基本信息

陈联国 男 博导 中国科学院水生生物研究所
电子邮件: lchenam@ihb.ac.cn
通信地址: 湖北省武汉市武昌区东湖南路7号中科院水生所
邮政编码:
电子邮件: lchenam@ihb.ac.cn
通信地址: 湖北省武汉市武昌区东湖南路7号中科院水生所
邮政编码:
招生信息
招生专业
071004-水生生物学
090801-水产养殖
090801-水产养殖
招生方向
环境有机污染物,生态毒理学,水生生物,毒性机理,污染物环境行为
教育背景
2012-09--2016-11 香港科技大学 哲学博士
2008-09--2012-06 中国科学院水生生物研究所 硕士
2004-09--2008-06 中国海洋大学 学士
2008-09--2012-06 中国科学院水生生物研究所 硕士
2004-09--2008-06 中国海洋大学 学士
工作经历
工作简历
2018-09~现在, 中国科学院水生生物研究所, 研究员
2016-09~2018-08,香港城市大学海洋污染国家重点实验室, 博士后
2012-09~2016-11,香港科技大学, 哲学博士
2008-09~2012-06,中国科学院水生生物研究所, 硕士
2004-09~2008-06,中国海洋大学, 学士
2016-09~2018-08,香港城市大学海洋污染国家重点实验室, 博士后
2012-09~2016-11,香港科技大学, 哲学博士
2008-09~2012-06,中国科学院水生生物研究所, 硕士
2004-09~2008-06,中国海洋大学, 学士
专利与奖励
奖励信息
(1) 中科院武汉分院优秀研究生导师奖, 院级, 2021
(2) 国家青年海外人才计划, 国家级, 2020
(3) 武汉市黄鹤英才, 市地级, 2020
(4) 武汉市青年科技朝阳计划, 市地级, 2020
(5) 教育部自然科学二等奖, 二等奖, 部委级, 2019
(6) 湖北省青年****, 省级, 2019
(7) 湖北省青年科技晨光计划, 省级, 2019
(2) 国家青年海外人才计划, 国家级, 2020
(3) 武汉市黄鹤英才, 市地级, 2020
(4) 武汉市青年科技朝阳计划, 市地级, 2020
(5) 教育部自然科学二等奖, 二等奖, 部委级, 2019
(6) 湖北省青年****, 省级, 2019
(7) 湖北省青年科技晨光计划, 省级, 2019
专利成果
( 1 ) 一种Pull-down鉴定污染物分子靶点的方法, 2019, 第 1 作者, 专利号: CN110045128A
出版信息
发表论文
(1) Variability in fecal metabolome depending on age, PFBS pollutant, and fecal transplantation in zebrafish: A non-invasive diagnosis of health, Variability in fecal metabolome depending on age, PFBS pollutant, and fecal transplantation in zebrafish: A non-invasive diagnosis of health, JOURNAL OF ENVIRONMENTAL SCIENCES, 2023, 第 6 作者 通讯作者
(2) In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants, JOURNAL OF HAZARDOUS MATERIALS, 2021, 第 6 作者
(3) Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 8 作者
(4) Shift in skin microbiota and immune functions of zebrafish after combined exposure to perfluorobutanesulfonate and probiotic Lactobacillus rhamnosus, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 第 6 作者 通讯作者
(5) Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 第 6 作者 通讯作者
(6) Disturbances in Microbial and Metabolic Communication across the Gut-Liver Axis Induced by a Dioxin-like Pollutant: An Integrated Metagenomics and Metabolomics Analysis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 9 作者 通讯作者
(7) Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish, ENVIRONMENTAL POLLUTION, 2020, 第 7 作者 通讯作者
(8) Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish, ENVIRONMENT INTERNATIONAL, 2020, 第 7 作者
(9) Visual system: An understudied target of aquatic toxicology, AQUATIC TOXICOLOGY, 2020, 第 1 作者 通讯作者
(10) Unexpected Observations: Probiotic Administration Greatly Aggravates the Reproductive Toxicity of Perfluorobutanesulfonate in Zebrafish, CHEMICAL RESEARCH IN TOXICOLOGY, 2020, 第 8 作者 通讯作者
(11) Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish, CHEMOSPHERE, 2020, 第 8 作者 通讯作者
(12) Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology, CHEMOSPHERE, 2020, 第 6 作者 通讯作者
(13) Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos, ENVIRONMENTAL POLLUTION, 2020, 第 7 作者 通讯作者
(14) Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos, AQUATIC TOXICOLOGY, 2020, 第 7 作者 通讯作者
(15) Probiotic Modulation of Lipid Metabolism Disorders Caused by Perfluorobutanesulfonate Pollution in Zebrafish, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 1 作者 通讯作者
(16) Optical toxicity of triphenyl phosphate in zebrafish larvae, AQUATIC TOXICOLOGY, 2019, 第 3 作者
(17) Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 1 作者 通讯作者
(18) Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 第 6 作者 通讯作者
(19) Organic ultraviolet (UV) filters in the South China sea coastal region: Environmental occurrence, toxicological effects and risk assessment, ECOTOXICOLOGYANDENVIRONMENTALSAFETY, 2019, 第 2 作者
(20) Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish, ENVIRONMENTAL POLLUTION, 2019, 第 8 作者 通讯作者
(21) Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 第 2 作者
(22) Contamination by perfluoroalkyl substances and microbial community structure in Pearl River Delta sediments, ENVIRONMENTAL POLLUTION, 2019, 第 1 作者 通讯作者
(23) Variation in microbial community structure in surface seawater from Pearl River Delta: Discerning the influencing factors, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 第 1 作者 通讯作者
