本课题组主要从事精准化学测量及纳米生物技术在癌症等重大疾病的诊断与治疗领域的基础应用研究。 

研究方向  

1. 精准化学测量； 

2. 疾病精准诊疗。 

   

0703J1-纳米科学与技术
070301-无机化学
070302-分析化学

2005-09--2010-07   北京大学   博士
2005-09--2010-07   内蒙古大学   学士

   

2012-11~2016-07,麻省理工学院／哈佛大学, 博士后
2010-09~2012-11,伊利诺伊大学厄巴纳-香槟分校, 博士后

   

（1） 基金委“优青”, 国家级, 2018
（2） 青年**** (A类), , 国家级, 2016

   

[1] Yu, Fangzhi, Li, Xiangfei, Zhao, Jian, Zhao, Yuliang, Li, Lele. Photoactivated DNA Assembly and Disassembly for On-Demand Activation and Termination of cGAS-STING Signaling. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023, http://dx.doi.org/10.1002/anie.202305837.
[2] Sheng, Chuangui, Zhao, Jian, Yu, Fangzhi, Li, Lele. Enzyme Translocation-Mediated Signal Amplification for Spatially Selective Aptasensing of ATP in Inflammatory Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023, 62(14): http://dx.doi.org/10.1002/anie.202217551.
[3] Yi, Deyu, Zhao, Hengzhi, Zhao, Jian, Li, Lele. Modular Engineering of DNAzyme-Based Sensors for Spatioselective Imaging of Metal Ions in Mitochondria. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 145(3): 1678-1685, http://dx.doi.org/10.1021/jacs.2c11081.
[4] Di, Zhenghan, Yi, Xiulin, Li, Lele. Protease-Triggered, Spatially Controlled DNA Assembly in Apoptotic Cells for Early Evaluation of Therapeutic Efficacy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 145(14): 7931-7940, http://dx.doi.org/10.1021/jacs.2c13214.
[5] Li, Mengyuan, Li, Lele. Enzyme-Triggered DNA Sensor Technology for Spatially-Controlled, Cell-Selective Molecular Imaging. ACCOUNTS OF CHEMICAL RESEARCHnull. 2023, 56(12): 1482-1493, http://dx.doi.org/10.1021/acs.accounts.3c00085.
[6] Feng, Xueyan, Liu, Bei, Zhou, Zehao, Li, Wei, Zhao, Jian, Li, Lele, Zhao, Yuliang. Engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment. NANO RESEARCH. 2023, http://dx.doi.org/10.1007/s12274-023-5909-2.
[7] Chai, Xin, Yi, Deyu, Sheng, Chuangui, Zhao, Jian, Li, Lele. A Remotely Controlled Nanosystem for Spatiotemporally Specific Gene Regulation and Combinational Tumor Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023, 62(22): http://dx.doi.org/10.1002/anie.202217702.
[8] Chen, Yaoxuan, Zhao, Rupeng, Li, Lele, Zhao, Yuliang. Upconversion Luminescence-Boosted Escape of DNAzyme from Endosomes for Enhanced Gene-Silencing Efficacy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(34): http://dx.doi.org/10.1002/anie.202206485.
[9] Zhao, Jian, Di, Zhenghan, Li, Lele. Spatiotemporally Selective Molecular Imaging via Upconversion Luminescence-Controlled, DNA-Based Biosensor Technology. ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONnull. 2022, 61(32): https://www.doi.org/10.1002/anie.202204277.
[10] Deng, Jinqi, Zhao, Shuai, Li, Junhong, Cheng, Yangchang, Liu, Chao, Liu, Zheng, Li, Lele, Tian, Fei, Dai, Bo, Sun, Jiashu. One-Step Thermophoretic AND Gate Operation on Extracellular Vesicles Improves Diagnosis of Prostate Cancer. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(33): http://dx.doi.org/10.1002/anie.202207037.
