基本信息
朱敦明 男 博导 中国科学院天津工业生物技术研究所
电子邮件： zhu_dm@tib.cas.cn
通信地址： 天津空港经济区西七道32号
邮政编码： 300308
电子邮件： zhu_dm@tib.cas.cn
通信地址： 天津空港经济区西七道32号
邮政编码： 300308
研究领域
生物催化与绿色化工
多酶催化与有机合成
招生信息
招生专业
081703-生物化工081701-化学工程
招生方向
生物催化与转化酶工程
教育背景
1994-02--1996-01 Southern Methodist University 博士后1990-09--1993-06 中国科学院上海有机化学研究所 博士1987-09--1990-06 中国科学院上海有机化学研究所 硕士1982-09--1987-06 中国科学技术大学 学士
工作经历
工作简历
2008-04~现在, 天津工业生物技术研究所, 研究员2004-08~2009-08,Southern Methodist University, 研究教授2000-01~2004-07,BioCatalytics, Inc., 科学家/化学部门主管1996-02~1999-12,University of Houston, 助理研究员/实验室经理1993-07~1994-01,中国科学院上海有机化学研究所, 助理研究员
社会兼职
2015-12-01-今,中国药学会制药工程专业委员会, 委员
2012-12-01-今,生物工程学报编委会成员,
2011-11-01-今,中国微生物学会酶工程专业委员会, 委员
2009-05-01-今,Journal of Molecular Catalysis B：Enzymatic，编委, 编委
2012-12-01-今,生物工程学报编委会成员,
2011-11-01-今,中国微生物学会酶工程专业委员会, 委员
2009-05-01-今,Journal of Molecular Catalysis B：Enzymatic，编委, 编委
教授课程
生物催化
专利与奖励
奖励信息
（1） 稀土金属有机配合物的合成、结构, 三等奖, 国家级, 1997（2） 镧系金属有机配合物的合成、结构, 一等奖, 院级, 1995
专利成果
[1] 姚培圆, 李宇, 崔云凤, 陈曦, 冯进辉, 吴洽庆, 朱敦明, 马延和. 手性1，3-二羟基-1-芳基丙酮化合物的合成方法. CN: CN112852793A, 2021-05-28.[2] 崔云凤, 姚培圆, 陈曦, 张红榴, 张瑞, 冯进辉, 吴洽庆, 朱敦明, 马延和. 制备(S)-1-(2-甲氧基-3-溴苯基)乙醇的方法. CN: CN112852769A, 2021-05-28.[3] 崔云凤, 陈曦, 张红榴, 朱良彦, 冯进辉, 吴洽庆, 朱敦明. 羰基还原酶突变体及其应用. CN: CN112852768A, 2021-05-28.[4] 姚培圆, 胡娜, 徐泽菲, 冯进辉, 吴洽庆, 朱敦明, 马延和. 酶催化合成手性氨基醇化合物. CN: CN112852771A, 2021-05-28.[5] 王玉, 陈曦, 张红榴, 刘祥涛, 冯进辉, 吴洽庆, 朱敦明, 马延和. 羰基还原酶突变体及其在催化合成17β-羟基甾体化合物中的应用. CN: CN112852767A, 2021-05-28.[6] 于珊珊, 姚培圆, 冯进辉, 吴洽庆, 朱敦明, 马延和. 腈水解酶突变体及其应用. CN: CN112852789A, 2021-05-28.[7] 陈曦, 龚靖尧, 李键煚, 崔云凤, 刘祥涛, 冯进辉, 吴洽庆, 朱敦明, 马延和. 光学纯2,2-双取代-1,3-环戊二醇的制备方法. CN: CN112522329A, 2021-03-19.[8] 马延和, 李雪梅, 吴洽庆, 冯进辉, 朱敦明, 张瑞, 王玉, 徐自祥, 卜丹丹. 基因工程菌及其制备9α,22-二羟基-23,24-双降胆甾-4-烯-3-酮的应用. CN: CN112094797B, 2021-02-12.[9] 马延和, 吴洽庆, 冯进辉, 朱敦明, 李雪梅, 王玉, 张瑞, 刘祥涛. 一种基因工程菌及其在制备22-羟基-23，24-双降胆甾-4-烯-3-酮中的应用. CN: CN112029701B, 2021-02-09.[10] 马延和, 冯进辉, 吴洽庆, 朱敦明, 李雪梅, 张瑞, 陈曦, 姚培圆, 李键煚. 微生物发酵生产HIP-IPA的方法、基因工程菌及应用. CN: CN112029700B, 2021-02-02.[11] 崔云凤, 陈曦, 刘祥涛, 卜丹丹, 张红榴, 冯进辉, 吴洽庆, 朱敦明, 马延和. 一种降低反应组分对酶活抑制的方法. CN: CN112210580A, 2021-01-12.[12] 于珊珊, 姚培圆, 冯进辉, 吴洽庆, 朱敦明, 马延和. 腈水解酶突变蛋白及其在催化合成(R)-3-取代-4-氰基丁酸类化合物中的应用. CN: CN112210549A, 2021-01-12.[13] 王玉, 李雪梅, 冯进辉, 吴洽庆, 朱敦明, 马延和. 一株生物合成22-羟基-23,24-二降胆-4-烯-3-酮的分枝杆菌及合成方法. CN: CN106854630B, 2020-11-27.