基本信息
时玉舫  男  博导  苏州大学
电子邮件: yufangshi@sibs.ac.cn
通信地址: 上海岳阳路320号新生命科学大楼1113室
邮政编码:

研究领域

   

招生信息

   
招生专业
071009-细胞生物学
招生方向
1不同T细胞群体的AICD过程;
2骨髓间质干细胞的免疫抑制
3肿瘤免疫

教育背景

1988-09--1992-09   加拿大阿尔伯塔大学   博士
1985-09--1988-08   加拿大阿尔伯塔大学   硕士
1977-09--1982-07   山东农业大学   学士
学历
   
学位
   

工作经历

   
工作简历
2014-07~现在, 中国科学院上海生命科学研究院, 研究员
2008-06~2014-06,中国科学院上海生命科学研究院, 所长/研究员
2003-07~2008-05,美国新泽西医科和牙科大学-罗伯特•伍德•约翰逊医学院, 终身教授
2001-08~2008-05,美国新泽西癌症研究所, 研究员
2001-08~2003-06,美国新泽西医科和牙科大学- 罗伯特•伍德•约翰逊医学院, 终身副教授
1999-07~2001-08,美国乔治华盛顿大学, 终身副教授
1999-07~2001-08,美国红十字协会Holland医学生物研究所, Scientist II 终身副教授
1999-07~2001-08,美国乔治•华盛顿大学, 助理教授
1996-07~1999-07,美国乔治•华盛顿大学, 助理教授
1995-02~1999-06,美国红十字协会Holland医学生物研究所, Scientist I 助理教授
1992-09~1995-02,加拿大多伦多大学, 博士后
1988-09~1992-09,加拿大阿尔伯塔大学, 博士
1986-09~1989-05,加拿大阿尔伯塔大学, 助教
1985-09~1988-08,加拿大阿尔伯塔大学, 硕士
1982-01~1985-09,山东农业大学, 助教
1977-09~1982-07,山东农业大学, 学士
社会兼职
2011-01-01-今,Stem Cells Translational Medicine, Member of Editorial Board
2010-01-01-今,Cell Death and Disease, Editor-in-Chief
2010-01-01-今,Cell &Biosciences, Associate Editor
2009-01-01-今,American Journal of Translational Research, Member of Editorial Board
2009-01-01-今,Journal of Biomedicine and Biotechnology, Member of Editorial Board
2009-01-01-今,Stem Cell Research and Therapy, Member of Editorial Board
2008-01-01-今,Oncogene, Receiving Editor
2008-01-01-今,Journal of Biological Chemistry, Member of Editorial Board
2008-01-01-今,Journal of Molecular Cell Biology, Member of Editorial board
2004-01-01-今,Cellular and Molecular Immunology, Member of Editorial Board
1999-01-01-今,Journal of Immunology, Associate Editor
1996-01-01-今,Cell Research, Editorial Board, Regional Editor, Associate Editor-in Chief and Editor

教授课程

免疫生物学

专利与奖励

   
奖励信息
(1) 国家特聘专家, 部委级, 2012
(2) 中组部千人计划, 国家级, 2008
专利成果
( 1 ) 间充质干细胞在预防或治疗应激反应导致的免疫力下降中的应用, 2013, 第 1 作者, 专利号: PCT/CN2014/076511
( 2 ) IL-17在提高间充质干细胞免疫功能中的应用, 2014, 第 1 作者, 专利号: PCT/CN2015/077862