[11] Di, Zhenghan, Lu, Xueguang, Zhao, Jian, Jaklenec, Ana, Zhao, Yuliang, Langer, Robert, Li, Lele. Mild Acidosis-Directed Signal Amplification in Tumor Microenvironment via Spatioselective Recruitment of DNA Amplifiers. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(31): http://dx.doi.org/10.1002/anie.202205436.
[12] 盛传归, di, zhenghan, huang yuanyu, Zhao, Yuliang, 李乐乐. Spatially Resolved In Vivo Imaging of Inflammation-Associated mRNA via Enzymatic Fluorescence Amplification in a Molecular Beacon. Nature Biomedical Engineering[J]. 2022, 6: 1074-1084, [13] Yu, Fangzhi, Shao, Yulei, Chai, Xin, Zhao, Yuliang, Li, Lele. Spatially Selective Monitoring of Subcellular Enzyme Dynamics in Response to Mitochondria-Targeted Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(28): http://dx.doi.org/10.1002/anie.202203238.
[14] 李乐乐. Merging DNA Probes with Nanotechnology for RNA Imaging In vivo. Curr. Anal. Chem.. 2021, [15] Zhou, Zehao, Zhao, Jian, Di, Zhenghan, Liu, Bei, Li, Zhaohui, Wu, Xuemin, Li, Lele. Core-shell gold nanorod@mesoporous-MOF heterostructures for combinational phototherapy. NANOSCALE[J]. 2021, 13(1): 131-137, http://dx.doi.org/10.1039/d0nr07681c.
[16] Guo, Shuai, Liu, Bei, Zhang, Mengjie, Li, Chunhui, Wang, Xiaoxia, Weng, Yuhua, Li, Lele, Huang, Yuanyu. A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery. CHINESE CHEMICAL LETTERS[J]. 2021, 32(1): 102-106, http://dx.doi.org/10.1016/j.cclet.2020.11.024.
[17] Zhang, Jingfang, Di, Zhenghan, Yan, Husheng, Zhao, Yuliang, Li, Lele. One-Step Synthesis of Single-Stranded DNA-Bridged Iron Oxide Supraparticles as MRI Contrast Agents. NANO LETTERS[J]. 2021, 21(7): 2793-2799, http://dx.doi.org/10.1021/acs.nanolett.0c04825.
[18] Shao, Yulei, Zhao, Jian, Yuan, Jinying, Zhao, Yuliang, Li, Lele. Organelle-Specific Photoactivation of DNA Nanosensors for Precise Profiling of Subcellular Enzymatic Activity. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(16): 8923-8931, http://dx.doi.org/10.1002/anie.202016738.
[19] Xiang, Zhichu, Zhao, Jian, Qu, Junle, Song, Jun, Li, Lele. A Multivariate-Gated DNA Nanodevice for Spatioselective Imaging of Pro-metastatic Targets in Extracellular Microenvironment. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2021, [20] Wang, Congli, Di, Zhenghan, Xiang, Zhichu, Zhao, Jian, Li, Lele. Coordination-driven assembly of proteins and nucleic acids in a single architecture for carrier-free intracellular co-delivery. NANO TODAY[J]. 2021, 38: http://dx.doi.org/10.1016/j.nantod.2021.101140.
[21] Liu, Congzhi, Chen, Yaoxuan, Zhao, Jian, Wang, Yong, Shao, Yulei, Gu, Zhanjun, Li, Lele, Zhao, Yuliang. Self-Assembly of Copper-DNAzyme Nanohybrids for Dual-Catalytic Tumor Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(26): 14324-14328, http://dx.doi.org/10.1002/anie.202101744.
[22] Zhao, Jian, Li, Zhixiang, Shao, Yulei, Hu, Wenping, Li, Lele. Spatially Selective Imaging of Mitochondrial MicroRNAs via Optically Programmable Strand Displacement Reactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(33): 17937-17941, http://dx.doi.org/10.1002/anie.202105696.
[23] Xiang, Zhichu, Zhao, Jian, Yi, Deyu, Di, Zhenghan, Li, Lele. Peptide Nucleic Acid (PNA)-Guided Peptide Engineering of an Aptamer Sensor for Protease-Triggered Molecular Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(42): 22659-22663, http://dx.doi.org/10.1002/anie.202106639.
