基本信息
张全斌  男  博导  中国科学院海洋研究所
电子邮件: qbzhang@qdio.ac.cn
通信地址: 青岛市南海路7号
邮政编码: 266071

招生信息

   
招生专业
070703-海洋生物学
086000-生物与医药
招生方向
海洋药物与制品
海洋生物天然产物与生物制品

教育背景

2000-09--2003-07   中国科学院海洋研究所   博士
1993-09--1996-07   中国科学院海洋研究所   硕士
1989-09--1993-07   南开大学生物系   本科/学士

工作经历

   
工作简历
2010-01~现在, 中国科学院海洋研究所, 研究员
2003-09~2009-12,中国科学院海洋研究所, 副研究员
2000-09~2003-07,中国科学院海洋研究所, 博士
1996-07~2000-07,山东省医药公司, 新药开发工作
1993-09~1996-07,中国科学院海洋研究所, 硕士
1989-09~1993-07,南开大学生物系, 本科/学士
社会兼职
2023-04-18-今,中国海洋学会海洋生物工程专业委员会, 副主任委员
2018-09-24-今,中国生物化学与分子生物学会糖复合物专业委员会, 委员
2018-05-25-今,中国生物工程学会糖生物工程专业委员会, 委员
2016-08-01-今,中国海洋湖沼学会药物学分会, 理事
2013-11-01-今,中国藻业协会专家委员会委员, 委员
2011-11-18-今,中国藻类学会理事, 理事

教授课程

海洋化学与海洋药物

专利与奖励

   
奖励信息
(1) 新型工业用褐藻繁育及其活性物质开发和产业化, 一等奖, 部委级, 2021
(2) 抗帕金森病海洋多糖/寡糖的发现,优化及机制研究, 二等奖, 部委级, 2019
(3) 山东省有突出贡献的中青年专家, 一等奖, 省级, 2019
(4) 海昆肾喜胶囊的开发与应用, 二等奖, 省级, 2016
(5) 中国科学院优秀研究生指导教师奖, 院级, 2015
(6) 肾病海洋新药褐藻多糖硫酸酯的研究与技术开发, 二等奖, 省级, 2014
(7) 青岛市第八届青年科技奖, , 市地级, 2011
(8) 紫菜生长发育的生理机制及其应用, 一等奖, 市地级, 2010
专利成果
( 1 ) 一种从含珍珠岩的红藻渣中提取可溶性膳食纤维的方法, 2023, 专利号: 202310510338.0

