聚焦于纳米生物技术用于肿瘤疫苗和免疫佐剂的研发，通过对天然免疫信号通路的分子调控，将纳米技术和纳米特性应用于抗感染免疫，抗肿瘤免疫，以及细胞自噬的干预中，从纳米结构-生物分子交互作用水平，研究高效纳米免疫制剂的新技术和新机制。

   

0710J1-纳米科学与技术

纳米生物医学
纳米生物效应

2004-09--2009-06   中国科学院高能物理研究所   博士
2000-09--2004-06   北京大学   理学学士

   

2021-03~现在, 国家纳米科学中心, 研究员
2019-11~2021-02,University of Southern California, Assistant Professor of Research
2017-11~2019-10,The Houston Methodist Research Institute, Research Associate
2017-02~2017-10,The Houston Methodist Research Institute, 博士后
2013-01~2017-01,国家纳米科学中心, 副研究员
2009-07~2012-12,国家纳米科学中心, 助理研究员

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（ 1 ） 一种抗原组合物及其制备方法和用途以及肿瘤疫苗, 发明, 2013, 第 3 作者, 专利号: CN103372203A
（ 2 ） 一种抗原组合物及其制备方法和用途以及肿瘤疫苗, 发明, 2013, 第 3 作者, 专利号: WO2013155890 A1
（ 3 ） SELF-ASSEMBLED PEPTIDE NANOPARTICLE AND USE THEREOF, 发明, 2020, 第 3 作者, 专利号: PCT/US2020/013417
（ 4 ） Antigen composition, preparation method and use thereof, and tumor vaccine, 发明, 2015, 第 3 作者, 专利号: US Patent US20150093415 A1; International Patent WO2013155890 A1; Chinese patent CN 103372203 A
（ 5 ） BECLIN 2 AND USES THEREOF FOR TREATING CANCER AND NEURODEGENERATIVE DISEASES, 发明, 2020, 第 3 作者, 专利号: US63/069,413

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[1] Deng, Guangtong, Li, Chaoran, Chen, Lang, Xing, Changsheng, Fu, Chuntang, Qian, Chen, Liu, Xin, Wang, Helen Y, Zhu, Motao, Wang, RongFu. BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1-and LC3-Independent Non-Canonical Autophagy. AUTOPHAGY[J]. 2022, 18(2): 340-356, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000664092700001.

[2] Xing, Changsheng, Wang, Mingjun, Ajibade, Adebusola A, Tan, Peng, Fu, Chuntang, Chen, Lang, Zhu, Motao, Hao, ZhaoZhe, Chu, Junjun, Yu, Xiao, Yin, Bingnan, Zhu, Jiahui, Shen, WanJou, Duan, Tianhao, Wang, Helen Y, Wang, RongFu. Microbiota regulate innate immune signaling and protective immunity against cancer. CELL HOST & MICROBE[J]. 2021, 29(6): 959-+, http://dx.doi.org/10.1016/j.chom.2021.03.016.

[3] Zhu, Motao, Deng, Guangtong, Xing, Changsheng, Nie, Guangjun, Wang, RongFu. BECN2 (beclin 2)-mediated non-canonical autophagy in innate immune signaling and tumor development. AUTOPHAGYnull. 2020, 16(12): 2310-2312, https://www.webofscience.com/wos/woscc/full-record/WOS:000582885700001.

[4] Zhu, Motao, Du, Libo, Zhao, Ruifang, Wang, Helen Y, Zhao, Yuliang, Nie, Guangjun, Wang, RongFu. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. ACS NANO[J]. 2020, 14(3): 3703-3717, https://www.webofscience.com/wos/woscc/full-record/WOS:000526301400104.

[5] Motao Zhu. Beclin 2 negatively regulates innate immune signaling and tumor development through non-canonical autophagy. J. Clin. Invest.. 2020, 
[6] Yu, Xiao, Du, Yang, Cai, Chunmei, Cai, Baowei, Zhu, Motao, Xing, Changsheng, Tan, Peng, Lin, Meng, Wu, Jian, Li, Jian, Wang, Mingjun, Wang, Helen Y, Su, Xinzhuan, Wang, RongFu. Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling. NATURE COMMUNICATIONS[J]. 2018, 9: https://www.webofscience.com/wos/woscc/full-record/WOS:000451047600005.

[7] Zhu, Motao, Wang, Rongfu, Nie, Guangjun. Applications of nanomaterials as vaccine adjuvants. HUMAN VACCINES & IMMUNOTHERAPEUTICSnull. 2014, 10(9): 2761-2774, https://www.webofscience.com/wos/woscc/full-record/WOS:000348316800052.

[8] Zhu, Motao, Perrett, Sarah, Nie, Guangjun. Understanding the Particokinetics of Engineered Nanomaterials for Safe and Effective Therapeutic Applications. SMALL[J]. 2013, 9(9-10): 1619-1634, http://www.irgrid.ac.cn/handle/1471x/756689.