[24] Mi, Yongsheng, Zhao, Jian, Chu, Hongqian, Li, Zhixiang, Yu, Mingming, Li, Lele. Upconversion Luminescence-Controlled DNA Computation for Spatiotemporally Resolved, Multiplexed Molecular Imaging. ANALYTICAL CHEMISTRY[J]. 2021, 93(4): 2500-2509, http://dx.doi.org/10.1021/acs.analchem.0c04531.
[25] Zhou, Ruyi, Yan, Liang, Dong, Xinghua, Zhu, Shuang, Chen, Kui, Wu, Yuanzheng, Xiang, Huandong, Li, Lele, Zhang, Guangjin, Gu, Zhanjun, Zhao, Yuliang. Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost. NANO TODAY[J]. 2021, 36: http://dx.doi.org/10.1016/j.nantod.2020.101003.
[26] Fan, Zetan, Zhao, Jian, Chai, Xin, Li, Lele. A Cooperatively Activatable, DNA-based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(27): 14887-14891, http://dx.doi.org/10.1002/anie.202104408.
[27] Yi, Deyu, Zhao, Jian, Li, Lele. An Enzyme-Activatable Engineered DNAzyme Sensor for Cell-Selective Imaging of Metal Ions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(12): 6300-6304, http://dx.doi.org/10.1002/anie.202015979.
[28] Xie, Jiani, Wang, Chengyan, Wang, Ning, Zhu, Shuang, Mei, Linqiang, Zhang, Xiao, Yong, Yuan, Li, Lele, Chen, Chunying, Huang, Changshui, Gu, Zhanjun, Li, Yuliang, Zhao, Yuliang. Graphdiyne nanoradioprotector with efficient free radical scavenging ability for mitigating radiation-induced gastrointestinal tract damage. BIOMATERIALS[J]. 2020, 244: http://dx.doi.org/10.1016/j.biomaterials.2020.119940.
[29] Zhao, Junxiang, Liu, Chao, Li, Yike, Ma, Yao, Deng, Jinqi, Li, Lele, Sun, Jiashu. Thermophoretic Detection of Exosomal microRNAs by Nanoflares. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(11): 4996-5001, https://www.webofscience.com/wos/woscc/full-record/WOS:000526392600009.
[30] Shao, Yulei, Liu, Bei, Di, Zhenghan, Zhang, Ge, Sun, LingDong, Li, Lele, Yan, ChunHua. Engineering of Upconverted Metal-Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic/Chemo-/Immunotherapy against Hypoxic Tumors. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(8): 3939-3946, https://www.webofscience.com/wos/woscc/full-record/WOS:000517360400032.
[31] Di, Zhenghan, Liu, Bei, Zhao, Jian, Gu, Zhanjun, Zhao, Yuliang, Li, Lele. An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment. SCIENCE ADVANCES[J]. 2020, 6(25): https://www.webofscience.com/wos/woscc/full-record/WOS:000542299800031.
[32] Liu, Bei, Ma, Rui, Zhao, Jian, Zhao, Yuliang, Li, Lele. A smart DNA nanodevice for ATP-activatable bioimaging and photodynamic therapy. SCIENCE CHINA-CHEMISTRY[J]. 2020, 63(10): 1490-1497, http://lib.cqvip.com/Qikan/Article/Detail?id=7103000171.
[33] Wang, Chengyan, Xie, Jiani, Dong, Xinghua, Mei, Linqiang, Zhao, Maoru, Leng, Zhengwei, Hu, Houxiang, Li, Lele, Gu, Zhanjun, Zhao, Yuliang. Clinically Approved Carbon Nanoparticles with Oral Administration for Intestinal Radioprotection via Protecting the Small Intestinal Crypt Stem Cells and Maintaining the Balance of Intestinal Flora. SMALL[J]. 2020, 16(16): https://www.webofscience.com/wos/woscc/full-record/WOS:000520260800001.
