天然产物化学、合成生物学

100705-微生物与生化药学
070703-海洋生物学
100800-中药学

天然产物化学，微生物学，分子生物学

2014-09--2018-06   中国科学院大学-中国科学院南海海洋研究所   理学博士
2011-09--2014-06   中国科学院大学-中国科学院昆明植物研究所   药学硕士
2007-09--2011-07   西南林业大学   农学学士

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2023-04~现在, 中国科学院上海药物研究所, 研究员
2018-10~2023-04,美国伊利诺伊大学厄巴纳-香槟分校, 博士后研究员
2018-06~2018-10,中国科学院南海海洋研究所, 研究助理

2024-11-16-今,中国药学会海洋药物专业委员会委员, 委员
2024-10-01-今,中国生物工程学会青年工作委员会委员, 委员
2024-09-01-今,上海市药学会海洋药物专业委员会委员, 委员

（1） 中科院引才计划, , 部委级, 2024
（2） 上海市领军人才（海外）青年, 省级, 2023
（3） 浦东新区明珠菁英人才, 市地级, 2023
（4） 上海市白玉兰人才计划浦江项目A类, 省级, 2023
（5） 中国科学院院长特别奖, 特等奖, 院级, 2018
（6） “中国化学会第十二届全国天然有机化学学术会议”优秀墙报奖, 一等奖, 其他, 2018

（ 1 ） 一种fluorene类抗生素及其制备方法和在制备抗肿瘤药物和酶抑制剂中的应用, 发明专利, 2021, 第 4 作者, 专利号: CN112300109A

（ 2 ） 一种二聚fluostatins类抗生素的制备方法, 发明专利, 2018, 第 2 作者, 专利号: CN108383806A

（ 3 ） 抗生素pyrazolofluostatin A‑C及其制备方法和应用, 专利授权, 2017, 第 4 作者, 专利号: CN106831589A

（ 4 ） 一种芳香聚酮类非典型角环素fluostatins的生物合成基因簇及其应用, 发明专利, 2015, 第 3 作者, 专利号: CN105200072A

（ 5 ） 抗生素difluostatin A及其制备方法和在制备抗菌药物中的应用, 发明专利, 2015, 第 4 作者, 专利号: CN105153073A

1.       C. Huang#, C. Yang#, W. Zhang, L. Zhang, B. C. De, Y. Zhu, X. Jiang, C. Fang, Q. Zhang, C. Yuan, H. Liu*, and C. Zhang*. Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines. Nature Communications, 2018, 9(1): 2088.

2.       C. Huang, H. Cui, H. Ren, and H. Zhao*. Investigation of the biosynthetic mechanism of bipentaromycin featuring an unprecedented cyclic head-to-tail dimeric scaffold. JACS Au, 2023, 3(1), 195−203.

3.      H. Ren#,  C. Huang#, Y. Pan, S. R. Dommaraju, H. Cui, M. Li, M. G. Gadgil, D. A. Mitchell, and H. Zhao*. Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature Chemistry, 2024, 16(8), 1320−1329.

4.       B. Enghiad#, C. Huang#, F. Guo, G. Jiang, B. Wang, S. Tabatabaei, T. Martin, and H. Zhao*. Cas12a assisted precise targeted cloning using in vivo Cre-lox recombination. Nature Communications, 2021, 12(1): 1171.

5.       C. Huang, C. Yang*, W. Zhang, L. Zhang, Y. Zhu, and C. Zhang*. Discovery of an unexpected 1,4-oxazepine-linked seco-fluostatin heterodimer by inactivation of the oxidoreductase-encoding gene flsP. Journal of Natural Products, 2021, 84(8): 2336–2344.

6.       C. Yang#, C. Huang#, C. Fang, L. Zhang, S. Chen, Q. Zhang, C. Zhang*, and W. Zhang*. Inactivation of flavoenzyme-encoding gene flsO1 in fluostatin biosynthesis leads to diversified angucyclinone derivatives. The Journal of Organic Chemistry, 2021, 86(16): 11019–11028.

7.       C. Huang, C. Yang, Y. Zhu*, W. Zhang, C. Yuan, and C. Zhang*. Marine bacterial aromatic polyketides from host-dependent heterologous expression and fungal mode of cyclization. Frontiers in Chemistry, 2018, 6(10): 528.

8.       C. Huang, C. Yang, Z. Fang, L. Zhang, W. Zhang, Y. Zhu, and C. Zhang*. Discovery of stealthin derivatives and Implication of the amidotransferase FlsN3 in the biosynthesis of nitrogen-containing fluostatins. Marine Drugs, 2019, 17(3): 150.

9.       C. Huang, C. Yang, W. Zhang, Y. Zhu, L. Ma, Z. Fang, and C. Zhang*. Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster. Journal of Antibiotics, 2019, 72(5): 311−315.

10.       C. Huang, S. Luo, Y. Li, C. Li, J. Hua, Y. Liu, S. Jing, Y. Wang, M. Yang, and S. Li*. Antifeedant and antiviral diterpenoids from the fresh roots of Euphorbia jolkinii. Natural Products and Bioprospecting, 2014, 4(2): 91−100.

11.    G. Jiang, C. Huang, W. Harrison, H. Li, M. Zhou, and H. Zhao*. Ene reductase enabled intramolecular β‐C−H functionalization of substituted cyclohexanones for efficient synthesis of bridged bicyclic nitrogen scaffolds. Angewandte Chemie International Edition, 2023. doi.org/10.1002/anie.202302125.

12.    H. Ren, S. R. Dommaraju, C. Huang, H. Cui, Y. Pan, M. Nesic, L. Zhu, D. Sarlah, D. A. Mitchell*, and H. Zhao*. Genome mining unveils a class of ribosomal peptides with two amino termini. Nature Communications, 2023, 14(1): 1624.

13.    B. Wang, F. Guo, C. Huang, and H. Zhao*. Unraveling the iterative type I polyketide synthases hidden in Streptomyces. Proceedings of National Academy of Sciences of the United States of America, 2020, 117(15): 8449−8454.

14.    C. Yang#, L. Zhang#, W. Zhang, C. Huang, Y. Zhu, X. Jiang, W. Liu, M. Zhao, B. C. De, and C. Zhang*. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. Nature Communications, 2022, 13(1): 5386.

15.    B. C. De#, W. Zhang#, C. Yang, A. Mándi, C. Huang, L. Zhang, W. Liu, M. W. Ruszczycky, Y. Zhu, M. Ma, G. Bashiri, T. Kurtán, H. Liu*, and C. Zhang*. Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nature Communications, 2022, 13(1): 4896.

16.    C. Yang, C. Huang, W. Zhang*, Y. Zhu, and C. Zhang*. Heterologous expression of fluostatin gene cluster leads to a bioactive heterodimer. Organic Letters, 2015, 17 (21): 5324-5327.

17.    W. Zhang#, C. Yang#, C. Huang, L. Zhang, H. Zhang, Q. Zhang, C. Yuan, Y. Zhu, and C. Zhang*. Pyrazolofluostatins A−C, pyrazole-fused benzo[a]fluorenes from South China sea-derived Micromonospora rosaria SCSIO N160. Organic Letters, 2017, 19(3): 592−595.

18.    S. Luo, C. Huang, J. Hua, S. Jing, L. Teng, T. Tang, Y. Liu*, and S. Li*. Defensive specialized metabolites from the latex of Euphorbia jolkinii. Journal of Chemical Ecology, 2023, 10.1007/s10886-023-01413-6.