[9] Tian, Xin, Zhu, Motao, Nie, Guangjun. How can nanotechnology help membrane vesicle-based cancer immunotherapy development?. HUMAN VACCINES & IMMUNOTHERAPEUTICSnull. 2013, 9(1): 222-225, https://www.webofscience.com/wos/woscc/full-record/WOS:000315577700040.

[10] 赵宇亮. Exosomes as Extrapulmonary Signaling Conveyors for Nanoparticle‐Induced Systemic Immune Activation. Small[J]. 2012, 8(3): 404-412, http://ir.ihep.ac.cn/handle/311005/223972.

[11] 赵宇亮. Nanoparticle‐Induced Exosomes Target Antigen‐Presenting Cells to Initiate Th1‐Type Immune Activation. Small[J]. 2012, 8(18): 2841-2848, 
[12] Wang Xiaofeng, Zhu Motao, Li Jingyuan. Biomedical Effects and Nanosafety of Engineered Nanomaterials: Recent Progress. CHINESE JOURNAL OF CHEMISTRY[J]. 2012, 30(9): 1931-1947, http://ir.ihep.ac.cn/handle/311005/224176.

[13] 赵宇亮. Physicochemical properties determine nanomaterial cellular uptake, transport, and fate. Accounts of chemical research. 2012, 46(3): 622-631, 
[14] 赵宇亮. A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma. Biomaterials[J]. 2012, 33(26): 6147-6154, http://dx.doi.org/10.1016/j.biomaterials.2012.05.034.

[15] 赵宇亮. Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis. Toxicology letters[J]. 2011, 203(2): 162-171, http://dx.doi.org/10.1016/j.toxlet.2011.03.021.

[16] Motao Zhu. Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Huaman Umbilical Endothelial Cells.. 2010, 
[17] Zhu MoTao, Feng WeiYue, Wang Yun, Wang Bing, Wang Meng, Ouyang Hong, Zhao YuLiang, Chai ZhiFang. Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment. Toxicological Sciences. 2009, 107(2): http://ir.ihep.ac.cn/handle/311005/237063.

[18] 赵宇亮. Comparative study of pulmonary responses to nano-and submicron-sized ferric oxide in rats. Toxicology[J]. 2008, 247(43134): 102-111, http://dx.doi.org/10.1016/j.tox.2008.02.011.

[19] Peng Tan, Lian He, Changsheng Xing, Jingrong Mao, Xiao Yu, Motao Zhu, Lixia Diao, Leng Han, Yubin Zhou, M James You, Helen Y Wang, RongFu Wang. Myeloid loss of Beclin 1 promotes PD-L1 hi precursor B cell lymphoma development. The Journal of Clinical Investigation. "null", 129(12): 5261-5277, https://www.webofscience.com/wos/woscc/full-record/WOS:000500567600024.

[20] Zhu Motao, Ding Xilai, Zhao Ruifang, Liu Xuewu, Shen Haifa, Cai Chunmei, Ferrari Mauro, Wang Helen Y, Wang RongFu. Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma. Journal of controlled release : official journal of the Controlled Release Society. 272: 72-82, http://www.corc.org.cn/handle/1471x/2178049.

（1） 纳米科学技术大系/纳米安全性丛书 《二氧化硅和氧化锌纳米材料生物效应与安全应用》第三、四章54-94, 科学出版社, 2010-02, 第 1 作者
（2） Nuclear Analytical Techniques for Metallomics and Metalloproteomics. Chapter 8 Applications of Nuclear Analytical Techniques for Iron-omics Studies 239-264, The Royal Society of Chemistry, 2010-06, 第 2 作者

   

（ 1 ） 膜泡系统介导的纳米颗粒细胞外排和肺外信号转导机制研究, 主持, 国家级, 2012-01--2014-12
（ 2 ） 基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究, 参与, 国家级, 2012-01--2016-12
（ 3 ） 纳米技术用于抗感染和抗肿瘤免疫治疗, 主持, 部委级, 2021-03--2024-02
（ 4 ） 美国国立卫生研究院(NIH), NCI R01项目CD4+ T cells and neoantigen in melanoma immunotherapy, 参与, 研究所（学校）, 2020-12--2025-11
（ 5 ） 基于纳米尺度天然膜泡结构exosome的双功能抗肿瘤疫苗设计及抗肿瘤效果研究, 主持, 国家级, 2015-01--2018-12
（ 6 ） 膜泡系统介导的纳米颗粒细胞外排和肺外信号转导, 主持, 国家级, 2012-01--2014-12
（ 7 ） 基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究, 参与, 国家级, 2012-01--2016-08
（ 8 ） 美国国防部Level 3项目NY-ESO-1-Specific TCR-Engineered T-Cell Immunotherapy for Triple Negative Breast Cancer, 参与, 研究所（学校）, 2016-09--2019-10

（1）Exosome as signaling conveyor for nanotoxicity   Motao Zhu   2012-09-04
（2）Endothelial toxicity of ferric oxide nanoparticles   Motao Zhu   2010-03-09