基本信息
王震  男  博导  中国科学院上海有机化学研究所
电子邮件: wangz@sioc.ac.cn
通信地址: 上海市徐汇区零陵路345号
邮政编码:

招生信息

   
招生专业
070303-有机化学
招生方向
激酶非催化功能的小分子调控
激酶小分子抑制剂的设计与合成

教育背景

2011-09--2016-07   中国科学院广州生物医药与健康研究院   博士
2007-09--2011-07   合肥工业大学   学士

工作经历

   
工作简历
2016-08~2021-05,美国Moffitt Cancer Center & Research Institute, 博士后
2011-09~2016-07,中国科学院广州生物医药与健康研究院, 博士
2007-09~2011-07,合肥工业大学, 学士

专利与奖励

   
专利成果
( 1 ) Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof, 2019, 第 5 作者, 专利号: US10,370,360

出版信息

   
发表论文
(1) Direct Targeting of β‐Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives, Medicinal Research Reviews, 2021, 第 1 作者
(2) Preclinical Evaluation of [225Ac]Ac-DOTA-TATE for Treatment of Lung Neuroendocrine Neoplasms, European Journal of Nuclear Medicine and Molecular Imaging, 2021, 第 5 作者
(3) Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction, Journal of Medicinal Chemistry, 2021, 第 1 作者
(4) Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction, Journal of Medicinal Chemistry, 2021, 第 1 作者
(5) Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer, Nature Cancer, 2021, 其他(合作组作者)
(6) Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein−Protein Interaction, Journal of Medicinal Chemistry, 2021, 第 1 作者
(7) Small-Molecule CSF1R Inhibitors as Anticancer Agents, Current Medicinal Chemistry, 2020, 第 2 作者
(8) Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein−Protein Interaction, Journal of Medicinal Chemistry, 2019, 第 1 作者
(9) Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as Dual Inhibitors of Discoidin Domain Receptor 1 and 2 (DDR1/2), Journal of Medicinal Chemistry, 2018, 第 1 作者
(10) Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction, Journal of Medicinal Chemistry, 2018, 第 2 作者
(11) GZD2202, a Novel TrkB Inhibitor, Suppresses BDNF-mediated Proliferation and Metastasis in Neuroblastoma Models, Journal of Drug Targeting, 2018, 第 7 作者
(12) Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors, Journal of Medicinal Chemistry, 2018, 第 6 作者
(13) Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors, ACS Medicinal Chemistry Letters, 2017, 第 1 作者
(14) Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma, Molecular Cancer Therapeutics, 2017, 第 5 作者
(15) Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors, Journal of Medicinal Chemistry, 2016, 第 1 作者
(16) Combined Inhibition of DDR1 and Notch Signaling is a Therapeutic Strategy for KRAS-driven Lung Adenocarcinoma, Nature Medicine, 2016, 其他(合作组作者)
(17) Small-Molecule BET Inhibitors in Clinical and Preclinical Development and Their Therapeutic Potential, Current Topics in Medicinal Chemistry, 2015, 第 2 作者