(24) Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 1 作者 通讯作者
(25) Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 5 作者
(26) TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure, CHEMOSPHERE, 2019, 第 1 作者 通讯作者
(27) Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2018, 第 1 作者 通讯作者
(28) Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 1 作者
(29) Dysregulation of Intestinal Health by Environmental Pollutants: Involvement of the Estrogen Receptor and Aryl Hydrocarbon Receptor, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 1 作者
(30) Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure, AQUATIC TOXICOLOGY, 2018, 第 1 作者
(31) Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern, Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern, 环境科学学报:英文版, 2017, 第 1 作者
(32) SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern, JOURNAL OF ENVIRONMENTAL SCIENCES, 2017, 第 1 作者 通讯作者
(33) Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3'-diindolylmethane (DIM), AQUATIC TOXICOLOGY, 2017, 第 1 作者
(34) Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 第 1 作者
(35) Optimization of antifouling coatings incorporating butenolide, a potent antifouling agent via field and laboratory tests, PROGRESS IN ORGANIC COATINGS, 2017, 第 1 作者
(36) Endocrine disruption throughout the hypothalamus-pituitary-gonadal-liver (hpgl) axis in marine medaka (oryzias melastigma) chronically exposed to the antifouling and chemopreventive agent, 3,3 '-diindolylmethane (dim), CHEMICAL RESEARCH IN TOXICOLOGY, 2016, 第 1 作者
(37) Chronic Exposure of Marine Medaka (Oryzias melastigma) to 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) Reveals Its Mechanism of Action in Endocrine Disruption via the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016, 第 1 作者
(38) High-throughput transcriptome sequencing of the cold seep mussel Bathymodiolus platifrons, SCIENTIFIC REPORTS, 2015, 第 4 作者
(39) Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT), AQUATIC TOXICOLOGY, 2014, 第 1 作者
(40) Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2013, 第 2 作者 通讯作者
(41) Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 第 1 作者
(42) Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio), AQUATIC TOXICOLOGY, 2012, 第 1 作者
(2) In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants, JOURNAL OF HAZARDOUS MATERIALS, 2021, 第 6 作者
(3) Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 8 作者
(4) Shift in skin microbiota and immune functions of zebrafish after combined exposure to perfluorobutanesulfonate and probiotic Lactobacillus rhamnosus, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 第 6 作者 通讯作者
(5) Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 第 6 作者 通讯作者
(6) Disturbances in Microbial and Metabolic Communication across the Gut-Liver Axis Induced by a Dioxin-like Pollutant: An Integrated Metagenomics and Metabolomics Analysis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 9 作者 通讯作者
(7) Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish, ENVIRONMENTAL POLLUTION, 2020, 第 7 作者 通讯作者
(8) Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish, ENVIRONMENT INTERNATIONAL, 2020, 第 7 作者
(9) Visual system: An understudied target of aquatic toxicology, AQUATIC TOXICOLOGY, 2020, 第 1 作者 通讯作者
(10) Unexpected Observations: Probiotic Administration Greatly Aggravates the Reproductive Toxicity of Perfluorobutanesulfonate in Zebrafish, CHEMICAL RESEARCH IN TOXICOLOGY, 2020, 第 8 作者 通讯作者
(11) Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish, CHEMOSPHERE, 2020, 第 8 作者 通讯作者
(12) Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology, CHEMOSPHERE, 2020, 第 6 作者 通讯作者
(13) Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos, ENVIRONMENTAL POLLUTION, 2020, 第 7 作者 通讯作者
(14) Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos, AQUATIC TOXICOLOGY, 2020, 第 7 作者 通讯作者
(15) Probiotic Modulation of Lipid Metabolism Disorders Caused by Perfluorobutanesulfonate Pollution in Zebrafish, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 1 作者 通讯作者
