（1）植物内源抗虫基因的生物学功能及分子调控机理。以水稻-稻飞虱为研究对象，以水稻抗虫种质资源为研究材料，通过抗虫基因克隆、功能验证及抗虫机理分析，研究基因的生理功能及其参与的代谢调控网络，阐明其抗虫的分子机理，验证水稻的抗虫性与产量、品质间的关系，为抗虫基因在水稻育种之中的应用提供理论依据。
（2）害虫防治关键靶标基因的作用机理及应用研究。以亚洲玉米螟、棉铃虫和烟青虫为研究对象，利用高通量测序技术获得害虫生长发育过程中的关键调控基因，研究这些基因的生理功能及其在害虫防治中的作用机理，探索将靶标基因应用于害虫无公害防治的可行性。

   

071002-动物学

动物分子遗传学; 植物保护学
植物－昆虫相互作用

1999-09--2002-06   中国科学院研究生院   博士
1992-09--1995-06   河南农业大学   硕士
1984-09--1988-06   河南农业大学   学士

1999.9-2002.6　中国科学院研究生院，动物学专业，研究方向：害虫生物防治，博士毕业

1992.9-1995.6　河南农业大学，生命科学院，应用微生物专业，硕士毕业

1984.9-1988.6　河南学业大学，植物保护系，本科毕业

1999.9-2002.6　中国科学院研究生院，动物学专业，获博士学位

1992.9-1995.6　河南农业大学，生命科学院，应用微生物专业，获硕士学位

1984.9-1988.6　河南学业大学，植物保护系，获学士学位

   

2007-01~2025-02,中国科学院上海生命科学研究院, 研究员
2006-01~2006-12,University of Paris Sud, 博士后
2002-07~2005-12,中国科学院上海生命科学研究院, 副研究员
1998-09~1999-08,中国科学院上海昆虫研究所, 助理研究员
1995-07~1998-08,河南农业大学, 讲师
1988-07~1992-08,河南金星啤酒厂, 助理工程师

2018-01-01-今,中国生态学会化学生态学专业委员会, 副主任委员
2015-10-31-今,上海市昆虫学会, 理事

昆虫-植物相互作用（一）
昆虫-植物相互作用

   

（1） 上海市科学技术奖, 二等奖, 省级, 2008

[1] 苗雪霞, 孙波, 李海超, 时振英. 一种新型的调控植物抗虫性的基因及其应用. 202111626010.2, 2021-12-28.

[2] 苗雪霞, 陈苏, 李海超, 时振英. OsF3'H基因在抵抗病原体中的应用. 202011529243.6, 2020-12-22.

   