[34] Zhao, Jian, Li, Yinghao, Yu, Mingming, Gu, Zhanjun, Li, Lele, Zhao, Yuliang. Time-Resolved Activation of pH Sensing and Imaging in Vivo by a Remotely Controllable DNA Nanomachine. NANO LETTERS[J]. 2020, 20(2): 874-880, http://dx.doi.org/10.1021/acs.nanolett.9b03471.
[35] Wang Congli, Di Zhenghan, Fan Zetan, Li Lele. Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2020, 36(2): 268-273, http://lib.cqvip.com/Qikan/Article/Detail?id=7101349542.
[36] Wang, Xin, Guo, Zhao, Zhang, Chenyang, Zhu, Shuang, Li, Lele, Gu, Zhanjun, Zhao, Yuliang. Ultrasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer. ADVANCED SCIENCE[J]. 2020, 7(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000507437400001.
[37] Liu, Chang, Liu, Bei, Zhao, Jian, Di, Zhenghan, Chen, Daquan, Gu, Zhanjun, Li, Lele, Zhao, Yuliang. Nd3+-Sensitized Upconversion Metal-Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(7): 2634-2638, https://www.webofscience.com/wos/woscc/full-record/WOS:000506217400001.
[38] Zhao, Jian, Chu, Hongqian, Zhao, Ya, Lu, Yi, Li, Lele. A NIR Light Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(17): 7056-7062, https://www.webofscience.com/wos/woscc/full-record/WOS:000466987900037.
[39] Xue, Wenting, Di, Zhenghan, Zhao, Ya, Zhang, Aiping, Li, Lele. DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells. CHINESE CHEMICAL LETTERS[J]. 2019, 30(4): 899-902, http://lib.cqvip.com/Qikan/Article/Detail?id=7002098515.
[40] Li, Mengyuan, Zhao, Jian, Chu, Hongqian, Mi, Yongsheng, Zhou, Zehao, Di, Zhenghan, Zhao, Meiping, Li, Lele. Light-Activated Nanoprobes for Biosensing and Imaging. ADVANCED MATERIALS[J]. 2019, 31(45): https://www.webofscience.com/wos/woscc/full-record/WOS:000496187400032.
[41] Mi, Yongsheng, Cheng, HongBo, Chu, Hongqian, Zhao, Jian, Yu, Mingming, Gu, Zhanjun, Zhao, Yuliang, Li, Lele. A photochromic upconversion nanoarchitecture: towards activatable bioimaging and dual NIR light-programmed singlet oxygen generation. CHEMICAL SCIENCE[J]. 2019, 10(44): 10231-10239, https://www.webofscience.com/wos/woscc/full-record/WOS:000497283300028.
[42] Hu, Feng, Liu, Bei, Chu, Hongqian, Liu, Chang, Li, Zhaohui, Chen, Daquan, Li, Lele. Real-time monitoring of pH-responsive drug release using a metal-phenolic network-functionalized upconversion nanoconstruct. NANOSCALE[J]. 2019, 11(18): 9201-9206, [43] Liu, Chang, Yu, Yingjie, Chen, Daquan, Zhao, Jian, Yu, Yang, Li, Lele, Lu, Yi. Cupredoxin engineered upconversion nanoparticles for ratiometric luminescence sensing of Cu2+. NANOSCALE ADVANCES[J]. 2019, 1(7): 2580-2585, http://dx.doi.org/10.1039/c9na00168a.
[44] Di, Zhenghan, Zhao, Jian, Chu, Hongqian, Xue, Wenting, Zhao, Yuliang, Li, Lele. An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor. ADVANCED MATERIALS[J]. 2019, 31(33): https://www.webofscience.com/wos/woscc/full-record/WOS:000481909600013.
[45] Li, Mengyuan, Wang, Congli, Di, Zhenghan, Li, Hui, Zhang, Jingfang, Xue, Wenting, Zhao, Meiping, Zhang, Ke, Zhao, Yuliang, Li, Lele. Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(5): 1350-1354, http://dx.doi.org/10.1002/anie.201810735.
