计算癌症基因组学，药物基因组学，RNA异常剪切

   

0710J3-生物信息学
0710Z1-基因组学

癌症基因组学

2010-09--2015-07   中国科学院数学与系统科学研究院   博士
2006-09--2010-07   中国农业大学   学士

   

2021-02~现在, 中国科学院北京基因组研究所（国家生物信息中心）, 研究员
2018-09~2020-08,Columbia University, Associate Research Scientist
2015-09~2018-08,Columbia University, Postdoctoral Researcher

2022-07-31-2027-07-31,中国运筹学会计算系统生物学分会, 理事
2020-08-31-2025-08-31,中国医药教育协会医学基因组学与生物信息学专业委员会, 委员

   

[1] Lieu, Yen K, Liu, Zhaoqi, Ali, Abdullah M, Wei, Xin, Penson, Alex, Zhang, Jian, An, Xiuli, Rabadan, Raul, Raza, Azra, Manley, James L, Mukherjee, Siddhartha. SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(1): http://dx.doi.org/10.1073/pnas.2111703119.
[2] Song Wu, Yue Huang, Mochen Zhang, Zheng Gong, Guoliang Wang, Xinchang Zheng, Wenting Zong, Wei Zhao, Peiqi Xing, Rujiao Li, Zhaoqi Liu, Yiming Bao. ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers. NUCLEIC ACIDS RESEARCH[J]. 2022, 51(D1): D1196-D1204, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825479/.
[3] Prieto, Camila, Nguyen, Diu T T, Liu, Zhaoqi, Wheat, Justin, Perez, Alexendar, Gourkanti, Saroj, Chou, Timothy, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Chow, Arthur, Taggart, James, Savino, Angela M, Hoskova, Katerina, Dhodapkar, Meera, Schurer, Alexandra, Barlowe, Trevor S, Vu, Ly P, Leslie, Christina, Steidl, Ulrich, Rabadan, Raul, Kharas, Michael G. Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. NATURE CANCER[J]. 2021, 2(7): 741-+, http://dx.doi.org/10.1038/s43018-021-00220-w.
[4] Zhaoqi Liu, Raul Rabadan. Computing the Role of Alternative Splicing in Cancer. TRENDS IN CANCER[J]. 2021, 7(4): 347-358, [5] Delin Chen, Bo Chu, Xin Yang, Zhaoqi Liu, Ying Jin, Ning Kon, Raul Rabadan, Xuejun Jiang, Brent R Stockwell, Wei Gu. iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4. NATURE COMMUNICATIONS[J]. 2021, 12(1): 1-15, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206155/.
[6] Sato, Mai, Liebau, Andrew Walter, Liu, Zhaoqi, Liu, Lizhi, Rabadan, Raul, Gautier, Jean. The UVSSA complex alleviates MYC-driven stress. JOURNAL OF CELL BIOLOGY[J]. 2021, 220(2): http://dx.doi.org/10.1083/jcb.201807163.
[7] Liu, Zhaoqi, Yoshimi, Akihide, Wang, Jiguang, Cho, Hana, Lee, Stanley ChunWei, Ki, Michelle, Bitner, Lillian, Chu, Timothy, Shah, Harshal, Liu, Bo, Mato, Anthony R, Ruvolo, Peter, Fabbri, Giulia, Pasqualucci, Laura, AbdelWahab, Omar, Rabadan, Raul. Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization. CANCER DISCOVERY[J]. 2020, 10(6): 806-821, http://dx.doi.org/10.1158/2159-8290.CD-19-1330.
[8] Zhaoqi Liu, Ioan Filip, Karen Gomez, Dewaldt Engelbrecht, Shabnum Meer, Pooja N Lalloo, Pareen Patel, Yvonne Perner, Junfei Zhao, Jiguang Wang, Laura Pasqualucci, Raul Rabadan, Pascale Willem. Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway. BLOOD CANCER DISCOVERY. 2020, 1(1): 112-125, [9] Liu, Bo, Liu, Zhaoqi, Chen, Sisi, Ki, Michelle, Erickson, Caroline, ReisFilho, Jorge S, Durham, Benjamin H, Chang, Qing, de Stanchina, Elisa, Sun, Yiwei, Rabadan, Raul, AbdelWahab, Omar, Chandarlapaty, Sarat. Mutant SF3B1 promotes AKT- and NF-kappa B driven mammary tumorigenesis. JOURNAL OF CLINICAL INVESTIGATION[J]. 2020, 131(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000607625100003.
[10] Liu, Zhaoqi, Zhang, Jian, Sun, Yiwei, PereaChamblee, Tomin E, Manley, James L, Rabadan, Raul. Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(19): 10305-10312, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229667/.