[1] Chen, Su, Sun, Bo, Shi, Zhenying, Miao, Xuexia, Li, Haichao. Identification of the rice genes and metabolites involved in dual resistance against brown planthopper and rice blast fungus. PLANT CELL AND ENVIRONMENT. 2022, [2] Ruobing Guan, Shaoru Huo, Xiang Li, Shiheng An, Xuexia Miao, Haichao Li. A TIL-type serine protease inhibitor involved in humoral immune response of Asian corn borer Ostrinia furnaculi. Frontiers in Immunology[J]. 2022, 13(900129): 1-9, https://doi.org/10.3389/fimmu.2022.900129.
[3] Guan, Ruobing, Chu, Dongdong, Han, Xinyi, Miao, Xuexia, Li, Haichao. Advances in the Development of Microbial Double-Stranded RNA Production Systems for Application of RNA Interference in Agricultural Pest Control. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGYnull. 2021, 9: http://dx.doi.org/10.3389/fbioe.2021.753790.
[4] Yang, Xiaofang, Zhao, Xiaoling, Dai, Zhengyan, Ma, Feilong, Miao, Xuexia, Shi, Zhenying. OsmiR396/growth regulating factor modulate rice grain size through direct regulation of embryo-specific miR408. PLANT PHYSIOLOGY[J]. 2021, 186(1): 519-533, http://dx.doi.org/10.1093/plphys/kiab084.
[5] Duan, Jianli, Zhao, Yunpo, Li, Haichao, Habernig, Lukas, Gordon, Michael D, Miao, Xuexia, Engstrom, Ylva, Buttner, Sabrina. Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development. CELL REPORTS[J]. 2020, 32(4): http://dx.doi.org/10.1016/j.celrep.2020.107972.
[6] Guo, HuiMin, Li, HaiChao, Zhou, ShiRong, Xue, HongWei, Miao, XueXia. Deficiency of mitochondrial outer membrane protein 64 confers rice resistance to both piercing-sucking and chewing insects in rice. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2020, 62(12): 1967-1982, http://lib.cqvip.com/Qikan/Article/Detail?id=7103653163.
[7] Ma, Feilong, Yang, Xiaofang, Shi, Zhenying, Miao, Xuexia. Novel crosstalk between ethylene- and jasmonic acid-pathway responses to a piercing-sucking insect in rice. NEW PHYTOLOGIST[J]. 2020, 225(1): 474-487, https://www.webofscience.com/wos/woscc/full-record/WOS:000501510500042.
[8] Dai, Zhengyan, Tan, Jiang, Zhou, Cong, Yang, Xiaofang, Yang, Fang, Zhang, Shijuan, Sun, Shichen, Miao, Xuexia, Shi, Zhenying. The OsmiR396-OsGRF8-OsF3H-flavonoid pathway mediates resistance to the brown planthopper in rice (Oryza sativa). PLANT BIOTECHNOLOGY JOURNAL[J]. 2019, 17(8): 1657-1669, https://www.webofscience.com/wos/woscc/full-record/WOS:000477934300018.
[9] Wang, Meiling, Yang, Dongyong, Ma, Feilong, Zhu, Mulan, Shi, Zhenying, Miao, Xuexia. OsHLH61-OsbHLH96 influences rice defense to brown planthopper through regulating the pathogen-related genes. RICE[J]. 2019, 12(1): https://doaj.org/article/d04483bfcc484e568482fd5727bf4fec.
[10] 胡少茹, 关若冰, 李海超, 苗雪霞. RNAi在害虫防治中应用的重要进展及存在问题. 昆虫学报[J]. 2019, 62(4): 506-515, http://lib.cqvip.com/Qikan/Article/Detail?id=7001804020.
[11] Tan, Jiang, Wang, Meiling, Shi, Zhenying, Miao, Xuexia. OsEXPA10 mediates the balance between growth and resistance to biotic stress in rice. PLANT CELL REPORTS[J]. 2018, 37(7): 993-1002, [12] Ruo-Bing Guan, Hai-Chao Li, Xue-Xia Miao. Prediction of effective RNA interference targets and pathway-related genes in lepidopteran insects by RNA sequencing analysis. 昆虫科学：英文版. 2018, 25(3): 356-367, http://lib.cqvip.com/Qikan/Article/Detail?id=675407384.
[13] Guan, RuoBing, Li, HaiChao, Fan, YuJie, Hu, ShaoRu, Christiaens, Olivier, Smagghe, Guy, Miao, XueXia. A nuclease specific to lepidopteran insects suppresses RNAi. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(16): 6011-6021, http://dx.doi.org/10.1074/jbc.RA117.001553.
[14] Guan, Ruobing, Li, Haichao, Miao, Xuexia. RNAi pest control and enhanced BT insecticidal efficiency achieved by dsRNA of chymotrypsin-like genes in Ostrinia furnacalis. JOURNAL OF PEST SCIENCE[J]. 2017, 90(2): 745-757, [15] Guo, HuiMin, Sun, ShiChen, Zhang, FengMing, Miao, XueXia. Identification of genes potentially related to herbivore resistance in OPR3 overexpression rice by microarray analysis. PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY[J]. 2015, 92: 166-174, http://dx.doi.org/10.1016/j.pmpp.2015.05.008.
[16] Li, Haichao, Guan, Ruobing, Guo, Huimin, Miao, Xuexia. New insights into an RNAi approach for plant defence against piercing-sucking and stem-borer insect pests. PLANT CELL AND ENVIRONMENT[J]. 2015, 38(11): 2277-2285, https://www.webofscience.com/wos/woscc/full-record/WOS:000363884600008.
[17] Zhao, Yunpo, Li, Haichao, Miao, Xuexia. Proteomic Analysis of Silkworm Antennae. JOURNAL OF CHEMICAL ECOLOGY[J]. 2015, 41(11): 1037-1042, https://www.webofscience.com/wos/woscc/full-record/WOS:000365815200008.
[18] Zhang, Hao, Li, Haichao, Guan, Ruobing, Miao, Xuexia. Lepidopteran insect species-specific, broad-spectrum, and systemic RNA interference by spraying dsRNA on larvae. ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA[J]. 2015, 155(3): 218-228, http://dx.doi.org/10.1111/eea.12300.
[19] Guo, HuiMin, Li, HaiChao, Zhou, ShiRong, Xue, HongWei, Miao, XueXia. Cis-12-Oxo-Phytodienoic Acid Stimulates Rice Defense Response to a Piercing-Sucking Insect. MOLECULAR PLANT[J]. 2014, 7(11): 1683-1692, http://lib.cqvip.com/Qikan/Article/Detail?id=663525632.
[20] Zhang, Hao, Li, HaiChao, Miao, XueXia. Feasibility, limitation and possible solutions of RNAi-based technology for insect pest control. INSECT SCIENCEnull. 2013, 20(1): 15-30, http://dx.doi.org/10.1111/j.1744-7917.2012.01513.x.
[21] Li, Haichao, Zhang, Hao, Guan, Ruobing, Miao, Xuexia. Identification of differential expression genes associated with host selection and adaptation between two sibling insect species by transcriptional profile analysis. BMC GENOMICS[J]. 2013, 14(1): 582-582, http://dx.doi.org/10.1186/1471-2164-14-582.
[22] Wang, Yubing, Li, Haichao, Si, Yuan, Zhang, Hao, Guo, Huimin, Miao, Xuexia. Microarray analysis of broad-spectrum resistance derived from an indica cultivar Rathu Heenati. PLANTA[J]. 2012, 235(4): 829-840, [23] Wang, Yubing, Guo, Huimin, Li, Haichao, Zhang, Hao, Miao, Xuexia. Identification of transcription factors potential related to brown planthopper resistance in rice via microarray expression profiling. BMC GENOMICS[J]. 2012, 13(1): 687-687, http://dx.doi.org/10.1186/1471-2164-13-687.
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[25] Miao Xuexia. Inheritance and linkage analysis of co-dominant SSR markers on the sex chromosome of the silkworm (Bombyx mori L.). Genetics Research. 2008, [26] Miao, Xuexia, Li, Muwang, Dai, Fangyin, Lu, Cheng, Goldsmith, Marian R, Huang, Yongping. Linkage analysis of the visible mutations Sel and Xan of Bombyx mori (Lepidoptera : Bombycidae) using SSR markers. EUROPEAN JOURNAL OF ENTOMOLOGY[J]. 2007, 104(4): 647-652, https://doaj.org/article/b674dace72ad44bfa414608495f80d94.
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（ 1 ） 生物逆境抗性与广谱高抗模块设计, 主持, 国家级, 2017-01--2019-08
（ 2 ） 水稻内源抗飞虱基因的功能及抗虫机理研究, 主持, 国家级, 2014-01--2017-12
（ 3 ） 蚜虫靶标的筛选及鉴定, 主持, 院级, 2014-10--2017-10
（ 4 ） 水稻拒虫性高抗褐飞虱QTL的定位克隆及功能研究, 主持, 国家级, 2016-01--2019-12
（ 5 ） 鳞翅目昆虫RNAi通路相关基因的功能及其作用机理研究, 主持, 国家级, 2017-01--2020-12
（ 6 ） RNA干扰制剂的研发, 主持, 国家级, 2017-07--2020-12
（ 7 ） 基于RNA干扰剂蚜虫防控技术体系的建立与示范, 主持, 部委级, 2019-01--2020-06
（ 8 ） 蔬菜害虫干扰剂的研究与创制, 主持, 省级, 2019-04--2022-04
（ 9 ） 水稻OsmiR396通过调控类黄酮合成介导对褐飞虱的抗性的分子机理研究, 参与, 国家级, 2019-01--2022-12