( 2 ) 一种褐藻胶寡糖衍生物的应用, 2022, 第 3 作者, 专利号: 202211493499.5

( 3 ) 抗光老化卡拉胶衍生物水凝胶及应用, 2022, 第 3 作者, 专利号: 202210828395.9

( 4 ) 一种降压肽及其制备方法和应用, 2022, 第 1 作者, 专利号: CN114195857A

( 5 ) 螺旋藻降压肽及应用, 2022, 第 1 作者, 专利号: CN113943346A

( 6 ) 一种可分解海带的菌株, 2022, 第 3 作者, 专利号: CN113930358A

( 7 ) 一种肠道菌群调节剂及应用, 2021, 第 1 作者, 专利号: CN113827610A

( 8 ) 一种海胆多糖在抗新型冠状病毒或SARS病 毒感染药物中的应用, 2021, 第 2 作者, 专利号: 202110528731 .3

( 9 ) 一种硫酸化甘露葡萄糖醛酸水凝胶的制备及应用, 2021, 第 3 作者, 专利号: CN113354836A

( 10 ) 一种褐藻来源的高硫酸化岩藻半乳聚糖在 预防和治疗肺纤维化药物和保健品中的应用, 2021, 第 2 作者, 专利号: CN 113332309 A

( 11 ) 一种半乳岩藻聚糖硫酸酯水凝胶制备方法和应用, 2021, 第 3 作者, 专利号: CN113307988A

( 12 ) 一种高品质琼脂糖的制备方法, 2021, 第 1 作者, 专利号: CN110698573B

( 13 ) 一种紫菜寡糖的制备方法及其在鱼饲料中的应用, 2021, 第 3 作者, 专利号: CN113045683A

( 14 ) 一种海洋盐单胞菌胞外多糖在制备免疫增强剂中的应用, 2021, 第 1 作者, 专利号: CN112458128A

( 15 ) 一种海洋芽孢杆菌胞外多糖在制备抗炎药物中的应用, 2021, 第 1 作者, 专利号: CN112274528A

( 16 ) 葡萄糖醛酸甘露寡糖的关键二糖重复单元及其制备方法, 2021, 第 1 作者, 专利号: CN112266398A

( 17 ) 一种紫菜提取物的制备方法及在水产养殖中的应用, 2020, 第 3 作者, 专利号: CN111919965A

( 18 ) 海蟑螂有机溶剂提取物的应用及组合物, 2020, 第 2 作者, 专利号: CN111714519A

( 19 ) 一种褐藻膳食纤维在制备治疗或预防代谢综合症的药品、食品和/或保健品中的应用, 2020, 第 1 作者, 专利号: CN111671765A

( 20 ) 一种褐藻多糖硫酸酯胶囊剂的制备方法及其应用, 2020, 第 1 作者, 专利号: CN110833535A

( 21 ) 一种用于创伤修复的有机-无机杂化敷料及其制备方法和应用, 2019, 第 2 作者, 专利号: CN110507847A

( 22 ) 一种用于创伤修复的多糖敷料及其制备方法和应用, 2019, 第 2 作者, 专利号: CN110404106A

( 23 ) 龙须菜降压肽提取物和龙须菜降压肽及其应用, 2018, 第 1 作者, 专利号: CN108892710A

( 24 ) 一种紫菜降压肽和紫菜降压肽提取物及应用, 2018, 第 1 作者, 专利号: CN108840909A

( 25 ) 硫酸化半乳寡糖的应用及药物组合物, 2018, 第 1 作者, 专利号: CN108210504A

( 26 ) 一种制备岩藻黄素顺式异构体的方法, 2018, 第 2 作者, 专利号: CN108047167A

( 27 ) 一种褐藻多糖硫酸酯胶囊的制备方法, 2018, 第 1 作者, 专利号: CN108014086A

( 28 ) 一种低硫酸化岩藻半乳聚糖在制备免疫增强剂中的应用, 2018, 第 1 作者, 专利号: CN107987179A

( 29 ) 一种低粘度褐藻胶的应用, 2016, 第 2 作者, 专利号: CN106139816A

( 30 ) 一种高硫酸化的海藻多糖在晒后修复面膜中的应用, 2016, 第 2 作者, 专利号: CN106038355A

( 31 ) 一种马尾藻多糖的应用, 2016, 第 2 作者, 专利号: CN105943550A

( 32 ) 一种全缘马尾藻多糖的应用, 2016, 第 4 作者, 专利号: CN105596376A

( 33 ) 一种褐藻多糖硫酸酯的降解方法, 2015, 第 1 作者, 专利号: CN105131147A

( 34 ) 甘露葡萄糖醛酸寡糖及衍生物在制备治疗和/或预防肾病药物或保健品中的应用, 2015, 第 1 作者, 专利号: CN105125566A

( 35 ) 舌状蜈蚣藻提取物在制备改善记忆功能药品或保健食品中应用, 2015, 第 1 作者, 专利号: CN104622915A

( 36 ) 一种低凝固温度琼脂糖的制备方法, 2015, 第 1 作者, 专利号: CN104448053A

( 37 ) 一种褐藻多糖硫酸酯的质量分析方法, 2015, 第 1 作者, 专利号: CN104280490A

( 38 ) 一种葡聚糖的应用, 2014, 第 1 作者, 专利号: CN103919800A

( 39 ) 一种海盘车多糖的应用, 2014, 第 1 作者, 专利号: CN103919801A

( 40 ) 一种从鲜海带漂烫废水中提取褐藻多糖硫酸酯的方法, 2014, 第 1 作者, 专利号: CN103923223A

( 41 ) 甘露葡萄糖醛酸寡糖在制备治疗或预防帕金森病和/或老年痴呆药物和/或保健品中的应用, 2014, 第 1 作者, 专利号: CN103800348A

( 42 ) 一种松藻多糖的应用, 2014, 第 1 作者, 专利号: CN103622990A

( 43 ) 一种羽藻多糖的应用, 2014, 第 2 作者, 专利号: CN103610690A

( 44 ) 褐藻来源的富含葡萄糖醛酸的低硫酸化杂聚糖在制备治疗帕金森病药物和保健品中的应用, 2014, 第 1 作者, 专利号: CN103539863A

( 45 ) 甲基化岩藻寡糖或甲基化硫酸酯化岩藻寡糖或其盐及制备和应用, 2013, 第 1 作者, 专利号: CN103374079A

( 46 ) 紫菜寡糖在紫菜病害防治中的应用, 2013, 第 1 作者, 专利号: CN103168784A

( 47 ) 紫菜多糖在制备肾脏疾病治疗药物或预防保健品中的应用, 2012, 第 1 作者, 专利号: CN102319256A

( 48 ) 一种岩藻半乳聚糖硫酸酯及其提取分离纯化方法与应用, 2011, 第 1 作者, 专利号: CN102234336A

( 49 ) 褐藻多糖硫酸酯在预防和治疗帕金森病中的用途, 2011, 第 3 作者, 专利号: CN101301310B

( 50 ) 一种半乳聚糖硫酸酯5-氟尿嘧啶复合物及其制备和应用, 2011, 第 1 作者, 专利号: CN102028952A

( 51 ) 一种乙酰化褐藻多糖硫酸酯的制备方法, 2008, 第 1 作者, 专利号: CN101230108A

( 52 ) 褐藻多糖硫酸酯在制备治疗老年性痴呆药物中的应用, 2008, 第 1 作者, 专利号: CN101152208A

( 53 ) 紫菜多糖在制备预防和治疗神经系统疾病药物中的应用, 2008, 第 1 作者, 专利号: CN101152207A

( 54 ) 海带中L-褐藻糖的制备方法, 2005, 第 3 作者, 专利号: CN1670028A

( 55 ) 低分子量海藻硫酸多糖的制备方法, 2005, 第 1 作者, 专利号: CN1616494A

出版信息

   
发表论文
(1) Effects of different dehydration methods on the preservation of aortic and renal glycocalyx structures in mice, HELIYON, 2023, 第 2 作者
(2) Inhibitory activity of a sulfated oligo-porphyran from Pyropia yezoensis against SARS-CoV-2, CARBOHYDRATE POLYMERS, 2023, 第 2 作者
(3) Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 通讯作者
(4) Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 通讯作者
(5) Isolation, identification and in vivo antihypertensive effect of novel angiotensin I-converting enzyme (ACE) inhibitory peptides from Spirulina protein hydrolysate, FOOD & FUNCTION, 2022, 通讯作者
(6) Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition, CARBOHYDRATE POLYMERS, 2021, 通讯作者
