基本信息
孙丽娜 女 博导 中国科学院海洋研究所
电子邮件： sunlina@qdio.ac.cn
通信地址： 山东省青岛市市南区南海路7号
邮政编码：
电子邮件： sunlina@qdio.ac.cn
通信地址： 山东省青岛市市南区南海路7号
邮政编码：
招生信息
招生专业
0707Z1-海洋生态学
086000-生物与医药
086000-生物与医药
招生方向
生物资源生态学，养殖生态学，海洋生物工程
海洋生物工程
海洋生物工程
教育背景
2008-09--2013-06 中国科学院海洋研究所 博士学位
2004-09--2008-06 中国海洋大学 学士学位
2004-09--2008-06 中国海洋大学 学士学位
工作经历
工作简历
2022-09~现在, 中国科学院海洋研究所, 研究员
2017-01~2022-09,中国科学院海洋研究所, 副研究员
2013-07~2016-12,中国科学院海洋研究所, 助理研究员
2017-01~2022-09,中国科学院海洋研究所, 副研究员
2013-07~2016-12,中国科学院海洋研究所, 助理研究员
社会兼职
2021-11-27-今,中国新农科水产联盟专家委员会, 委员
2020-01-01-今,山东省青年联合会, 委员
2020-01-01-今,山东省青年联合会, 委员
专利与奖励
奖励信息
（1） 刺参对环境胁迫的特殊行为响应及其调控机制, 二等奖, 省级, 2021
（2） 中国科学院沈阳分院优秀青年科技人才奖, 一等奖, 院级, 2020
（3） 刺参高效配合饲料关键技术与产业化应用, 二等奖, 省级, 2019
（4） 现代海洋牧场构建技术创新与集成应用团队, 一等奖, 部委级, 2017
（5） 刺参良种生态高效增养殖设施和关键技术创新与应用, 二等奖, 部委级, 2014
（2） 中国科学院沈阳分院优秀青年科技人才奖, 一等奖, 院级, 2020
（3） 刺参高效配合饲料关键技术与产业化应用, 二等奖, 省级, 2019
（4） 现代海洋牧场构建技术创新与集成应用团队, 一等奖, 部委级, 2017
（5） 刺参良种生态高效增养殖设施和关键技术创新与应用, 二等奖, 部委级, 2014
专利成果
[1] 邢丽丽, 刘石林, 江春嬉, 杨红生, 孙丽娜, 张立斌. 一种刺参基因编辑体系的构建方法. CN: CN114214364A, 2022-03-22.
[2] 刘石林, 林承刚, 孙景春, 孙丽娜, 邢丽丽, 茹小尚, 张立斌, 杨红生. 一种多刺速生刺参品系的选育方法. CN: CN113424785A, 2021-09-24.
[3] 刘石林, 孙景春, 林承刚, 张永安, 孙丽娜, 邢丽丽, 茹小尚, 许帅, 张立斌, 杨红生. 一种刺参养殖池塘底质改良设施. CN: CN214126584U, 2021-09-07.
[4] 张立斌, 许帅, 刘石林, 林承刚, 孙景春, 孙丽娜, 杨红生. 一种冷冻保护液及刺参精子超低温冷冻保存方法. CN: CN112075415B, 2021-08-31.
[5] 林承刚, 孙景春, 孙丽娜, 刘石林, 张立斌, 杨红生, 王旭, 范鑫昊, 高焕鑫. 一种快速批量测定海胆壳径的装备. CN: CN213335988U, 2021-06-01.
[6] 刘石林, 孙景春, 林承刚, 张永安, 孙丽娜, 邢丽丽, 茹小尚, 许帅, 张立斌, 杨红生. 一种刺参养殖池塘底质改良设施及其使用方法. CN: CN112425556A, 2021-03-02.
[7] 林承刚, 孙景春, 孙丽娜, 刘石林, 张立斌, 杨红生, 王旭, 范鑫昊, 高焕鑫. 一种快速批量测定海胆壳径的装备及其测定方法. CN: CN112240750A, 2021-01-19.
[8] 林承刚, 范鑫昊, 张立斌, 杨红生, 孙景春, 丁奎, 茹小尚, 孙丽娜, 刘石林, 周文礼. 一种浅海海参诱捕器. CN: CN112042608A, 2020-12-08.
[9] 杨红生, 宋肖跃, 林承刚, 周毅, 王先锋, 王金霞, 张涛, 张立斌, 孙丽娜, 刘石林, 孙景春. 一种磁力约束单向流阀负压式潮间带浅水沉积物采集器. CN: CN106950075A, 2017-07-14.
