基本信息
孙黎  女  博导  中国科学院海洋研究所
电子邮件: lsun@ms.qdio.ac.cn
通信地址: 青岛市南海路7号
邮政编码: 266071
部门/实验室:实验海洋生物学重点实验室

招生信息

   
招生专业
070703-海洋生物学
090801-水产养殖
招生方向
免疫学基础及应用
水产养殖生物病害防治

教育背景

1992-09--1999-01   美国波士顿大学   理学博士
1987-09--1990-06   南开大学   理学硕士
1983-09--1987-06   南开大学   理学学士

工作经历

   
工作简历
2005-01~现在, 中国科学院海洋研究所, 研究员
1999-02~2003-11,英国牛津大学和美国哈佛大学, 博士后
1992-09~1999-01,美国波士顿大学, 理学博士
1987-09~1990-06,南开大学, 理学硕士
1983-09~1987-06,南开大学, 理学学士
社会兼职
2012-12-31-2017-12-31,山东省人大常委会委员,

教授课程

海洋生物免疫与病害防控
海水养殖生物病害与防控
微生物与免疫学文献阅读
免疫学

专利与奖励

   
奖励信息
(1) 海水养殖鱼类细菌性疫病的免疫防控, 二等奖, 部委级, 2015
专利成果
( 1 ) 一种鱼类高迁移率族蛋白及其应用, 2015, 第 1 作者, 专利号: ZL201310480020.9
( 2 ) 一种含有未甲基化CpG的DNA序列(CpG-DNA)及其应用, 2015, 第 1 作者, 专利号: ZL201310479972.9
( 3 ) 一种海豚链球菌DNA疫苗及其应用, 2015, 第 1 作者, 专利号: ZL201310557674.7
( 4 ) 一种海豚链球菌细菌素及其应用, 2015, 第 1 作者, 专利号: ZL201410067698.9
( 5 ) 一种大菱鲆自然杀伤细胞增强因子表达载体的应用, 2015, 第 1 作者, 专利号: ZL2013102944639
( 6 ) 一种抗菌肽及其应用, 2015, 第 1 作者, 专利号: ZL2014100676974
( 7 ) 一种荧光假单胞菌TonB依赖型外膜受体及其应用, 2015, 第 1 作者, 专利号: ZL201410140163X
( 8 ) 基于大菱鲆铁调素的肽及其应用, 2016, 第 1 作者, 专利号: ZL201410037471.X
( 9 ) 条石鲷白细胞介素12亚基IL-12p40及其应用, 2016, 第 1 作者, 专利号: ZL201410140353.1

