基本信息
赵勇  男  博导  中国科学院动物研究所
电子邮件: zhaoy@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院5号
邮政编码: 100101

招生信息

   
招生专业
100102-免疫学
招生方向
移植免疫学

教育背景

1995-07--2000-08   哈佛大学/麻省总医院   博士后
1993-07--1995-09   三菱化成生命科学研究所   特别研究员
1990-09--1993-07   吉林大学(原白求恩医科大学)   医学博士
1987-09--1990-07   吉林大学(原白求恩医科大学)   硕士
1982-09--1987-07   吉林大学(原白求恩医科大学)   学士

工作经历

   
工作简历
2003-04~现在, 中国科学院动物研究所, 研究员/博士生导师
2000-05~2004-04,内布拉斯加大学医学医学院外科, 助教授
1995-07~2000-08,哈佛大学/麻省总医院, 博士后
1993-07~1995-09,三菱化成生命科学研究所, 特别研究员
1990-09~1993-07,吉林大学(原白求恩医科大学), 医学博士
1987-09~1990-07,吉林大学(原白求恩医科大学), 硕士
1982-09~1987-07,吉林大学(原白求恩医科大学), 学士
社会兼职
2014-10-01-今,中国免疫学会, 理事
2010-01-01-今,Frontiers in Immunology, 编委
2010-01-01-今,Cellular & Molecular Immunology, 编委
2008-01-01-今,Expert Review of Clinical Immunology, 编委

