基本信息
李青连 女 博导 中国科学院南海海洋研究所
电子邮件： liql@scsio.ac.cn
通信地址： 广州市海珠区新港西路164号5号楼405
邮政编码： 510301
电子邮件： liql@scsio.ac.cn
通信地址： 广州市海珠区新港西路164号5号楼405
邮政编码： 510301
招生信息
招生专业
070703-海洋生物学
招生方向
海洋微生物活性次级代谢产物发现和生物合成
教育背景
2010-09--2013-07 北京协和医学院 博士
2007-09--2010-07 首都师范大学 硕士
2003-09--2007-07 首都师范大学 本科
2007-09--2010-07 首都师范大学 硕士
2003-09--2007-07 首都师范大学 本科
工作经历
工作简历
2022-12~现在, 中国科学院南海海洋研究所, 研究员
2020-12~2022-11,中国科学院南海海洋研究所, 项目研究员
2016-01~2020-11,中国科学院南海海洋研究所, 副研究员
2013-07~2015-12,中国科学院南海海洋研究所, 助理研究员
2020-12~2022-11,中国科学院南海海洋研究所, 项目研究员
2016-01~2020-11,中国科学院南海海洋研究所, 副研究员
2013-07~2015-12,中国科学院南海海洋研究所, 助理研究员
专利与奖励
奖励信息
（1） 广东省自然资源科学技术奖, 一等奖, 省级, 2021
专利成果
[1] 李青连, 鞠建华, 梁智铖, 李骏, 凌春耀. 4’-N-demethyl-vicenistatin及其制备方法和应用. CN: CN113912658A, 2022-01-11.
[2] 李青连, 许润, 宋永相, 李骏, 鞠建华. 一种环六肽化合物desotamide A4及其在制备抗菌药物中的应用. CN: CN113150077A, 2021-07-23.
[3] 鞠建华, 陈姜, 桂春, 李青连, 田新朋. 一种定向生产抗病毒和抗菌活性化合物的基因工程菌株及其应用. CN: CN111269867A, 2020-06-12.
[4] 鞠建华, 邵明伟, 孙长利, 李青连, 王晓雪. 一种海洋真菌-细菌共生体及其代谢产物和在制备抗菌药物中的应用. CN: CN112694983A, 2021-04-23.
[5] 鞠建华, 刘梦婵, 孙长利, 马俊英, 李青连. 一类双脱甲基放线菌素衍生物及其在制备抗耐药菌感染药物中的应用. CN: CN110669103A, 2020-01-10.
[6] 鞠建华, 宋永相, 李青连, 胡云峰. 一类大环内酯化合物及其在制备抗肿瘤药物中的应用. CN: CN106632221A, 2017-05-10.
[7] 鞠建华, 桂春, 李青连, 程伟鸽. 一种海洋链霉菌及其在制备那西肽中的应用. CN: CN106119157A, 2016-11-16.
[8] 李青连, 鞠建华, 秦湘静, 刘静. 一种高产环肽类化合物的菌株. CN: CN108587991A, 2018-09-28.
[9] 李青连, 鞠建华, 秦湘静, 刘静. 一种高产含有L-Val结构单元的化合物的菌株△mfnH. CN: CN108486028A, 2018-09-04.
[10] 鞠建华, 李青连, 秦湘静, 刘静. 氨基转移酶和异构酶在催化形成L-allo-Ile中的应用. CN: CN105154487A, 2015-12-16.
[11] 鞠建华, 朱清华, 黄洪波, 宋永相, 马俊英, 李青连. 一类核苷类抗生素及其在制备抗菌药物中的应用. CN: CN105061537A, 2015-11-18.
[12] 鞠建华, 马俊英, 张云, 李青连, 黄洪波, 宋永相, 王博, 谢运昌. 环酯肽类抗生素黑莫他丁的高产菌株及其构建方法. CN: CN104164399A, 2014-11-26.
[2] 李青连, 许润, 宋永相, 李骏, 鞠建华. 一种环六肽化合物desotamide A4及其在制备抗菌药物中的应用. CN: CN113150077A, 2021-07-23.
[3] 鞠建华, 陈姜, 桂春, 李青连, 田新朋. 一种定向生产抗病毒和抗菌活性化合物的基因工程菌株及其应用. CN: CN111269867A, 2020-06-12.