[10] 杨红生, 宋肖跃, 林承刚, 周毅, 王先锋, 刘清远, 张涛, 张立斌, 孙丽娜, 刘石林, 孙景春. 适用于海洋牧场底栖环境调查的沉积物采集与分切装置. CN: CN106840776A, 2017-06-13.
[11] 林承刚, 杨红生, 张立斌, 张涛, 周毅, 许强, 刘石林, 孙丽娜, 孙景春. 一种海洋底栖生物附着力测定装置. CN: CN104542395A, 2015-04-29.
[12] 杨红生, 林承刚, 张立斌, 邱天龙, 张涛, 阚仁涛, 周毅, 许强, 刘石林, 孙丽娜. 一种实验用可调节流速的模拟水流装置. CN: CN103404456A, 2013-11-27.
[2] 刘石林, 林承刚, 孙景春, 孙丽娜, 邢丽丽, 茹小尚, 张立斌, 杨红生. 一种多刺速生刺参品系的选育方法. CN: CN113424785A, 2021-09-24.
[3] 刘石林, 孙景春, 林承刚, 张永安, 孙丽娜, 邢丽丽, 茹小尚, 许帅, 张立斌, 杨红生. 一种刺参养殖池塘底质改良设施. CN: CN214126584U, 2021-09-07.
[4] 张立斌, 许帅, 刘石林, 林承刚, 孙景春, 孙丽娜, 杨红生. 一种冷冻保护液及刺参精子超低温冷冻保存方法. CN: CN112075415B, 2021-08-31.
[5] 林承刚, 孙景春, 孙丽娜, 刘石林, 张立斌, 杨红生, 王旭, 范鑫昊, 高焕鑫. 一种快速批量测定海胆壳径的装备. CN: CN213335988U, 2021-06-01.
[6] 刘石林, 孙景春, 林承刚, 张永安, 孙丽娜, 邢丽丽, 茹小尚, 许帅, 张立斌, 杨红生. 一种刺参养殖池塘底质改良设施及其使用方法. CN: CN112425556A, 2021-03-02.
[7] 林承刚, 孙景春, 孙丽娜, 刘石林, 张立斌, 杨红生, 王旭, 范鑫昊, 高焕鑫. 一种快速批量测定海胆壳径的装备及其测定方法. CN: CN112240750A, 2021-01-19.
[8] 林承刚, 范鑫昊, 张立斌, 杨红生, 孙景春, 丁奎, 茹小尚, 孙丽娜, 刘石林, 周文礼. 一种浅海海参诱捕器. CN: CN112042608A, 2020-12-08.
[9] 杨红生, 宋肖跃, 林承刚, 周毅, 王先锋, 王金霞, 张涛, 张立斌, 孙丽娜, 刘石林, 孙景春. 一种磁力约束单向流阀负压式潮间带浅水沉积物采集器. CN: CN106950075A, 2017-07-14.
[10] 杨红生, 宋肖跃, 林承刚, 周毅, 王先锋, 刘清远, 张涛, 张立斌, 孙丽娜, 刘石林, 孙景春. 适用于海洋牧场底栖环境调查的沉积物采集与分切装置. CN: CN106840776A, 2017-06-13.
[11] 林承刚, 杨红生, 张立斌, 张涛, 周毅, 许强, 刘石林, 孙丽娜, 孙景春. 一种海洋底栖生物附着力测定装置. CN: CN104542395A, 2015-04-29.
[12] 杨红生, 林承刚, 张立斌, 邱天龙, 张涛, 阚仁涛, 周毅, 许强, 刘石林, 孙丽娜. 一种实验用可调节流速的模拟水流装置. CN: CN103404456A, 2013-11-27.
出版信息
发表论文
[1] Xing, Lili, Liu, Shilin, Zhang, Libin, Yang, Hongsheng, Sun, Lina. MITF Contributes to the Body Color Differentiation of Sea Cucumbers Apostichopus japonicus through Expression Differences and Regulation of Downstream Genes. BIOLOGY-BASEL[J]. 2023, 12(1): [2] Da Huo, Libin Zhang, Hongsheng Yang, Lina Sun. Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber. ENVIRONMENTAL POLLUTION[J]. 2023, 330: http://dx.doi.org/10.1016/j.envpol.2023.121766.
[3] Da Huo, Fang Su, Hongsheng Yang, Lina Sun. Exosomal microRNAs regulate the heat stress response in sea cucumber Apostichopus japonicus. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2023, 249: http://dx.doi.org/10.1016/j.ecoenv.2022.114419.