[11] Fiore, Danilo, Cappelli, Luca Vincenzo, Zumbo, Paul, Phillips, Jude M, Liu, Zhaoqi, Cheng, Shuhua, Yoffe, Liron, Ghione, Paola, Di Maggio, Federica, Dogan, Ahmet, Khodos, Inna, de Stanchina, Elisa, Casano, Joseph, Kayembe, Clarisse, Tam, Wayne, Betel, Doron, Foa, Robin, Cerchietti, Leandro, Rabadan, Raul, Horwitz, Steven, Weinstock, David M, Inghirami, Giorgio. A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries. CANCERS[J]. 2020, 12(6): https://doaj.org/article/6958d3085d5c47fdba82781ea47c3692.
[12] Zhang, Jian, Ali, Abdullah M, Lieu, Yen K, Liu, Zhaoqi, Gao, Jianchao, Rabadan, Raul, Raza, Azra, Mukherjee, Siddhartha, Manley, James L. Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1. MOLECULAR CELL[J]. 2019, 76(1): 82-+, http://dx.doi.org/10.1016/j.molcel.2019.07.017.
[13] Arnes, Luis, Liu, Zhaoqi, Wang, Jiguang, Maurer, Carlo, Sagalovskiy, Irina, SanchezMartin, Marta, Bommakanti, Nikhil, Garofalo, Diana C, Balderes, Dina A, Sussel, Lori, Olive, Kenneth P, Rabadan, Raul. Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. GUT[J]. 2019, 68(3): 499-511, http://dx.doi.org/10.1136/gutjnl-2017-314353.
[14] Han, Suji, Shin, Hyemi, Lee, JinKu, Liu, Zhaoqi, Rabadan, Raul, Lee, Jeongwu, Shin, Jihye, Lee, Cheolju, Yang, Heekyoung, Kim, Donggeon, Kim, Sung Heon, Kim, Jooyeon, Oh, JeongWoo, Kong, DooSik, Lee, JungIl, Seol, Ho Jun, Choi, Jung Won, Kang, Hyun Ju, Nam, DoHyun. Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target. EXPERIMENTAL AND MOLECULAR MEDICINE[J]. 2019, 51(12): 1-11, http://dx.doi.org/10.1038/s12276-019-0351-y.
[15] Djurec, Magdolna, Grana, Osvaldo, Lee, Albert, Troule, Kevin, Espinet, Elisa, Cabras, Lavinia, Navas, Carolina, Blasco, Maria Teresa, MartinDiaz, Laura, Burdiel, Miranda, Li, Jing, Liu, Zhaoqi, Vallespinos, Mireia, SanchezBueno, Francisco, Sprick, Martin R, Trumpp, Andreas, Sainz, Bruno, Jr, AlShahrour, Fatima, Rabadan, Raul, Guerra, Carmen, Barbacid, Mariano. Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(6): E1147-E1156, http://dx.doi.org/10.1073/pnas.1717802115.
[16] JinKu Lee, Zhaoqi Liu, Jason K Sa, Sang Shin, Jiguang Wang, Mykola Bordyuh, Hee Jin Cho, Oliver Elliott, Timothy Chu, Seung Won Choi, Daniel I S Rosenbloom, InHee Lee, Yong Jae Shin, Hyun Ju Kang, Donggeon Kim, Sun Young Kim, MoonHee Sim, Jusun Kim, Taehyang Lee, Yun Jee Seo, Hyemi Shin, Mijeong Lee, Sung Heon Kim, YongJun Kwon, JeongWoo Oh, Minsuk Song, Misuk Kim, DooSik Kong, Jung Won Choi, Ho Jun Seol, JungIl Lee, Seung Tae Kim, Joon Oh Park, KyoungMee Kim, SangYong Song, JeongWon Lee, HeeCheol Kim, Jeong Eon Lee, Min Gew Choi, Sung Wook Seo, Young Mog Shim, Jae Zo, Byong Chang Jeong, Yeup Yoon, Gyu Ha Ryu, Nayoung KD Kim, Joon Seol Bae, WoongYang Park, Jeongwu Lee, Roel G W Verhaak, Antonio Iavarone, Jeeyun Lee, Raul Rabadan, DoHyun Nam. Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy. NATURE GENETICS[J]. 2018, 50(10): 1399-1411, [17] Wang, Jiguang, Cazzato, Emanuela, Ladewig, Erik, Frattini, Veronique, Rosenbloom, Daniel I S, Zairis, Sakellarios, Abate, Francesco, Liu, Zhaoqi, Elliott, Oliver, Shin, YongJae, Lee, JinKu, Lee, InHee, Park, WoongYang, Eoli, Marica, Blumberg, Andrew J, Lasorella, Anna, Nam, DoHyun, Finocchiaro, Gaetano, Iavarone, Antonio, Rabadan, Raul. Clonal evolution of glioblastoma under therapy. NATURE GENETICS[J]. 2016, 48(7): 768-+, http://dx.doi.org/10.1038/ng.3590.

   

（ 1 ） 泛癌基因组可变剪切调控关系的深度挖掘, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 卵巢癌发生机制及精准防治, 参与, 国家任务, 2023-01--2025-12
（ 3 ） 基于单细胞与空间组学SF3B1突变肿瘤微环境特性解析, 负责人, 地方任务, 2022-10--2026-10
（ 4 ） 科学数据分析自主软件研发, 负责人, 国家任务, 2024-01--2026-12
（ 5 ） ****B类, 负责人, 中国科学院计划, 2022-01--2024-12

现指导学生

韩学帅  博士研究生  0710J3-生物信息学  

吕萱  博士研究生  0710J3-生物信息学  

韩楠  硕士研究生  0710J3-生物信息学  

黄悦  博士研究生  0710J3-生物信息学  

谢金豆  硕士研究生  0710J3-生物信息学  

许瑞鸿  硕士研究生  0710J3-生物信息学  

宋梦怡  硕士研究生  0710J3-生物信息学  

赵坤宇  硕士研究生  0710J3-生物信息学  

左一帆  硕士研究生  1001Z1-精准医学  

殷晚晴  博士研究生  0710J3-生物信息学  

周雷  博士研究生  0710J3-生物信息学  

隋静茹  博士研究生  0710J3-生物信息学