基本信息
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韩方普 男 博导 中国科学院遗传与发育生物学研究所
电子邮件: fphan@genetics.ac.cn
通信地址: 中国科学院遗传与发育生物学研究所
邮政编码: 100101
电子邮件: fphan@genetics.ac.cn
通信地址: 中国科学院遗传与发育生物学研究所
邮政编码: 100101
招生信息
招生专业
071007-遗传学
071009-细胞生物学
090102-作物遗传育种
071009-细胞生物学
090102-作物遗传育种
招生方向
植物分子遗传学
植物细胞生物学
植物细胞生物学
工作经历
工作简历
2004-03~2009-04,美国密苏里大学生物学系, 博士后
2001-01~2004-03,加拿大农业部, Visiting Fellow & Biologist
1998-08~2001-01,以色列 Weizmann 研究所, 博士后
2001-01~2004-03,加拿大农业部, Visiting Fellow & Biologist
1998-08~2001-01,以色列 Weizmann 研究所, 博士后
社会兼职
2014-01-10-今,PAG Plant Chromosome Biology workshop, 召集人
2013-01-01-今,作物学报, 编委
2013-01-01-今,作物学报, 编委
教授课程
分子细胞遗传学
遗传学实验
遗传学实验课
遗传发育学系列讲座
遗传学实验
遗传学实验课
遗传发育学系列讲座
专利与奖励
奖励信息
(1) 中科院遗传所益海嘉里优秀教师奖, 一等奖, 研究所(学校), 2014
专利成果
( 1 ) 小麦-长穗偃麦草抗赤霉病易位系的选育方法及分子标记, 2018, 第 1 作者, 专利号: 201710462612.6
( 2 ) 一种基因编辑系统及应用其对植物基因组进行编辑的方法, 2018, 第 1 作者, 专利号: 201710599030.2
( 3 ) 一种快速分析和鉴定小麦外源染色体的多色荧光原位杂交方法, 2016, 第 1 作者, 专利号: 20131027485.6
( 2 ) 一种基因编辑系统及应用其对植物基因组进行编辑的方法, 2018, 第 1 作者, 专利号: 201710599030.2
( 3 ) 一种快速分析和鉴定小麦外源染色体的多色荧光原位杂交方法, 2016, 第 1 作者, 专利号: 20131027485.6
出版信息
发表论文
(1) Non-B-form DNA is associated with centromere stability in newly-formed polyploid wheat, Sci China Life Sci, 2024, 第 9 作者 通讯作者
(2) Young retrotransposons and non-B DNA structures promote the establishment of dominant rye centromere in the 1RS.1BL fused centromere, New Phytologist, 2024, 第 9 作者 通讯作者
(3) Unveiling the distinctive traits of functional rye centromeres: minisatellites, retrotransposons, and R-loop formation, Sci China Life Sci, 2024, 第 10 作者 通讯作者
(4) Wide hybridizations reveal the robustness of functional centromeres in Triticum-Aegilops species complex lines, JGG, 2024, 第 8 作者 通讯作者
(5) Cytological analysis of the diploid-like inheritance of newly synthesized allotetraploid wheat, Chromosome Research, 2023, 第 8 作者 通讯作者
(6) Functional analysis of the glutathione S-transferases from Thinopyrum and its derivatives on wheat Fusarium head blight resistance, PLANT BIOTECHNOLOGY JOURNAL, 2023, 第 13 作者 通讯作者
(7) New insights on the evolution of nucleolar dominance in newly resynthesized hexaploid wheat Triticum zhukovskyi, PLANT JOURNAL, 2023, 第 12 作者 通讯作者
(8) Non���B-form DNA tends to form in centromeric regions and has undergone changes in polyploid oat subgenomes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 12 作者
(9) Pan-centromere reveals widespread centromere repositioning of soybean genomes, Proceedings of the National Academy of Sciences of the United States of America, 2023, 第 1 作者
(10) Development and cytological characterization of wheat��� Thinopyrum intermedium translocation lines with novel stripe rust resistance gene, FRONTIERS IN PLANT SCIENCE, 2023, 第 11 作者
(11) Young retrotransposons and non-B DNA structures promote the establishment of dominant rye centromere in the 1RS.1BL fused centromere, The New Phytologist, 2023, 第 1 作者
(12) Systemic development of wheat-Thinopyrum elongatum translocation lines and their deployment in wheat breeding for Fusarium head blight resistance, PLANT JOURNAL, 2023, 第 17 作者 通讯作者