[14] 张红榴, 陈曦, 刘祥涛, 冯进辉, 吴洽庆, 朱敦明, 马延和. 12-羟基胆酸脱氢酶及其应用. CN: CN111826358A, 2020-10-27.[15] 张瑞, 李雪梅, 冯进辉, 刘祥涛, 陈曦, 吴洽庆, 朱敦明, 马延和. 一种甾体化合物菌渣无害化的处理方法. CN: CN111194825A, 2020-05-26.[16] 张红榴, 陈曦, 李娟, 冯进辉, 吴洽庆, 朱敦明. 羰基还原酶及其突变体在茚达特罗药物中间体合成中的应用. CN: CN110713991A, 2020-01-21.[17] 冯进辉, 崔云凤, 陈曦, 王玉, 刘祥涛, 吴洽庆, 朱敦明. 氧化态烟酰胺类辅因子再生的方法. CN: CN110628849A, 2019-12-31.[18] 姚培圆, 徐泽菲, 于珊珊, 吴洽庆, 朱敦明, 马延和. 酶催化不对称合成右美沙芬关键中间体的新方法. CN: CN110628841A, 2019-12-31.[19] 陈曦, 陈启佳, 冯进辉, 吴洽庆, 朱敦明. 检测苏式β-羟基-α-氨基酸含量的方法. CN: CN110596029A, 2019-12-20.[20] 陈曦, 刘卫东, 赵雷明, 李键煚, 冯进辉, 吴洽庆, 朱敦明, 马延和. 嗜热共生杆菌meso-二氨基庚二酸脱氢酶突变体应用. CN: CN105821090B, 2019-12-13.[21] 陈曦, 张红榴, 刘祥涛, 冯进辉, 吴洽庆, 朱敦明. 羰基还原酶突变体及其在环戊二酮类化合物还原中的应用. CN: CN110551701A, 2019-12-10.[22] 姚培圆, 徐泽菲, 于珊珊, 吴洽庆, 朱敦明. 一种苏沃雷生关键中间体的酶法制备方法. CN: CN110272925A, 2019-09-24.[23] 崔云凤, 姚培圆, 陈曦, 冯进辉, 吴洽庆, 朱敦明, 马延和. 3β-羟基甾体脱氢酶制备脱氢表雄酮（DHEA）. CN: CN109750051A, 2019-05-14.[24] 姚培圆, 吴洽庆, 袁京, 韩超, 冯进辉, 朱敦明, 马延和. 酶催化高浓度β-氨基丙腈水解制备β-丙氨酸的方法. CN: CN104195193B, 2019-05-10.[25] 陈曦, 崔云凤, 王玉, 黄清东, 冯进辉, 吴洽庆, 朱敦明, 马延和. 7β-羟基胆酸脱氢酶及其应用. CN: CN109722442A, 2019-05-07.[26] 冯进辉, 陈曦, 姚培圆, 刘娜, 张瑞, 李雪梅, 吴洽庆, 朱敦明, 马延和, 张峥斌. 微生物发酵生产谷内酯的方法、工程菌及应用. CN: CN109722455A, 2019-05-07.[27] 王玉, 陈曦, 刘媛媛, 冯进辉, 吴洽庆, 朱敦明, 马延和. 一种新的17β-羟基甾体脱氢酶、其基因及应用. CN: CN109306342A, 2019-02-05.[28] 姚培圆, 于珊珊, 张慕姣, 冯进辉, 吴洽庆, 朱敦明, 马延和. 可水解对苯二甲腈制备对氰基苯甲酸的腈水解酶. 中国: CN107641622A, 2018-01-30.[29] 刘卫东, 朱敦明, 吴洽庆, 陈曦, 冯进辉, 马延和. D‑叔亮氨酸的一种生物催化制备方法. 中国: CN104513839B, 2017.12.26.[30] 李键煚, 陈曦, 崔云凤, 刘卫东, 冯进辉, 吴洽庆, 朱敦明, 马延和. 一种利用共固定化酶合成D-丙氨酸的方法. 中国: CN106191150A, 2016-12-07.[31] 刘卫东, 陈曦, 赵雷明, 李键煚, 冯进辉, 吴洽庆, 朱敦明, 马延和. 嗜热共生杆菌meso-二氨基庚二酸脱氢酶突变体. 中国: CN105821014A, 2016-08-03.[32] 姚培圆, 崔云凤, 冯进辉, 吴洽庆, 朱敦明, 马延和. 一种光学纯2-羟基丁酸的生物制备新方法. 中国: CN105695519A, 2016-06-22.[33] 陈曦, 崔云凤, 梅婷, 陈启佳, 刘祥涛, 冯进辉, 吴洽庆, 朱敦明. (S)-1,2-戊二醇的生物制备. 中国: CN105624214A, 2016-06-01.[34] 姚培圆, 李广悦, 冯进辉, 吴洽庆, 朱敦明, 马延和. 酶催化拆分1-(4-甲氧基苄基)-1,2,3,4,5,6,7,8-八氢异喹啉的新方法. 中国: CN105524971A, 2016-04-27.[35] 陈曦, 张铮斌, 张大龙, 张汝金, 冯进辉, 吴洽庆, 朱敦明, 马延和. 雄烯二酮（4-AD）制备脱氢表雄酮（DHEA）的新方法. 中国: CN105483198A, 2016-04-13.[36] 吴洽庆, 冯进辉, 陈曦, 马延和, 朱敦明. 一种高通量筛选羰基还原酶活性和对映选择性的方法. 中国: CN105463060A, 2016-04-06.[37] 姚培圆, 于姗姗, 李键煚, 吴洽庆, 朱敦明, 马延和. 酶催化高浓度3-羟基丙腈水解制备3-羟基丙酸的新方法. 中国: CN105441491A, 2016-03-30.[38] 朱敦明, 姜进举, 陈曦, 吴洽庆, 冯进辉, 马延和. 一种来源于尖孢镰刀菌的新(R)-转氨酶及其应用. 中国: CN104630171A, 2015-05-20.[39] 朱敦明, 姜进举, 陈曦, 吴洽庆, 冯进辉, 马延和. 一种来源于里氏木霉的新(R)-转氨酶及其应用. 