教授课程

免疫组织化学实验
分子与细胞免疫学
医学免疫学
生殖免疫学
免疫组织化学实验技术
细胞免疫学
“**学者论坛”系列讲座
“学者论坛”系列讲座

专利与奖励

   
专利成果
( 1 ) Wip1抑制剂的医学用途, 2020, 第 1 作者, 专利号: CN 105727295 B

出版信息

   
发表论文
(1) Primed macrophages gain long-term specific memory to reject allogeneic tissues in mice, Cell Mol Immunol, 2020, 通讯作者
(2) The functional diversity of neutrophils and clustered polarization of immunity, Cellular & Molecular Immunology, 2020, 通讯作者
(3) The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets, Journal of Immunology Research, 2020, 通讯作者
(4) Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways, Cellular & Molecular Immunology, 2020, 通讯作者
(5) Myeloid-derived suppressor cells in transplantation tolerance induction, International Immunopharmacology, 2020, 通讯作者
(6) The biological function and the regulatory roles of wild-type p53-induced phosphatase 1 in immune system, International Reviews of Immunology, 2020, 通讯作者
(7) The regulatory roles of neutrophils in adaptive immunity, Cell Commun Signal, 2019, 通讯作者
(8) Molecular regulatory networks of thymic epithelial cell differentiation., Differentiation, 2019, 通讯作者
(9) The amino acid sensor general control nonderepressible 2 (GCN2) controls TH9 cells and allergic airway inflammation, J Allergy Clin Immunol, 2019, 通讯作者
(10) Adoptive transfer of IFN-γ-induced M-MDSCs promotes immune tolerance to allografts through iNOS pathway, Inflamm Research, 2019, 通讯作者
(11) Primed macrophages directly and specifically reject allografts, Cell Mol Immunol, 2019, 通讯作者
(12) Spaceflight/microgravity inhibits the proliferation of hematopoietic stem cells by decreasing Kit-Ras/cAMP-CREB pathway networks as evidenced by RNA-Seq assays, FASEB Journal, 2019, 通讯作者
(13) IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis, Protein&Cell, 2018, 通讯作者
(14) mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8, Blood, 2018, 通讯作者
(15) MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance, Autophagy, 2018, 通讯作者
(16) The regulatory roles of B cell subsets in transplantation, Expert Review of Clinical Immunology, 2018, 通讯作者
(17) The origins and homeostasis of monocytes and tissue-resident macrophages in physiological situation, J Cell Physiol., 2018, 通讯作者
(18) mTORC2 Controls Th9 Polarization and Allergic Airway Inflammation, Allergy, 2017, 通讯作者
(19) 2-Deoxy-D-Glucose Treatment Decreases Antiinflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation, Frontiers in Immunology, 2017, 通讯作者
(20) The Diverse Biological Functions of Neutrophils, Beyond the Defense Against Infections, Inflammation, 2017, 通讯作者
(21) The Immunological Function of CD52 and Its Targeting in Organ Transplantation, Inflammation Research, 2017, 通讯作者
(22) The Biological Function and Significance of CD74 in Immune Diseases, Inflammation Research, 2017, 通讯作者
(23) Impact of Aging Immune System on Neurodegeneration and Potential Immunotherapies, Progress in Neurobiology, 2017, 通讯作者
(24) Wip1 Deficiency Promotes Neutrophil Recruitment to the Infection Site and Improves Sepsis Outcome, Frontiers in Immunology, 2017, 通讯作者
(25) IL-9 and Th9 Cells in Health and Diseases-From Tolerance to Immunopathology, Cytokine & Growth Factor Reviews, 2017, 第 4 作者
(26) The Brain Interstitial System: Anatomy, Modeling, in Vivo Measurement, and Applications, Progress In Neurobiology, 2017, 第 5 作者
(27) MTOR Signaling Is Essential for the Development of Thymic Epithelial Cells and the Induction of Central Immune Tolerance, Autophagy, 2017, 通讯作者
(28) TSC1 controls IL-1b expression in macrophages via mTORC1-dependent C/EBPb pathway, Cellular & Molecular Immunology, 2016, 通讯作者
(29) The phenotypes, development and function of myeloid-derived suppressor cells, OncoImmunology, 2016, 通讯作者
(30) TNFα-induced M-MDSCs promote transplant immune tolerance via nitric oxide, Journal of Molecular Medicine, 2016, 通讯作者
(31) Phosphatase Wip1 Masters IL-17–producing Neutrophil-mediated Colitis in Mice, Inflammatory Bowel Diseases, 2016, 通讯作者
(32) A reciprocal inhibitory relationship between adiponectin and mammalian cytosolic thioredoxin, Science Bulletin, 2016, 第 4 作者
(33) miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells, International Journal of Oncology, 2016, 通讯作者
(34) Direct effects of airborne PM 2.5 exposure on macrophage polarizations, Biochimica et BiophysicaActa (BBA) - General Subjects, 2016, 通讯作者
(35) mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors, Scientific Reports, 2016, 通讯作者
(36) 天然免疫细胞在急性器官移植免疫排斥中的作用, 中国科学: 生命科学, 2016, 通讯作者
(37) FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of thymic medullary zone, Scientific Reports, 2015, 通讯作者
(38) Phosphatase Wip1 controls antigen-independent B cell development in a p53-dependent manner, Blood, 2015, 通讯作者
(39) Microgravity activates p38 MAPK-C/EBPβ pathway to regulate the expression of arginase and inflammatory cytokines in macrophages, Inflammation Research, 2015, 通讯作者
(40) TSC1 controls IL-1β expression in macrophages by mTORC1-dependent C/EBPβ pathway, Cell Mol Immunol, 2015, 通讯作者
(41) The phenotypes, development and function of myeloid-derived suppressor cells, OncoImmunology, 2015, 通讯作者
(42) miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury, Cell Death Differ, 2015, 通讯作者
(43) Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient, J. Exp. Med, 2015, 通讯作者
(44) IFN-γ inhibits non-opsonized phagocytosis of macrophages via an mTORC1-c/EBPβ pathway, Journal of Innate Immunology, 2015, 通讯作者
(45) Cellular metabolism and macrophage functional polarization, International Review of Immunology, 2015, 通讯作者
(46) Cellular metabolism on T-cell development and function, International Review of Immunology, 2015, 通讯作者