(13) Autoploid origin and rapid diploidization of the tetraploid Thinopyrum elongatum revealed by genome differentiation and chromosome pairing in meiosis, PLANT JOURNAL, 2022, 第 7 作者 通讯作者
(14) Prospects and challenges of epigenomics in crop improvement, GENES & GENOMICS, 2022, 第 5 作者 通讯作者
(15) Distribution, Polymorphism and Function Characteristics of the GST-Encoding Fhb7 in Triticeae, PLANTS-BASEL, 2022, 第 5 作者 通讯作者
(16) Centromeres: From chromosome biology to biotechnology applications and synthetic genomes in plants, PLANT BIOTECHNOLOGY JOURNAL, 2022, 第 5 作者 通讯作者
(17) Establishment of a set of wheat���rye addition lines with resistance to stem rust, TAG, 2022, 第 1 作者 通讯作者
(18) Phosphorylation of histone H3 by Haspin regulates chromosome alignment and segregation during mitosis in maize, JOURNAL OF EXPERIMENTAL BOTANY, 2021, 第 5 作者 通讯作者
(19) Sequence of the supernumerary B chromosome of maize provides insight into its drive mechanism and evolution, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 31 作者 通讯作者
(20) Knl1 participates in spindle assembly checkpoint signaling in maize, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 9 作者
(21) Genome-wide mapping reveals R-loops associated with centromeric repeats in maize, GENOME RESEARCH, 2021, 第 9 作者 通讯作者
(22) Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize, PLOS BIOLOGY, 2020, 第 6 作者 通讯作者
(23) Rapid Birth or Death of Centromeres on Fragmented Chromosomes in Maize, PLANT CELL, 2020, 第 11 作者 通讯作者
(24) The Cohesin Complex Subunit ZmSMC3 Participates in Meiotic Centromere Pairing in Maize., Plant Cell, 2020, 第 1 作者 通讯作者
(25) Centromere Satellite Repeats Have Undergone Rapid Changes in Polyploid Wheat Subgenomes, PLANT CELL, 2019, 第 6 作者 通讯作者
(26) The deposition of CENH3 in maize is stringtently regulated, Plant Journal, 2019, 第 1 作者 通讯作者
(27) High-efficiency genome editing using a dmc1 promoter-controlled CRISPR/Cas9 system in maize, PLANT BIOTECHNOLOGY JOURNAL, 2018, 第 11 作者 通讯作者
(28) The Behavior of the Maize B Chromosome and Centromere, GENES, 2018, 第 5 作者 通讯作者
(29) Barbara McClintock���s Unsolved Chromosomal Mysteries: Parallels to Common Rearrangements and Karyotype Evolution, THE PLANT CELL, 2018, 第 2 作者
(30) Meiotic Studies on Combinations of Chromosomes With Different Sized Centromeres in Maize., FRONTIERS IN PLANT SCIENCE, 2018, 第 1 作者
(31) Site-specific transfer of chromosomal segments and genes in wheat engineered chromosomes, JOURNAL OF GENETICS AND GENOMICS, 2017, 第 8 作者
(32) Centromere structure and function analysis in wheat-rye translocation lines, PLANT JOURNAL, 2017, 第 5 作者 通讯作者
(33) Cohesion and centromere activity are required for phosphorylation of histone H3 in maize, THE PLANT JOURNAL, 2017, 第 7 作者
(34) De nove centromere formation and centromeric sequence expansion in wheat and its wide hybrids., PLOS GENETICS, 2016, 第 1 作者 通讯作者
(35) Dynamic chromatin changes associated with de novo centromere formation in maize euchromatin, PLANT JOURNAL, 2016, 第 12 作者 通讯作者
(36) Sequential de novo centromere formation and inactivation on a chromosomal fragment in maize., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 7 作者
