淡水生态毒理学

   

071004-水生生物学

淡水生态学,生态毒理学

   

-- 研究生

-- 博士

2011.11--今：中国科学院水生生物研究所，研究员，2013年任博士生导师

2010.01--2010.12：英国阿伯丁大学，中国科学院访问学者，访学期间作为独立获奖人荣获英国著名信托基金会颁发的“利华休姆信托—海外访问学者奖学金”

2009.05--2009.10：英国阿伯丁大学，受“国家自然科学基金国际（地区）合作交流项目—微囊藻毒素及鱼类病原菌对鱼类免疫系统基因的影响”资助，开展合作研究

2007.07--2011.11：中国科学院水生生物研究所，副研究员，2008年任硕士生导师

2006.07--2007.07：中国科学院水生生物研究所，助理研究员

1998.07--2003.08：武汉市疾病控制中心，中级

研究方向：自水生所工作以来，主要从事蓝藻衍生污染物的生态毒理学、检测技术以及蓝藻生物控制的生理生态学机制等方面的基础研究。

2017-10-31-2020-10-31,武昌区人大代表,
2016-01-01-2020-12-31,中国海洋湖沼学会湖泊分会常务理事,

   

（1） 第三届武汉青年科技奖, , 市地级, 2012
（2） 利华休姆信托—海外访问学者奖学, , 其他, 2010
（3） 中科院院长优秀奖, , 院级, 2005

   