出版信息

   
发表论文
(1) Japanese flounder pol-miR-3p-2 suppresses Edwardsiella tarda infection by regulation of autophagy via p53, Dev Comp Immunol., 2020, 第 11 作者
(2) Gene network analysis reveals a core set of genes involved in the immune response of Japanese flounder (Paralichthys olivaceus) against Vibrio anguillarum infection., Fish Shellfish Immunol., 2020, 第 11 作者
(3) Characterization of Streptococcus iniae-induced microRNA profiles in Paralichthys olivaceus and identification of pol-3p-10740_175 as a regulator of antibacterial immune response., Fish Shellfish Immunol., 2020, 第 11 作者
(4) The novel fish miRNA pol-miR-novel_171 and its target gene FAM49B play a critical role in apoptosis and bacterial infection., Dev Comp Immunol., 2020, 第 11 作者
(5) pol-miR-7133 and pol-miR-3p-9227 of Japanese flounder Paralichthys olivaceus modulate Streptococcus iniae infection through regulation of the common target gene LAMP2., Aquaculture, 2020, 第 11 作者
(6) Japanese flounder (Paralichthys olivaceus) Bmal1 is involved in the regulation of inflammatory response and bacterial infection, Aquaculture, 2020, 第 11 作者
(7) Japanese flounder Paralichthys olivaceus interleukin 21 induces inflammatory response and plays a vital role in the immune defense against bacterial pathogen., Fish Shellfish Immunol., 2020, 第 11 作者
(8) Particle and bacteria uptake by Japanese flounder (Paralichthys olivaceus) red blood cells: size dependence and pathway specificity, Tissue Cell., 2019, 第 11 作者
(9) Teleost gasdermin E is cleaved by caspase 1, 3 and 7 and induces pyroptosis., J Immunol, 2019, 第 11 作者
(10) Characterization of the genome feature and toxic capacity of a Bacillus wiedmannii isolate from the hydrothermal field in Okinawa Trough, Front Cell Infect Microbiol., 2019, 第 11 作者
(11) A first study of the virulence potential of a Bacillus subtilis isolate from deep-sea hydrothermal vent, Front Cell Infect Microbiol., 2019, 第 11 作者
(12) Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection, Dev Comp Immunol, 2019, 第 11 作者
(13) pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection, Fish Shellfish Immunol., 2019, 第 11 作者
(14) A comparative analysis of Edwardsiella tarda-induced transcriptome profiles in RAW264.7 cells reveals new insights into the strategy of bacterial immune evasion, Int J Mol Sci., 2019, 第 11 作者
(15) Histones and chymotrypsin-like elastases play significant roles in the antimicrobial activity of tongue sole neutrophil extracellular traps., Fish Shellfish Immunol, 2018, 第 11 作者
(16) Internalization of large particles by turbot (Scophthalmus maximus) IgM+ B cells mainly depends on macropinocytosis., Dev Comp Immunol, 2018, 第 11 作者
(17) Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin, archives of microbiology, 2018, 第 11 作者
(18) First characterization of two C-type lectins of the tubeworm Alaysia sp. from a deep-sea hydrothermal vent., Dev Comp Immunol, 2018, 第 11 作者
(19) Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin, archives of microbiology, 2018, 第 11 作者
(20) Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection., Dev Comp Immunol, 2018, 第 11 作者
(21) Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin, archives of microbiology, 2018, 第 11 作者
(22) Edwardsiella tarda Sip2: A serum-induced protein that is essential to serum survival, acid resistance, intracellular replication, and host infection, Front Microbiol, 2018, 第 11 作者
(23) Comparative metagenomic analysis of the microbial communities in the surroundings of Iheya north and Iheya ridge hydrothermal fields reveals insights into the survival strategy of microorganisms in deep-sea environments, J Mar Syst, 2018, 第 11 作者
(24) Bacterial communities associated with Shinkaia crosnieri from the Iheya North, Okinawa Trough: microbial diversity and metabolic potentials, J Mar Syst, 2018, 第 11 作者
(25) Transcriptome analysis reveals temperature-regulated antiviral response in turbot Scophthalmus maximus, Fish & Shellfish Immunology, 2017, 第 11 作者
(26) First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes, Veterinary Immunology and Immunopathology, 2017, 第 11 作者
(27) A comparative study revealed first insights into the diversity and metabolisms of the microbial communities in the sediments of Pacmanus and Desmos hydrothermal fields, PLOS ONE, 2017, 第 11 作者
(28) Comparative transcriptome analysis of Rimicaris sp. reveals novel molecular features associated with survival in deep-sea hydrothermal vent, Scientific Reports, 2017, 第 11 作者
(29) A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish, Dev Comp Immunol, 2017, 第 11 作者
