基本信息
乔增莹  女  博导  国家纳米科学中心
电子邮件: qiaozy@nanoctr.cn
通信地址: 北京市中关村北一条11号
邮政编码:

招生信息

   
招生专业
070305-高分子化学与物理
0703J1-纳米科学与技术
招生方向
纳米药物载体,生物医用高分子,自组装多肽

教育背景

2007-09--2012-07   北京大学   理学博士
2003-09--2007-07   山东大学   理学学士

工作经历

   
工作简历
2023-03~现在, 国家纳米科学中心, 研究员
2019-03~2023-03,国家纳米科学中心, 项目研究员
2018-06~2019-06,美国布兰迪斯大学, 访问学者
2016-03~2019-03,国家纳米科学中心, 副研究员
2012-07~2016-03,国家纳米科学中心, 助理研究员
2007-09~2012-07,北京大学, 理学博士
2003-09~2007-07,山东大学, 理学学士

专利与奖励

   
专利成果
( 1 ) 一种pH敏感的多肽聚合物及其制备方法和应用, 2020, 第 2 作者, 专利号: ZL201710137612.9

( 2 ) 一种具有抗肿瘤活性的多肽聚合物制备方法, 2016, 第 2 作者, 专利号: ZL201410160139.2

出版信息

   
发表论文
(1) An Ultrasound-Induced Self-Clearance Hydrogel for Male Reversible Contraception, ACS NANO, 2022, 通讯作者
(2) Intracellular Self-Immolative Polyprodrug with Near-Infrared Light Guided Accumulation and in Vivo Visualization of Drug Release, ADVANCED MATERIALS, 2022, 通讯作者
(3) Precise magnetic resonance imaging-guided sonodynamic therapy for drug-resistant bacterial deep infection, BIOMATERIALS, 2021, 通讯作者
(4) Regulating Twisted Skeleton to Construct Organ-Specific Perylene for Intensive Cancer Chemotherapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(5) In Vivo Self-Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(6) Hybrid Plasmonic Nanodumbbells Engineering for Multi-Intensified Second Near-Infrared Light Induced Photodynamic Therapy, ACS NANO, 2021, 通讯作者
(7) Near-Infrared Laser-Triggered In Situ Dimorphic Transformation of BF2-Azadipyrromethene Nanoaggregates for Enhanced Solid Tumor Penetration, ACS NANO, 2020, 通讯作者
(8) Cell-Penetrating Peptides and Polymers for Improved Drug Delivery, CHEMNANOMAT, 2020, 通讯作者
(9) Photothermal-Promoted Morphology Transformation in Vivo Monitored by Photoacoustic Imaging, NANO LETTERS, 2020, 通讯作者
(10) Ultrasound-Activated Cascade Effect for Synergistic Orthotopic Pancreatic Cancer Therapy, ISCIENCE, 2020, 通讯作者
(11) Site-Specific Construction of Long-Term Drug Depot for Suppression of Tumor Recurrence, SMALL, 2019, 通讯作者
(12) Endogenous Reactive Oxygen Species-Triggered Morphology Transformation for Enhanced Cooperative Interaction with Mitochondria, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 通讯作者
(13) Autocatalytic Morphology Transformation Platform for Targeted Drug Accumulation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 通讯作者
(14) Microenvironment-Induced In Situ Self-Assembly of Polymer-Peptide Conjugates That Attack Solid Tumors Deeply, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 通讯作者
(15) Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics, ADVANCED MATERIALS, 2019, 通讯作者
(16) Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration, BIOMATERIALS SCIENCE, 2018, 通讯作者
(17) Near-Infrared Laser-Driven in Situ Self-Assembly as a General Strategy for Deep Tumor Therapy, NANO LETTERS, 2018, 通讯作者
(18) A self-destructive nanosweeper that captures and clears amyloid beta-peptides, NATURE COMMUNICATIONS, 2018, 第 6 作者
(19) High-Performance Identification of Human Bladder Cancer Using a Signal Self-Amplifiable Photoacoustic Nanoprobe, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者
(20) An in Situ Intracellular Self-Assembly Strategy for Quantitatively and Temporally Monitoring Autophagy, ACS NANO, 2017, 第 8 作者
(21) One-pot synthesis of pH-responsive hyperbranched polymer-peptide conjugates with enhanced stability and loading efficiency for combined cancer therapy, POLYMER CHEMISTRY, 2017, 通讯作者
(22) Polymer-klak peptide conjugates induce cancer cell death through synergistic effects of mitochondria damage and autophagy blockage, BIOCONJUGATE CHEMISTRY, 2017, 第 1 作者
(23) Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment, BIOMATERIALS, 2017, 第 6 作者
(24) Reconfigurable peptide nanotherapeutics at tumor microenvironmental ph, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 1 作者
(25) In situ monitoring intracellular structural change of nanovehicles through photoacoustic signals based on phenylboronate-linked rgd-dextran/purpurin 18 conjugates, BIOMACROMOLECULES, 2017, 通讯作者
(26) An "on-site transformation" strategy for treatment of bacterial infection, ADVANCED MATERIALS, 2017, 通讯作者
(27) Ph-sensitive polymeric nanoparticles modulate autophagic effect via lysosome impairment, SMALL, 2016, 第 6 作者
(28) A general strategy for facile synthesis and in situ screening of self-assembled polymer-peptide nanomaterials, ADVANCED MATERIALS, 2016, 第 1 作者
(29) Self-assembled ros-sensitive polymer-peptide therapeutics incorporating built-in reporters for evaluation of treatment efficacy, BIOMACROMOLECULES, 2016, 第 1 作者
(30) Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH, CHEMICAL COMMUNICATIONS, 2015, 第 1 作者
(31) A pH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy, JOURNAL OF MATERIALS CHEMISTRY B, 2015, 第 1 作者
(32) Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo, ADVANCED MATERIALS, 2015, 第 3 作者
(33) Self-assembly of cytotoxic peptide conjugated poly(beta-amino ester)s for synergistic cancer chemotherapy, JOURNAL OF MATERIALS CHEMISTRY B, 2015, 第 1 作者
(34) One-pot Synthesis of pH-sensitive Poly(RGD-co-β-amino ester)s for Targeted Intracellular Drug Delivery, Polym. Chem., 2014, 

科研活动

   
科研项目
( 1 ) 温敏型聚合物-多肽连接体的体内自组装行为及抗癌性能研究, 负责人, 国家任务, 2017-01--2020-12
( 2 ) 新型功能性多肽聚合物的制备及其抗癌性能研究, 负责人, 国家任务, 2013-01--2016-12
( 3 ) 可形变多肽纳米材料在体原位构建抗癌药物库及其生物学效应研究, 负责人, 国家任务, 2019-01--2022-12
( 4 ) 自组装多肽聚合物, 负责人, 国家任务, 2023-01--2025-12
( 5 ) 微环境响应原位聚集诱导发光材料及其在肿瘤动态可视化中的研究, 负责人, 国家任务, 2021-12--2025-12