[1] Rao, Qingyang, Su, Haojie, Ruan, Linwei, Xia, Wulai, Deng, Xuwei, Wang, Lantian, Xu, Pengke, Shen, Hong, Chen, Jun, Xie, Ping. Phosphorus enrichment affects trait network topologies and the growth of submerged macrophytes. ENVIRONMENTAL POLLUTION[J]. 2022, 292: http://dx.doi.org/10.1016/j.envpol.2021.118331.
[2] Wang, Li, Chen, Jun, Su, Haojie, Ma, Xufa, Wu, Zhixu, Shen, Hong, Yu, Jia, Liu, Jiarui, Wu, Yao, Ding, Guangyi, Xie, Ping. Is Zooplankton Body Size an Indicator of Water Quality in (Sub)tropical Reservoirs in China?. ECOSYSTEMS[J]. 2022, 25(2): 308-319, http://dx.doi.org/10.1007/s10021-021-00656-2.
[3] Liang Chen, Ting Shi, YuTing Wang, Jun He, Xu Zhao, YeKe Wang, John P Giesy, Feng Chen, Yang Chen, Xun Tuo, Jun Chen, Ping Xie. Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 778: [4] Deng, Xuwei, Chen, Jun, Hansson, LarsAnders, Zhao, Xia, Xie, Ping. Eco-chemical mechanisms govern phytoplankton emissions of dimethylsulfide in global surface waters. NATIONAL SCIENCE REVIEW[J]. 2021, 8(2): 38-45, http://lib.cqvip.com/Qikan/Article/Detail?id=7104077535.
[5] Chen, Liang, Giesy, John P, Adamovsky, Ondrej, Svircev, Zorica, Meriluoto, Jussi, Codd, Geoffrey A, Mijovic, Biljana, Shi, Ting, Tuo, Xun, Li, ShangChun, Pan, BaoZhu, Chen, Jun, Xie, Ping. Challenges of using blooms of Microcystis spp. in animal feeds: A comprehensive review of nutritional, toxicological and microbial health evaluation. SCIENCE OF THE TOTAL ENVIRONMENTnull. 2021, 764: http://dx.doi.org/10.1016/j.scitotenv.2020.142319.
[6] Zhu, Rong, Wang, Huan, Shen, Hong, Deng, Xuwei, Chen, Jun. The dynamics and release characteristics of microcystins in the plateau Lake Erhai, Southwest China. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH[J]. 2021, 28(18): 23473-23481, http://dx.doi.org/10.1007/s11356-020-12312-8.
[7] Wang, Yeke, Chen, Feng, He, Jun, Xue, Ge, Chen, Jun, Xie, Ping. Cellular and molecular modification of egg envelope hardening in fertilization. BIOCHIMIE[J]. 2021, 181: 134-144, http://dx.doi.org/10.1016/j.biochi.2020.12.007.
[8] Rao, Qingyang, Su, Haojie, Ruan, Linwei, Deng, Xuwei, Wang, Lantian, Rao, Xiao, Liu, Jiarui, Xia, Wulai, Xu, Pengke, Shen, Hong, Chen, Jun, Xie, Ping. Stoichiometric and physiological mechanisms that link hub traits of submerged macrophytes with ecosystem structure and functioning. WATER RESEARCH[J]. 2021, 202: http://dx.doi.org/10.1016/j.watres.2021.117392.
[9] Chen, Feng, Smith, Carl, Wang, Yeke, He, Jun, Xia, Wulai, Xue, Ge, Chen, Jun, Xie, Ping. The Evolution of Alternative Buoyancy Mechanisms in Freshwater Fish Eggs. FRONTIERS IN ECOLOGY AND EVOLUTION[J]. 2021, 9: http://dx.doi.org/10.3389/fevo.2021.736718.
[10] Su, Haojie, Wang, Rong, Feng, Yuhao, Li, Yanling, Li, Yun, Chen, Jun, Xu, Chi, Wang, Shaopeng, Fang, Jingyun, Xie, Ping. Long-term empirical evidence, early warning signals and multiple drivers of regime shifts in a lake ecosystem. JOURNAL OF ECOLOGY[J]. 2021, 109(9): 3182-3194, http://dx.doi.org/10.1111/1365-2745.13544.
[11] Su, Haojie, Feng, Yuhao, Chen, Jianfeng, Chen, Jun, Ma, Suhui, Fang, Jingyun, Xie, Ping. Determinants of trophic cascade strength in freshwater ecosystems: a global analysis. ECOLOGY[J]. 2021, 102(7): http://dx.doi.org/10.1002/ecy.3370.
[12] Zhang, Weizhen, Shen, Hong, Zhang, Jia, Yu, Jia, Xie, Ping, Chen, Jun. Physiological differences between free-floating and periphytic filamentous algae, and specific submerged macrophytes induce proliferation of filamentous algae: A novel implication for lake restoration. CHEMOSPHERE[J]. 2020, 239(1): http://dx.doi.org/10.1016/j.chemosphere.2019.124702.
[13] Xia, Wulai, Chen, Liang, Deng, Xuwei, Liang, Gaodao, Giesy, John P, Rao, Qingyang, Wen, Zihao, Wu, Yao, Chen, Jun, Xie, Ping. Spatial and interspecies differences in concentrations of eight trace elements in wild freshwater fishes at different trophic levels from middle and eastern China. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2019, 672: 883-892, http://dx.doi.org/10.1016/j.scitotenv.2019.03.134.
[14] Zhang, Weizhen, Wang, Li, Chen, Liang, Shen, Hong, Chen, Jun. Proliferation of filamentous green algae along with submerged macrophytes planting, and the role of microbe. ECOLOGICAL ENGINEERING[J]. 2019, 139: http://dx.doi.org/10.1016/j.ecoleng.2019.07.040.
[15] Li, Wei, He, Jun, Chen, Jun, Xie, Ping. Excretion pattern and dynamics of glutathione detoxification of microcystins in Sprague Dawley rat. CHEMOSPHERE[J]. 2018, 191(1): 357-364, http://dx.doi.org/10.1016/j.chemosphere.2017.09.083.