中国: CN104630170A, 2015-05-20.[40] 朱敦明, 吴洽庆, 姚培圆, 袁京, 李键煚, 冯进辉, 马延和. (R)-3-羟基戊二酸单酯的生物合成方法. 中国: CN104561142A, 2015-04-29.[41] 吴洽庆, 王玉, 杨贝贝, 陈曦, 朱敦明, 马延和. 一株能生物合成1,2-二氢睾内酯(testololactone)的简单青霉及合成方法. 中国: CN104419646A, 2015-03-18.[42] 姚培圆, 吴洽庆, 袁京, 王雷, 冯进辉, 朱敦明, 马延和. 一种生物合成(R)-3-羟基戊二酸单酯的新方法. 中国: CN104152500A, 2014-11-19.[43] 袁京, 董文玥, 吴洽庆, 朱敦明. 一种高产β-丙氨酸的基因工程菌的构建、表达及应用. 中国: CN103898033A, 2014-07-02.[44] 朱敦明, 吴洽庆, 陈曦, 高秀珍, 刘卫东, 冯进辉. 合成D-氨基酸的一种新方法. 中国: CN103667380A, 2014-03-26.[45] 朱敦明, 吴洽庆, 任杰, 王玉, 张红榴, 生措. 一株能生物合成睾内酯的尖孢镰刀菌及合成方法. 中国: CN103484375A, 2014-01-01.[46] 陈曦, 高秀珍, 吴洽庆, 朱敦明. 光学纯(1S,2R,5R)-二氢香芹醇的生物催化合成方法. 中国: CN103088075A, 2013-05-08.[47] 李键煚, 王玉, 吴洽庆, 朱敦明. 一株能将奎宁酮转化为(R)-3-奎宁醇的诺卡氏菌及转化方法. 中国: CN102952761A, 2013-03-06.[48] 王玉, 李建煚, 吴洽庆, 朱敦明. 一株能将奎宁酮转化为(S)-3-奎宁醇的红串红球菌及转化方法. 中国: CN102952760A, 2013-03-06.[49] 朱敦明, 吴洽庆, 李正华, 赵青, 任杰, 董文玥, 刘祥涛. 一种新的顺丁烯二酸异构酶及应用. 中国: CN102604922A, 2012-07-25.[50] 朱敦明. 可重复使用的智能生物催化剂(包括固定化酶和应激载体)及其在有机合成中的应用. 中国: CN102604923A, 2012-07-25.
出版信息
发表论文
[1] Tong lv, Jinhui Feng, Xi Chen, 罗阳阳, Qiaqing Wu, 朱敦明, Yanhe Ma. Creating novel amine dehydrogenases for precise synthesis of single stereoisomer of β-amino ketones with an all-carbon quaternary stereocenter via desymmetric reductive amination. Acs Catalysis[J]. 2023, 13: 5053-5061, [2] 李雪梅, 张瑞, 李键煚, 冯进辉, 吴洽庆, 朱敦明, 马延和. The function of steroid terminal monooxygenase in cholesterol or phytosterol degradation by the Mycobacterium neoaurum NRRL B‑3805. Systems Microbiology and Biomanufacturing[J]. 2023, [3] Chuanhua Zhou, 朱敦明, Xi Chen, Tong lv, Jinhui Feng, Qiaqing Wu. Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for Green Synthesis of Chiral 4-Aryl-2-oxazolidinones from Readily Available Epoxides. Acs Catalysis[J]. 2023, 13: 4768-4777, [4] Yu Li, Na Hu, 徐泽菲, yunfeng cui, 姚培圆, Jinhui Feng, 吴洽庆, 朱敦明, Yanhe Ma. Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols via One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination. Angewandte Chemie[J]. 2022, 61: e202116344-, [5] 陈曦, 吴凤礼, 樊飞宇, 吴洽庆, 朱敦明. 手性医药化学品的绿色生物合成. 生物工程学报[J]. 2022, 38(11): 4240-4262, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545594.[6] 冯进辉, 张汝金, 张峥斌, 吴洽庆, 朱敦明. 系列甾体药物关键中间体转化菌种构建及智能化生产应用. 生物工程学报[J]. 2022, 38(11): 4335-4342, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545599.