(30) Neutrophil extracellular traps of Cynoglossus semilaevis: production characteristics and antibacterial effect, Front Immunol., 2017, 第 11 作者
(31) Description of Domibacillus iocasensis sp. nov., isolated from the deep sea sediment of Okinawa Trough, and emended description of the genus Domibacillus., Int J Syst Evol Microbiol., 2017, 第 11 作者
(32) Shewanella inventionis sp. nov., isolated from deep-sea sediment., Int J Syst Evol Microbiol., 2017, 第 11 作者
(33) Comparative metagenomic analysis of the microbial communities in the surroundings of Iheya north and Iheya ridge hydrothermal fields reveals insights into the survival strategy of microorganisms in deep-sea environments., J Mar Syst., 2017, 第 11 作者
(34) Description of Algoriphagus iocasae sp. nov., isolated from the deep sea sediment of Okinawa Trough., Int J Syst Evol Microbiol., 2017, 第 11 作者
(35) Bacterial communities associated with Shinkaia crosnieri from the Iheya North, Okinawa Trough: microbial diversity and metabolic potentials., J Mar Syst., 2017, 第 11 作者
(36) Comparative metagenomics reveals insights into the deep-sea adaptation mechanism of the microorganisms in Iheya hydrothermal fields., World J Microb Biot., 2017, 第 11 作者
(37) A teleost CD46 is involved in the regulation of complement activation and pathogen infection, Sci Rep, 2017, 第 11 作者
(38) Edwardsiella tarda-induced miRNAs in a teleost host: global profile and role in bacterial infection as revealed by integrative miRNA–mRNA analysis, Virulence, 2017, 第 11 作者
(39) Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis, International Journal of Molecular Sciences, 2017, 第 11 作者
(40) Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrinand Caveolin-Mediated Endocytosis to Endosome and Lysosome, Frontiers in Cellular and Infection Microbiology, 2017, 第 11 作者
(41) Bacillus iocasae sp. nov., isolated from Pacmanus hydrothermal field, Manus Basin, International Journal of Systematic and Evolutionary Microbiology, 2017, 第 11 作者
(42) A teleost bactericidal permeability-increasing protein kills Gram-negative bacteria, modulates innate immune response, and enhances resistance against bacterial and viral infection., PLoS ONE, 2016, 第 11 作者
(43) Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection., Fish Shellfish Immunol., 2016, 第 11 作者
(44) pol-miR-731, a teleost miRNA upregulated by megalocytivirus, negatively regulates virus-induced type I interferon response, apoptosis, and cell cycle arrest., Sci Rep., 2016, 第 11 作者
(45) First comparative analysis of the community structures and carbon metabolic pathways of the bacteria associated with Alvinocaris longirostris in a hydrothermal vent of Okinawa Trough., PLoS ONE, 2016, 第 11 作者
(46) The global regulatory effect of Edwardsiella tarda Fur on iron acquisition, stress resistance, and host infection: a proteomics-based interpretation., J Proteomics, 2016, 第 11 作者
(47) The serine protease autotransporter Tsh contributes to the virulence of Edwardsiella tarda, Vet Microbiol., 2016, 第 11 作者
(48) Description of Domibacillus iocasensis sp. nov., isolated from the deep sea sediment of Okinawa Trough, and emended description of the genus Domibacillus., Int J Syst Evol Microbiol., 2016, 第 11 作者
(49) Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection., Dev Comp Immunol., 2016, 第 11 作者
(50) Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria., Dev Comp Immunol., 2016, 第 11 作者
(51) CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection., Dev Comp Immunol., 2016, 第 11 作者
(52) Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-?B-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus)., Dev Comp Immunol , 2015, 第 11 作者
(53) CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif., Dev Comp Immunol , 2015, 第 11 作者
(54)  CD83 is required for the induction of protective immunity by a DNA vaccine in a teleost model, Dev Comp Immunol , 2015, 第 11 作者
(55) Edwardsiella tarda evades serum killing by preventing complement activation via the alternative pathway, Fish Shellfish Immunol , 2015, 第 11 作者
(56) Pseudomonas fluorescens: Fur is required for multiple biological properties associated with pathogenesis, Vet Microbiol, 2015, 第 11 作者
(57) Edwardsiella tarda Sip1: A serum-induced zinc metalloprotease that is essential to serum resistance and host infection., Vet Microbiol , 2015, 第 11 作者
(58) Edwardsiella tarda MliC: a lysozyme inhibitor that participates in pathogenesis in a manner that parallels Ivy,  Infect Immun, 2015, 第 11 作者
