基本信息

李鑫 男 硕导 中国科学院海洋研究所
电子邮件: lixin@qdio.ac.cn
通信地址: 山东省青岛市市南区南海路7号
邮政编码:
电子邮件: lixin@qdio.ac.cn
通信地址: 山东省青岛市市南区南海路7号
邮政编码:
招生信息
招生专业
070703-海洋生物学
招生方向
海洋生物天然产物及生物制品
教育背景
2011-09--2016-07 中国科学院大学 理学博士
2006-09--2010-07 青岛科技大学 理学学士
2006-09--2010-07 青岛科技大学 理学学士
工作经历
工作简历
2019-04~现在, 中国科学院海洋研究所, 副研究员
2018-09~2019-04,中国科学院海洋研究所, 助理研究员
2016-07~2018-09,中国科学院海洋研究所, 博士后
2018-09~2019-04,中国科学院海洋研究所, 助理研究员
2016-07~2018-09,中国科学院海洋研究所, 博士后
专利与奖励
专利成果
( 1 ) 一种细胞松弛素类化合物及其制备方法和应用, 发明专利, 2021, 第 5 作者, 专利号: CN113861208A
( 2 ) 一种硫代二酮哌嗪类化合物及其制备方法和应用, 发明专利, 2022, 第 4 作者, 专利号: CN111205308B
( 3 ) 一种降二萜化合物及其分离方法和抗神经氨酸酶活性应用, 发明专利, 2018, 第 2 作者, 专利号: CN108774115A
( 2 ) 一种硫代二酮哌嗪类化合物及其制备方法和应用, 发明专利, 2022, 第 4 作者, 专利号: CN111205308B
( 3 ) 一种降二萜化合物及其分离方法和抗神经氨酸酶活性应用, 发明专利, 2018, 第 2 作者, 专利号: CN108774115A
出版信息
发表论文
(1) Antimicrobial sesterterpenoids with a unique 5/8/6/5 tetracyclic carbon-ring-system and diepoxide polyketides from a deep sea-sedimentsourced fungus Chaetomium globosum SD-347, Organic & Biomolecular Chemistry, 2024, 通讯作者
(2) Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258, Marine Drugs, 2024, 通讯作者
(3) Bialorastins A–F, highly oxygenated and polycyclic andrastin-type meroterpenoids with proangiogenic activity from the deep-sea cold-seep-derived fungus Penicillium bialowiezense CS-283, Bioorganic Chemistry, 2024, 通讯作者
(4) New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682, Chemistry & Biodiversity, 2024, 通讯作者
(5) Antibacterial Indole Diketopiperazine Alkaloids from the Deep-Sea Cold Seep-Derived Fungus Aspergillus chevalieri, MARINE DRUGS, 2023, 通讯作者
(6) Aspertides A−E: Antimicrobial Pentadepsipeptides with a Unique p‑Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512, Journal of Agricultural and Food Chemistry, 2023, 通讯作者
(7) Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum), Deep-Sea Research Part I, 2023, 通讯作者
(8) Chevalinulins A and B, Proangiogenic Alkaloids with a Spirobicyclo2.2.2octane-diketopiperazine Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122, ORGANIC LETTERS, 2022, 通讯作者
(9) Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406, MARINE DRUGS, 2022, 通讯作者
(10) Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512, CHEMISTRY & BIODIVERSITY, 2021, 通讯作者
(11) Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5, NATURAL PRODUCT RESEARCH, 2021, 第 1 作者
(12) Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388, MARINE DRUGS, 2020, 通讯作者
(13) Ophiobolin Sesterterpenoids and Farnesylated Phthalide Derivatives from the Deep Sea Cold-Seep-Derived Fungus Aspergillus insuetus SD-512, JOURNAL OF NATURAL PRODUCTS, 2020, 通讯作者
(14) New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388, CHEMISTRY & BIODIVERSITY, 2020, 通讯作者
(15) Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330, MARINE DRUGS, 2019, 通讯作者
(16) Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis, MARINE DRUGS, 2018, 第 1 作者
(17) Wentinoids A-F, six new isopimarane diterpenoids from Aspergillus wentii SD-310, a deep-sea sediment derived fungus, RSC ADVANCES, 2017, 第 1 作者
