基本信息
![](/self/img/9552266f-222f-48e3-9b36-5c6f78fa9aaf.jpg)
何康敏 男 博导 中国科学院遗传与发育生物学研究所
电子邮件: kmhe@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路1号院2号
邮政编码:
电子邮件: kmhe@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路1号院2号
邮政编码:
招生信息
招生专业
071009-细胞生物学
071011-生物物理学
071011-生物物理学
招生方向
囊泡运输和信号脂质的时空动态、调控与疾病
活细胞单分子荧光成像技术
活细胞单分子荧光成像技术
教育背景
2008-09--2013-07 北京大学 博士
2003-09--2008-07 北京大学医学部 学士
2003-09--2008-07 北京大学医学部 学士
工作经历
工作简历
2017-08~2019-03,哈佛医学院和波士顿儿童医院, 讲师
2013-07~2017-07,哈佛医学院和波士顿儿童医院, 博士后
2008-09~2013-07,北京大学, 博士
2003-09~2008-07,北京大学医学部, 学士
2013-07~2017-07,哈佛医学院和波士顿儿童医院, 博士后
2008-09~2013-07,北京大学, 博士
2003-09~2008-07,北京大学医学部, 学士
教授课程
生物影像技术
专利与奖励
奖励信息
(1) 哈佛华人生命医学优秀学术奖, 其他, 2018
(2) 北京大学优秀毕业生, 研究所(学校), 2013
(2) 北京大学优秀毕业生, 研究所(学校), 2013
出版信息
发表论文
(1) Clathrin-associated carriers enable recycling through a kiss-and-run mechanism, Nature Cell Biology, 2024, 第 16 作者 通讯作者
(2) Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions, Molecular Cell, 2024, 第 22 作者 通讯作者
(3) AMPK Attenuation of ��-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of ��-Arrestin-1-ser330, CIRCULATION RESEARCH, 2024, 第 14 作者
(4) Bacterial-host adhesion dominated by collagen subtypes remodelled by osmotic pressure, npj Biofilms and Microbiomes, 2024, 第 9 作者
(5) Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development, ISCIENCE, 2024, 第 10 作者
(6) Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation, eLife, 2024, 第 9 作者 通讯作者
(7) Mammalian IRE1�� dynamically and functionally coalesces with stress granules, NATURE CELL BIOLOGY, 2024, 第 13 作者
(8) Probing and imaging phospholipid dynamics in live cells, Life Metabolism, 2024, 第 4 作者 通讯作者
(9) CRISPR-Cas9基因编辑技术对细胞内源蛋白进行荧光标记的实验操作, The protocol of tagging endogenous proteins with fluorescent tags using CRISPR-Cas9 genome editing, 遗传, 2023, 第 5 作者 通讯作者
(10) Crosstalk between adrenergic receptors and catalytic receptors, CURRENT OPINION IN PHYSIOLOGY, 2023, 第 3 作者 通讯作者
(11) Geometric constraint-triggered collagen expression mediates bacterial-host adhesion, NATURE COMMUNICATIONS, 2023, 第 13 作者
(12) Structure and dynamics of the EGFR/HER2 heterodimer, CELL DISCOVERY, 2023, 第 11 作者 通讯作者
(13) The Salmonella Typhimurium effector SpvB subverts host membrane trafficking by targeting clathrin and AP-1, MOLECULAR & CELLULAR PROTEOMICS, 2023, 第 8 作者 通讯作者
(14) The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling, CELL, 2021, 第 15 作者 通讯作者
(15) Inherited nuclear pore substructures template post-mitotic pore assembly, DEVELOPMENTAL CELL, 2021, 第 4 作者
(16) Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic, JOURNAL OF CELL BIOLOGY, 2020, 第 1 作者
(17) Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface, NEURON, 2020, 第 15 作者
(18) Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis, CELL DEATH & DISEASE, 2018, 第 5 作者
(19) Single-molecule imaging and tracking of molecular dynamics in living cells, Single-molecule imaging and tracking of molecular dynamics in living cells, NATIONAL SCIENCE REVIEW, 2017, 第 5 作者 通讯作者
(20) Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation, SCIENTIFIC REPORTS, 2017, 第 1 作者
(21) Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic, NATURE, 2017, 第 1 作者 通讯作者
(22) Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by ��2-adrenergic receptor, SCIENCE CHINA. CHEMISTRY, 2017, 第 2 作者
(23) Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion, JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 第 3 作者
(24) mAbp1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction, FASEB Journal, 2015, 第 1 作者
(25) Internalization of the TGF-�� type I receptor into caveolin-1 and EEA1 double-positive early endosomes, CELL RESEARCH, 2015, 第 1 作者
(26) Single-molecule imaging revealed enhanced dimerization of transforming growth factor beta type II receptors in hypertrophic cardiomyocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 1 作者