(59) Pseudomonas fluorescens: iron-responsive proteins and their involvement in host infection., Vet Microbiol , 2015, 第 11 作者
(60)  P247 and P523: two in vivo-expressed megalocytivirus proteins that induce protective immunity and are essential to viral infection, Plos ONE, 2015, 第 11 作者
(61) Edwardsiella tarda-regulated proteins in Japanese flounder (Paralichthys olivaceus): identification and evaluation of antibacterial potentials,  J Proteomics, 2015, 第 11 作者
(62) Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection, Dev Comp Immunol, 2014, 第 11 作者
(63) Turbot (Scophthalmus maximus) hepcidin-1 and hepcidin-2 possess antimicrobial activity and promote resistance against bacterial and viral infection, Fish Shellfish Immunol, 2014, 第 11 作者
(64)  Edwardsiella tarda Hfq: impact on host infection and global protein expression, Vet Res, 2014, 第 11 作者
(65)  Streptococcus iniae SF1: complete genome sequence, proteomic profile, and immunoprotective antigens., Plos ONE, 2014, 第 11 作者
(66)  Sil: a Streptococcus iniae bacteriocin with dual role as an antimicrobial and an immunomodulator that inhibits innate immune response and promotes S. iniae infection, Plos ONE, 2014, 第 11 作者
(67) In-depth profiling and analysis of host and viral microRNAs in Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus reveal involvement of microRNAs in host-virus interaction in teleost fish, BMC Genomics, 2014, 第 11 作者
(68) Nuclear factor 45 of tongue sole (Cynoglossus semilaevis): evidence for functional differentiation between two isoforms in immune defense against viral and bacterial pathogens, Dev Comp Immunol , 2014, 第 11 作者
(69) Poly(I:C) induces antiviral immune responses in Japanese flounder (Paralichthys olivaceus) that require TLR3 and MDA5 and is negatively regulated by Myd88, Plos ONE, 2014, 第 11 作者
(70) NKLP27: a teleost NK-lysin peptide that modulates immune response, induces degradation of bacterial DNA, and inhibits bacterial and viral infection, Plos ONE , 2014, 第 11 作者
(71)  C7: a CpG oligodeoxynucleotide that induces protective immune response against megalocytivirus in Japanese flounder (Paralichthys olivaceus) via toll-like receptor 9-mediated signaling pathway, Dev Comp Immunol, 2014, 第 11 作者
(72) Antibacterial and antiviral properties of tongue sole (Cynoglossus semilaevis) high mobility group B2 protein are largely independent on the acidic C-terminal domain., Fish Shellfish Immunol, 2014, 第 11 作者
(73) Characterization of a c-type lysozyme of Scophthalmus maximus: expression, activity, and antibacterial effect, Fish Shellfish Immunol., 2013, 第 11 作者
(74) 3. Chen C, Chi H, Sun B, Sun L. The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis., Dev Comp Immunol, 2013, 第 11 作者
(75)  Macrophage migration inhibitory factor of Sciaenops ocellatus regulates immune cell trafficking and is involved in pathogen-induced immune response, Dev Comp Immunol, 2013, 第 11 作者
(76)  The C-reactive protein of tongue sole Cynoglossus semilaevis is an acute phase protein that interacts with bacterial pathogens and stimulates the antibacterial activity of peripheral blood leukocytes., Fish Shellfish Immunol., 2013, 第 11 作者
(77)  Identification and characterization of a cell surface scavenger receptor cysteine-rich protein of Sciaenops ocellatus: bacterial interaction and its dependence on the conserved structural features of the SRCR domain, Fish Shellfish Immunol., 2013, 第 11 作者
(78)  Selection of normalization factors for quantitative real time RT-PCR studies in Japanese flounder (Paralichthys olivaceus) and turbot (Scophthalmus maximus) under conditions of viral infection,  Vet Immunol Immunopathol., 2013, 第 11 作者
(79) Complete genome sequence and transcription profiles of the rock bream iridovirus RBIV-C1.,  Dis Aquat Org. , 2013, 第 11 作者
(80) SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop., Dev Comp Immunol. , 2013, 第 11 作者
(81) A NK-lysin from Cynoglossus semilaevis enhances antimicrobial defense against bacterial and viral pathogens. , Dev Comp Immunol. , 2013, 第 11 作者
(82) Comparative study of four flagellins of Vibrio anguillarum: vaccine potential and adjuvanticity., Fish Shellfish Immunol., 2013, 第 11 作者
(83) Overexpression of NF-?B inhibitor alpha in Cynoglossus semilaevis impairs pathogen-induced immune response., DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 第 11 作者
(84) A peptidoglycan recognition protein from Sciaenops ocellatus is a zinc amidase and a bactericide with a substrate range limited to Gram-positive bacteria., FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 11 作者