[16] Chen, Liang, Hu, Yufei, He, Jun, Chen, Jun, Giesy, John P, Xie, Ping. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2017, 51(1): 596-607, http://ir.ihb.ac.cn/handle/342005/28861.
[17] He, Jun, Li, Guangyu, Chen, Jun, Lin, Juan, Zeng, Cheng, Chen, Jing, Deng, Junliang, Xie, Ping. Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study. ARCHIVES OF TOXICOLOGY[J]. 2017, 91(1): 465-480, https://www.webofscience.com/wos/woscc/full-record/WOS:000392320700031.
[18] Yu, Dezhao, Xie, Ping, Zeng, Cheng, Xie, Lijuan, Chen, Jun. In situ enclosure experiments on the occurrence, development and decline of black bloom and the dynamics of its associated taste and odor compounds. ECOLOGICAL ENGINEERING[J]. 2016, 87: 246-253, http://dx.doi.org/10.1016/j.ecoleng.2015.11.039.
[19] Chen, Liang, Chen, Jun, Zhang, Xuezhen, Xie, Ping. A review of reproductive toxicity of microcystins. JOURNAL OF HAZARDOUS MATERIALS[J]. 2016, 301: 381-399, http://dx.doi.org/10.1016/j.jhazmat.2015.08.041.
[20] Jun Chen. The role of GSH in microcystin-induced apoptosis in rat liver: involvement of oxidative stress and NF-kB. Environmental Toxicology. 2016, [21] Guo, Xiaochun, Chen, Liang, Chen, Jun, Xie, Ping, Li, Shangchun, He, Jun, Li, Wei, Fan, Huihui, Yu, Dezhao, Zeng, Cheng. Quantitatively evaluating detoxification of the hepatotoxic microcystin-LR through the glutathione (GSH) pathway in SD rats. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH[J]. 2015, 22(23): 19273-19284, http://www.irgrid.ac.cn/handle/1471x/1012132.
[22] Chen, Jing, Xie, Ping, Lin, Juan, He, Jun, Zeng, Cheng, Chen, Jun. Effects of microcystin-LR on gut microflora in different gut regions of mice. JOURNAL OF TOXICOLOGICAL SCIENCES[J]. 2015, 40(4): 485-494, http://dx.doi.org/10.2131/jts.40.485.
[23] 朱荣, 王欢, 余得昭, 曾诚, 沈宏, 陈隽. 2013年洱海水华期间微囊藻毒素和浮游植物动态变化. 湖泊科学[J]. 2015, 27(3): 378-, http://lib.cqvip.com/Qikan/Article/Detail?id=664755599.
[24] Jun Chen. The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats.. Environmental Toxicology. 2015, [25] Li, Wei, Chen, Jun, Xie, Ping, He, Jun, Guo, Xiaochun, Tuo, Xun, Zhang, Wei, Wu, Laiyan. Rapid conversion and reversible conjugation of glutathione detoxification of microcystins in bighead carp (Aristich-thys nobilis). AQUATIC TOXICOLOGY[J]. 2014, 147: 18-25, http://dx.doi.org/10.1016/j.aquatox.2013.12.001.
[26] Guo, Xiaochun, Xie, Ping, Chen, Jun, Tuo, Xun, Deng, Xuwei, Li, Shangchun, Yu, Dezhao, Zeng, Cheng. Simultaneous quantitative determination of microcystin-LR and its glutathione metabolites in rat liver by liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2014, 963(-): 54-61, http://dx.doi.org/10.1016/j.jchromb.2014.05.046.
[27] Jun Chen. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring.. Journal of Proteomics. 2014, [28] Wei Li, Ping Xie, Jun Chen, Jun He, Xiaochun Guo, Dezhao Yu, Liang Chen. Quantitative liquid chromatography–tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile. JOURNAL OF CHROMATOGRAPHY B. 2014, 963: 113-118, http://dx.doi.org/10.1016/j.jchromb.2014.05.057.
[29] Chen, Jun, Xu, Qiaoqing, Wang, Tiehui, Collet, Bertrand, CorripioMiyar, Yolanda, Bird, Steve, Xie, Ping, Nie, Pin, Secombes, Christopher J, Zou, Jun. Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2013, 41(2): 137-152, http://dx.doi.org/10.1016/j.dci.2013.05.006.
[30] Ma, Zhimei, Niu, Yuan, Xie, Ping, Chen, Jun, Tao, Min, Deng, Xuwei. Off-flavor compounds from decaying cyanobacterial blooms of Lake Taihu. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA[J]. 2013, 25(3): 495-501, http://dx.doi.org/10.1016/S1001-0742(12)60101-6.
[31] Yan, Wei, Zhou, Youxiang, Yang, Jie, Li, Shuqian, Hu, Dingjin, Wang, Jianghua, Chen, Jun, Li, Guangyu. Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae. CHEMOSPHERE[J]. 2012, 87(11): 1301-1307, http://dx.doi.org/10.1016/j.chemosphere.2012.01.041.
[32] Qi, Min, Chen, Jun, Sun, Xiaoxue, Deng, Xuwei, Niu, Yuan, Xie, Ping. Development of Models for Predicting the Predominant Taste and Odor Compounds in Taihu Lake, China. PLOS ONE[J]. 2012, 7(12): http://www.irgrid.ac.cn/handle/1471x/733564.
[33] Jun Chen. The role of cysteine conjugation in the detoxification of microcystin-LR in liver of bighead carp (Aristichthys nobilis): a field and laboratory laboratory study.. Ecotoxicology. 2012, [34] He, Jun, Chen, Jun, Wu, Laiyan, Li, Guangyu, Xie, Ping. Metabolic Response to Oral Microcystin-LR Exposure in the Rat by NMR-Based Metabonomic Study. JOURNAL OF PROTEOME RESEARCH[J]. 2012, 11(12): 5934-5946, http://www.irgrid.ac.cn/handle/1471x/733566.
