
（2） A flexible, efficient, and scalable platform to produce circular RNAs as new therapeutics, bioRxiv, 2022, 第 1 作者
（3） The splicing switch of SLK, a promising target for cancer metastasis regulation., biorxiv, 2022, 通讯作者
（4） A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation, SCIENCE BULLETIN, 2021, 通讯作者
（5） RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H, EBIOMEDICINE, 2020, 第 8 作者
（6） Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning, CELL SYSTEMS, 2018, 第 5 作者
（7） Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, 第 1 作者
（8） Conformational Features of ACE-Inhibitory Valine-Isoleucine-Proline Tripeptide in Aqueous Medium According to Molecular Dynamic Simulations and 2D-NMR Spectroscopy, JOURNAL OF SOLUTION CHEMISTRY, 2016, 第 3 作者
（9） A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation, NATURE COMMUNICATIONS, 2016, 第 6 作者
（10） Engineering RNA-binding proteins with diverse activities, WILEY INTERDISCIPLINARY REVIEWS-RNA, 2015, 第 1 作者
（11） U0126 inhibits pancreatic cancer progression via the KRAS signaling pathway in a zebrafish xenotransplantation model, ONCOLOGY REPORTS, 2015, 第 2 作者
（12） DNA methylation regulates bromodomain-containing protein 2 expression during adipocyte differentiation, MOLECULAR AND CELLULAR BIOCHEMISTRY, 2015, 第 5 作者
（13） Paecilomycins J–M, four new β-resorcylic acid lactones from Paecilomyces sp. SC0924, TETRAHEDRON LETTERS, 2013, 第 3 作者
（14） Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following Fc epsilon RI Aggregation, PLOS ONE, 2012, 第 5 作者
（15） Monocillin II Inhibits Human Breast Cancer Growth Partially by Inhibiting MAPK Pathways and CDK2 Thr160 Phosphorylation, CHEMBIOCHEM, 2012, 第 1 作者
（16） Sesquiterpenes and Lignans from Tephrosia vogelii, HELVETICA CHIMICA ACTA, 2009, 第 1 作者
（17） Chemical constituents of the seeds of Ammopiptanthus (Leguminosae) and their systematic and ecological significance, BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2007, 第 1 作者

   

（ 1 ） 剪接因子精氨酸甲基化修饰在癌症相关可变剪接中功能的研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 癌症中SLK异常剪接的生物功能、分子机制和人工干预, 负责人, 地方任务, 2020-07--2024-06

（1）Systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global regulation of splicing and translation    2022-02-02
（2）A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation   2021-06-21