[4] 鞠建华, 邵明伟, 孙长利, 李青连, 王晓雪. 一种海洋真菌-细菌共生体及其代谢产物和在制备抗菌药物中的应用. CN: CN112694983A, 2021-04-23.
[5] 鞠建华, 刘梦婵, 孙长利, 马俊英, 李青连. 一类双脱甲基放线菌素衍生物及其在制备抗耐药菌感染药物中的应用. CN: CN110669103A, 2020-01-10.
[6] 鞠建华, 宋永相, 李青连, 胡云峰. 一类大环内酯化合物及其在制备抗肿瘤药物中的应用. CN: CN106632221A, 2017-05-10.
[7] 鞠建华, 桂春, 李青连, 程伟鸽. 一种海洋链霉菌及其在制备那西肽中的应用. CN: CN106119157A, 2016-11-16.
[8] 李青连, 鞠建华, 秦湘静, 刘静. 一种高产环肽类化合物的菌株. CN: CN108587991A, 2018-09-28.
[9] 李青连, 鞠建华, 秦湘静, 刘静. 一种高产含有L-Val结构单元的化合物的菌株△mfnH. CN: CN108486028A, 2018-09-04.
[10] 鞠建华, 李青连, 秦湘静, 刘静. 氨基转移酶和异构酶在催化形成L-allo-Ile中的应用. CN: CN105154487A, 2015-12-16.
[11] 鞠建华, 朱清华, 黄洪波, 宋永相, 马俊英, 李青连. 一类核苷类抗生素及其在制备抗菌药物中的应用. CN: CN105061537A, 2015-11-18.
[12] 鞠建华, 马俊英, 张云, 李青连, 黄洪波, 宋永相, 王博, 谢运昌. 环酯肽类抗生素黑莫他丁的高产菌株及其构建方法. CN: CN104164399A, 2014-11-26.
出版信息
发表论文
[1] Journal of Antibiotics (Tokyo). 2024, 通讯作者
[2] Jounal of Natural Products. 2023, 通讯作者
[3] Tetrahedron. 2023, 通讯作者
[4] ACS Catalysis. 2023, 通讯作者
[5] Zhang, Huaran, Zhang, Chunyan, Li, Qinglian, Ma, Junying, Ju, Jianhua. Metabolic Blockade-Based Genome Mining Reveals Lipochain-Linked Dihydro-beta-alanine Synthetases Involved in Autucedine Biosynthesis. ORGANIC LETTERS[J]. 2022, 第 3 作者24(30): 5535-5540, http://dx.doi.org/10.1021/acs.orglett.2c01957.
[6] Organic Letters. 2022, 第 3 作者
[7] Frontiers in Microbiology. 2022, 第 5 作者
[8] ACS Synthetic Biology. 2022, 第 5 作者
[9] Organic Letters. 2022, 第 4 作者
[10] Journal of Natural Products. 2022, 通讯作者
[11] Marine Drugs. 2021, 通讯作者
[12] Chinese Journal of Chemistry. 2021, 通讯作者
[13] Jounal of Natural Products. 2021, 第 7 作者
[14] PLoS One. 2021, 通讯作者
[15] Marine Drugs. 2021, 通讯作者
[16] Applied Microbiology and Biotechnology. 2020, 通讯作者
[17] ACS Catalysis. 2020, 通讯作者
[18] Organic Letters. 2020, 通讯作者
[19] Shao, Mingwei, Sun, Changli, Liu, Xiaoxiao, Wang, Xiaoxue, Li, Wenli, Wei, Xiaoyi, Li, Qinglian, Ju, Jianhua. Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont. COMMUNICATIONS BIOLOGY[J]. 2020, 第 7 作者 通讯作者 3(1): http://dx.doi.org/10.1038/s42003-020-01239-y.
[20] Chen, Jiang, Gui, Chun, Wei, Qiuyu, Liu, Jie, Ye, Li, Tian, Xinpeng, Gu, YuCheng, Li, Qinglian, Ju, Jianhua. Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity. ORGANIC LETTERS[J]. 2020, 第 8 作者22(12): 4627-4632, https://www.webofscience.com/wos/woscc/full-record/WOS:000543669800009.