[35] He, Jun, Chen, Jun, Xie, Ping, Zhang, Dawen, Li, Guangyu, Wu, Laiyan, Zhang, Wei, Guo, Xiaochun, Li, Shangchun. Quantitatively evaluating detoxification of the hepatotoxic microcystins through the glutathione and cysteine pathway in the cyanobacteria-eating bighead carp. AQUATIC TOXICOLOGY[J]. 2012, 116(-): 61-68, http://dx.doi.org/10.1016/j.aquatox.2012.03.004.
[36] Cai, Yan, Li, Huiying, Hao, Le, Li, Guangyu, Xie, Ping, Chen, Jun. Identification of cda gene in bighead carp and its expression in response to microcystin-LR. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2012, 79: 206-213, http://dx.doi.org/10.1016/j.ecoenv.2012.01.001.
[37] Liang, Gaodao, Xie, Ping, Chen, Jun, Yu, Ting. Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS. THESCIENTIFICWORLDJOURNAL[J]. 2011, 11: 20-26, http://ir.ihb.ac.cn/handle/342005/15474.
[38] Wu, Laiyan, Xie, Ping, Chen, Jun, Zhang, Dawen, Liang, Gaodao. Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous quantitation of microcystin-RR and its metabolites in fish liver. JOURNAL OF CHROMATOGRAPHY A[J]. 2010, 1217(9): 1455-1462, http://dx.doi.org/10.1016/j.chroma.2009.12.068.
[39] Chen, Jun, Xie, Ping, Ma, Zhimei, Niu, Yuan, Tao, Min, Deng, Xuwei, Wang, Qing. A systematic study on spatial and seasonal patterns of eight taste and odor compounds with relation to various biotic and abiotic parameters in Gonghu Bay of Lake Taihu, China. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2010, 409(2): 314-325, http://dx.doi.org/10.1016/j.scitotenv.2010.10.010.
[40] Zhang, Dawen, Xie, Ping, Chen, Jun. Effects of Temperature on the Stability of Microcystins in Muscle of Fish and Its Consequences for Food Safety. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY[J]. 2010, 84(2): 202-207, http://ir.scsio.ac.cn/handle/344004/6327.
[41] Chen, Jun, Xie, Ping, Li, Li, Xu, Jun. First Identification of the Hepatotoxic Microcystins in the Serum of a Chronically Exposed Human Population Together with Indication of Hepatocellular Damage. TOXICOLOGICAL SCIENCES[J]. 2009, 108(1): 81-89, http://ir.ihb.ac.cn/handle/152342/7850.
[42] Chen, Jun, Zhang, Dawen, Xie, Ping, Wang, Qing, Ma, Zhimei. Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2009, 407(10): 3317-3322, http://dx.doi.org/10.1016/j.scitotenv.2009.02.005.
[43] Chen, Jun, Xie, Ping. Accumulation of hepatotoxic microcystins in freshwater mussels, aquatic insect larvae and oligochaetes in a large, shallow eutrophic lake (Lake Chaohu) of subtropical China. FRESENIUS ENVIRONMENTAL BULLETIN[J]. 2008, 17(7A): 849-854, http://ir.ihb.ac.cn/handle/152342/8034.
[44] Chen, Jun, Xie, Ping. Microcystin accumulation in freshwater bivalves from Lake Taihu, China, and the potential risk to human consumption. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY[J]. 2007, 26(5): 1066-1073, http://ir.ihb.ac.cn/handle/152342/8628.
[45] Chen, Jun, Xie, Ping, Zhang, Dawen, Lei, Hehua. In situ studies on the distribution patterns and dynamics of microcystins in a biomanipulation fish - bighead carp (Aristichthys nobilis). ENVIRONMENTAL POLLUTION[J]. 2007, 147(1): 150-157, http://dx.doi.org/10.1016/j.envpol.2006.08.015.
[46] Chen, Jun, Xie, Ping, Zhang, Dawen, Ke, Zhixin, Yang, Hua. In situ studies on the bioaccumulation of microcystins in the phytoplanktivorous silver carp (Hypophthalmichthys molitrix) stocked in Lake Taihu with dense toxic Microcystis blooms. AQUACULTURE[J]. 2006, 261(3): 1026-1038, http://dx.doi.org/10.1016/j.aquaculture.2006.08.028.
[47] Chen, J, Xie, P. Seasonal dynamics of the hepatotoxic microcystins in various organs of four freshwater bivalves from the large eutrophic Lake Taihu of subtropical China and the risk to human consumption. ENVIRONMENTAL TOXICOLOGY[J]. 2005, 20(6): 572-584, http://ir.ihb.ac.cn/handle/152342/9088.
[48] Chen, J, Xie, P, Guo, LG, Zheng, L, Ni, LY. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) from a large shallow, eutrophic lake of the subtropical China. ENVIRONMENTAL POLLUTION[J]. 2005, 134(3): 423-430, http://dx.doi.org/10.1016/j.envpol.2004.09.014.
[49] Chen, J, Xie, P. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China. TOXICON[J]. 2005, 45(5): 615-625, http://dx.doi.org/10.1016/j.toxicon.2005.01.003.