出版信息

   
发表论文
(1) Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGFβ Promotes Breast Cancer Metastasis., Oncogene, 2016, 第 11 作者
(2) TNFα-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils., Oncogene, 2016, 第 11 作者
(3) SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation., Cell Reports, 2016, 第 11 作者
(4) Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities., Oncogene, 2016, 第 11 作者
(5) Type I Interferons Exert Anti-tumor Effect via Reversing Immunosuppression Mediated by Mesenchymal Stromal Cells., Oncogene, 2016, 第 11 作者
(6) Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?, Cell Death and Differentiation, 2016, 第 11 作者
(7) Local proliferation initiates macrophage accumulation in adipose tissue during obesity., Cell Death and Diseases, 2016, 第 11 作者
(8) P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development., Cell Death and Diseases, 2016, 第 11 作者
(9) Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages, Cell Death and Differentiation, 2016, 第 11 作者
(10) CD11b Regulates Obesity-Induced Insulin Resistance via Limiting Alternative Activation and Proliferation of Adipose Tissue Macrophages., Proceedings of the National Academy of Sciences, 2015, 第 11 作者
(11) Rethinking regeneration: empowerment of stem cells by inflammation., Cell Death and Differentiation, 2015, 第 1 作者
(12) The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation., J Mol Cell Biol., 2015, 第 11 作者
(13) Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity., Oncogene, 2015, 第 11 作者
(14) Mesenchymal stem cells and adaptive immune responses., Immunology Letter, 2015, 第 11 作者
(15) Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications., Nature Immunology, 2014, 第 11 作者
(16) The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease., Cell Death and Diseases, 2014, 第 11 作者
(17) Interleukin-17 enhances immunosuppression by mesenchymal stem cells., Cell Death and Differentiation, 2014, 第 11 作者
(18) Immunobiology of mesenchymal stem cells., Cell Death and Differentiation, 2014, 第 11 作者
(19) Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation., Cell Death and Diseases, 2014, 第 11 作者
(20) Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4., Brain, Behavior and Immunity., 2014, 第 11 作者
(21) The interaction between mesenchymal stem cells and steroids during inflammation., Cell Death and Diseases, 2014, 第 11 作者
(22) Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment., Cancer Research, 2014, 第 11 作者
(23) TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells., Journal of Immunology, 2014, 第 11 作者
(24) Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties., Oncogene, 2014, 第 11 作者
(25) p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation., Oncogene, 2014, 第 11 作者
(26) Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species., Cell Death and Differentiation, 2014, 第 11 作者
(27) An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells., Stem cells, 2014, 第 11 作者
(28) Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in vivo., Oncogene, 2014, 第 11 作者
(29) A novel subset of helper T cells promotes immune responses by secreting GM-CSF., Cell Death and Differentiation, 2013, 第 11 作者
(30) Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis., Cell Death and Diseases, 2013, 第 11 作者
(31) MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2., Journal of Biological Chemistry, 2013, 第 11 作者
(32) One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment., Cell & Bioscience, 2013, 第 11 作者
(33) Reprogramming cancer cells: back to the future., Oncogene, 2013, 第 2 作者
(34) CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα., Cell Stem Cell, 2012, 第 11 作者
(35) A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling., Cellular & Molecular Immunology, 2012, 第 11 作者
(36) Mesenchymal stem cells: a double-edged sword in regulating immune responses., Cell Death and Differentiation, 2012, 第 11 作者
(37) How mesenchymal stem cells interact with tissue immune responses., Trends in Immunology, 2012, 第 11 作者
(38) How mesenchymal stem cells interact with tissue immune responses., Trends in Immunology, 2012, 第 11 作者
(39) How mesenchymal stem cells interact with tissue immune responses., Trends in Immunology, 2012, 第 11 作者
(40) Stem Cells Deployed for Bone Repair Hijacked by T Cells., Cell Stem Cell, 2012, 第 11 作者
(41) Stem Cells Deployed for Bone Repair Hijacked by T Cells., Cell Stem Cell, 2012, 第 11 作者
(42) Concise review: mesenchymal stem cells and rranslational medicine: emerging issues., Stem Cells Transl Med., 2012, 第 11 作者
(43) Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression., Cell Adhesion & Migration, 2011, 第 11 作者
(44) The putative cannabinoid receptor GPR55 promotes cancer cell proliferation., Oncogene, 2011, 第 11 作者
(45) Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair., Cell Research, 2010, 第 11 作者
(46) Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression., Journal of Immunology, 2010, 第 11 作者
(47) Brief report: IFN-γ induces expansion of Lin-Sca-1+C-Kit+ Cells., Stem Cells, 2010, 第 11 作者
(48) Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation., Journal of Experimental Medicine, 2009, 第 11 作者
(49) Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression., Stem Cells, 2009, 第 11 作者
(50) A Sino-British frontier workshop of cancer biology., Cell Death and Differentiation, 2009, 第 11 作者
(51) C/EBPβ Mdiates the Synergistic Upregulation of Gene Expression by IFN-γ and TNF-α in Bone Marrow-Derived Mesenchymal Stem Cells., Stem Cells, 2009, 第 11 作者
(52) Natural killer cells go inside: entosis versus cannibalism., Cell Research, 2009, 第 11 作者
(53) Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide., Biochem Biophys Res Commun., 2008, 第 11 作者
(54) Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide., Journal of Immunology, 2008, 第 11 作者
(55) New Hope for Cancer Treatment: exploring the distinction betweennormal adult stem cells and cancer stem cells., Pharmacology and Therapeutics, 2008, 第 11 作者
(56) Th17 Cells Undergo Fas-mediated Activation-induced Cell Independent of IFN-γ., Journal of Immunology, 2008, 第 11 作者
(57) Chloramphenicol induces abnormal cell differentiation and inhibits apoptosis in activated T cells: possible links to leukemogenesis., Cancer Research, 2008, 第 11 作者
(58) Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide., Cell Stem Cell, 2008, 第 11 作者
发表著作
   

科研活动

   
科研项目
( 1 ) 基于间充质干细胞的肿瘤免疫反应调控机制和对抗新策略, 主持, 国家级, 2014-01--2018-12
( 2 ) 干细胞治疗帕金森氏病:从基础研究到动物模型, 主持, 部委级, 2013-01--2016-09
参与会议
   

合作情况

   
项目协作单位
   

指导学生