(18) 20-nor-isopimarane cycloethers from the deep-sea sediment-derived fungus aspergillus wentii sd-310, RSC ADVANCES, 2016, 第 1 作者
(19) A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 第 1 作者
(20) Antioxidant metabolites from marine alga-derived fungus Aspergillus wentii EN-48, PHYTOCHEMISTRY LETTERS, 2014, 第 1 作者
(2) Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258, Marine Drugs, 2024, 通讯作者
(3) Bialorastins A–F, highly oxygenated and polycyclic andrastin-type meroterpenoids with proangiogenic activity from the deep-sea cold-seep-derived fungus Penicillium bialowiezense CS-283, Bioorganic Chemistry, 2024, 通讯作者
(4) New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682, Chemistry & Biodiversity, 2024, 通讯作者
(5) Antibacterial Indole Diketopiperazine Alkaloids from the Deep-Sea Cold Seep-Derived Fungus Aspergillus chevalieri, MARINE DRUGS, 2023, 通讯作者
(6) Aspertides A−E: Antimicrobial Pentadepsipeptides with a Unique p‑Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512, Journal of Agricultural and Food Chemistry, 2023, 通讯作者
(7) Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum), Deep-Sea Research Part I, 2023, 通讯作者
(8) Chevalinulins A and B, Proangiogenic Alkaloids with a Spirobicyclo2.2.2octane-diketopiperazine Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122, ORGANIC LETTERS, 2022, 通讯作者
(9) Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406, MARINE DRUGS, 2022, 通讯作者
(10) Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512, CHEMISTRY & BIODIVERSITY, 2021, 通讯作者
(11) Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungusAspergillus ustusTK-5, NATURAL PRODUCT RESEARCH, 2021, 第 1 作者
(12) Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388, MARINE DRUGS, 2020, 通讯作者
(13) Ophiobolin Sesterterpenoids and Farnesylated Phthalide Derivatives from the Deep Sea Cold-Seep-Derived Fungus Aspergillus insuetus SD-512, JOURNAL OF NATURAL PRODUCTS, 2020, 通讯作者
(14) New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388, CHEMISTRY & BIODIVERSITY, 2020, 通讯作者
(15) Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330, MARINE DRUGS, 2019, 通讯作者
(16) Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis, MARINE DRUGS, 2018, 第 1 作者
(17) Wentinoids A-F, six new isopimarane diterpenoids from Aspergillus wentii SD-310, a deep-sea sediment derived fungus, RSC ADVANCES, 2017, 第 1 作者
(18) 20-nor-isopimarane cycloethers from the deep-sea sediment-derived fungus aspergillus wentii sd-310, RSC ADVANCES, 2016, 第 1 作者
(19) A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 第 1 作者
(20) Antioxidant metabolites from marine alga-derived fungus Aspergillus wentii EN-48, PHYTOCHEMISTRY LETTERS, 2014, 第 1 作者
科研活动
科研项目
( 1 ) 基于原位富集培养和PSMPA策略的深海冷泉微生物药物先导化合物挖掘技术, 负责人, 国家任务, 2022-11--2025-10
( 2 ) 深海冷泉富硫环境中冷泉真菌含硫代谢产物的靶向分离及其抗肝癌活性研究, 负责人, 国家任务, 2021-01--2024-12
( 3 ) 中国科学院青促会经费, 负责人, 中国科学院计划, 2023-01--2026-12
( 2 ) 深海冷泉富硫环境中冷泉真菌含硫代谢产物的靶向分离及其抗肝癌活性研究, 负责人, 国家任务, 2021-01--2024-12
( 3 ) 中国科学院青促会经费, 负责人, 中国科学院计划, 2023-01--2026-12