[4] Su, Fang, Liu, Shilin, Xing, Lili, Huo, Da, Yang, Hongsheng, Sun, Lina. Understanding gene regulation during the development of the sea cucumber Apostichopus japonicus using comparative transcriptomics. FRONTIERS IN MARINE SCIENCE[J]. 2023, 10: http://dx.doi.org/10.3389/fmars.2023.1087339.
[5] Huo, Da, Su, Fang, Cui, Wei, Liu, Shilin, Zhang, Libin, Yang, Hongsheng, Sun, Lina. Heat stress and evisceration caused lipid metabolism and neural transduction changes in sea cucumber: Evidence from metabolomics. MARINE POLLUTION BULLETIN[J]. 2022, 182: http://dx.doi.org/10.1016/j.marpolbul.2022.113993.
[6] Xing, Lili, Liu, Shilin, Zhang, Libin, Yang, Hongsheng, Sun, Lina. Landscape and dynamics of accessible chromatin during pigmentation process in green, white and purple sea cucumber Apostichopus japonicus. AQUACULTURE REPORTS[J]. 2022, 23: https://doaj.org/article/23af458bb9624ff2a30bc8b257673a5a.
[7] Cui, Wei, Huo, Da, Liu, Shilin, Xing, Lili, Su, Fang, Yang, Hongsheng, Sun, Lina. Construction of a High-Density Genetic Linkage Map for the Mapping of QTL Associated with Growth-Related Traits in Sea Cucumber (Apostichopus japonicus). BIOLOGY-BASEL[J]. 2022, 11(1): [8] Su, Fang, Yang, Hongsheng, Sun, Lina. A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians. BIOLOGY-BASELnull. 2022, 11(8): [9] Xing, Lili, Sun, Lina, Liu, Shilin, Zhang, Libin, Sun, Jingchun, Yang, Hongsheng. Metabolomic analysis of white, green and purple morphs of sea cucumber Apostichopus japonicus during body color pigmentation process. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2021, 39: http://dx.doi.org/10.1016/j.cbd.2021.100827.
[10] Mohsen, Mohamed, Zhang, Libin, Sun, Lina, Lin, Chenggang, Wang, Qing, Liu, Shilin, Sun, Jinchun, Yang, Hongsheng. Effect of chronic exposure to microplastic fibre ingestion in the sea cucumber Apostichopus japonicus. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2021, 209: http://dx.doi.org/10.1016/j.ecoenv.2020.111794.
[11] Mohsen, Mohamed, Sun, Lina, Lin, Chenggang, Huo, Da, Yang, Hongsheng. Mechanism underlying the toxicity of the microplastic fibre transfer in the sea cucumber Apostichopus japonicus. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 416: http://dx.doi.org/10.1016/j.jhazmat.2021.125858.
[12] 许帅, 孙景春, 刘石林, 林承刚, 张立斌, 孙丽娜, 杨红生. 棘皮动物精子超低温冷冻保存技术研究进展. 渔业科学进展[J]. 2021, 42(3): 26-37, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2021&filename=HYSC202103003&v=MjY3ODg3RGgxVDNxVHJXTTFGckNVUjd1ZlllZG1GeTdtVXIzTkxUVFliYkc0SE5ETXJJOUZaNFI4ZVgxTHV4WVM=.
[13] Yang, Yujia, Li, Xiaoni, Sun, Lina. Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2021, 39(6): 2295-2308, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000661406900001.
[14] Huo, Da, Sun, Lina, Sun, Jingchun, Zhang, Libin, Liu, Shilin, Su, Fang, Yang, Hongsheng. Sea cucumbers in a high temperature and low dissolved oxygen world: Roles of miRNAs in the regulation of environmental stresses. ENVIRONMENTAL POLLUTION[J]. 2021, 268: http://dx.doi.org/10.1016/j.envpol.2020.115509.
[15] Da Huo, Lina Sun, Jingchun Sun, Chenggang Lin, Shilin Liu, Libin Zhang, Hongsheng Yang. Emerging roles of circRNAs in regulating thermal and hypoxic stresses in Apostichopus japonicus (Echinodermata: Holothuroidea). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2021, 228: [16] Xing, Lili, Sun, Lina, Liu, Shilin, Zhang, Libin, Yang, Hongsheng. Comparative metabolomic analysis of the body wall from four varieties of the sea cucumber Apostichopus japonicus. FOOD CHEMISTRY[J]. 2021, 352: http://dx.doi.org/10.1016/j.foodchem.2021.129339.