(7) Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin–Strongylocentyotus internedius, CARBOHYDRATE POLYMERS, 2021, 通讯作者
(8) Structural characteristics and immune-enhancing activity of an extracellular polysaccharide produced by marine Halomonas sp. 2E1, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 通讯作者
(9) Glucuronomannan GM2 from Saccharina japonica Enhanced Mitochondrial Function and Autophagy in a Parkinson's Model, MARINE DRUGS, 2021, 第 4 作者
(10) Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet, JOURNAL OF FUNCTIONAL FOODS, 2021, 通讯作者
(11) Low molecular weight fucoidan alleviates diabetic nephropathy by binding fibronectin and inhibiting ECM-receptor interaction in human renal mesangial cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 第 2 作者
(12) A tropomyosin-like Meretrix meretrix Linnaeus polypeptide inhibits the proliferation and metastasis of glioma cells via microtubule polymerization and FAK/Akt/MMPs signaling, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 第 5 作者
(13) Proteoglycan from Bacillus sp. BS11 Inhibits the Inflammatory Response by Suppressing the MAPK and NF-kappa B Pathways in Lipopolysaccharide-Induced RAW264.7 Macrophages, MARINE DRUGS, 2020, 通讯作者
(14) Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats, MARINE DRUGS, 2020, 通讯作者
(15) 经济海藻繁育、养殖及综合利用的回顾与展望, Perspective on propagation,cultivation and utilization of economical seaweeds, 海洋科学, 2020, 第 2 作者
(16) 絮凝剂-树脂联合法从琼胶中制备琼脂糖工艺研究, Flocculant-resin combined method for preparation of agarose from agar, 海洋科学, 2020, 第 2 作者
(17) Degradation of different molecular weight fucoidans and their inhibition of TGF-beta 1 induced epithelial-mesenchymal transition in mouse renal tubular epithelial cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 通讯作者
(18) Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats, MARINEDRUGS, 2020, 第 6 作者
(19) Proteoglycan from Bacillus sp. BS11 Inhibits the Inflammatory Response by Suppressing the MAPK and NF-κB Pathways in Lipopolysaccharide-Induced RAW264.7 Macrophages, MARINEDRUGS, 2020, 第 5 作者
(20) Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model, MARINE DRUGS, 2020, 通讯作者
(21) Degradation of different molecular weight fucoidans and their inhibition of TGF-β1 induced epithelial–mesenchymal transition in mouse renal tubular epithelial cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 通讯作者
(22) Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications, FRONTIERS IN PHARMACOLOGY, 2020, 第 4 作者
(23) Use of fucoidan to treat renal diseases: A review of 15 years of clinic studies, GLYCANS AND GLYCOSAMINOGLYCANS AS CLINICAL BIOMARKERS AND THERAPEUTICS, PT B, 2019, 通讯作者
(24) Structure and Bioactivities of Porphyrans and Oligoporphyrans, CURRENT PHARMACEUTICAL DESIGN, 2019, 通讯作者
(25) Integrated Gas Chromatograph-Mass Spectrometry (GC/MS) and MS/MS-Based Molecular Networking Reveals the Analgesic and Anti-Inflammatory Phenotypes of the Sea Slater Ligia exotica, MARINE DRUGS, 2019, 通讯作者
(26) Structural analysis and anti-complement activity of polysaccharides extracted from Grateloupia livida (Harv.) Yamada, JOURNALOFOCEANOLOGYANDLIMNOLOGY, 2019, 通讯作者
(27) In vitro evaluation of the neuroprotective effect of oligo-porphyran from Porphyra yezoensis in PC12 cells, JOURNAL OF APPLIED PHYCOLOGY, 2019, 通讯作者
(28) Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats, JOURNAL OF ETHNOPHARMACOLOGY, 2018, 第 5 作者
(29) The structural features of the sulfated heteropolysaccharide (ST-1) from Sargassum thunbergii and its neuroprotective activities, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 通讯作者
(30) Low molecular weight fucoidan attenuates liver injury via SIRTI/AMPK/PGC1 alpha axis in db/db mice, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 第 5 作者
(31) Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity, MARINE DRUGS, 2018, 通讯作者
(32) Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway, MARINE DRUGS, 2018, 通讯作者
(33) A heteropolysaccharide from Saccharina japonica with immunomodulatory effect on RAW 264.7 cells, CARBOHYDRATE POLYMERS, 2018, 通讯作者