[46] Liu, Bei, Hu, Feng, Zhang, Jingfang, Wang, Congli, Li, Lele. A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug-Gene Combinations. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(26): 8804-8808, [47] Liu, Bei, Zhang, Jingfang, Li, Lele. Metal-DNA Coordination-Driven Self-Assembly: A Conceptual Methodology to Expand the Repertoire of DNA Nanobiotechnology. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2019, 25(59): 13452-13457, [48] Jiang, Wenyu, Ma, Yanhong, Zhao, Jian, Li, Lele, Xu, Yuanqing, Guo, Hongbo, Song, Luting, Chen, Zhexue, Zhang, Yong. Robust Assembly of Colloidal Nanoparticles for Controlled-Reflectance Surface Construction. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(26): 23773-23779, [49] Chu, Hongqian, Zhao, Jian, Mi, Yongsheng, Zhao, Yuliang, Li, Lele. Near-Infrared Light-Initiated Hybridization Chain Reaction for Spatially and Temporally Resolved Signal Amplification. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(42): 14877-14881, http://dx.doi.org/10.1002/anie.201906224.
[50] Wenting Xue, Zhenghan Di, Ya Zhao, Aiping Zhang, Lele Li. DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells. 中国化学快报英文版[J]. 2019, 30(4): 899-902, http://lib.cqvip.com/Qikan/Article/Detail?id=7002098515.
[51] Li, Lele, Xing, Hang, Zhang, Jingjing, Lu, Yi. Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications. ACCOUNTS OF CHEMICAL RESEARCHnull. 2019, 52(9): 2415-2426, http://dx.doi.org/10.1021/acs.accounts.9b00167.
[52] Hongqian Chu, Jian Zhao, Yongsheng Mi, Zhenghan Di, Lele Li. NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-11, [53] 赵宇亮. Imparting Designer Biorecognition Functionality to Metal–Organic Frameworks by a DNA‐Mediated Surface Engineering Strategy. SMALL[J]. 2018, 14(11): http://www.corc.org.cn/handle/1471x/2178079.
[54] Zhou, Zehao, Li, Mengyuan, Zhao, Jian, Di, Zhenghan, Di, Chunzhi, Liu, Bei, Zhang, Chao, Yan, ChunHua, Li, Lele. Trace water mediated growth of oriented single-crystalline mesoporous metal-organic frameworks on gold nanorods. CHEMICAL COMMUNICATIONS[J]. 2018, 54(59): https://www.webofscience.com/wos/woscc/full-record/WOS:000439315500005.
[55] Zhao, Jian, Gao, Jinhong, Xue, Wenting, Di, Zhenghan, Xing, Hang, Lu, Yi, Li, Lele. Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(2): 578-581, https://www.webofscience.com/wos/woscc/full-record/WOS:000423012600013.
[56] Li, Yifan, Di, Zhenghan, Gao, Jinhong, Cheng, Ping, Di, Chunzhi, Zhang, Ge, Liu, Bei, Shi, Xinghua, Sun, LingDong, Li, Lele, Yan, ChunHua. Heterodimers Made of Upconversion Nanoparticles and Metal-Organic Frameworks. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(39): 13804-13810, https://www.webofscience.com/wos/woscc/full-record/WOS:000412716900041.
[57] Li, Lele, Tong, Rong, Li, Mengyuan, Kohane, Daniel S. Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. ACTA BIOMATERIALIA[J]. 2016, 33: 34-39, http://dx.doi.org/10.1016/j.actbio.2016.01.039.
[58] Li, LeLe, Lu, Yi. Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(16): 5272-5275, https://www.webofscience.com/wos/woscc/full-record/WOS:000353931500008.
[59] Li, Lele, Tong, Rong, Chu, Hunghao, Wang, Weiping, Langer, Robert, Kohane, Daniel S. Aptamer photoregulation in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(48): 17099-17103, https://www.webofscience.com/wos/woscc/full-record/WOS:000345920800038.
