基本信息
何君  女  硕导  中国科学院水生生物研究所
电子邮件: hejun@ihb.ac.cn
通信地址: 湖北省武汉市武昌区东湖南路7号水生生物研究所东湖台站
邮政编码:

招生信息

   
招生专业
071004-水生生物学
招生方向
微囊藻毒素对动物的毒性效应和机制与人群健康风险研究
微囊藻毒素监测及在生态系统中的迁移转化规律研究

教育背景

2009-09--2014-06   中国科学院水生生物研究所   博士
2005-09--2009-06   西南科技大学   学士学位

工作经历

   
工作简历
2023-01~现在, 中国科学院水生生物研究所, 副研究员
2015-02~2022-12,中国科学院水生生物研究所, 助理研究员
2009-09~2014-06,中国科学院水生生物研究所, 博士
2005-09~2009-06,西南科技大学, 学士学位

专利与奖励

   
专利成果
( 1 ) 一种生物体内微囊藻毒素及其代谢产物的检测方法, 2010, 第 8 作者, 专利号: CN101788538A

出版信息

   
发表论文
(1) First insights into region-specific lipidome alterations of prefrontal cortex and hippocampus of mice exposed chronically to microcystins, Environment International, 2023, 第 1 作者
(2) Acute exposure to microcystins affects hypothalamic-pituitary axes of male rats, ENVIRONMENTAL POLLUTION, 2023, 第 4 作者
(3) Molecular Mechanisms of Spawning Habits for the Adaptive Radiation of Endemic East Asian Cyprinid Fishes, RESEARCH, 2022, 第 3 作者
(4) Health Risks of Chronic Exposure to Small Doses of Microcystins: AnIntegrative Metabolomic and Biochemical Study of Human Serum, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 第 1 作者
(5) Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 第 4 作者
(6) Cellular and molecular modification of egg envelope hardening in fertilization, BIOCHIMIE, 2021, 第 3 作者
(7) The Evolution of Alternative Buoyancy Mechanisms in Freshwater Fish Eggs, FRONTIERS IN ECOLOGY AND EVOLUTION, 2021, 第 4 作者
(8) Excretion pattern and dynamics of glutathione detoxification of microcystins in Sprague Dawley rat, CHEMOSPHERE, 2018, 第 2 作者
(9) Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 第 3 作者
(10) Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study, ARCHIVES OF TOXICOLOGY, 2017, 第 1 作者
(11) Quantitatively evaluating detoxification of the hepatotoxic microcystin-LR through the glutathione (GSH) pathway in SD rats (vol 22, pg 19273, 2015), ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2016, 第 6 作者
(12) A review of neurotoxicity of microcystins, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2016, 第 5 作者
(13) Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut, TOXICON, 2015, 第 3 作者
(14) Quantitatively evaluating detoxification of the hepatotoxic microcystin-LR through the glutathione (GSH) pathway in SD rats, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2015, 第 6 作者
(15) Effects of microcystin-LR on gut microflora in different gut regions of mice, JOURNAL OF TOXICOLOGICAL SCIENCES, 2015, 第 4 作者
(16) Rapid conversion and reversible conjugation of glutathione detoxification of microcystins in bighead carp (Aristichthys nobilis), AQUATIC TOXICOLOGY, 2014, 第 4 作者
(17) Quantitative liquid chromatography-tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2014, 第 4 作者
(18) Quantitative liquid chromatography���tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile, JOURNAL OF CHROMATOGRAPHY B, 2014, 第 4 作者
(19) Metabolic Response to Oral Microcystin-LR Exposure in the Rat by NMR-Based Metabonomic Study, JOURNAL OF PROTEOME RESEARCH, 2012, 第 1 作者
(20) Quantitatively evaluating detoxification of the hepatotoxic microcystins through the glutathione and cysteine pathway in the cyanobacteria-eating bighead carp, AQUATIC TOXICOLOGY, 2012, 第 1 作者
(21) The evolutions of the Yangtze River and its biodiversity, THE INNOVATION, 第 7 作者

科研活动

   
科研项目
( 1 ) 微囊藻毒素在巢湖食物网中的累积特征调查, 负责人, 地方任务, 2022-02--2025-03
( 2 ) 鲤科鱼类东亚特有类群对江湖复合生态系统的繁殖适应策略, 负责人, 中国科学院计划, 2018-07--2023-06
( 3 ) 斑马鱼对微囊藻毒素神经毒性的代谢应答, 负责人, 地方任务, 2018-01--2019-12
( 4 ) 鲤科鱼类东亚特有类群关键特征--产卵习性演化的系统生物学研究, 负责人, 中国科学院计划, 2017-08--2018-07
( 5 ) 基于代谢组学研究微囊藻毒素MCLR诱导大鼠认知损伤的毒性效应及机制, 负责人, 国家任务, 2017-01--2019-12
( 6 ) 微囊藻毒素MCLR对斑马鱼认知能力影响的代谢组学研究, 负责人, 研究所自主部署, 2017-01--2018-12