[7] Liu, Na, Wu, Lian, Feng, Jinhui, Sheng, Xiang, Li, Jian, Chen, Xi, Li, Jianjiong, Liu, Weidong, Zhou, Jiahai, Wu, Qiaqing, Zhu, Dunming. Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(18): 10203-10210, https://www.webofscience.com/wos/woscc/full-record/WOS:000632027800001.[8] Yao, Peiyuan, Marshall, James R, Xu, Zefei, Lim, Jesmine, Charnock, Simon J, Zhu, Dunming, Turner, Nicholas J. Asymmetric Synthesis of N-Substituted alpha-Amino Esters from alpha-Ketoesters via Imine Reductase-Catalyzed Reductive Amination. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(16): 8717-8721, http://dx.doi.org/10.1002/anie.202016589.[9] 陈启佳, 陈曦, 郝建雄, 朱敦明. 苏氨酸醛缩酶的催化机理、分子改造及合成应用. 生物工程学报[J]. 2021, 37(12): 4215-4230, http://lib.cqvip.com/Qikan/Article/Detail?id=7106517358.[10] Yu, Shanshan, Li, Jinlong, Yao, Peiyuan, Feng, Jinhui, Cui, Yunfeng, Li, Jianjiong, Liu, Xiangtao, Wu, Qiaqing, Lin, Jianping, Zhu, Dunming. Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(7): 3679-3684, http://dx.doi.org/10.1002/anie.202012243.[11] 李梦, 李雪梅, 冯进辉, 张瑞, 吴洽庆, 朱敦明, 马延和. 耻垢分枝杆菌中3-甾酮-Δ1-脱氢酶对植物甾醇转化积累9α-羟基雄甾-4-烯-3，17-二酮的影响. 应用与环境生物学报[J]. 2020, 26(4): 739-746, http://lib.cqvip.com/Qikan/Article/Detail?id=7102791925.[12] Zhu Dunming. Crystal structures and substrate recognition mechanism of 2, 3-dihydroxybenzoic acid decarboxylase from Fusarium oxysporum. ChemBioChem. 2020, [13] Li, Juan, Feng, Jinhui, Chen, Xi, Gong, Jingyao, Cui, Yunfeng, Zhang, Hongliu, Bu, Dandan, Wu, Qiaqing, Zhu, Dunming. Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction. ORGANIC LETTERS[J]. 2020, 22(9): 3444-3448, https://www.webofscience.com/wos/woscc/full-record/WOS:000530076400028.[14] Song, Mengkun, Zhang, Xuemei, Liu, Weidong, Feng, Jinghui, Cui, Yunfeng, Yao, Peiyuan, Wang, Min, Guo, ReyTing, Wu, Qiaqing, Zhu, Dunming. 2,3-Dihydroxybenzoic Acid Decarboxylase fromFusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism. CHEMBIOCHEM[J]. 2020, 21(20): 2950-2956, https://www.webofscience.com/wos/woscc/full-record/WOS:000544734500001.[15] 程新宽, 陈曦, 冯进辉, 吴洽庆, 朱敦明. 内消旋-二氨基庚二酸脱氢酶关键氨基酸位点的改造提高对烷基取代2-酮酸的催化活力. 微生物学通报[J]. 2020, 47(7): 2119-2127, http://lib.cqvip.com/Qikan/Article/Detail?id=7102497484.[16] Xu, Zefei, Yao, Peiyuan, Sheng, Xiang, Li, Jinlong, Li, Jianjiong, Yu, Shanshan, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination. ACS CATALYSIS[J]. 