基本信息
胡新天  男  博导  中国科学院昆明动物研究所
电子邮件: xthu@mail.kiz.ac.cn
通信地址: 中国科学院昆明动物研究所
邮政编码: 650223

招生信息

   
招生专业
071006-神经生物学
招生方向
中枢系统疾病猕猴模型的建立和机理研究
猕猴认知功能相关神经回路的研究

教育背景

1994-09--2000-08   Princeton University,USA   博士学位
1988-07--1991-07   中国科学院昆明动物研究所   硕士学位
1984-09--1988-06   中国科学技术大学   学士学位

工作经历

   
工作简历
2015-01~现在, 中国科学院脑卓越中心, 核心骨干
2005-12~现在, 中国科学院昆明动物研究所, 研究员
2000-09~2005-12,美国贝勒医学院, 博士后
1994-09~2000-08,Princeton University,USA, 博士学位
1991-07~1994-08,中国科学院昆明动物研究所, 研究实习员
1988-07~1991-07,中国科学院昆明动物研究所, 硕士学位
1984-09~1988-06,中国科学技术大学, 学士学位

专利与奖励

   
奖励信息
(1) 云南省引进海外高层次人才, , 省级, 2011
(2) 云南省有突出贡献优秀专业技术人才奖, 三等奖, 省级, 2008
(3) 中国科学院“引进国外杰出人才”称号, , 院级, 2007
(4) 恒河猴工作记忆的儿茶酚胺受体机制研究, 一等奖, 省级, 2001
(5) NIH 博士后fellowship, , 研究所(学校), 2001
(6) 普林斯顿大学心理系优秀助教奖, , 研究所(学校), 1998
专利成果
( 1 ) 模拟老年痴呆病变的非人灵长类动物模型的建立方法, 2012, 第 1 作者, 专利号: ZL 2010 1 0039183.X
( 2 ) 一种电刺激噪声消除仪, 2010, 第 1 作者, 专利号: ZL2007 1 0031057.8
( 3 ) 多功能可调猴椅, 2009, 第 3 作者, 专利号: ZL2008 1 0027194.4
( 4 ) 脑组织微量取样器, 2013, 第 2 作者, 专利号: ZL 201 1 0110829.8
( 5 ) 深部硬脑膜穿孔装置, 2014, 第 5 作者, 专利号: ZL 2012 10102811.3
( 6 ) 脑内给药建立帕金森病动物模型的专用药液、工具和方法, 2013, 第 3 作者, 专利号: ZL 2013 1 0268450.4
( 7 ) 触屏多功能非人灵长类动物认知功能测试方法, 2016, 第 5 作者, 专利号: ZL 2016 1 0076431. 5
( 8 ) 触屏多功能非人灵长类动物认知功能测试笼, 2019, 第 5 作者, 专利号: ZL 2016 1 0076775. 6
( 9 ) 一种照明光源对猕猴属动物眼轴发育的对比研究方法, 2020, 第 1 作者, 专利号: ZL 2017 1 1273533.7
( 10 ) 猕猴矫正触屏的训练方法及训练装置, 2019, 第 5 作者, 专利号: ZL2017 1 0108175.8
( 11 ) 植入式巩膜电极, 2019, 第 1 作者, 专利号: ZL 2017 2 1688563.X