(85) CsCXCe1: a novel Cynoglossus semilaevis CXC chemokine that functions as a chemoattractant and an immunomodulator for peripheral blood leukocytes, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 第 11 作者
(86) Cynoglossus semilaevis thioredoxin: a reductase and an antioxidant with immunostimulatory property, CELL STRESS AND CHAPERONES, 2012, 第 11 作者
(87) Edwardsiella tarda DnaK: expression, activity, and the basis for the construction of a bivalent live vaccine against E. tarda and Streptococcus iniae, FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 11 作者
(88) A divalent DNA vaccine based on Sia10 and OmpU induces cross protection against Streptococcus iniae and Vibrio anguillarum in Japanese flounder, FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 11 作者
(89) Development and efficacy of an attenuated Vibrio harveyi vaccine candidate with cross protectivity against Vibrio alginolyticus., FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 11 作者
(90) Molecular characterization of Cynoglossus semilaevis CD28, FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 11 作者
(91) Inv1: an Edwardsiella tarda invasin and a protective immunogen that is required for host infection., FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 11 作者
(92) Edwardsiella tarda Eta1: an in vivo-induced antigen that is involved in host infection, INFECTION AND IMMUNITY, 2012, 第 11 作者
(93) Construction and evaluation of a live vaccine against Edwardsiella tarda and Vibrio harveyi: laboratory vs mock field trial, Vaccine, 2011, 第 11 作者
(94) Edwardsiella tarda DnaJ is a virulence-associated molecular chaperone with immunoprotective potential, Fish and Shellfish Immunology , 2011, 第 11 作者
(95) A pathogenic Vibrio harveyi lineage causes recurrent disease outbreaks in cultured Japanese flounder (Paralichthys olivaceus) and induces apoptosis in host cells, Aquaculture, 2011, 第 11 作者
(96)  Ferritin M of Cynoglossus semilaevis: an iron binding protein and a broad-spectrum antimicrobial that depends on the integrity of the ferroxidase center and nucleation center for biological activity., Fish and Shellfish Immunology , 2011, 第 11 作者
(97) An inflammatory CC chemokine of Cynoglossus semilaevis is involved in immune defense against bacterial infection, Fish and Shellfish Immunology , 2011, 第 11 作者
(98) Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus)., Fish and Shellfish Immunology , 2011, 第 11 作者
(99) HtpG is involved in the pathogenesis of Edwardsiella tarda, Veterinary Microbiology, 2011, 第 11 作者
(100) A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum., Fish and Shellfish Immunology , 2011, 第 11 作者
(101) Suppressor of cytokine signaling 3 inhibits head kidney macrophage activation and cytokine expression in Scophthalmus maximus, Developmental and Comparative Immunology , 2011, 第 11 作者
(102) The tissue factor pathway inhibitor 1 of Sciaenops ocellatus possesses antimicrobial activity and is involved in the immune response against bacterial infection, Developmental and Comparative Immunology , 2011, 第 11 作者
(103) The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation, Developmental and Comparative Immunology , 2011, 第 11 作者
(104) CXCL8 of Scophthalmus maximus: expression, biological activity, and immunoregulatory effect, Developmental and Comparative Immunology , 2011, 第 11 作者
(105) Construction and analysis of the immune effect of an Edwardsiella tarda DNA vaccine encoding a D15-like surface antigen, Fish and Shellfish Immunology, 2011, 第 11 作者
(106) Identification and analysis of the tissue factor pathway inhibitor 2 of Sciaenops ocellatus. , Fish and Shellfish Immunology , 2011, 第 11 作者
(107) The g-type lysozyme of Scophthalmus maximus has a broad substrate spectrum and is involved in the immune response against bacterial infection, Fish and Shellfish Immunology , 2011, 第 11 作者
(108) Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: subunit vaccine vs DNA vaccine., Vaccine, 2011, 第 11 作者
(109) A bivalent Vibrio harveyi DNA vaccine induces strong protection in Japanese flounder (Paralichthys olivaceus), Vaccine, 2011, 第 11 作者
(110) Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus)., Fish and Shellfish Immunology , 2011, 第 11 作者
(111) Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property, Fish and Shellfish Immunology , 2011, 第 11 作者

科研活动

   
科研项目
( 1 ) 病毒和细菌共诱导的多效型牙鲆microRNA及其功能解析和应用探索, 主持, 国家级, 2018-01--2022-12
( 2 ) 水产动物疫病发生的分子基础与免疫机制, 主持, 国家级, 2018-12--2022-12
( 3 ) 深海极端环境微生物资源的挖掘和生物安保探索, 主持, 部委级, 2019-01--2022-12
( 4 ) 山东省重大科技创新工程专项项目“深蓝渔业生物学基础与前沿关键技术研发”, 主持, 省级, 2018-07--2020-12