   

（ 1 ） 谷胱甘肽途径对微囊藻毒素-LR/RR诱导大鼠肝脏DNA损伤的抑制作用及机制探讨, 主持, 国家级, 2011-01--2013-12
（ 2 ） 蓝藻水华生态灾害形成机理及防治的基础研究, 主持, 国家级, 2008-07--2012-06
（ 3 ） 水生态毒理学, 主持, 国家级, 2014-01--2017-12
（ 4 ） 湖泛监控指标及环境效应综合评估技术研究, 主持, 国家级, 2012-12--2016-12
（ 5 ） 洱海藻类水华风险预测技术, 主持, 国家级, 2012-12--2017-12
（ 6 ） 东湖典型生态系统长期变化趋势分析, 主持, 部委级, 2015-12--2016-12
（ 7 ） 城市湖泊多组分在线监测平台建设, 主持, 部委级, 2016-06--2018-12
（ 8 ） 三河三湖”重点流域水生动物入侵种调查编目, 主持, 国家级, 2016-01--2018-12
（ 9 ） 滨湖城市湖泊生态系统退化识别与草型湖泊弹性变化阈值, 主持, 国家级, 2017-01--2020-06
（ 10 ） 微囊藻毒素-LR慢性暴露对哺乳动物大鼠生殖与发育毒性的系统毒理学研究, 主持, 国家级, 2018-01--2021-12

已指导学生

谢丽娟  硕士研究生  071004-水生生物学  

朱荣  博士研究生  071004-水生生物学  

现指导学生

刘佳睿  硕士研究生  085238-生物工程  

张佳  硕士研究生  071004-水生生物学  

张蔚珍  博士研究生  071004-水生生物学  

陈阳  硕士研究生  085238-生物工程  

陈峰  博士研究生  071004-水生生物学