出版信息

   
发表论文
(1) Behavioral screening tools for identifying autism in macaques: existing and promising tests, Brain research bulletin, 2019, 通讯作者
(2) Chronic glucocorticoid exposure induces depression-like phenotype in rhesus macaque (Macaca mulatta), Frontiers in neuroscience, 2019, 通讯作者
(3) Direct sunlight exposure reduces hair cortisol levels in rhesus monkeys (Macaca mulatta), ZOOLOGICAL RESEARCH, 2019, 通讯作者
(4) 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates, Genome biology, 2019, 通讯作者
(5) Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Nonhuman Primates, Current Alzheimer research, 2018, 通讯作者
(6) Alterations of gray matter volume and white matter integrity in maternal deprivation monkeys, Neuroscience, 2018, 通讯作者
(7) Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP, Neuroscience, 2018, 通讯作者
(8) Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging, Cell discovery, 2018, 第 9 作者
(9) Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys, cell, 2017, 第 6 作者
(10) Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells, Frontiers in Neuroscience, 2017, 通讯作者
(11) Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Accepted, cell report, 2016, 通讯作者
(12) Early adversity contributes to chronic stress induced depression-like behavior in adolescent male rhesus monkeys,, Behavioural Brain Research, 2016, 通讯作者
(13) Social correlates of the dominance rank and long-term cortisol levels in adolescent and adult male rhesus macaques (Macaca mulatta), Sci Rep, 2016, 通讯作者
(14) An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning.,  Sci Rep. , 2015, 通讯作者
(15) A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections. , J Neurosci Methods., 2015, 通讯作者
(16) 1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque.,  PLoS One., 2015, 通讯作者
(17) A spontaneous depressive pattern in adult female rhesus macaques., Sci Rep. , 2015, 通讯作者
(18) Drift in centrality of different brain regions in an anatomical neural network with Parkinson’s disease: A view from complex network analysis, neurocience, 2015, 通讯作者
(19) Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference, Front Behav Neurosci., 2015, 通讯作者
(20) Formaldehyde as a trigger for protein aggregation and potential target for mitigation of age-related, progressive cognitive impairment, Curr Top Med Chem., 2015, 第 2 作者
(21) The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys., Sci Rep., 2015, 通讯作者
(22) The first observation of seasonal affective disorder symptoms in rhesus macaque., Behav Brain Res., 2015, 通讯作者
(23) Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological methods., Sci Rep., 2015, 通讯作者
(24) the role of contrast adaptation in saccadic suppression in humans, Plos/one, 2014, 通讯作者
(25) Acute morphine treatments alleviate tremor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys, Plos one, 2014, 通讯作者
(26) Face recognition increases during saccade preparation., Plos one, 2014, 通讯作者
(27) Alzheimer’s Disease and Methanol Toxicity (Pt.2): Lessons from four rhesus macaques (macaca mulatta) chronically fed methanol,  J Alzheimers Dis, 2014, 通讯作者
(28) Alzheimer’s Disease and Methanol Toxicity (Pt.1): Chronic methanol feeding led to memory impairments, tau hyperphosphorylation in mice,  J Alzheimers Dis, 2014, 通讯作者
(29) Is formaldehyde the missing link in AD pathology The differential aggregation of Amyloid-beta with APOE isoforms in vitro. , Current Alzheimer Research., 2014, 通讯作者
(30) Cortisol responses to chronic stress in adult macaques: moderation by a polymorphism in the serotonin transporter gene.,  Behavioural Brain Research., 2014, 通讯作者
(31) Kisspeptin-10 modulates the proliferation and differentiation of the rhesus monkey derived stem cell line: r366.4, ScientificWorldJournal, 2013, 通讯作者
(32) Interactive effects of morphine and dopaminergic compounds on spatial working memory in rhesus monkeys, Neuroscience Bulletin, 2013, 通讯作者
(33) Feature-reduction and semi-simulated data in functional connectivity-based cortical parcellation, Neurosci Bull, 2013, 通讯作者
(34) What interests them in the pictures The difference in eye tracking between rhesus monkeys and humans, Neuroscience Bulletin, 2013, 通讯作者
(35) A new method for piercing the tentorium cerebelli for implanting fragile electrodes into the brain stem in the rhesus monkey (Macaca mulatta), J Neurophysiol, 2013, 通讯作者
(36) Nonhuman Primates: Important Animal Models for Regenerative Medicine, Science Supplement J, 2012, 第 1 作者
(37) The egocentric spatial reference frame used in dorsal-lateral prefrontal working memory in primates, Neurosci. Biobehav. Rev, 2012, 第 2 作者
(38) Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys, Proc. Natl. Acad. Sci, 2011, 通讯作者
(39) Dissociable modulation of overt visual attention in valence and arousal revealed by topology of scan path, PLoS One, 2011, 通讯作者
(40) Effect of morphine on conditioned place preference in rhesus monkeys, Addict. Biol, 2011, 通讯作者
(41) Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats, Brain Research, 2010, 通讯作者
(42) Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory, Behavioural Brain Research, 2010, 第 4 作者
(43) A new MRI approach for accurately implanting microelectrodes into deep brain structures of the rhesus monkey (Macaca mulatta), J Neurosci Methods, 2010, 通讯作者
(44) Somatosensory Cortices Are Required for the Acquisition of Morphine-Induced Conditioned Place Preference, PLoS One, 2009, 通讯作者
(45) Maze model to study spatial learning and memory in freely moving monkeys, Journal of Neuroscience Methods, 2008, 通讯作者
(46) Chronic Morphine Selectively Impairs Cued Fear Extinction in Rats: Implications for Anxiety Disorders Associated with Opiate Use, Neuropsychopharmacology, 2008, 通讯作者
(47) Reliability of oculomotor command signals carried by individual neurons, PNAS, 2007, 通讯作者
(48) Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey, Journal of Neurobiology (Dev Neurobiol.), 2007, 通讯作者
(49) Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal,  Neuroscience, 2006, 通讯作者
(50)  Gender related effects of heroin abuse on the simple reaction time task, Addict Behav, 2006, 通讯作者
(51) EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys, Brain Res, 2005, 通讯作者
(52) Effects of extremely low-frequency electromagnetic fields on morphine-induced conditioned place preferences in rats, Neurosci. Lett, 2005, 通讯作者
(53)  the clothing effect: tactile neurons in the precentral gyrus do not respond to the touch of the familiar primate chair, Proc. Natl. Acad. Sci, 2002, 第 4 作者
(54)  coding the location of objects in the dark, Science, 1997, 第 3 作者
(55) visuospatial properties of ventral premotor cortex, J. Neurophysiol, 1997, 第 3 作者
(56) reserpine impairs spatial working memory performance in monkeys: reversal by the alpha-2 adrenergic agonist clonidine, Brain Res, 1993, 第 4 作者
(57) the relation between evolution of spatial working memory functionand of morphology of the dorsolateral prefrontal cortex among therhesus monkey, slow loris and tree shrew, Zoological research, 1993, 第 3 作者
(58) deficit of delayed go/no-go task performance induced by local injection of alpha-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in monkeys, Acta Psychologic Sinica, 1992, 第 2 作者
(59) the effects of acetylcholine (ach) applied iontophoretically on neurons of dorsalprefrontal cortex in the tree shrew, Primatology Today, 1991, 第 1 作者
(60)  the influence of auditory, visual stimulation on the unit activity of dorsal prefrontal cortices in the tree shrew, Primatology Today, 1991, 第 2 作者
(61) the effects of acetylcholine (ach) on neurons sensitive to auditory and visual stimulation of dorsal prefrontal cortex in tree shrews,  Primatology Today, 1991, 第 2 作者
(62) excitative and inhibitory effects clonidine-induced in the slow lores and rhesusmonkey, Primatology Today, 1991, 第 3 作者
发表著作
( 1 ) 神经生物学基础(第41章: 脑干的运动控制), Basis of neurobiology, 北京大学出版社, 2009-02, 第 1 作者
( 2 ) 思维的力量, The power of thinking, 云南科技出版社, 2010-08, 第 3 作者