2020, 10(15): 8780-8787, http://dx.doi.org/10.1021/acscatal.0c02400.[17] Gong, Jingyao, Li, Jianjiong, Chen, Xi, Zhang, Hongliu, Zhu, Liangyan, Bu, Dandan, Wang, Qin, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Highly Diastereoselective Synthesis of 2,2-Disubstituted Cyclopentane-1,3-diols via Stepwise Ketone Reduction Enabling Concise Chirality Construction. 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CHEMISTRYOPEN[J]. 2015, 4(4): 483-488, http://www.irgrid.ac.cn/handle/1471x/1111578.[83] Yitao Duan, Peiyuan Yao, Yuncheng Du, Jinhui Feng, Qiaqing Wu, Dunming Zhu. Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 11(1): https://doaj.org/article/cd2f3413b8fb42ac9e5441a8c2b67754.[84] Yao, Peiyuan, Li, Jianjiong, Yuan, Jing, Han, Chao, Liu, Xiangtao, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase-Catalyzed Hydrolysis of Ethyl (R)-4-Cyano-3-hydroxybutyate at High Substrate Concentration. CHEMCATCHEM[J]. 2015, 7(2): 271-275, https://www.webofscience.com/wos/woscc/full-record/WOS:000347781400012.[85] 梅婷, 张大龙, 冯进辉, 王敏, 吴洽庆, 朱敦明, 马延和. 自剪切及活性相关位点的组合突变提高头孢菌素C酰化酶水解活力. 应用与环境生物学报[J]. 2015, 21(3): 427-434, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5463197&detailType=1.[86] Liu, Weidong, Guo, ReyTing, Chen, Xi, Li, Zhe, Gao, Xiuzhen, Huang, ChunHsiang, Wu, Qiaqing, Feng, Jinhui, Zhu, Dunming. Structural Analysis Reveals the Substrate-Binding Mechanism for the Expanded Substrate Specificity of Mutant meso-Diaminopimelate Dehydrogenase. CHEMBIOCHEM[J]. 2015, 16(6): 924-929, http://www.irgrid.ac.cn/handle/1471x/1111569.[87] Duan YiTao, Yao PeiYuan, Ren Jie, Han Chao, Li Qian, Yuan Jing, Feng JinHui, Wu QiaQing, Zhu DunMing. Biocatalytic desymmetrization of 3-substituted glutaronitriles by nitrilases. A convenient chemoenzymatic access to optically active (S)-Pregabalin and (R)-Baclofen. SCIENCE CHINA-CHEMISTRY[J]. 2014, 57(8): 1164-1171, http://www.irgrid.ac.cn/handle/1471x/930450.[88] Zhang, Hailing, Gao, Xiuzhen, Ren, Jie, Feng, Jinhui, Zhang, Tongcun, Wu, Qiaqing, Zhu, Dunming. Enzymatic hydrogenation of diverse activated alkenes. Identification of two Bacillus old yellow enzymes with broad substrate profiles. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2014, 105: 118-125, http://dx.doi.org/10.1016/j.molcatb.2014.04.004.