(34) The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 第 3 作者
(35) Glucofucogalactan, a heterogeneous low-sulfated polysaccharide from Saccharina japonica and its bioactivity, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 通讯作者
(36) Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs), MARINE DRUGS, 2018, 通讯作者
(37) Comparative study of the effect of different fucoidans from Sargassum maclurei and Saccharina japonica on FGFs/FGFR signaling activation in BaF3 cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 通讯作者
(38) A heteropolysaccharide from Saccharina japonica with immnuomodulatory effect on RAW 264.7 cells, Carbohydrate Polymers, 2018, 通讯作者
(39) 海带膳食纤维的理化特性及通便作用研究, Physicochemical properties and laxative effect of dietary fiber from Saccharina japonica, 海洋科学, 2018, 第 4 作者
(40) Two novel angiotensin I-converting enzyme (ACE) inhibitory peptides from Gracilariopsis lemaneiformis (Rhodophyta) protein hydrolysates, and their antihypertensive effect in spontaneously hypertensive rats, Marine Drugs, 2018, 通讯作者
(41) The Structure and Nephroprotective Activity of Oligo-Porphyran on Glycerol-Induced Acute Renal Failure in Rats, MARINE DRUGS, 2017, 通讯作者
(42) Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-β1 or FGF-2, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 第 3 作者
(43) 褐藻多糖硫酸酯的结构与生物活性研究, A Study on the Structure and Activity of Fucoidan, 海洋科学集刊, 2017, 第 2 作者
(44) The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 第 7 作者
(45) Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy, JOURNAL OF APPLIED PHYCOLOGY, 2017, 通讯作者
(46) 低硫酸化杂多糖水解单糖高效液相色谱指纹图谱研究, HPLC fingerprints of monosaccharides from sulfated heteropolysaccharides by precolumn derivatization, 海洋科学, 2017, 第 4 作者
(47) 莫氏马尾藻多糖的分离及理化性质评价, Isolation and Characterization of polysaccharides from Sargassum maclurei, 海洋科学, 2017, 第 3 作者
(48) Polysaccharide from Costaria costata: Characterization and Anticoagulant and FGF/FGFR Signal Activating Activities, International Journal of Biological Macromolecules, 2017, 通讯作者
(49) The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 通讯作者
(50) Sulfated hetero-polysaccharides protect sh-sy5y cells from h2o2-induced apoptosis by affecting the pi3k/akt signaling pathway, MARINE DRUGS, 2017, 通讯作者
(51) Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 通讯作者
(52) Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 第 4 作者
(53) The structure and nephroprotective activity of oligo-porphyran on glycerol-induced Aacute renal failure in rats, Marine Drugs, 2017, 通讯作者
(54) Fucoidan degradation and preparation of fuco-oligosaccharides from saccharina japonica, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2017, 通讯作者
(55) Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by tgf-beta 1 or fgf-2, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 通讯作者
(56) 海带褐藻多糖硫酸酯的降解与岩藻寡糖的制备, Fucoidan Degradation and Preparation of Fuco-oligosaccharides from Saccharina japonica, 高等学校化学学报, 2017, 第 4 作者
(57) Polysaccharides and their depolymerized fragments from costaria costata: molecular weight and sulfation-dependent anticoagulant and fgf/fgfr signal activating activities, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 通讯作者
(58) Polysaccharides from Sargassum thunbergii: Monthly variations and anti-complement and anti-tumour activities, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 通讯作者
(59) Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 通讯作者
(60) Low molecular weight fucoidan ameliorates streptozotocin-induced hyper-responsiveness of aortic smooth muscles in type 1 diabetes rats, JOURNAL OF ETHNOPHARMACOLOGY, 2016, 第 4 作者
(61) Structure–activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 通讯作者
(62) Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2016, 通讯作者
(63) Inhibitory effects of Enteromorpha linza polysaccharide on micronucleus of Allium sativum root cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 第 5 作者
(64) Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload, SCIENTIFIC REPORTS, 2016, 第 5 作者