(27) Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes, CARDIOVASCULAR RESEARCH, 2011, 第 1 作者
(28) Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes, ACS NANO, 2010, 第 1 作者
(29) Blood lead levels of children and its trend in China, SCIENCE OF THE TOTAL ENVIRONMENT, 2009, 第 1 作者
(2) Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions, Molecular Cell, 2024, 第 22 作者 通讯作者
(3) AMPK Attenuation of ��-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of ��-Arrestin-1-ser330, CIRCULATION RESEARCH, 2024, 第 14 作者
(4) Bacterial-host adhesion dominated by collagen subtypes remodelled by osmotic pressure, npj Biofilms and Microbiomes, 2024, 第 9 作者
(5) Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development, ISCIENCE, 2024, 第 10 作者
(6) Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation, eLife, 2024, 第 9 作者 通讯作者
(7) Mammalian IRE1�� dynamically and functionally coalesces with stress granules, NATURE CELL BIOLOGY, 2024, 第 13 作者
(8) Probing and imaging phospholipid dynamics in live cells, Life Metabolism, 2024, 第 4 作者 通讯作者
(9) CRISPR-Cas9基因编辑技术对细胞内源蛋白进行荧光标记的实验操作, The protocol of tagging endogenous proteins with fluorescent tags using CRISPR-Cas9 genome editing, 遗传, 2023, 第 5 作者 通讯作者
(10) Crosstalk between adrenergic receptors and catalytic receptors, CURRENT OPINION IN PHYSIOLOGY, 2023, 第 3 作者 通讯作者
(11) Geometric constraint-triggered collagen expression mediates bacterial-host adhesion, NATURE COMMUNICATIONS, 2023, 第 13 作者
(12) Structure and dynamics of the EGFR/HER2 heterodimer, CELL DISCOVERY, 2023, 第 11 作者 通讯作者
(13) The Salmonella Typhimurium effector SpvB subverts host membrane trafficking by targeting clathrin and AP-1, MOLECULAR & CELLULAR PROTEOMICS, 2023, 第 8 作者 通讯作者
(14) The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling, CELL, 2021, 第 15 作者 通讯作者
(15) Inherited nuclear pore substructures template post-mitotic pore assembly, DEVELOPMENTAL CELL, 2021, 第 4 作者
(16) Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic, JOURNAL OF CELL BIOLOGY, 2020, 第 1 作者
(17) Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface, NEURON, 2020, 第 15 作者
(18) Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis, CELL DEATH & DISEASE, 2018, 第 5 作者
(19) Single-molecule imaging and tracking of molecular dynamics in living cells, Single-molecule imaging and tracking of molecular dynamics in living cells, NATIONAL SCIENCE REVIEW, 2017, 第 5 作者 通讯作者
(20) Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation, SCIENTIFIC REPORTS, 2017, 第 1 作者
(21) Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic, NATURE, 2017, 第 1 作者 通讯作者
(22) Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by ��2-adrenergic receptor, SCIENCE CHINA. CHEMISTRY, 2017, 第 2 作者
(23) Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion, JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 第 3 作者
(24) mAbp1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction, FASEB Journal, 2015, 第 1 作者
(25) Internalization of the TGF-�� type I receptor into caveolin-1 and EEA1 double-positive early endosomes, CELL RESEARCH, 2015, 第 1 作者
(26) Single-molecule imaging revealed enhanced dimerization of transforming growth factor beta type II receptors in hypertrophic cardiomyocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 1 作者
(27) Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes, CARDIOVASCULAR RESEARCH, 2011, 第 1 作者
(28) Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes, ACS NANO, 2010, 第 1 作者
(29) Blood lead levels of children and its trend in China, SCIENCE OF THE TOTAL ENVIRONMENT, 2009, 第 1 作者
科研活动
科研项目
( 1 ) 开发新型磷脂探针在超分辨水平解析内吞体相关细胞器互作的时空动态和机制, 负责人, 国家任务, 2024-01--2025-12
( 2 ) 膜脂调控与疾病, 参与, 国家任务, 2024-01--2028-12
( 3 ) 面向细胞间通讯的化学生物学新技术及其在肿瘤免疫研究中的应用, 参与, 国家任务, 2022-12--2027-11
( 4 ) 分泌蛋白对能量稳态的调控和机制, 参与, 国家任务, 2021-12--2026-11
( 2 ) 膜脂调控与疾病, 参与, 国家任务, 2024-01--2028-12
( 3 ) 面向细胞间通讯的化学生物学新技术及其在肿瘤免疫研究中的应用, 参与, 国家任务, 2022-12--2027-11
( 4 ) 分泌蛋白对能量稳态的调控和机制, 参与, 国家任务, 2021-12--2026-11