(47) Wip1-deficient neutrophils significantly promote intestinal ischemia/reperfusion injury in mice, Current Molecule Medicin, 2015, 通讯作者
(48) Influenza viral neuraminidase primes bacterial coinfection through TGF-beta-mediated expression of host cell receptors, Proc Natl Acad Sci U S A, 2015, 通讯作者
(49) Phosphatase Wip1 negatively regulates neutrophil antimicrobial immunity., Journal of Immunology,, 2014, 通讯作者
(50) IFN-γ inhibits TLR ligands-induced protease HTRA1, Journal of Immunology, 2014, 通讯作者
(51) Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-α expression in macrophage cells., Inflamm. Res. , 2014, 通讯作者
(52) Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner. , Int. J. Med. Sci., 2014, 通讯作者
(53) TSC1 controls macrophage polarization to prevent inflammatory disorder, Nature Communications, 2014, 通讯作者
(54) The roles of myeloid-derived suppressor cells in transplantation, Expert Review of Clinical Immunology, 2014, 通讯作者
(55) Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells, Apoptosis, 2014, 通讯作者
(56) The balance of intestinal Foxp3+ regulatory T cells and Th17 cells and its biological significance, Expert Review of Clinical Immunology , 2014, 通讯作者
(57) Thymic epithelial cell development and its dysfunction in human diseases, BioMed Research International, 2014, 通讯作者
(58) Microgravity inhibits resting T cell immunity in an exposure time-dependent manner, International Journal of Medical Sciences, 2014, 通讯作者
(59) Biological effects of (125)I seeds radiation on A549 lung cancer cells: G2/M arrest and enhanced cell death, Cancer Invest , 2014, 通讯作者
(60) 巨噬细胞极化与细胞代谢的相互调控, 细胞与分子免疫学杂志, 2014, 通讯作者
(61) 生理病理学意义及信号通路, 免疫学杂志, 2014, 通讯作者
(62) 单核-巨噬细胞起源及发育分化的特征与分子调控, 中国免疫学杂志, 2014, 通讯作者
(63) Phosphatase Wip1 Negatively Regulates Neutrophil Development through p38, BLOOD, 2013, 通讯作者
(64) Phosphatase Wip1 is essential for the maturation and homeostasis of medullary thymic epithelial cells in mice., Journal of Immunology, 2013, 通讯作者
(65) TSC1/2 complex negatively regulates thymic CD4+CD25+Foxp3+Treg development in mice., FASEB J, 2013, 通讯作者
(66) LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression., Arthritis and Rheumatism, 2013, 通讯作者
(67) Thymic epithelial cell development and differentiation: cellular and molecular regulation. , Protein Cell, 2013, 通讯作者
(68) 天然型调节性T细胞发育分化的研究进展, 生物化学与生物物理进展, 2013, 通讯作者
(69) 中性粒细胞发育分化调控机制, 中华微生物学和免疫学杂志, 2013, 通讯作者
(70) 胸腺上皮细胞的发育分化及其分子调控, 细胞与分子免疫学杂志, 2013, 通讯作者
(71) 微重力对免疫细胞影响的研究进展, 科学通报, 2013, 通讯作者
(72) 脂多糖促进小肠缺血再灌注损伤的机制探讨, 中华普外科手术学杂志(电子版), 2013, 通讯作者
(73) 尾静脉注射及皮下接种方法建立小鼠高表达miR-17-92的L1210白血病模型的比较研究, 中华临床医师杂志(电子版), 2013, 通讯作者
(74) miR-17-92对急性白血病L1210/DDP细胞多药耐药性影响研究, 现代生物医学进展, 2013, 通讯作者
(75) 高表达miR-17-92的L1210细胞系的构建与鉴定, 中华临床医师杂志(电子版), 2013, 通讯作者
(76)  DNA甲基化通过锌指蛋白185调控慢性粒细胞白血病细胞的增殖, 生物化学与生物物理进展, 2013, 通讯作者
(77) The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications, Journal of Molecular Medicine, 2012, 通讯作者
(78) Alterations of peripheral CD41CD251Foxp31 T regulatory cells in mice with STZ-induced diabetes, Cellular Molecular Immunology, 2012, 通讯作者
(79) The effects of leflunomide on CD4+CD25+Foxp3+ T regulatory cells in mice receiving allogeneic bone marrow transplantation, Inflammation Research, 2012, 通讯作者
(80) The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term, Journal of Cellular Physiology, 2012, 通讯作者
(81) Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo, Transpl Immunol., 2012, 通讯作者
(82) Smad3-deficient CD11b+Gr1+ myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway, Journal of Immunology, 2012, 通讯作者
(83) Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4+CD25+ regulatory T cells, Cellular Molecular Immunology, 2012, 通讯作者
(84) The Characteristics of Th1/Th2 Cytokine Receptors on Monocytes in Untreated Patients of Long Term Nonprogressor or Chronic HIV Infection, Current Molecular Medicine, 2012, 通讯作者
(85) TSC1/2 Signaling Complex Is Essential for Peripheral Na?¨ve CD8+ T Cell Survival and Homeostasis in Mice, PlosOne, 2012, 通讯作者
(86) An instructive role of donor macrophages in mixed chimeras in the induction of recipient CD4+Foxp3+ Treg cells, Immunology and Cell Biology, 2011, 通讯作者
(87) Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice, Inflammation Research, 2011, 通讯作者
(88) Efficient peripheral construction of functional human regulatory CD4+CD25highFoxp3+ T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34+ cells, Transplant Immunology, 2011, 通讯作者
(89) Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice, Immunology and Cell Biology, 2011, 通讯作者
(90) Phenotypic and functional switch of macrophages induced by regulatory CD4(+)CD25(+) T cells in mice., Immunology and Cell Biology, 2010, 通讯作者
(91) Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice., Journal of Molecular Medicine, 2009, 通讯作者
(92) Mouse models with human immunity and their application in biomedical research, Journal of Cellular and Molecular Medicine, 2009, 通讯作者
(93) Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice., Transplantation, 2009, 通讯作者
(94) Transcription factor FoxO3a mediates cell apoptosis in HIV-1 infected macrophages., J of immunology, 2008, 通讯作者
(95) Transplant tolerance is it really free of concerns, Trends in Immunology, 2007, 通讯作者
(96) Presence of functional mouse regulatory CD4+CD25+T cells in xenogeneic neonatal porcine thymus-grafted athymic mice:, American Journal of Transplantation, 2006, 通讯作者
发表著作
( 1 ) 异种移植免疫学, Xenotransplantation Immunology, 中国医药科技出版社, 2003-11, 第 1 作者
( 2 ) 移植免疫学, Transplant immunology, 中国医药科技出版社, 2005-04, 第 1 作者