[60] Hu, Xiaoxia, Wei, Ting, Wang, Jie, Liu, ZiEn, Li, Xinyang, Zhang, Binhao, Li, Zhihao, Li, Lele, Yuan, Quan. Near-Infrared-Light Mediated Ratiometric Luminescent Sensor for Multimode Visualized Assays of Explosives. ANALYTICAL CHEMISTRY[J]. 2014, 86(20): 10484-10491, https://www.webofscience.com/wos/woscc/full-record/WOS:000343639800067.
[61] Li, LeLe, Wu, Peiwen, Hwang, Kevin, Lu, Yi. An Exceptionally Simple Strategy for DNA-Functionalized Up-Conversion Nanoparticles as Biocompatible Agents for Nanoassembly, DNA Delivery, and Imaging. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(7): 2411-2414, https://www.webofscience.com/wos/woscc/full-record/WOS:000315373000004.
[62] Li, LeLe, Xie, Mengying, Wang, Jie, Li, Xinyang, Wang, Cheng, Yuan, Quan, Pang, DaiWen, Lu, Yi, Tan, Weihong. A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting. CHEMICAL COMMUNICATIONS[J]. 2013, 49(52): 5823-5825, https://www.webofscience.com/wos/woscc/full-record/WOS:000319905100003.
[63] Li, LeLe, Yin, Qian, Cheng, Jianjun, Lu, Yi. Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells. ADVANCED HEALTHCARE MATERIALS[J]. 2012, 1(5): 567-572, https://www.webofscience.com/wos/woscc/full-record/WOS:000315114500004.
[64] Li, LeLe, Ge, Pinghua, Selvin, Paul R, Lu, Yi. Direct Detection of Adenosine in Undiluted Serum Using a Luminescent Aptamer Sensor Attached to a Terbium Complex. ANALYTICAL CHEMISTRY[J]. 2012, 84(18): 7852-7856, https://www.webofscience.com/wos/woscc/full-record/WOS:000308829700040.
[65] Li, LeLe, Zhang, Ruobing, Yin, Leilei, Zheng, Kezhi, Qin, Weiping, Selvin, Paul R, Lu, Yi. Biomimetic Surface Engineering of Lanthanide-Doped Upconversion Nanoparticles as Versatile Bioprobes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2012, 51(25): 6121-6125, https://www.webofscience.com/wos/woscc/full-record/WOS:000305180400013.
[66] Li, LeLe, Sun, Hao, Fang, ChenJie, Yuan, Quan, Sun, LingDong, Yan, ChunHua. Mesostructured Hybrids Containing Potential Donors and Acceptors with Molecular-Scale and Meso-Scale Segregation and Ordering: Toward the Development of Smart Materials through Hierarchical Self-Assembly. CHEMISTRY OF MATERIALS[J]. 2009, 21(19): 4589-4597, https://www.webofscience.com/wos/woscc/full-record/WOS:000270461700031.
[67] 李乐乐. Hierarchical r-Al2O3 Monoliths with Highly Ordered 2D Hexagonal Mesopores in Macroporous Walls. Chem. Commun.. 2009, [68] 李乐乐. Facile Synthesis of Macrocellular Mesoporous Foam-like Ce-Sn Mixed Oxide with Nanocrystalline Frameworks by Using Triblock Copolymer as Single-Template. Small. 2009, [69] Li, LeLe, Fang, ChenJie, Sun, Hao, Yan, ChunHua. Hierarchical Self-Assembly of pH-Responsive Nanocomposites with Molecular-Scale and Mesoscale Periodicities. CHEMISTRY OF MATERIALS[J]. 2008, 20(19): 5977-5986, https://www.webofscience.com/wos/woscc/full-record/WOS:000259871500008.
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（ 1 ） 基于功能核酸的系统性靶向纳米给药体系, 主持, 市地级, 2016-08--2019-08
（ 2 ） 青年****, 主持, 国家级, 2016-09--2019-09
（ 3 ） 化学测量学, 主持, 国家级, 2019-01--2021-12
（ 4 ） 近红外光触发的靶向性上转换纳米组装体的构建及抗肿瘤效应研究, 主持, 国家级, 2018-01--2021-12