Bioinformatics: developing new methods and tools for human genetics data.

Statistical genetics: genetic diversity, GWAS, statistical genetics for complex traits, etc.

2005-12--2008-10   Postdoc in Bioinformatics, CHUV, University of Lausanne (Switzerland). Postdoc in Statistics, EPFL (Ecole Polytechnique Fédérale de Lausanne, Switzerland).

2000-09--2005-06   PhD in Bioinformatics, Peking University (China).

1996-09--2000-06   Bachelor in Statistics and Probability, Peking University (China).

2012.03--now        Associate Professor,  Institute of Psychology, Chinese Academy of Sciences.

2008.11--2012.02  Assistant Professor,  Institute of Psychology, Chinese Academy of Sciences.

Papers（# co-first，* corresponding）：

First or corresponding author

1.         Zhang K, Wang L*, Cao C, Li G, Fang R, Liu P, Luo S, Zhang X, Liberzon I. (2018) A DRD2/ANNK1-COMT interaction, consisting of functional variants, confers risk of post-traumatic stress disorder in traumatized Chinese. Frontiers in Psychiatry 9:170. doi: 10.3389/fpsyt.2018.00170

2.         Zhang K#, Qu S#, Chang S#, Li G, Cao C, Fang K, Olff M, Wang L*, Wang J*. (2017). An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene. Neuroscience and Biobehavioral Reviews 83:647-656. doi: 10.1016/j.neubiorev.2017.08.021

3.         Qu S, Du Y, Chang S, Guo L, Fang K, Li Y, Zhang F, Zhang K*, Wang J* (2017). Common variants near IKZF1 are associated with primary Sjögren's syndrome in Han Chinese. PLoS One 12(5): e0177320.

4.         Zhang K#, Fan Z#, Wang Y, Faraone SV, Yang L*, Chang S*. (2017). Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level. World J Biol Psychiatry. doi: 10.1080/15622975.2017.1386324.

5.         Piao W#, Guo J#, Bao Y, Wang F, Zhang T, Huo J*, Zhang K*. (2016). Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han population. Birth Defects Research Part A: Clinical and Molecular Teratology 106(4): 232-239.

6.         Zhang K#, Chang S#, Guo L, Wang J*. (2015). I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein & Cell 6(3): 221-224.

7.         Li Y#, Zhang K#, Chen H#, Sun F, Xu J, Wu Z, Li P, Zhang L, Du Y, Luan H, Li X, Wu L, Li H, Wu H, Li X, Li X, Zhang X, Gong L, Dai L, Sun L, Zuo X, Xu J, Gong H, Li Z, Tong S, Wu M, Li X, Xiao W, Wang G, Zhu P, Shen M, Liu S, Zhao D, Liu W, Wang Y, Huang C, Jiang Q, Liu G, Liu B, Hu S, Zhang W, Zhang Z, You X, Li M, Hao W, Zhao C, Leng X, Bi L, Wang Y, Zhang F, Shi Q, Qi W, Zhang X, Jia Y, Su J, Li Q, Hou Y, Wu Q, Xu D, Zheng W, Zhang M, Wang Q, Fei Y, Zhang X, Li J, Jiang Y, Tian X, Zhao L, Wang L, Zhou B, Li Y, Zhao Y, Zeng X, Ott J, Wang J *, & Zhang F *. (2013). A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nature Genetics 45(11): 1361-1365.

8.         Zhang K, Chang S, Cui S, Guo L, Zhang L and Wang J*. (2011). ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Research 39(Web Server issue): W437-443.

9.         Zhang K, Zhang L, Zhang W and Wang J*. (2011). Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study. Chinese Science Bulletin 56(32): 3398-3402.

10.     Yang L#, Zhang K#, Dai W, He X, Zhao Q, Wang J*, Sun ZS*. (2011). Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array. BMC Genomics 12: 10.

11.     Zhang K#, Cui S#, Chang S, Zhang L and Wang J*. (2010). i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Research 38 Web Server issue): W90-95.

12.     Zhang K-L, Mangeat B, Ortiz M, Zoete V, Trono D, Telenti A *, & Michielin O *. (2007). Model structure of human APOBEC3G. PLoS ONE 2(4): e378.

13.     Zhang K, Luo JC, Liu CQ *. (2005). Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation. Journal of Molecular Structure: THEOCHEM 715(1-3): 15-20.

14.     Zhang K-L, Zhang J *, Luo JC. (2005). Potential Transcriptional Synergy between Upstream Regions and Introns of Yeast Genes. Progress in Biochemistry and Biophysics 32(1): 46-52.

15.     Zhang K-L, Zhang J, Luo J-C. (2005). Possible Short- and Long-Range Transcriptional Synergistic Regulation between Upstream Regions and Introns in Yeast Genes. Acta Biophysica Sinica (《生物物理学报》) 21(4): 277-283. (in Chinese)

Co-author

16.     Yang L#, Chang S#, Lu Q, Zhang Y, Wu Z, Sun X, Cao Q, Qian Y, Jia T, Xu B, Duan Q, Li Y, Zhang K, Gunter S, Lu L, Liu D*, Wang J*, Wang Y*, Lu L. (2018). A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Molecular Psychiatry 23(4):1014-1020. doi: 10.1038/mp.2017.74

17.     Xue Y, Lameijer EW, Ye K, Zhang K, Chang S, Wang X, Wu J, Gao G, Zhao F, Li J, Han C, Xu S, Xiao J, Yang X, Ying X, Zhang X, Chen WH, Liu Y, Zhang Z, Huang K, Yu J*. (2016). Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics 14(5):253-261.

