基本信息
郁峰 男 博导 中国科学院上海应用物理研究所
电子邮件: yufeng@sinap.ac.cn
通信地址: 上海市浦东新区张衡路239号
邮政编码:
电子邮件: yufeng@sinap.ac.cn
通信地址: 上海市浦东新区张衡路239号
邮政编码:
招生信息
招生专业
071011-生物物理学070301-无机化学
招生方向
结构生物学
教育背景
2005-09--2009-06 中国科学院上海应用物理研究所 博士2000-09--2004-06 南京师范大学 学士
工作经历
工作简历
2021-01~现在, 中国科学院上海高等研究院, 研究员2018-10~2020-12,中国科学院上海高等研究院, 副研究员2009-07~2018-10,中国科学院上海应用物理研究所, 副研究员2005-09~2009-06,中国科学院上海应用物理研究所, 博士2000-09~2004-06,南京师范大学, 学士
专利与奖励
专利成果
( 1 ) 一种原位结晶装置及方法, 2022, 第 4 作者, 专利号: CN113912668A( 2 ) 一种用于自动上样机械手测试的杜瓦结构, 2020, 第 3 作者, 专利号: CN111103314A( 3 ) 膜蛋白自动化脂立方相结晶系统, 2016, 第 4 作者, 专利号: CN205368542U
出版信息
发表论文
(1) Complex Crystal Structure Determination of Hsp90(N)-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922, FRONTIERS IN ONCOLOGY, 2022, 通讯作者(2) Structural Study of the Complex of cblC Methylmalonic Aciduria and Homocystinuria-Related Protein MMACHC with Cyanocobalamin, CRYSTALS, 2022, 第 9 作者(3) 生物大分子晶体学在药物发现中的应用, Application of Macromolecular X-ray Crystallography in Drug Discovery, 药物生物技术, 2021, 第 3 作者(4) Deploying the Big Data Science Center at the Shanghai Synchrotron Radiation Facility: the first superfacility platform in China, MACHINE LEARNING-SCIENCE AND TECHNOLOGY, 2021, 第 2 作者(5) Structure and Function of Piezophilic Hyperthermophilic Pyrococcus yayanosii pApase, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 通讯作者(6) Protein Crystal Instance Segmentation Based on Mask R-CNN, CRYSTALS, 2021, 第 4 作者(7) Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478, JOURNAL OF STRUCTURAL BIOLOGY, 2021, 通讯作者(8) Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 通讯作者(9) Crystal structure and biochemical studies of the bifunctional DNA primase-polymerase from phage NrS-1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 通讯作者(10) Crystal structures of phage NrS-1 N300-dNTPs-Mg2+ complex provide molecular mechanisms for substrate specificity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 通讯作者(11) Aquarium: an automatic data-processing and experiment information management system for biological macromolecular crystallography beamlines, JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2019, 通讯作者(12) Crystal structure of the Vibrio cholerae VqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 通讯作者(13) Large conformation shifts of Vibrio cholerae VqmA dimer in the absence of target DNA provide insight into DNA-binding mechanisms of LuxR-type receptors, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 通讯作者(14) Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD, BIOCHEMICAL JOURNAL, 2016, 通讯作者(15) Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtE, PLOS ONE, 2013, 通讯作者(16) Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry., ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, 2009, 第 1 作者(17) Crystal structure and function of C-terminal Sau3AI domain, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2009, 第 2 作者(18) Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2009, 第 1 作者(19) Equations for determining tetartohedral twin fractions, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2008, 第 2 作者
科研活动
科研项目
( 1 ) 弧菌属群体感应关键蛋白VqmA的结构、机制、特异性小分子药物设计及噬菌体治疗研究, 负责人, 国家任务, 2020-01--2023-12( 2 ) 临床严重耐药致病菌通用疫苗研发, 参与, 国家任务, 2021-12--2024-11