(65) Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes, AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2015, 第 3 作者
(66) Hydrogen peroxide released from Pyropia yezoensis induced by oligo-porphyrans: Mechanisms and effect, JOURNAL OF APPLIED PHYCOLOGY, 2015, 通讯作者
(67) The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity, MDPI, 2015, 第 4 作者
(68) Structural Analysis and Anti-Complement Activity of Polysaccharides from Kjellmaniella crsaaifolia, MARINE DRUGS, 2015, 通讯作者
(69) Characterization of laminaran and a highly sulfated polysaccharide from Sargassum fusiforme, CARBOHYDRATE RESEARCH, 2014, 通讯作者
(70) The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy, MARINE DRUGS, 2014, 第 4 作者
(71) Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats, LABORATORY INVESTIGATION, 2014, 第 3 作者
(72) 褐藻多糖硫酸酯对脂多糖诱导大鼠肾小球系膜细胞NO 产生量的影响, Effect of fucoidan on NO production induced by LPS in rat glomerular mesangial cells, 海洋科学, 2014, 第 3 作者
(73) A study of neuroprotective and antioxidant activities of heteropolysaccharides from six Sargassum species, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2014, 通讯作者
(74) 四种绿藻和四种褐藻脂肪酸组成的比较研究, Comparison of fatty acid compositions of four green algae and four brown algae, 海洋科学, 2014, 第 3 作者
(75) Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis, JOURNAL OF DIABETES RESEARCH, 2014, 第 2 作者
(76) The neuroprotective activities and antioxidant activities of the polysaccharides from Saccharina japonica, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 通讯作者
(77) Low Molecular Weight Fucoidan against Renal Ischemia–Reperfusion Injury via Inhibition of the MAPK Signaling Pathway, PLOSONE, 2013, 第 3 作者
(78) Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats, FOOD AND CHEMICAL TOXICOLOGY, 2013, 通讯作者
(79) Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism, CARBOHYDRATE POLYMERS, 2013, 通讯作者
(80) Structural analysis of sulfated fucan from Saccharina japonica by electrospray ionization tandem mass spectrometry, CARBOHYDRATE RESEARCH, 2013, 通讯作者
(81) 南非紫菜多糖抗衰老作用的研究, Anti-Ageing effect of polysaccharide from Porphyra capensis on ageing mice, 海洋科学, 2013, 第 4 作者
(82) A comparative study of the anticoagulant activities of eleven fucoidans, CARBOHYDRATE POLYMERS, 2013, 通讯作者
(83) Structural analysis of heteropolysaccharide from Saccharina japonica and its derived oligosaccharides, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 通讯作者
(84) Chemical composition and moisture-absorption/retention ability of polysaccharides extracted from five algae, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 通讯作者
(85) The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica, CARBOHYDRATE POLYMERS, 2013, 通讯作者
(86) The antioxidant activities and neuroprotective effect of polysaccharides from the starfish Asterias rollestoni, CARBOHYDRATE POLYMERS, 2013, 通讯作者
(87) Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor, EXPERIMENTAL EYE RESEARCH, 2013, 第 3 作者
(88) egradation of Laminaria japonica fucoidan by hydrogen peroxide and antioxidant activities of the degradation products of different molecular weights, CARBOHYDRATE POLYMERS, 2012, 通讯作者
(89) Degradation of Laminaria japonica fucoidan by hydrogen peroxide and antioxidant activities of the degradation products of different molecular weights, CARBOHYDRATE POLYMERS, 2012, 通讯作者
(90) Fucoidan Protects against Lipopolysaccharide‐Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia, CNS NEUROSCIENCE & THERAPEUTICS, 2012, 第 4 作者
(91) Structural Analysis of a Heteropolysaccharide from Saccharina japonica by Electrospray Mass Spectrometry in Tandem with Collision-Induced Dissociation Tandem Mass Spectrometry (ESI-CID-MS/MS), MARINE DRUGS, 2012, 通讯作者
(92) Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease, JOURNAL OF ETHNOPHARMACOLOGY, 2012, 通讯作者
(93) Synthesis and antihyperlipidemic activity of acetylated derivative of ulvan from Ulva pertusa, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2012, 通讯作者
(94) Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta), CARBOHYDRATE POLYMERS, 2012, 通讯作者