18.     Fang K, Zhang K, Wang J *. (2015). Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese. Scientific Reports 5:18855.

19.     Chang S #, Fang K #, Zhang K, Wang J *. (2015). Network-based analysis of schizophrenia genome-wide association data to detect the joint functional association signals. PLoS One 10(7):e0133404.

20.     Guo L #, Du Y #, Chang S, Zhang K, & Wang J *. (2014). rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Research 42(Database issue): D1033-D1039.

21.     Zhang W-N, Chang S-H, Guo L-Y, Zhang K-L, & Wang J *. (2013). The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies. Journal of Affective Disorders 151(2): 531-539.

22.     Zhang L #, Chang S #, Li Z, Zhang K, Du Y, Ott Y, Wang J *. (2012). ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Research 40 (Database issue): D1003-1009.

23.     Fang K #, Zhao H #, Sun C, Lam C M-C, Chang S, Zhang K, Panda G, Godinho M, Martins dos Santos V ^# and Wang J *. (2011). Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. BMC systems Biology 5:83.

24.     Fellay J #, Ge D #, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A *, Goldstein DB *; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genetics 5: e1000791.  

25.     Ge D *, Zhang K, Need AC, Martin O, Fellay J, Telenti A and Goldstein DB *. (2008). WGAViewer: A software tool for genomic annotation of whole genome association studies. Genome Research 18(4): 640-3.

26.     Ortiz M, Kaessmann H, Zhang K, Bashirova A, Carrington M, Quintana-Murci L, Telenti A *. (2008). The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates. Genes & Immunity 9(6): 483-92.

27.     Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, Luca AD, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A *, and Goldstein DB *. (2007). A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1. Science (ScienceXpress, 19 July 2007) 317(5840): 944-7.

28.     Rotger M #, Saumoy M #, Zhang K, Flepp M, Sahli R, Decosterd L, Telenti A * and the Swiss HIV Cohort Study. (2007). Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7. Pharmacogenetics and Genomics 17(10): 885-90.

29.     Zhou W, Chen X-F, Zhang K-L, Liu C-Q *. (2005). The identification and quantification of highly stable ‘common hairpin’ in the dynamic process of co-transcriptional mRNA folding. Journal of Molecular Structure: THEOCHEM 722(1-3): 41-50.

30.     Zhong L, Zhang K, Huang X, Ni P, Han Y, Wang K, Wang J, Li S. (2003). A statistical approach designed for finding mathematically defined repeats in shotgun data and determining the length distribution of clone-inserts. Genomics, Proteomics & Bioinformatics 1(1): 43-51.

31.     Yu J #, Hu S #, Wang J #, Wong GK #, Li S, Liu B, Deng Y, Dai L, Zhou Y, Zhang X, Cao M, Liu J, Sun J, Tang J, Chen Y, Huang X, Lin W, Ye C, Tong W, Cong L, Geng J, Han Y, Li L, Li W, Hu G, Huang X, Li W, Li J, Liu Z, Li L, Liu J, Qi Q, Liu J, Li L, Li T, Wang X, Lu H, Wu T, Zhu M, Ni P, Han H, Dong W, Ren X, Feng X, Cui P, Li X, Wang H, Xu X, Zhai W, Xu Z, Zhang J, He S, Zhang J, Xu J, Zhang K, Zheng X, Dong J, Zeng W, Tao L, Ye J, Tan J, Ren X, Chen X, He J, Liu D, Tian W, Tian C, Xia H, Bao Q, Li G, Gao H, Cao T, Wang J, Zhao W, Li P, Chen W, Wang X, Zhang Y, Hu J, Wang J, Liu S, Yang J, Zhang G, Xiong Y, Li Z, Mao L, Zhou C, Zhu Z, Chen R, Hao B, Zheng W, Chen S, Guo W, Li G, Liu S, Tao M, Wang J, Zhu L *, Yuan L *, Yang H *. (2002). A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science 296(5565): 79-92.

32.     Wang J *, Wong GK *, Ni P, Han Y, Huang X, Zhang J, Ye C, Zhang Y, Hu J, Zhang K, Xu X, Cong L, Lu H, Ren X, Ren X, He J, Tao L, Passey DA, Wang J, Yang H, Yu J, Li S. (2002). RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Research 12(5): 824-31.

33.     于军 等。籼稻(Oryza Sativa ssp. indica)全基因组框架序列。(2001). 科学通报 46(23): 1937-1941. (in Chinese)

34.     Yu J et al. A draft sequence of the rice (Oryza sativa ssp. indica) genome. (2001). Chinese Science Bulletin 46(23): 1937-1942.

Bioinformatics: developing new methods and tools for human genetics data.

Statistical genetics: genetic diversity, GWAS, statistical genetics for complex traits, etc.