[89] Jinju Jiang, Xi Chen, Jinhui Feng, Qiaqing Wu, Dunming Zhu. Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids. JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC. 2014, 100: 32-39, http://dx.doi.org/10.1016/j.molcatb.2013.11.013.[90] Li, Guangyue, Ren, Jie, Yao, Peiyuan, Duan, Yitao, Zhang, Hailing, Wu, Qiaqing, Feng, Jinhui, Lau, Peter C K, Zhu, Dunming. Deracemization of 2-Methyl-1,2,3,4-Tetrahydroquinoline Using Mutant Cyclohexylamine Oxidase Obtained by Iterative Saturation Mutagenesis. ACS CATALYSIS[J]. 2014, 4(3): 903-908, http://www.irgrid.ac.cn/handle/1471x/1111566.[91] Jiang, Jinju, Chen, Xi, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Substrate profile of an omega-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2014, 100: 32-39, http://www.irgrid.ac.cn/handle/1471x/1111563.[92] Yang, Beibei, Wang, Yu, Chen, Xi, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming, Ma, Yanhe. Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2. TETRAHEDRON[J]. 2014, 70(1): 41-46, http://dx.doi.org/10.1016/j.tet.2013.11.039.[93] Zhang, Dalong, Zhang, Rui, Zhang, Jie, Chen, Liying, Zhao, Chunxia, Dong, Wenyue, Zhao, Qing, Wu, Qiaqing, Zhu, Dunming. Engineering a hydroxysteroid dehydrogenase to improve its soluble expression for the asymmetric reduction of cortisone to 11 beta-hydrocortisone. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 98(21): 8879-8886, http://www.irgrid.ac.cn/handle/1471x/1111562.[94] Li, Guangyue, Ren, Jie, Iwaki, Hiroaki, Zhang, Dalong, Hasegawa, Yoshie, Wu, Qiaqing, Feng, Jinhui, Lau, Peter C K, Zhu, Dunming. Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 98(4): 1681-1689, http://www.irgrid.ac.cn/handle/1471x/1111567.[95] Liu, Weidong, Li, Zhe, Huang, ChunHsiang, Guo, ReyTing, Zhao, Leiming, Zhang, Dalong, Chen, Xi, Wu, Qiaqing, Zhu, Dunming. Structural and Mutational Studies on the Unusual Substrate Specificity of meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum. 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The catalytic promiscuity of a microbial 7 alpha-hydroxysteroid dehydrogenase. Reduction of non-steroidal carbonyl compounds. STEROIDS[J]. 2011, 76(10-11): 1136-1140, http://dx.doi.org/10.1016/j.steroids.2011.05.001.