[21] Qinglian Li, Wenjuan Ding, Jiajia Tu, Changbiao Chi, Hongbo Huang, Xiaoqi Ji, Ziwei Yao, Ming Ma, Jianhua Ju. Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes 4+2 Cycloaddition during Neoabyssomicin Biosynthesis. ACS OMEGA[J]. 2020, 第 1 作者 通讯作者 5(32): 20548-20557, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000563015100063.
[22] Communications Biology. 2019, 第 8 作者
[23] Marine Drugs. 2019, 第 3 作者
[24] Shao, Mingwei, Ma, Juying, Li, Qinglian, Ju, Jianhua. Identification of the Anti-Infective Aborycin Biosynthetic Gene Cluster from Deep-Sea-Derived Streptomyces sp. SCSIO ZS0098 Enables Production in a Heterologous Host. MARINE DRUGS[J]. 2019, 第 3 作者17(2): https://doaj.org/article/7f373699161b46e38245d30799538d3f.
[25] Marine Drugs. 2019, 第 3 作者
[26] Zhu, Qinghua, Song, Yongxiang, Huang, Hongbo, Li, Qinglian, Ju, Jianhua. Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2019, 第 4 作者 通讯作者 17(15): 3760-3764,
[27] Sun, Changli, Zhang, Chunyan, Qin, Xiangjing, Wei, Xiaoyi, Liu, Qing, Li, Qinglian, Ju, Jianhua. Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations. TETRAHEDRON[J]. 2018, 第 6 作者74(1): 199-203, http://dx.doi.org/10.1016/j.tet.2017.11.069.
[28] Zhang, Chunyan, Sun, Changli, Huang, Hongbo, Gui, Chun, Wang, Liyan, Li, Qinglian, Ju, Jianhua. Biosynthetic Baeyer-Villiger Chemistry Enables Access to Two Anthracene Scaffolds from a Single Gene Cluster in Deep-Sea-Derived Streptomyces olivaceus SCSIO T05. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 第 6 作者81(7): 1570-1577, https://www.webofscience.com/wos/woscc/full-record/WOS:000440505900010.
[29] Tu, Jiajia, Li, Siting, Chen, Jiang, Song, Yongxiang, Fu, Shaobin, Ju, Jianhua, Li, Qinglian. Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802. MICROBIAL CELL FACTORIES[J]. 2018, 第 7 作者 通讯作者 17(1): https://doaj.org/article/1a921d3caeea4a7fbc7fab8c898002f5.
[30] Li, Qinglian, Ding, Wenjuan, Yao, Ziwei, Tu, Jiajia, Wang, Liyan, Huang, Hongbo, Li, Shengying, Ju, Jianhua. AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis. ORGANIC LETTERS[J]. 2018, 第 1 作者 通讯作者 20(16): 4854-4857, http://ir.qibebt.ac.cn/handle/337004/11990.
[31] Sun, Jianbin, Shao, Junli, Sun, Changli, Song, Yongxiang, Li, Qinglian, Lu, Laichun, Hu, Yunfeng, Gui, Chun, Zhang, Hua, Ju, Jianhua. Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2018, 第 5 作者26(8): 1488-1494, http://dx.doi.org/10.1016/j.bmc.2018.01.010.
[32] Zhu, Qinghua, Chen, Qi, Song, Yongxiang, Huang, Hongbo, Li, Jun, Ma, Junying, Li, Qinglian, Ju, Jianhua. Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 7 作者114(19): 4948-4953, http://ir.scsio.ac.cn/handle/344004/16284.
[33] 陈奇, 秦湘静, 李青连, 鞠建华. Marinacarbolines甲基化基因mcbD的筛选及其功能. 微生物学报[J]. 2017, 第 3 作者57(7): 1095-1105, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20170715?st=article_issue.
[34] 黄洪波, 贾艳玺, 谢运昌, 李青连, 马俊英, 鞠建华. 海洋放线菌Streptomyces costaricanus SCSIO ZS0073中fungichromin生物合成基因簇的分析鉴定. 中国海洋药物[J]. 2017, 第 4 作者36(6): 1-10, http://lib.cqvip.com/Qikan/Article/Detail?id=674273463.
[35] 李宏志, 刘静, 李青连, 鞠建华. 抗感染海洋天然产物marformycin生物合成基因簇中调控基因及转运基因的功能研究. 中国海洋药物[J]. 2016, 第 3 作者35(1): 10-18, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5645495&detailType=1.