科研活动

   
科研项目
( 1 ) (微)重力影响细胞生命活动的力学-生物学耦合规律研究, 参与, 国家级, 2011-01--2015-12
( 2 ) 混合嵌合体小鼠巨噬细胞免疫耐受特征及其分子机制研究, 主持, 国家级, 2011-01--2015-12
( 3 ) 巨噬细胞作为效应细胞参与移植排斥反应及其机制研究, 主持, 国家级, 2015-01--2018-12
( 4 ) 混合嵌合体小鼠巨噬细胞免疫耐受特征及其分子机制研究, 主持, 国家级, 2012-01--2016-12
( 5 ) 微重力条件下造血干细胞三维培养, 参与, 国家级, 2011-01--2015-12
( 6 ) 动物细胞对(微)重力的感知、传导、响应规律, 参与, 国家级, 2011-01--2015-08
( 7 ) 髓系抑制性细胞亚群的诱导及其移植免疫耐受的意义, 主持, 国家级, 2016-01--2020-12
( 8 ) 临床级干细胞资源及其HLA配型队列研究, 主持, 国家级, 2017-07--2021-12
( 9 ) 器官异体再造, 主持, 部委级, 2017-12--2022-11
( 10 ) 临床级诱导功能细胞的有效性评价及移植方案临床前研究, 主持, 国家级, 2017-07--2022-12
( 11 ) 嗜中性粒细胞新亚群的鉴定及其在器官移植免疫应答中的作用, 主持, 国家级, 2020-01--2024-12
参与会议
(1)天然免疫细胞亚群在移植免疫排斥及耐受中的作用   第十二届全国免疫学学术大会   2017-10-26
(2)天然免疫细胞亚群在移植免疫排斥及耐受中的作用   第十一届全国免疫学学术大会   2016-11-05
(3)免疫抑制剂对免疫抑制细胞亚群的抑制作用及其临床意义   国际类风湿性关节炎大会   2015-08-30
(4)TLR配体及细胞因子调控作用在RA中的意义   第五届类风湿关节炎国际论坛会议   赵勇   2013-09-14
(5)基础移植生物学前沿与热点   2011年北京医学会器官移植专业委员会第四季度学术会议   赵勇   2011-12-10
(6)Smad3在Gr1+CD11b+ 髓系抑制细胞发育及功能中的作用   第二届全国器官移植免疫学学术会议   赵勇   2011-11-18
(7)The important roles of Wip1 in immune cell development and graft rejection   第二届海峡两岸四地免疫学研讨会   赵勇   2011-08-26
(8)Wip1对中性粒细胞的负性调控作用   中国细胞生物学大会   刘光伟,胡雪莲,史剑锋,孙波   2011-07-15