基本信息
张国范  男  博导  中国科学院海洋研究所
电子邮件: gfzhang@ms.qdio.ac.cn
通信地址: 青岛市丰县路2号博思公寓
邮政编码: 266000

招生信息

   
招生专业
070703-海洋生物学
090801-水产养殖
招生方向
海洋生物遗传学,基因组学
贝类养殖遗传学与育种生物技术

教育背景

1989-09--1992-12   中国科学院海洋研究所   博士
1980-09--1982-12   中国科学院南海海洋研究所   硕士
1975-09--1978-09   厦门大学   无

工作经历

   
工作简历
2013-04~现在, 海洋生态养殖技术国家地方联合工程实验室 , 主任
2013-01~2016-12,中国科学院海洋研究所, 学术委员会主任
2007-07~2012-12,中国科学院海洋研究所, 副所长
2000-03~2010-07,中科院海洋所海洋生物技术研发中心, 副主任/主任/研究员
1996-12~2000-03,农业部海水增养殖生态学重点实验室, 主任
1993-01~2000-03,大连海洋大学, 教研室主任
1989-09~1992-12,中国科学院海洋研究所, 博士
1983-01~1989-09,大连水产学院, 教研室主任
1980-09~1982-12,中国科学院南海海洋研究所, 硕士
1978-08~1980-09,国家海洋局海洋环境保护所, 研究实习员
1975-09~1978-09,厦门大学, 无
社会兼职
2015-09-30-2019-09-29,中国动物学会贝类学分会, 主任委员
2014-07-01-2019-06-30,中国动物学会, 常务理事

教授课程

贝类养殖学
贝类遗传育种
贝类遗传育种学

专利与奖励

   
奖励信息
(1) 牡蛎基因组解析与潮间带适应的分子机制, 二等奖, 部委级, 2016
(2) 菲律宾蛤仔现代养殖产业技术体系的构建与应用, 二等奖, 国家级, 2009
(3) 海湾扇贝养殖遗传学的研究与应用, 二等奖, 研究所(学校), 2008
(4) 皱纹盘鲍杂交育种技术及其养殖工艺体系, 二等奖, 国家级, 2007
(5) 贝类选择性杂交制种方法, 三等奖, 国家级, 2006
(6) 皱纹盘鲍杂交及杂种优势的产业化应用, 一等奖, 省级, 2004
(7) 菲律宾蛤仔健康苗种培育和高效养殖技术, 一等奖, 省级, 2004
(8) 鲍多倍体育种技术研究, 二等奖, 省级, 2001
(9) 太平洋牡蛎三倍体规模生产技术研究, 二等奖, 省级, 2000
(10) 魁蚶人工育苗与增养殖技术, 二等奖, 国家级, 1991
(11) 魁蚶人工育苗与增养试验, 一等奖, 部委级, 1991
专利成果
( 1 ) 一种筛选长牡蛎高糖原含量亲贝的方法及其相关的SNP引物对, 2018, 第 2 作者, 专利号: 201710855507.9