[36] 程伟鸽, 桂春, 鞠建华, 李青连. 1株海洋来源Streptomyces sp.SCSIO 1682中那西肽（nosiheptide）的分离鉴定及其生物合成基因簇分析. 中国海洋药物[J]. 2016, 第 4 作者35(6): 7-14, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5874405&detailType=1.
[37] Li, Qinglian, Qin, Xiangjing, Liu, Jing, Gui, Chun, Wang, Bo, Li, Jie, Ju, Jianhua. Deciphering the Biosynthetic Origin of L-allo-Isoleucine. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 第 1 作者138(1): 408-415, http://ir.scsio.ac.cn/handle/344004/15511.
[38] Gui, Chun, Li, Qinglian, Mo, Xuhua, Qin, Xiangjing, Ma, Junying, Ju, Jianhua. Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis. ORGANICLETTERS[J]. 2015, 第 2 作者17(3): 628-631, http://ir.scsio.ac.cn/handle/344004/14863.
[39] Li, Qinglian, Song, Yongxiang, Qin, Xiangjing, Zhang, Xing, Sun, Aijun, Ju, Jianhua. Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 第 1 作者78(4): 944-948, http://ir.scsio.ac.cn/handle/344004/14841.
[40] Changtao Ji, Qi Chen, Qinglian Li, Hongbo Huang, Yongxiang Song, Junying Ma, Jianhua Ju. Chemoenzymatic synthesis of β-carboline derivatives using McbA, a new ATP-dependent amide synthetase. TETRAHEDRON LETTERS. 2014, 第 3 作者55(35): 4901-4904, http://dx.doi.org/10.1016/j.tetlet.2014.07.004.
[41] Ji, Changtao, Chen, Qi, Li, Qinglian, Huang, Hongbo, Song, Yongxiang, Ma, Junying, Ju, Jianhua. Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase. TETRAHEDRON LETTERS[J]. 2014, 第 3 作者55(35): 4901-4904, https://www.webofscience.com/wos/woscc/full-record/WOS:000340985800013.
[42] Li, Qinglian, Wang, Lifei, Xie, Yunying, Wang, Songmei, Chen, Ruxian, Hong, Bin. SsaA, a Member of a Novel Class of Transcriptional Regulators, Controls Sansanmycin Production in Streptomyces sp Strain SS through a Feedback Mechanism. JOURNAL OF BACTERIOLOGY[J]. 2013, 第 1 作者195(10): 2232-2243, https://www.webofscience.com/wos/woscc/full-record/WOS:000318027800014.
[2] Jounal of Natural Products. 2023, 通讯作者
[3] Tetrahedron. 2023, 通讯作者
[4] ACS Catalysis. 2023, 通讯作者
[5] Zhang, Huaran, Zhang, Chunyan, Li, Qinglian, Ma, Junying, Ju, Jianhua. Metabolic Blockade-Based Genome Mining Reveals Lipochain-Linked Dihydro-beta-alanine Synthetases Involved in Autucedine Biosynthesis. ORGANIC LETTERS[J]. 2022, 第 3 作者24(30): 5535-5540, http://dx.doi.org/10.1021/acs.orglett.2c01957.
[6] Organic Letters. 2022, 第 3 作者
[7] Frontiers in Microbiology. 2022, 第 5 作者
[8] ACS Synthetic Biology. 2022, 第 5 作者
[9] Organic Letters. 2022, 第 4 作者
[10] Journal of Natural Products. 2022, 通讯作者
[11] Marine Drugs. 2021, 通讯作者
[12] Chinese Journal of Chemistry. 2021, 通讯作者
[13] Jounal of Natural Products. 2021, 第 7 作者
[14] PLoS One. 2021, 通讯作者
[15] Marine Drugs. 2021, 通讯作者
[16] Applied Microbiology and Biotechnology. 2020, 通讯作者
[17] ACS Catalysis. 2020, 通讯作者
[18] Organic Letters. 2020, 通讯作者
[19] Shao, Mingwei, Sun, Changli, Liu, Xiaoxiao, Wang, Xiaoxue, Li, Wenli, Wei, Xiaoyi, Li, Qinglian, Ju, Jianhua. Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont. COMMUNICATIONS BIOLOGY[J]. 2020, 第 7 作者 通讯作者 3(1): http://dx.doi.org/10.1038/s42003-020-01239-y.