[126] Yang Liu, Tong Lv, Jie Ren, Min Wang, Qiaqing Wu, Dunming Zhu. The catalytic promiscuity of a microbial 7α-hydroxysteroid dehydrogenase. Reduction of non-steroidal carbonyl compounds. STEROIDS. 2011, 76(10): 1136-1140, http://dx.doi.org/10.1016/j.steroids.2011.05.001.[127] 吕彤, 刘扬, 赵青, 任杰, 王敏, 吴洽庆, 朱敦明. 烯酮还原酶基因的克隆与优化表达. 应用与环境生物学报[J]. 2011, 17(1): 87-90, http://lib.cqvip.com/Qikan/Article/Detail?id=36817550.[128] Dunming Zhu, Brooke A Hyatt, Ling Hua. Enzymatic hydrogen transfer reduction of α-chloro aromatic ketones catalyzed by a hyperthermophilic alcohol dehydrogenase. 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发表著作
（ 1 ） 海洋来源酶在立体选择合成中应用, Stereoselective Synthesis Using Marine Enzymes “Marine enzymes for biocatalysis. Sources, biocatalytic characteristics and bioprocesses of marine enzymes”, Edited by A. Trincone, Biohealthcare Publishing (Oxford), 2013-05, 第 1 作者
科研活动
科研项目
（ 1 ） “生物制造手性化学品的科学基础”之课题1“生物合成的手性识别机理解析”, 主持, 国家级, 2011-01--2015-08（ 2 ） “重大化工产品的先进生物制造”之课题“甾体类化合物的生物转化技术”, 参与, 国家级, 2011-01--2015-12（ 3 ） 甾体药物中间体的产业化, 参与, 部委级, 2014-05--2015-12（ 4 ） “食品安全检测技术及生物农药和制剂的研制与应用示范”子课题“手性农药丙环唑的生物合成”, 主持, 部委级, 2013-05--2015-12（ 5 ） 芳香羧酸脱羧酶催化C-H键活化及二氧化碳固定化的研究, 主持, 国家级, 2015-01--2018-12
参与会议
（1）Discovery and Engineering of Amino Acid Dehydrogenases for the Synthesis of D- and -Amino Acids Dunming Zhu 2015-09-07（2）氨基酸脱氢酶的改造与非天然氨基酸的绿色合成 2014戈登绿色化学会议-工业成功和挑战 朱敦明 2014-07-28（3）Rational Mutagenesis of meso-2,6-D-Diaminopimelic Acid Dehydrogenase to Alter the Substrate Specificity 第62届美国工业微生物与生物技术协会年会 朱敦明 2012-08-12（4）Novel meso-2,6-D-Diaminopimelic Acid Dehydrogenase with Expanded Substrate Specificity：Discovery and Applications 第二届分子与功能催化国际会议（ICMFC-2） 朱敦明 2012-07-30（5）基于基因组数据分析发现高效酶催化剂 中国化学会第七届有机化学学术会议 朱敦明 2011-11-12（6）Production of High Value Chemicals through Biocatalysis 朱敦明 2011-08-26（7）From Genome to Versatile Biocatalysts 朱敦明 2010-12-15（8）酶-底物嵌合指导定点突变产生高立体选择性羰基还原酶 中国化学会第27届学术年会, 朱敦明 2010-06-20（9）酶-底物嵌合研究指导生物催化剂的基因工程改造 第七届中国酶工程学术研讨会 朱敦明 2009-09-16（10）Altering the enantioselectivity of carbonyl reductase via enzyme-substrate docking-guided saturation mutagenesis 朱敦明 2009-08-16
指导学生
已指导学生
韩磊 02 19586
陈杰 02 19294
李广悦 01 19294
高秀珍 01 19294
熊鑫 02 63220
迟婧 02 19294
姜进举 01 19294
丛培乾 02 63220
任杰 01 19294
现指导学生
刘娜 02 19294
鲁玮 01 19295
陈启佳 01 19295
李娟 02 63220