(37) Characterization of two CENH3 genes and their roles in wheat evolution, NEW PHYTOLOGIST, 2015, 第 5 作者 通讯作者
(38) Asymmetric Epigenetic Modification and Elimination of rDNA Sequences by Polyploidization in Wheat, PLANT CELL, 2014, 第 2 作者 通讯作者
(39) Centromere Pairing in Early Meiotic Prophase Requires Active Centromeres and Precedes Installation of the Synaptonemal Complex in Maize, PLANT CELL, 2013, 第 3 作者 通讯作者
(40) Formation of a functional maize centromere after loss of centromeric sequences and gain of ectopic sequences, PLANT CELL, 2013, 第 12 作者 通讯作者
(41) De novo centromere formation on a chromosome fragment in maize, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 11 作者
(42) Phosphorylation of histone H2A is associated with centromere function and maintenance in meiosis, PLANT JOURNAL, 2012, 第 2 作者 通讯作者
(43) istinct DNA methylation patterns associated with active and inactive centromeres of the maize B chromosome., Genome Res., 2011, 第 1 作者
(44) Epigenetic aspects of centromere function in plants, CURRENT OPINION IN PLANT BIOLOGY, 2011, 第 5 作者
(45) Inactivation of a centromere during the formation of a translocation in maize, CHROMOSOME RESEARCH, 2011, 第 4 作者
(46) Centromere inactivation and reactivation reveal both genetic and epigenetic components for centromere specification, 2009,
(47) Maize centromeres: structure, function, epigenetics., ANNUAL REVIEW OF GENETICS, 2009, 第 2 作者
(48) Minichromosome Analysis of Chromosome Pairing, Disjunction, and Sister Chromatid Cohesion in Maize W, THE PLANT CELL, 2007, 第 1 作者
(49) “远中”号小偃麦在小麦育种中的应用, 麦类作物学报, 2000, 第 9 作者
(50) 普通小麦7B染色体的显微分离和低拷贝专化DNA序列的克隆, 科学通报, 1999, 第 6 作者
(51) 应用荧光原位杂交和染色体配对研究八倍体小冰麦中2的染色体组构成及染色体特征, 植物学报, 1999, 第 5 作者
(52) 应用荧光原位杂交技术研究小冰麦异附加系TAI—14中的冰草染色体的变异, 植物学报:英文版, 1998, 第 1 作者
(53) 应用FISH技术鉴定一个小冰麦易位系, 植物学报:英文版, 1998, 第 1 作者
(54) 应用荧光原位杂交技术研究小冰麦异附加系TAI—27的变异, 中国科学:C辑, 1998, 第 2 作者
(55) 应用FISH技术鉴定一个小冰麦易位系, 植物学报:英文版, 1998, 第 2 作者
(56) 应用荧光原位杂交技术研究小冰麦异附加系TAI—27的变异, 中国科学:C辑, 1998, 第 1 作者
(2) Young retrotransposons and non-B DNA structures promote the establishment of dominant rye centromere in the 1RS.1BL fused centromere, New Phytologist, 2024, 第 9 作者 通讯作者
(3) Unveiling the distinctive traits of functional rye centromeres: minisatellites, retrotransposons, and R-loop formation, Sci China Life Sci, 2024, 第 10 作者 通讯作者
(4) Wide hybridizations reveal the robustness of functional centromeres in Triticum-Aegilops species complex lines, JGG, 2024, 第 8 作者 通讯作者
(5) Cytological analysis of the diploid-like inheritance of newly synthesized allotetraploid wheat, Chromosome Research, 2023, 第 8 作者 通讯作者
(6) Functional analysis of the glutathione S-transferases from Thinopyrum and its derivatives on wheat Fusarium head blight resistance, PLANT BIOTECHNOLOGY JOURNAL, 2023, 第 13 作者 通讯作者
(7) New insights on the evolution of nucleolar dominance in newly resynthesized hexaploid wheat Triticum zhukovskyi, PLANT JOURNAL, 2023, 第 12 作者 通讯作者
(8) Non���B-form DNA tends to form in centromeric regions and has undergone changes in polyploid oat subgenomes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 12 作者
