083001-环境科学

DNA损伤机制

2004-09--2010-07   美国纽约大学   博士
2000-09--2004-06   北京大学   学士

   

2022-01~现在, 中国科学院生态环境研究中心, 副研究员
2011-01~2022-01,中国科学院生态环境研究中心, 助理研究员
2004-09~2010-07,美国纽约大学, 博士
2000-09~2004-06,北京大学, 学士

自由基化学生物学

   

（1） 致癌性卤代醌类消毒副产物造成 DNA 损伤的分子机理研究, Mechanism Investigation on DNA Damage Induced by Carcinogenic Haloquinoid Disinfection Byproducts, 化学进展, 2022, 通讯作者
（2） Potent oxidation of DNA by Ru(ii) tri(polypyridyl) complexes under visible light irradiation via a singlet oxygen-mediated mechanism, INORGANIC CHEMISTRY FRONTIERS, 2021, 第 1 作者
（3） The cell-impermeable Ru(II) polypyridyl complex as a potent intracellular photosensitizer under visible light irradiation via ion-pairing with suitable lipophilic counter-anions, FREE RADICAL BIOLOGY AND MEDICINE, 2021, 通讯作者
（4） Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity, ANTIOXIDANTS, 2021, 第 5 作者
（5） The critical role of superoxide anion radicals on delaying tetrachlorohydroquinone autooxidation by penicillamine, FREE RADICAL BIOLOGY AND MEDICINE, 2021, 第 8 作者
（6） Mechanistic Study on Oxidative DNA Damage and Modifications by Haloquinoid Carcinogenic Intermediates and Disinfection Byproducts, CHEMICAL RESEARCH IN TOXICOLOGY, 2021, 通讯作者
（7） First Direct and Unequivocal Electron Spin Resonance Spin-Trapping Evidence for pH-Dependent Production of Hydroxyl Radicals from Sulfate Radicals, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 5 作者
（8） Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism, Environmental Science & Technology, 2020, 第 1 作者
（9） Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting, THERANOSTICS, 2020, 第 3 作者
（10） An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine, FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 3 作者
（11） Unprecedented strong intrinsic chemiluminescence generation from degradation of halogenated hydroxy-quinoid pollutants by Co(II)-mediated advanced oxidation processes: The critical role of site-specific production of hydroxyl radicals, CHEMICAL ENGINEERING JOURNAL, 2020, 第 7 作者
（12） An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids (vol 146, pg 150, 2020), FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 6 作者
（13） Mechanism of synergistic DNA damage induced by caffeic acid phenethyl ester (CAPE) and Cu(II): Competitive binding between CAPE and DNA with Cu(II)/Cu(I), FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 3 作者
（14） Unexpected activation of N-alkyl hydroxamic acids to produce reactive N-centered free radicals and DNA damage by carcinogenic chlorinated quinones under normal physiological conditions, FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 9 作者
（15） An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions, FREE RADICAL BIOLOGY AND MEDICINE, 2019, 第 2 作者
（16） Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens, CARCINOGENESIS, 2019, 第 6 作者
（17） Targeted live-cell nuclear delivery of the DNA ‘light-switching’ Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes, NUCLEICACIDSRESEARCH, 2019, 第 5 作者
（18） Investigation of the mechanism of cellular uptake, distribution and toxicity of the dna 'light-switch' ru(ii) polypyridyl complexes, PROGRESS IN CHEMISTRY, 2018, 第 6 作者
（19） Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications, Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications, 环境科学学报：英文版, 2017, 第 5 作者
（20） The Unexpected and Exceptionally Facile Chemical Modification of the Phenolic Hydroxyl Group of Tyrosine by Polyhalogenated Quinones under Physiological Conditions, CHEMICAL RESEARCH IN TOXICOLOGY, 2016, 第 4 作者
（21） An Exceptionally Facile Two-Step Structural Isomerization and Detoxication via a Water-Assisted Double Lossen Rearrangement, SCIENTIFIC REPORTS, 2016, 第 5 作者
（22） 一种新型以碳为中心的醌酮自由基的检测和鉴定, 科学通报, 2013, 第 7 作者
（23） Potent methyl oxidation of 5-methyl-2′-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism, FREE RADICAL BIOLOGY AND MEDICINE, 2013, 第 1 作者
（24） Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens, FREE RADICAL BIOLOGY AND MEDICINE, 2013, 第 6 作者
（25） 不依赖于过渡金属离子的卤代醌介导的新型有机类Fenton反应机理, A Novel Mechanism for Halogenated Quinone- Mediated and Metal-Independent Organic Fenton-Like Reaction, 生物物理学报, 2012, 第 4 作者

   

（ 1 ） 致癌性卤代醌和脂质氢过氧化物诱导产生DNA氧化损伤的自由基机理研究, 负责人, 国家任务, 2020-01--2023-12
（ 2 ） 致癌性卤代醌和过氧化氢诱导DNA氧化损伤的机理研究, 负责人, 国家任务, 2013-01--2015-12
（ 3 ） 新型手性多环芳胺-DNA加合物的自由基形成机理和生物学效应, 参与, 国家任务, 2019-01--2023-12
（ 4 ） 新型马兜铃酸DNA加合物的形成及致肝癌发生机理研究, 参与, 中国科学院计划, 2019-09--2024-08