基本信息
周宇波  男  博导  中国科学院上海药物研究所
电子邮件: ybzhou@simm.ac.cn
通信地址: 上海浦东张江高科技园区郭守敬路189号
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
抗肿瘤创新药物与机制研究

教育背景

2001-03--2005-04   上海交通大学   博士
1994-09--2000-07   华中农业大学   学士+硕士

工作经历

   
工作简历
2006-08~现在, 中科院上海药物研究所, 助理研究员、副研究员、研究员
2005-04~2006-07,国家人类基因组南方研究中心, 助理研究员
2001-03~2005-04,上海交通大学, 博士
1994-09~2000-07,华中农业大学, 学士+硕士

专利与奖励

   
专利成果
( 1 ) 一类噻唑类化合物及其制备方法和用途, 2016, 第 5 作者, 专利号: PCT/CN2012/075142
( 2 ) 杂环构建的三肽环氧酮类化合物、其制备方法和应用, 2018, 第 5 作者, 专利号: PCT/CN2015/073989

出版信息

   
发表论文
(1) Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor., Bioorg Med Chem Lett., 2019, 通讯作者
(2) Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors., Eur J Med Chem., 2019, 通讯作者
(3) Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors, Eur J Med Chem., 2019, 通讯作者
(4) Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors., J Med Chem., 2018, 通讯作者
(5) Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L, Tetrahedron Letters, 2018, 通讯作者
(6) Tying up Tranylcypromine: Novel Selective Histone Lysine Specific Demethylase 1 (LSD1) Inhibitors, Eur J Med Chem., 2017, 通讯作者
(7) Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors., Eur J Med Chem., 2017, 通讯作者
(8) Preparation of 5'-deoxy-5'-amino-5'-C-methyl adenosine derivatives and their activity against DOT1L, Bioorg Med Chem Lett., 2017, 通讯作者
(9) Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition., Acta Pharmacol Sin., 2016, 通讯作者
(10) Design and synthesis of benzylpiperidine inhibitors targeting the menin–MLL1 interface, Bioorg Med Chem Lett., 2016, 通讯作者
(11) Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors, Bioorg Med Chem., 2016, 通讯作者
(12) Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, Cancer Lett., 2015, 通讯作者
(13) Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro., Acta Pharmacol Sin., 2015, 通讯作者
(14) Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold., Bioorg Med Chem., 2015, 通讯作者
(15) Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors., Bioorg Med Chem., 2014, 通讯作者
(16) nvolvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation., Biochem Biophys Res Commun., 2014, 通讯作者
(17) Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro., BBA-General Subjects., 2014, 通讯作者
(18) Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUBs inhibition, is synergistic with Bortezomib against multiple myeloma cell growth., BBA-General Subjects., 2014, 通讯作者
(19) Berberine combined with 2-deoxy-D-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption., BBA-General Subjects., 2013, 通讯作者
(20) Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms, Acta Pharmacol Sin., 2013, 通讯作者
(21) A novel microtubule-targeted agent, 6-Chloro-4-(Methoxyphenyl) Coumarin, induces G2-M arrest and apoptosis in Hela cells., Acta Pharmacol Sin., 2013, 通讯作者

科研活动

   
科研项目
( 1 ) 基于靶向抑制未折叠蛋白反应(UPR)的抗肿瘤活性化合物发现与作用机制研究, 主持, 国家级, 2015-01--2018-12
( 2 ) XBP1 mRNA 剪切抑制剂发现及其抗非酒精性脂肪性肝病的作用与机制研究, 主持, 国家级, 2013-01--2016-12
( 3 ) 表观遗传重要靶点DOT1L的候选药物发现, 主持, 国家级, 2014-01--2016-12
( 4 ) CHK1选择性抑制剂抗急性白血病的临床前个性化特征研究, 主持, 部委级, 2016-01--2018-12
( 5 ) 基于规模化、信息化乳腺癌病人来源的异源移植瘤(Patient-derived xenograft, PDX)药效学评价模型的个性化靶向药物研究, 主持, 市地级, 2017-11--2019-10
( 6 ) 创新药物新型蛋白酶体抑制剂E-83抗多发性骨髓瘤临床前研究, 主持, 省级, 2017-07--2020-06
( 7 ) CHK1新型抑制剂抗急性白血病敏感标志物的发现与作用机制研究, 主持, 国家级, 2017-01--2020-12