[17] Lin Chenggang, Liu Xiaolu, Sun Lina, Liu Shilin, Sun Jingchun, Zhang Libin, Yang Hongsheng. Effects of different flow velocities on behavior and TRPA1 expression in the sea cucumberApostichopus japonicas. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2020, 38(4): 1328-1340, http://lib.cqvip.com/Qikan/Article/Detail?id=7102292183.
[18] Liu, Xiaolu, Chenggang, Lin, Sun, Lina, Liu, Shilin, Sun, Jingchun, Yang, Hongsheng. Behavioural response of different epithelial tissues of sea cucumber (Apostichopus japonicus) to light and differential expression of the light-related genePax6. MARINE AND FRESHWATER BEHAVIOUR AND PHYSIOLOGY[J]. 2020, 53(2): 73-85, https://www.webofscience.com/wos/woscc/full-record/WOS:000567656800003.
[19] 杨红生, 孙景春, 茹小尚, 张灿影, 邢丽丽, 孙丽娜, 林承刚, 刘石林, 张立斌. 我国刺参种业态势分析与技术创新展望. 海洋科学[J]. 2020, 44(7): 2-9, http://lib.cqvip.com/Qikan/Article/Detail?id=7102292954.
[20] Mohsen, Mohamed, Zhang, Libin, Sun, Lina, Lin, Chenggang, Wang, Qing, Yang, Hongsheng. Microplastic fibers transfer from the water to the internal fluid of the sea cucumber Apostichopus japonicus. ENVIRONMENTAL POLLUTION[J]. 2020, 257: http://dx.doi.org/10.1016/j.envpol.2019.113606.
[21] Xiaolu Liu, Chenggang Lin, Lina Sun, Shilin Liu, Jingchun Sun, Libin Zhang, Hongsheng Yang. Transcriptome analysis of phototransduction-related genes in tentacles of the sea cucumber Apostichopus japonicus. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART D: GENOMICS AND PROTEOMICS. 2020, 34: http://dx.doi.org/10.1016/j.cbd.2020.100675.
[22] Zhang, Hongxia, Wang, Qing, Zhao, Jianmin, Liu, Shilin, Zhang, Libin, Zhao, Ye, Yang, Hongsheng, Sun, Lina. Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus. GENOMICS[J]. 2020, 112(6): 5012-5020, http://dx.doi.org/10.1016/j.ygeno.2020.09.017.
[23] Wang, Tianming, Cao, Zheng, Shen, Zhangfei, Yang, Jingwen, Chen, Xu, Yang, Zhen, Xu, Ke, Xiang, Xiaowei, Yu, Qiuhan, Song, Yimin, Wang, Weiwei, Tian, Yanan, Sun, Lina, Zhang, Libin, Guo, Su, Zhou, Naiming. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species. ELIFE[J]. 2020, 9: https://doaj.org/article/dbed66ebd48648e886835c50c880eeff.
[24] Huo, Da, Sun, Lina, Storey, Kenneth B, Zhang, Libin, Liu, Shilin, Sun, Jingchun, Yang, Hongsheng. The regulation mechanism of lncRNAs and mRNAs in sea cucumbers under global climate changes: Defense against thermal and hypoxic stresses. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2020, 709: http://dx.doi.org/10.1016/j.scitotenv.2019.136045.
[25] Liu, Xiaolu, Lin, Chenggang, Sun, Lina, Liu, Shilin, Sun, Jingchun, Zhang, Libin, Yang, Hongsheng. Transcriptome analysis of phototransduction-related genes in tentacles of the sea cucumber Apostichopus japonicus. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2020, 34: http://dx.doi.org/10.1016/j.cbd.2020.100675.
[26] Yang, Yujia, Zheng, Yingqiu, Sun, Lina, Chen, Muyan. Genome-Wide DNA Methylation Signatures of Sea CucumberApostichopus japonicusduring Environmental Induced Aestivation. GENES[J]. 2020, 11(9): http://dx.doi.org/10.3390/genes11091020.
[27] Mohsen, Mohamed, Zhang, Libin, Sun, Lina, Lin, Chenggang, Liu, Shilin, Wang, Qing, Yang, Hongsheng. A deposit-feeder sea cucumber also ingests suspended particles through the mouth. JOURNAL OF EXPERIMENTAL BIOLOGY[J]. 2020, 223(24): https://www.webofscience.com/wos/woscc/full-record/WOS:000605472600010.
[28] Huo, Da, Sun, Lina, Zhang, Libin, Ru, Xiaoshang, Liu, Shilin, Yang, Hongsheng. Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia. MARINE POLLUTION BULLETIN[J]. 2019, 138: 407-420, http://dx.doi.org/10.1016/j.marpolbul.2018.11.063.