(95) 几种海藻中无机阴离子的组成及与海水环境的关系, Inorganic anion compositions of marine algae and the relationship with seawater environment, 海洋科学, 2012, 第 3 作者
(96) In-vitro anticoagulant activity of fucoidan derivatives from brown seaweed Laminaria japonica, In-vitro anticoagulant activity of fucoidan derivatives from brown seaweed Laminaria japonica, 中国海洋湖沼学报:英文版, 2011, 第 2 作者
(97) In-vitro anticoagulant activity of fucoidan derivatives from brown seaweed Laminaria japonica, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2011, 通讯作者
(98) Effects and mechanism of low molecular weight fucoidan in mitigating the peroxidative and renal damage induced by adenine, CARBOHYDRATE POLYMERS, 2011, 通讯作者
(99) In vitro antioxidant activity of polysaccharides extracted from Bryopsis plumosa, CARBOHYDRATE POLYMERS, 2010, 通讯作者
(100) Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2010, 通讯作者
(101) Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil, CARBOHYDRATE POLYMERS, 2010, 通讯作者
(102) Extraction of the polysaccharides from five algae and their potential antioxidant activity in vitro, CARBOHYDRATE POLYMERS, 2010, 通讯作者
(103) Chemical modification and influence of function groups on the in vitro-antioxidant activities of porphyran from Porphyra haitanensis, CARBOHYDRATE POLYMERS, 2010, 通讯作者
(104) Structural studies on a novel fucogalactan sulfate extracted from the brown seaweed Laminaria japonica, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2010, 通讯作者
(105) 褐藻多糖硫酸酯对阿尔茨海默病模型小鼠认知功能及脑内胆碱能系统的影响, Effect of Fucoidan on Cognitive Ability and Cerebral Cholinergic System in Mice with Alzheimer's Disease, 中药新药与临床药理, 2010, 第 2 作者
(106) Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation, THROMBOSIS RESEARCH, 2010, 第 2 作者
(107) 羽藻基本营养成分分析及评价, Analysis on Basic Nutrition Constituents of Bryopsis plumose and its Evaluation, 时珍国医国药, 2010, 第 2 作者
(108) In vitro antioxidant activity of polysaccharides extracted from Bryopsis plumose, 2010, 通讯作者
(109) Regioselective syntheses of sulfated porphyrans from Porphyra haitanensis and their antioxidant and anticoagulant activities in vitro, CARBOHYDRATE POLYMERS, 2010, 通讯作者
(110) 浒苔多糖的分级纯化及保湿活性研究, Polysaccharides from Enteromorpha linza: Purification and moisture-preserving activity, 海洋科学, 2010, 第 6 作者
(111) 褐藻多糖硫酸酯对6-羟基多巴胺所致MN9D细胞损伤的保护作用及其机制, Neuroprotective effect of fucoidan against 6-OHDA-induced damage and its mechanism on MNgD cell line, 中华神经医学杂志, 2010, 第 2 作者
(112) In vitro antioxidant activity of acetylated derivatives of polysaccharide extracted from Ulva pertusa (Cholorophta), JOURNAL OF MEDICINAL PLANTS RESEARCH, 2010, 通讯作者
(113) Synthesized phosphorylated and aminated derivatives of fucoidan and their potential antioxidant activity in vitro, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2009, 通讯作者
(114) Synthesized oversulphated, acetylated and benzoylated derivatives of fucoidan extracted from Laminaria japonica and their potential antioxidant activity in vitro, FOOD CHEMISTRY, 2009, 通讯作者
(115) 不同分子量的角叉菜(Chondrus ocllatus)λ-卡拉胶的抗氧化活性, ANTIOXIDANT ACTIVITY OF A-CARRAGEENANS OF DIFFERENT MOLECULAR WEIGHTS FROM CHONDRUS OCELLATUS, 海洋与湖沼, 2009, 第 5 作者
(116) Synthesized different derivatives of low molecular fucoidan extracted from Laminaria japonica and their potential antioxidant activity in vitro, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2009, 通讯作者
(117) Analysis of the monosaccharide composition of fucoidan by precolumn derivation HPLC, Analysis of the monosaccharide composition of fucoidan by precolumn derivation HPLC, 中国海洋湖沼学报:英文版, 2009, 第 2 作者
(118) 不同相对分子质量坛紫菜多糖抗疲劳作用的实验研究, 医药导报, 2009, 第 4 作者
(119) Analysis of the monosaccharide composition of fucoidan by precolumn derivation HPLC, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2009, 通讯作者
(120) In vitro antioxidant activities of acetylated, phosphorylated and benzoylated derivatives of porphyran extracted from Porphyra haitanensis, CARBOHYDRATE POLYMERS, 2009, 通讯作者