科研活动

   
科研项目
( 1 ) 先导B-学习记忆和老年痴呆, 主持, 国家级, 2012-07--2017-08
( 2 ) 情绪相关的皮层下通路--基于猕猴的研究, 主持, 国家级, 2014-01--2016-12
( 3 ) 建立阿尔茨海默病(AD)转基因猴模型, 主持, 国家级, 2015-01--2018-12
( 4 ) 灵长类神经回路精细结构成像的新方法和新工具, 参与, 国家级, 2015-01--2019-08
( 5 ) 阿尔兹海默病(AD)猕猴自发模型的筛选鉴定, 主持, 国家级, 2018-01--2021-12
( 6 ) 基于病毒介导基因编辑的孤独症非人灵长类模型建立及神经环路研究-2, 主持, 国家级, 2018-01--2019-12
( 7 ) 脑认知与类脑前沿研究, 主持, 部委级, 2018-07--2023-07
( 8 ) 面向猕猴模型三维视觉认知脑功能解析的高通量实验装置, 主持, 部委级, 2018-01--2019-12
( 9 ) XXX项目(保密项目), 主持, 部委级, 2018-01--2020-12
( 10 ) 通过环境和基因因素相互作用诱导建立阿尔茨海默症猕猴, 主持, 国家级, 2020-01--2022-12
( 11 ) 基因编辑创制发育退行性与神经退行性疾病的猴模型, 主持, 国家级, 2019-10--2024-10
( 12 ) 自闭症诊治的基础和应用研究, 主持, 省级, 2019-09--2023-08