(9) Pan-centromere reveals widespread centromere repositioning of soybean genomes, Proceedings of the National Academy of Sciences of the United States of America, 2023, 第 1 作者
(10) Development and cytological characterization of wheat��� Thinopyrum intermedium translocation lines with novel stripe rust resistance gene, FRONTIERS IN PLANT SCIENCE, 2023, 第 11 作者
(11) Young retrotransposons and non-B DNA structures promote the establishment of dominant rye centromere in the 1RS.1BL fused centromere, The New Phytologist, 2023, 第 1 作者
(12) Systemic development of wheat-Thinopyrum elongatum translocation lines and their deployment in wheat breeding for Fusarium head blight resistance, PLANT JOURNAL, 2023, 第 17 作者 通讯作者
(13) Autoploid origin and rapid diploidization of the tetraploid Thinopyrum elongatum revealed by genome differentiation and chromosome pairing in meiosis, PLANT JOURNAL, 2022, 第 7 作者 通讯作者
(14) Prospects and challenges of epigenomics in crop improvement, GENES & GENOMICS, 2022, 第 5 作者 通讯作者
(15) Distribution, Polymorphism and Function Characteristics of the GST-Encoding Fhb7 in Triticeae, PLANTS-BASEL, 2022, 第 5 作者 通讯作者
(16) Centromeres: From chromosome biology to biotechnology applications and synthetic genomes in plants, PLANT BIOTECHNOLOGY JOURNAL, 2022, 第 5 作者 通讯作者
(17) Establishment of a set of wheat���rye addition lines with resistance to stem rust, TAG, 2022, 第 1 作者 通讯作者
(18) Phosphorylation of histone H3 by Haspin regulates chromosome alignment and segregation during mitosis in maize, JOURNAL OF EXPERIMENTAL BOTANY, 2021, 第 5 作者 通讯作者
(19) Sequence of the supernumerary B chromosome of maize provides insight into its drive mechanism and evolution, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 31 作者 通讯作者
(20) Knl1 participates in spindle assembly checkpoint signaling in maize, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 9 作者
(21) Genome-wide mapping reveals R-loops associated with centromeric repeats in maize, GENOME RESEARCH, 2021, 第 9 作者 通讯作者
(22) Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize, PLOS BIOLOGY, 2020, 第 6 作者 通讯作者
(23) Rapid Birth or Death of Centromeres on Fragmented Chromosomes in Maize, PLANT CELL, 2020, 第 11 作者 通讯作者
(24) The Cohesin Complex Subunit ZmSMC3 Participates in Meiotic Centromere Pairing in Maize., Plant Cell, 2020, 第 1 作者 通讯作者
(25) Centromere Satellite Repeats Have Undergone Rapid Changes in Polyploid Wheat Subgenomes, PLANT CELL, 2019, 第 6 作者 通讯作者
(26) The deposition of CENH3 in maize is stringtently regulated, Plant Journal, 2019, 第 1 作者 通讯作者
(27) High-efficiency genome editing using a dmc1 promoter-controlled CRISPR/Cas9 system in maize, PLANT BIOTECHNOLOGY JOURNAL, 2018, 第 11 作者 通讯作者
(28) The Behavior of the Maize B Chromosome and Centromere, GENES, 2018, 第 5 作者 通讯作者
(29) Barbara McClintock���s Unsolved Chromosomal Mysteries: Parallels to Common Rearrangements and Karyotype Evolution, THE PLANT CELL, 2018, 第 2 作者
(30) Meiotic Studies on Combinations of Chromosomes With Different Sized Centromeres in Maize., FRONTIERS IN PLANT SCIENCE, 2018, 第 1 作者
(31) Site-specific transfer of chromosomal segments and genes in wheat engineered chromosomes, JOURNAL OF GENETICS AND GENOMICS, 2017, 第 8 作者