(16) Optical toxicity of triphenyl phosphate in zebrafish larvae, AQUATIC TOXICOLOGY, 2019, 第 3 作者
(17) Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 1 作者 通讯作者
(18) Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 第 6 作者 通讯作者
(19) Organic ultraviolet (UV) filters in the South China sea coastal region: Environmental occurrence, toxicological effects and risk assessment, ECOTOXICOLOGYANDENVIRONMENTALSAFETY, 2019, 第 2 作者
(20) Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish, ENVIRONMENTAL POLLUTION, 2019, 第 8 作者 通讯作者
(21) Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 第 2 作者
(22) Contamination by perfluoroalkyl substances and microbial community structure in Pearl River Delta sediments, ENVIRONMENTAL POLLUTION, 2019, 第 1 作者 通讯作者
(23) Variation in microbial community structure in surface seawater from Pearl River Delta: Discerning the influencing factors, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 第 1 作者 通讯作者
(24) Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 1 作者 通讯作者
(25) Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 5 作者
(26) TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure, CHEMOSPHERE, 2019, 第 1 作者 通讯作者
(27) Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2018, 第 1 作者 通讯作者
(28) Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 1 作者
(29) Dysregulation of Intestinal Health by Environmental Pollutants: Involvement of the Estrogen Receptor and Aryl Hydrocarbon Receptor, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 1 作者
(30) Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure, AQUATIC TOXICOLOGY, 2018, 第 1 作者
(31) Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern, Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern, 环境科学学报:英文版, 2017, 第 1 作者
(32) SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern, JOURNAL OF ENVIRONMENTAL SCIENCES, 2017, 第 1 作者 通讯作者
(33) Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3'-diindolylmethane (DIM), AQUATIC TOXICOLOGY, 2017, 第 1 作者
(34) Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 第 1 作者
(35) Optimization of antifouling coatings incorporating butenolide, a potent antifouling agent via field and laboratory tests, PROGRESS IN ORGANIC COATINGS, 2017, 第 1 作者
(36) Endocrine disruption throughout the hypothalamus-pituitary-gonadal-liver (hpgl) axis in marine medaka (oryzias melastigma) chronically exposed to the antifouling and chemopreventive agent, 3,3 '-diindolylmethane (dim), CHEMICAL RESEARCH IN TOXICOLOGY, 2016, 第 1 作者
(37) Chronic Exposure of Marine Medaka (Oryzias melastigma) to 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) Reveals Its Mechanism of Action in Endocrine Disruption via the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016, 第 1 作者
(38) High-throughput transcriptome sequencing of the cold seep mussel Bathymodiolus platifrons, SCIENTIFIC REPORTS, 2015, 第 4 作者
(39) Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT), AQUATIC TOXICOLOGY, 2014, 第 1 作者
(40) Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2013, 第 2 作者 通讯作者
(41) Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 第 1 作者
(42) Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio), AQUATIC TOXICOLOGY, 2012, 第 1 作者
科研活动
科研项目
( 1 ) 湖北省杰出青年基金, 负责人, 地方任务, 2021-10--2024-09
( 2 ) 国家青年海外人才计划科研经费, 负责人, 国家任务, 2021-06--2026-12
( 3 ) 益生菌Lactobacillus rhamnosus对全氟丁烷磺酸盐(PFBS)脂质代谢毒性的调节能力和分子机制, 负责人, 国家任务, 2021-01--2023-12
( 4 ) 典型抗污损污染物DCOIT的内分泌干扰效应和繁殖毒性机制, 负责人, 国家任务, 2020-01--2023-12
( 5 ) 益生菌Lactobacillus rhamnosus添加剂抑制全氟丁烷磺酸污染物(PFBS)健康危害的效能研究, 负责人, 研究所自主部署, 2020-01--2021-12
( 6 ) 缺氧环境下全氟丁烷磺酸盐的毒性效应与机理, 负责人, 其他国际合作项目, 2019-03--2021-03
( 7 ) 中科院“****”引进人才科研启动经费, 负责人, 研究所自主部署, 2018-09--2023-08
( 2 ) 国家青年海外人才计划科研经费, 负责人, 国家任务, 2021-06--2026-12
( 3 ) 益生菌Lactobacillus rhamnosus对全氟丁烷磺酸盐(PFBS)脂质代谢毒性的调节能力和分子机制, 负责人, 国家任务, 2021-01--2023-12
( 4 ) 典型抗污损污染物DCOIT的内分泌干扰效应和繁殖毒性机制, 负责人, 国家任务, 2020-01--2023-12
( 5 ) 益生菌Lactobacillus rhamnosus添加剂抑制全氟丁烷磺酸污染物(PFBS)健康危害的效能研究, 负责人, 研究所自主部署, 2020-01--2021-12
( 6 ) 缺氧环境下全氟丁烷磺酸盐的毒性效应与机理, 负责人, 其他国际合作项目, 2019-03--2021-03
( 7 ) 中科院“****”引进人才科研启动经费, 负责人, 研究所自主部署, 2018-09--2023-08