基本信息
张永安  男  博导  华中农业大学
email: yzhang@ihb.ac.cn
address: 湖北省武汉市东湖南路7号
postalCode: 430072

招生信息

   
招生专业
071007-遗传学
071004-水生生物学
招生方向
鱼类分子免疫与疾病预防
鱼类疫苗学
进化免疫学

教育背景

1998-09--2001-06   中国科学院水生生物研究所   理学博士

工作经历

   
工作简历
2011-03~现在, 中国科学院水生生物研究所, 研究员
2005-03~2011-02,美国宾夕法尼亚大学, 博士后/研究助理
2004-03~2005-02,美国新墨西哥大学, 博士后
2002-10~2003-10,英国阿伯丁大学, 博士后
2002-01~2002-06,英国阿伯丁大学, 名誉研究员
2001-07~2002-10,中国科学院水生生物研究所, 助理研究员/副研究员
1998-09~2001-06,中国科学院水生生物研究所, 理学博士
社会兼职
2015-02-28-今,中国水产学会鱼病学专业委员会副主任委员兼秘书长,
2014-09-01-今,湖北省生物工程学会理事,
2013-10-01-今,中国致公党湖北省委科技教育工作专委会委员,
2012-04-28-今,农业部水产养殖病害防治专家委员会委员,
2012-01-01-今,湖北省特聘专家,

专利与奖励

   
奖励信息
(1) 鳜鱼河鲈锚首吸虫的病原生物学与种群生态学研究, 二等奖, 市地级, 1999
专利成果
( 1 ) 一种枯草芽孢杆菌GC5表面展示GCRV VP7蛋白的重组芽孢及制备方法, 2017, 第 1 作者, 专利号: ZL201510041532.4

( 2 ) 一种枯草芽孢杆菌制剂及制备方法和应用, 2017, 第 1 作者, 专利号: ZL201510154074.5

出版信息

   
发表论文
(1) Comparative study of the immunoprotective effect of two DNA vaccines against grass carp reovirus, Fish & Shellfish Immunology, 2018, 通讯作者
(2) B cell functions can be modulated by antimicrobial peptides in rainbow trout Oncorhynchus mykiss: novel insights into the innate nature of b cells in fish, Frontiers in Immunology, 2017, 通讯作者
(3) Grass Carp Reovirus VP41 Targets Fish MITA to Abrogate the IFN Response, Journal of Virology, 2017, 通讯作者
(4) Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss), Developmental & Comparative Immunology, 2017, 通讯作者
(5) Spring viremia of carp virus N protein suppresses fish IFNφ1 production by targeting the mitochondrial antiviral signaling protein., Journal of Immunology, 2016, 通讯作者
(6) Preferential combination between the light and heavy chain isotypes of fish immunoglobulins, Developmental and Comparative Immunology, 2016, 通讯作者
(7) Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed, Fish & Shellfish Immunology, 2016, 通讯作者
(8) The P Protein of Spring Viremia of Carp Virus Negatively Regulates Fish IFN Response by Inhibiting the Kinase Activity of TANK-binding kinase 1, Journal of Virology, 2016, 通讯作者
(9) Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7, Fish and Shellfish Immunology, 2015, 通讯作者
(10) Regulation pattern of fish irf4 (the gene encoding IFN regulatory factor 4) by STAT6, c-Rel and IRF4, Developmental and Comparative Immunology, 2015, 通讯作者
(11) Distinctive Structural Hallmarks and Biological Activities of the Multiple Cathelicidin Antimicrobial Peptides in a Primitive Teleost Fish, Journal of Immunology, 2015, 通讯作者
(12) Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen, Fish and Shellfish Immunology, 2014, 通讯作者
(13) Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta, Fish and Shellfish Immunology, 2014, 第 2 作者
(14) Interferon regulatory factor 10 is a negative regulator of the interferon responses in fish, Journal of Immunology, 2014, 通讯作者
(15) 罗非鱼链球菌病疫苗的研究进展, 南方水产科学, 2013, 通讯作者
(16) Teleost skin, an ancient mucosal surface that elicits gut-like immune responses, Proceedings of the National Academy of Sciences of the United States of America, 2013, 通讯作者
(17) Pivotal Advance: Peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells, Journal of Leukocyte Biology, 2012, 第 4 作者
(18) 鱼类自然杀伤样细胞的研究进展, 水生生物学报, 2012, 通讯作者
(19) Recent findings on the structure and function of IgT, Fish and Shellfish Immunology, 2011, 第 1 作者
(20) Mucosal immunoglobulins and B cells in teleost fish, Developmental and Comparative Immunology, 2011, 第 1 作者
(21) IgT, a primitive immunoglobulin class specialized in mucosal immunity, Nature Immunology, 2010, 第 1 作者
(22) Conservation of structural and functional features in a primordial CD80/86 molecule from rainbow trout (Oncorhynchus mykiss), a primitive teleost fish, Journal of Immunology, 2009, 第 1 作者
(23) B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities, Nature Immunology, 2006, 第 2 作者
(24) Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar), Antimicrobial Agents and Chemotherapy, 2006, 第 1 作者
(25) Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout, Veterinary Immunology and Immunopathology, 2004, 第 1 作者
(26) cDNA sequence encoding immunoglobulin M heavy chain of the mandarin fish Siniperca chuatsi, Fish and Shellfish Immunology, 2003, 第 1 作者
(27) Characterization of cDNA encoding immunoglobulin light chain of the mandarin fish (Siniperca chuatsi), Veterinary Immunology and Immunopathology, 2003, 第 1 作者
(28) Serum immunoglobulin of the mandarin fish, Siniperca chuatsi with development of polyclonal antibody, Chinese Journal of Oceanlolgy and Limnology, 2002, 第 1 作者

科研活动

   
科研项目
( 1 ) 鱼类重要免疫分子和细胞的结构和功能, 负责人, 中国科学院计划, 2011-04--2013-03
( 2 ) “青年****”, 负责人, 国家任务, 2012-01--2015-12
( 3 ) 重要养殖鱼类IgD和IgT的免疫功能及其与IgM的比较研究, 负责人, 国家任务, 2012-01--2015-12
( 4 ) 草鱼疾病诊断试剂盒、疫苗和免疫增强剂的研发, 负责人, 地方任务, 2013-06--2016-05
( 5 ) 鲤抗病分子模块解析-3, 负责人, 中国科学院计划, 2013-08--2017-12
( 6 ) 鱼类的摄食选择与消化道健康, 负责人, 国家任务, 2014-01--2018-08
( 7 ) 鱼类先天免疫, 负责人, 国家任务, 2018-01--2022-12
( 8 ) 鱼类病毒病的发生机理, 负责人, 地方任务, 2018-01--2020-12