(32) Centromere structure and function analysis in wheat-rye translocation lines, PLANT JOURNAL, 2017, 第 5 作者 通讯作者
(33) Cohesion and centromere activity are required for phosphorylation of histone H3 in maize, THE PLANT JOURNAL, 2017, 第 7 作者
(34) De nove centromere formation and centromeric sequence expansion in wheat and its wide hybrids., PLOS GENETICS, 2016, 第 1 作者 通讯作者
(35) Dynamic chromatin changes associated with de novo centromere formation in maize euchromatin, PLANT JOURNAL, 2016, 第 12 作者 通讯作者
(36) Sequential de novo centromere formation and inactivation on a chromosomal fragment in maize., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 7 作者
(37) Characterization of two CENH3 genes and their roles in wheat evolution, NEW PHYTOLOGIST, 2015, 第 5 作者 通讯作者
(38) Asymmetric Epigenetic Modification and Elimination of rDNA Sequences by Polyploidization in Wheat, PLANT CELL, 2014, 第 2 作者 通讯作者
(39) Centromere Pairing in Early Meiotic Prophase Requires Active Centromeres and Precedes Installation of the Synaptonemal Complex in Maize, PLANT CELL, 2013, 第 3 作者 通讯作者
(40) Formation of a functional maize centromere after loss of centromeric sequences and gain of ectopic sequences, PLANT CELL, 2013, 第 12 作者 通讯作者
(41) De novo centromere formation on a chromosome fragment in maize, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 11 作者
(42) Phosphorylation of histone H2A is associated with centromere function and maintenance in meiosis, PLANT JOURNAL, 2012, 第 2 作者 通讯作者
(43) istinct DNA methylation patterns associated with active and inactive centromeres of the maize B chromosome., Genome Res., 2011, 第 1 作者
(44) Epigenetic aspects of centromere function in plants, CURRENT OPINION IN PLANT BIOLOGY, 2011, 第 5 作者
(45) Inactivation of a centromere during the formation of a translocation in maize, CHROMOSOME RESEARCH, 2011, 第 4 作者
(46) Centromere inactivation and reactivation reveal both genetic and epigenetic components for centromere specification, 2009,
(47) Maize centromeres: structure, function, epigenetics., ANNUAL REVIEW OF GENETICS, 2009, 第 2 作者
(48) Minichromosome Analysis of Chromosome Pairing, Disjunction, and Sister Chromatid Cohesion in Maize W, THE PLANT CELL, 2007, 第 1 作者
(49) “远中”号小偃麦在小麦育种中的应用, 麦类作物学报, 2000, 第 9 作者
(50) 普通小麦7B染色体的显微分离和低拷贝专化DNA序列的克隆, 科学通报, 1999, 第 6 作者
(51) 应用荧光原位杂交和染色体配对研究八倍体小冰麦中2的染色体组构成及染色体特征, 植物学报, 1999, 第 5 作者
(52) 应用荧光原位杂交技术研究小冰麦异附加系TAI—14中的冰草染色体的变异, 植物学报:英文版, 1998, 第 1 作者
(53) 应用FISH技术鉴定一个小冰麦易位系, 植物学报:英文版, 1998, 第 1 作者
(54) 应用荧光原位杂交技术研究小冰麦异附加系TAI—27的变异, 中国科学:C辑, 1998, 第 2 作者
(55) 应用FISH技术鉴定一个小冰麦易位系, 植物学报:英文版, 1998, 第 2 作者
(56) 应用荧光原位杂交技术研究小冰麦异附加系TAI—27的变异, 中国科学:C辑, 1998, 第 1 作者
科研活动
科研项目
( 1 ) 异源多倍体小麦核型稳定的遗传机制, 负责人, 国家任务, 2020-01--2024-12
( 2 ) 植物着丝粒失活及新着丝粒形成的表观遗传学研究, 负责人, 国家任务, 2020-01--2024-12
( 3 ) 植物减数分裂染色体配对起始及染色体分离的分子机理, 负责人, 国家任务, 2017-01--2022-12
( 4 ) 主要农作物染色体细胞工程育种, 负责人, 国家任务, 2016-07--2020-12
( 2 ) 植物着丝粒失活及新着丝粒形成的表观遗传学研究, 负责人, 国家任务, 2020-01--2024-12
( 3 ) 植物减数分裂染色体配对起始及染色体分离的分子机理, 负责人, 国家任务, 2017-01--2022-12
( 4 ) 主要农作物染色体细胞工程育种, 负责人, 国家任务, 2016-07--2020-12