基本信息
王猛  男  博导  中国科学院天津工业生物技术研究所
电子邮件: wangmeng@tib.cas.cn
通信地址: 天津空港经济区西七道32号
邮政编码:

招生信息

   
招生专业
071005-微生物学
071010-生物化学与分子生物学
081703-生物化工
招生方向
合成生物学,生物学自动化,高通量筛选,天然产物生物合成

教育背景

2005-09--2009-12   美国锡拉丘兹大学   化学系博士学位
2001-09--2005-05   浙江大学   化学系学士学位
2001-09--2005-05   浙江大学   生物信息学第二学位

工作经历

   
工作简历
2015-05~现在, 中国科学院天津工业生物技术研究所, 研究员
2010-02~2015-04,伊利诺伊大学厄巴纳香槟分校, 博士后

专利与奖励

   

出版信息

   
发表论文
(1) Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization, Biotechnology and Bioengineering, 2016, 第 1 作者
(2) Identification of an important motif that controls the activity and specificity of sugar transporters, Biotechnology and Bioengineering, 2016, 第 1 作者
(3) Combined and Iterative Use of Computational Design and Directed Evolution for Protein-Ligand Binding Design, Methods in Molecular Biology, 2016, 第 1 作者
(4) Development of a Synthetic Malonyl-CoA Sensor in Saccharomyces cerevisiae for Intracellular Metabolite Monitoring and Genetic Screening. ACS synthetic biology, ACS synthetic biology, 2015, 第 3 作者
(5) Design and engineering of intracellular-metabolite-sensing/regulation gene circuits in Saccharomyces cerevisiae, Biotechnology and Bioengineering, 2015, 第 1 作者
(6) Characterization and engineering of the adenylation domain of a NRPS-like protein: a potential biocatalyst for aldehyde generation, ACS catalysis, 2014, 第 1 作者
(7) Resorcylic acid lactone biosynthesis relies on a stereo-tolerant macrocyclizing thioesterase, Organic Letters, 2014, 第 3 作者
(8) Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism, Chemistry & Biology, 2013, 第 1 作者
(9) Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster, Nature Communications, 2013, 第 4 作者
(10) 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective, Organic Letters, 2012, 第 2 作者
(11) Biocatalyst development by directed evolution., Bioresource Technology, 2011, 第 1 作者
(12) Microbial synthesis of drugs and fuels via synthetic biology, Chinese Bulletin of Life Sciences, 2011, 第 1 作者
(13) A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading, Biochemistry, 2009, 第 1 作者
(14) Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters, Bioorganic and Medicinal Chemistry Letter, 2009, 第 1 作者
(15) Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains, Biochemistry, 2008, 第 1 作者
(16) Synthesis of metronidazole esters and their monosaccharide ester derivatives, Enzyme Microbiology and Technology, 2006, 第 2 作者

科研活动

   

合作情况