[20] Chen, Jiang, Gui, Chun, Wei, Qiuyu, Liu, Jie, Ye, Li, Tian, Xinpeng, Gu, YuCheng, Li, Qinglian, Ju, Jianhua. Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity. ORGANIC LETTERS[J]. 2020, 第 8 作者22(12): 4627-4632, https://www.webofscience.com/wos/woscc/full-record/WOS:000543669800009.
[21] Qinglian Li, Wenjuan Ding, Jiajia Tu, Changbiao Chi, Hongbo Huang, Xiaoqi Ji, Ziwei Yao, Ming Ma, Jianhua Ju. Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes 4+2 Cycloaddition during Neoabyssomicin Biosynthesis. ACS OMEGA[J]. 2020, 第 1 作者 通讯作者 5(32): 20548-20557, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000563015100063.
[22] Communications Biology. 2019, 第 8 作者
[23] Marine Drugs. 2019, 第 3 作者
[24] Shao, Mingwei, Ma, Juying, Li, Qinglian, Ju, Jianhua. Identification of the Anti-Infective Aborycin Biosynthetic Gene Cluster from Deep-Sea-Derived Streptomyces sp. SCSIO ZS0098 Enables Production in a Heterologous Host. MARINE DRUGS[J]. 2019, 第 3 作者17(2): https://doaj.org/article/7f373699161b46e38245d30799538d3f.
[25] Marine Drugs. 2019, 第 3 作者
[26] Zhu, Qinghua, Song, Yongxiang, Huang, Hongbo, Li, Qinglian, Ju, Jianhua. Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2019, 第 4 作者 通讯作者 17(15): 3760-3764,
[27] Sun, Changli, Zhang, Chunyan, Qin, Xiangjing, Wei, Xiaoyi, Liu, Qing, Li, Qinglian, Ju, Jianhua. Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations. TETRAHEDRON[J]. 2018, 第 6 作者74(1): 199-203, http://dx.doi.org/10.1016/j.tet.2017.11.069.
[28] Zhang, Chunyan, Sun, Changli, Huang, Hongbo, Gui, Chun, Wang, Liyan, Li, Qinglian, Ju, Jianhua. Biosynthetic Baeyer-Villiger Chemistry Enables Access to Two Anthracene Scaffolds from a Single Gene Cluster in Deep-Sea-Derived Streptomyces olivaceus SCSIO T05. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 第 6 作者81(7): 1570-1577, https://www.webofscience.com/wos/woscc/full-record/WOS:000440505900010.
[29] Tu, Jiajia, Li, Siting, Chen, Jiang, Song, Yongxiang, Fu, Shaobin, Ju, Jianhua, Li, Qinglian. Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802. MICROBIAL CELL FACTORIES[J]. 2018, 第 7 作者 通讯作者 17(1): https://doaj.org/article/1a921d3caeea4a7fbc7fab8c898002f5.
[30] Li, Qinglian, Ding, Wenjuan, Yao, Ziwei, Tu, Jiajia, Wang, Liyan, Huang, Hongbo, Li, Shengying, Ju, Jianhua. AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis. ORGANIC LETTERS[J]. 2018, 第 1 作者 通讯作者 20(16): 4854-4857, http://ir.qibebt.ac.cn/handle/337004/11990.
[31] Sun, Jianbin, Shao, Junli, Sun, Changli, Song, Yongxiang, Li, Qinglian, Lu, Laichun, Hu, Yunfeng, Gui, Chun, Zhang, Hua, Ju, Jianhua. Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2018, 第 5 作者26(8): 1488-1494, http://dx.doi.org/10.1016/j.bmc.2018.01.010.
[32] Zhu, Qinghua, Chen, Qi, Song, Yongxiang, Huang, Hongbo, Li, Jun, Ma, Junying, Li, Qinglian, Ju, Jianhua. Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 7 作者114(19): 4948-4953, http://ir.scsio.ac.cn/handle/344004/16284.
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科研活动
科研项目
（ 1 ） 海洋稀有放线菌07399中聚酮聚肽类天然产物的挖掘及其生物合成, 负责人, 地方任务, 2021-01--2024-12
（ 2 ） 近海岸海洋微塑料原位生物降解技术, 负责人, 国家任务, 2023-12--2026-11
（ 2 ） 近海岸海洋微塑料原位生物降解技术, 负责人, 国家任务, 2023-12--2026-11