(121) Preparation of the different derivatives of the low-molecular-weight porphyran from Porphyra haitanensis and their antioxidant activities in vitro, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2009, 通讯作者
(122) 不同分子量的角叉菜(Chondrus ocellatus)λ-卡拉胶的抗氧化活性, ANTIOXIDANT ACTIVITY OF A-CARRAGEENANS OF DIFFERENT MOLECULAR WEIGHTS FROM CHONDRUS OCELLATUS, 海洋与湖沼, 2009, 第 5 作者
(123) Fucoidan protects against dopaminergic neuron death in vivo and in vitro, EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 第 2 作者
(124) 浒苔多糖的分级纯化及体外抗氧化活性研究, Polysaccharides from Enteromorpha linza : Purification and in vitro antioxidant activity, 中国海洋药物, 2009, 第 5 作者
(125) Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis, PHARMACOLOGICAL RESEARCH, 2008, 通讯作者
(126) 海带褐藻糖胶磺化工艺研究, Study on the Preparation of Sulfated Fucoidan Extracted from Laminaria japonica, 时珍国医国药, 2008, 第 4 作者
(127) 海带多糖的含量测定方法正确性研究, Determination for the Content of Polysaccharides in Laminaria japonica by Phenol - Vitriolic, 时珍国医国药, 2008, 第 5 作者
(128) Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity, Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity, 中国海洋湖沼学报:英文版, 2008, 第 5 作者
(129) Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 通讯作者
(130) Study on extraction of agaropectin from gelidium amansii and its anticoagulant activity, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2008, 通讯作者
(131) 乙酰化海带褐藻多糖硫酸酯的制备及其抗氧化活性研究, Preparation and in vitro antioxidative activity of acetylated fucoidan extracted from Laminaria japonica, 中国海洋药物, 2008, 第 2 作者
(132) The preparation of low electroendosmosis agarose and its physico-chemical property, The preparation of low electroendosmosis agarose and its physico-chemical property, 中国海洋湖沼学报:英文版, 2007, 第 4 作者
(133) Positive effect of porphyrans on the lifespan and vitality of Drosophila melanogaster, Positive effect of porphyrans on the lifespan and vitality of Drosophila melanogaster, 中国海洋湖沼学报:英文版, 2007, 第 2 作者
(134) 微波水提黄芪皂苷的工艺研究, Study on Microwave Water- extraction Technology of Saponins from Radix Astragali, 时珍国医国药, 2007, 第 3 作者
(135) The preparation of low electroendosmosis agarose and its physico-chemical property, The preparation of low electroendosmosis agarose and its physico-chemical property, 中国海洋湖沼学报:英文版, 2007, 第 4 作者
(136) Positive effect of porphyrans on the lifespan and vitality of Drosophila melanogaster, Positive effect of porphyrans on the lifespan and vitality of Drosophila melanogaster, 中国海洋湖沼学报:英文版, 2007, 第 2 作者
(137) 褐藻多糖硫酸酯抗凝血活性的研究, Studies on anticoagulant activity of fucoidan, 中国海洋药物, 2005, 第 2 作者
(138) 超微粉碎在孔石莼多糖提取中的应用, The application of supermicro-pulverization to the extraction process of ulvan, 海洋科学, 2005, 第 3 作者
(139) 紫菜的营养价值研究概况, Review of the nutritional properties of nori, 海洋科学, 2005, 第 1 作者
(140) Preparation of polysaccharides in different molecular weights from Ulva pertusa Kjellm (Chorophyta), Preparation of polysaccharides in different molecular weights from Ulva pertusa Kjellm (Chorophyta), 中国海洋湖沼学报:英文版, 2004, 第 2 作者
(141) 毛细管气相色谱法测定海带提取多糖中的L-褐藻糖含量, Determination of L-fucose content in polysaccharide extracted from Laminaria japonica using capillary gas chromatography, 海洋科学, 2004, 第 2 作者
(142) 坛紫菜多糖对脾细胞活性的影响, Effect of polysaccharides from Porphyra haitanensis on the activities of spleen cells, 中国海洋药物, 2003, 第 1 作者
(143) Immunosuppressive Activities of Fucoidan from Laminaria japonica, Immunosuppressive Activities of Fucoidan from Laminaria japonica, 中国海洋湖沼学报:英文版, 2003, 第 1 作者
(144) 孔石莼多糖降血脂活性的初步研究, A preliminary study on antilipemic activity of polysaccharides from Ulva pertusa in mice, 中国海洋药物, 2003, 第 5 作者
(145) 褐藻多糖硫酸酯, Fucoidan, 精细与专用化学品, 2003, 第 2 作者
(146) 海带褐藻多糖硫酸酯的抗氧化活性研究, Studies on antioxidant activities of fucoidan from Laminaria japonica, 中草药, 2003, 第 1 作者
(147) 孔石莼多糖的分离分析, Separation and analysis of polysaccharides from Ulva pertusa (Chlorophyta), 中国海洋药物, 2002, 第 5 作者
(148) 几种褐藻中褐藻多糖硫酸酯的分离及分析, 海洋科学, 1997, 第 2 作者
(149) 褐藻多糖硫酸酯化学研究的进展, 中国海洋药物, 1996, 第 1 作者
(150) Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 通讯作者
发表著作
( 1 ) 现代海藻资源综合利用, 科学出版社, 2016-06, 第 3 作者
( 2 ) 岩藻多糖的功能与应用, 中国轻工出版社, 2020-09, 第 2 作者