（1）Reasonable explanation and solution for RNAi efficiency of lepidopteran insects   2019-07-26
（2）Reasonable explanation and solution for RNAi efficiency of lepidopteran insects   RNA干扰机理及应用   2019-07-22
（3）A nuclease specific to lepidopteran insects suppresses RNAi    美国昆虫学年会   2018-11-11
（4）绿色生物农药－核酸杀虫剂的研发现状及应用前景   第二届农作物病虫害绿色防控新技术交流大会   2018-07-06
（5）核酸杀虫剂研发与应用进展    全国第十 二届化学生态术研讨会   2018-06-22
（6）Enhance Lepidopteran insects RNAi efficiency and accelerate its application in pest control   2016-09-25
（7）The molecular mechanism of rice resistance to chewing and piercing-sucking insect pests   中澳双边“CAS-CSIRO环境胁迫与作物生产”学术研讨会   2016-05-13
（8）水稻同时抵抗刺吸式和咀嚼式害虫的分子机制   第九届大北农科技奖颁奖大会暨中关村全球农业生物技术创新论坛   2015-11-23
（9）New insights into RNAi strategies in insect pest control   2014-11-19

已指导学生

张浩  博士研究生  071002-动物学  

郭惠民  博士研究生  071002-动物学  

关若冰  博士研究生  071002-动物学  

现指导学生

王美玲  博士研究生  071002-动物学  

胡少茹  博士研究生  071002-动物学  

马飞龙  博士研究生  071002-动物学  

陈苏  硕士研究生  071002-动物学  

杨小芳  博士研究生  071002-动物学  

申彦洁  硕士研究生  071007-遗传学  

孙波  硕士研究生  071002-动物学