[29] Ding, Kui, Zhang, Libin, Sun, Lina, Lin, Chenggang, Feng, Qiming, Zhang, Shuangyan, Yang, Hongsheng, Brinkman, Richard, Lin, Gang, Huang, Zhen. Transcriptome analysis provides insights into the molecular mechanisms responsible for evisceration behavior in the sea cucumber Apostichopus japonicus. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2019, 30: 143-157, http://dx.doi.org/10.1016/j.cbd.2019.02.008.
[30] Mohsen, Mohamed, Wang, Qing, Zhang, Libin, Sun, Lina, Lin, Chenggang, Yang, Hongsheng. Microplastic ingestion by the farmed sea cucumber Apostichopus japonicus in China. ENVIRONMENTAL POLLUTION[J]. 2019, 245: 1071-1078, http://dx.doi.org/10.1016/j.envpol.2018.11.083.
[31] Yang, MeiJie, Song, Hao, Sun, LiNa, Yu, ZhengLin, Hu, Zhi, Wang, XiaoLong, Zhu, JiaYi, Zhang, Tao. Effect of temperature on the microflora community composition in the digestive tract of the veined rapa whelk (Rapana venosa) revealed by 16S rRNA gene sequencing. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2019, 29: 145-153, http://ir.qdio.ac.cn/handle/337002/155292.
[32] Zhang, Hongxia, Wang, Qing, Liu, Shilin, Huo, Da, Zhao, Jianmin, Zhang, Libin, Zhao, Ye, Sun, Lina, Yang, Hongsheng. Genomic and Metagenomic Insights Into the Microbial Community in the Regenerating Intestine of the Sea Cucumber Apostichopus japonicus. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/05d8ac5bcc8741c28d79233126e79159.
[33] Yuan, Jianbo, Gao, Yi, Sun, Lina, Jin, Songjun, Zhang, Xiaojun, Liu, Chengzhang, Li, Fuhua, Xiang, Jianhai. Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus. FRONTIERS IN GENETICS[J]. 2019, 10: http://ir.qdio.ac.cn/handle/337002/155560.
[34] Huo, Da, Sun, Lina, Zhang, Libin, Ru, Xiaoshang, Liu, Shilin, Yang, Xinyuan, Yang, Hongsheng. Global-warming-caused changes of temperature and oxygen alter the proteomic profile of sea cucumber Apostichopus japonicus. JOURNAL OF PROTEOMICS[J]. 2019, 193: 27-43, http://ir.qdio.ac.cn/handle/337002/155313.
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[76] Song, Hao, Yu, ZhengLin, Sun, LiNa, Gao, Yan, Zhang, Tao, Wang, HaiYan. De novo transcriptome sequencing and analysis of Rapana venosa from six different developmental stages using Hi-seq 2500. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2016, 17: 48-57, http://dx.doi.org/10.1016/j.cbd.2016.01.006.
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科研活动
科研项目
（ 1 ） 刺参再生的基因组特征解析与关键调控基因分析, 负责人, 国家任务, 2018-01--2021-12
（ 2 ） 仿刺参生长与品质性状的遗传调控机制研究, 负责人, 国家任务, 2018-12--2022-12
（ 3 ） 青年创新促进会, 负责人, 中国科学院计划, 2019-01--2022-12
（ 4 ） 基于单细胞RNA-Seq技术分析刺参肠道再生原 基细胞的演化命运, 负责人, 国家任务, 2021-01--2024-12
（ 5 ） 中国科学院海洋研究所汇泉青年学者人才项目, 负责人, 研究所自选, 2019-11--2022-11
（ 6 ） 棘皮动物可变结缔组织可塑性的遗传基础与调控机制, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 仿刺参生长与品质性状的遗传调控机制研究, 负责人, 国家任务, 2018-12--2022-12
（ 3 ） 青年创新促进会, 负责人, 中国科学院计划, 2019-01--2022-12
（ 4 ） 基于单细胞RNA-Seq技术分析刺参肠道再生原 基细胞的演化命运, 负责人, 国家任务, 2021-01--2024-12
（ 5 ） 中国科学院海洋研究所汇泉青年学者人才项目, 负责人, 研究所自选, 2019-11--2022-11
（ 6 ） 棘皮动物可变结缔组织可塑性的遗传基础与调控机制, 负责人, 国家任务, 2023-01--2026-12
指导学生
已指导学生
崔玮 硕士研究生 085238-生物工程
现指导学生
李金琪 硕士研究生 085700-资源与环境