科研活动

   
科研项目
( 1 ) 治疗慢性肾衰的海洋新药GFS的临床前研究, 负责人, 国家任务, 2010-07--2015-06
( 2 ) 褐藻硫酸寡糖GFS对糖尿病肾病的作用及其机制研究, 负责人, 国家任务, 2014-01--2017-12
( 3 ) 高纯度褐藻多糖硫酸酯的制备技术与产业化, 负责人, 地方任务, 2014-01--2015-12
( 4 ) 新型褐藻资源综合利用技术, 负责人, 国家任务, 2014-01--2017-12
( 5 ) 红藻高值化利用关键技术开发与应用, 负责人, 其他国际合作项目, 2013-08--2015-07
( 6 ) 海藻饮品开发与残渣高值化利用, 负责人, 其他国际合作项目, 2013-10--2015-12
( 7 ) 褐藻酸性寡糖的制备及其肾脏保护作用研究, 负责人, 地方任务, 2014-01--2016-12
( 8 ) 岩藻半乳聚糖硫酸酯的制备技术研究与开发, 负责人, 其他国际合作项目, 2014-12--2019-12
( 9 ) 芦笋高值化利用技术开发, 负责人, 其他国际合作项目, 2014-04--2016-06
( 10 ) 褐藻酸性寡糖制备及其抗肾衰活性研究, 负责人, 地方任务, 2014-01--2015-12
( 11 ) 低分子量褐藻多糖硫酸酯的药学制备与检测, 负责人, 地方任务, 2015-01--2017-12
( 12 ) 辽东特色生物资源高值化利用关键技术研究, 负责人, 境内委托项目, 2015-12--2019-12
( 13 ) 抗帕金森病海洋糖类先导化合物的发现与评价, 负责人, 中国科学院计划, 2016-11--2018-06
( 14 ) 海带活性成分的制备技术及其功效作用机制, 负责人, 地方任务, 2016-11--2019-12
( 15 ) 典型海洋生物繁育平台建设, 负责人, 国家任务, 2017-01--2018-12
( 16 ) 王宽诚率先人才计划(产研人才扶持项目 ), 负责人, 中国科学院计划, 2017-09--2020-08
( 17 ) 抗帕金森病海洋糖类化合物的开发, 负责人, 境内委托项目, 2017-03--2019-12
( 18 ) 福建重要海产品产业化关键技术集成与示范, 负责人, 中国科学院计划, 2017-01--2018-06
( 19 ) 高性能琼脂糖生产关键技术开发与产业化应用, 负责人, 地方任务, 2017-09--2020-08
( 20 ) 水产品特征糖的构效关系及营养作用机制, 负责人, 国家任务, 2018-12--2022-12
( 21 ) 新型微生物胞外多糖的应用潜力评价与应用示范, 负责人, 国家任务, 2018-10--2020-12
( 22 ) 褐藻功能饮品技术开发, 负责人, 境内委托项目, 2019-01--2021-12
( 23 ) 辽东特色生物资源高值化利用技术, 负责人, 中国科学院计划, 2020-01--2021-12
( 24 ) 岩藻多糖绿色规模化制备技术及高值化应用, 负责人, 地方任务, 2019-01--2021-12
( 25 ) 药物创新研究院华南分部建设, 负责人, 中国科学院计划, 2019-01--2024-12
( 26 ) 褐藻硫酸多糖LMWF改善糖尿病血管内皮糖萼损伤的作用及机制研究, 负责人, 国家任务, 2022-01--2025-12
( 27 ) 具有神经营养功能的海洋功能食品开发, 负责人, 境内委托项目, 2021-10--2023-12