( 2 ) 一种筛选提高不饱和脂肪酸C20:3Ω6含量长牡蛎的方法相关的SNP的引物对, 2018, 第 1 作者, 专利号: 201710855506.4

( 3 ) 一种筛选高糖原含量长牡蛎亲贝的方法及其相关的SNP引物对, 2018, 第 1 作者, 专利号: 201710855508.3

( 4 ) 一种与长牡蛎糖原含量性状相关的SNP标记及其应用, 2017, 第 3 作者, 专利号: ZL201410355436

( 5 ) 一种金黄色闭壳肌海湾扇贝新品系的选育方法, 2017, 第 4 作者, 专利号: 201611036617.4

( 6 ) 一种基于生物信息学获得双DNA限制性内切酶组合的方法, 2017, 第 5 作者, 专利号: 201410490468.3

( 7 ) 一种与牡蛎抗病毒特性相关的SNP标记及其应用, 2017, 第 4 作者, 专利号: 201410723155.8

( 8 ) 一种适用于海湾扇贝的跨海区低碳常温育苗方法, 2016, 第 2 作者, 专利号: 201611036598.5

( 9 ) 一种获得栉孔扇贝凋亡抑制蛋白基因编码全序列的方法, 2016, 第 5 作者, 专利号: 201410620497.7

( 10 ) 一种提高养殖鲍度夏存活率的育种方法, 2016, 第 2 作者, 专利号: 201310744854.6

( 11 ) 一种测定贝壳体积和质量的方法, 2016, 第 2 作者, 专利号: 201310612214.X

( 12 ) 一种与牡蛎抗病毒特性相关的SNP标记及其应用, 2014, 第 4 作者, 专利号: 201410723155.8

( 13 ) 一种获得栉孔扇贝凋亡抑制蛋白基因编码全序列的方法, 2014, 第 5 作者, 专利号: 201410620497.7

( 14 ) 一种获得栉孔扇贝凋亡抑制蛋白基因编码全序列的方法, 2014, 第 5 作者, 专利号: 201410620497.7

( 15 ) 一种测定贝壳体积和质量的方法, 2014, 第 2 作者, 专利号: 201310612214.X

( 16 ) 一种牡蛎近缘物种鉴定的方法, 2013, 第 4 作者, 专利号: ZL 201210189381.3

( 17 ) 一种海湾扇贝的同代多点复合选育方法, 2013, 第 2 作者, 专利号: ZL 201110414942.0

( 18 ) 一种海湾扇贝雄性不育体的制备方法, 2010, 第 1 作者, 专利号: 201010147849.3

( 19 ) 一种橘红壳色皱纹盘鲍新品系的制种方法., 2009, 第 1 作者, 专利号: 4437091(日本)

( 20 ) 一种橘红壳色皱纹盘鲍新品系的制种方法. , 2008, 第 1 作者, 专利号: US 7,320,293 B2(美国)

( 21 ) 一种橘红壳色皱纹盘鲍新品系的制种方法. , 2007, 第 1 作者, 专利号: 10-0676214(韩国)

( 22 ) 一种采育器及其应用, 2005, 第 1 作者, 专利号: ZL 03133597.7

( 23 ) 一种适用于滩涂贝类苗种后期中间育成方法, 2005, 第 1 作者, 专利号: ZL 02133031.X

( 24 ) 一种适用于埋栖生活型滩涂贝类的人工采苗方法, 2004, 第 1 作者, 专利号: ZL02132740.8

( 25 ) 贝类选择性杂交制种方法, 2004, 第 1 作者, 专利号: ZL 01128003.4

( 26 ) 一种贝类纯系制备方法., 2003, 第 1 作者, 专利号: ZL 01106081.6

出版信息

   
发表论文
(1) Construction and evaluation of a high-density SNP array for the Pacific oyster (Crassostrea gigas), Plos One, 2017, 通讯作者
(2) Respiration disruption and detoxification at the protein expression levels in the Pacific oyster (&ITCrassostrea gigas&IT) under zinc exposure, Aquatic Toxicology, 2017, 通讯作者
(3) Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas, Cell Death & Disease, 2017, 通讯作者
(4) Integrated application of transcriptomics and metabolomics provides insights into glycogen content regulation in the Pacific oyster Crassostrea gigas, Bmc Genomics, 2017, 通讯作者
(5) Identification and Functional Characterization of the Glycogen Synthesis Related Gene Glycogenin in Pacific Oysters (Crassostrea gigas), Journal of Agricultural and Food Chemistry, 2017, 通讯作者
(6) Temperature, energy metabolism, and adaptive divergence in two oyster subspecies, Ecology and Evolution, 2017, 通讯作者
(7) Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates, Scientific Reports, 2017, 通讯作者
(8) TANK-binding kinase-1 broadly affects oyster immune response to bacteria and viruses, Fish & Shellfish Immunology, 2016, 通讯作者
(9) Characterization of CgHIF alpha-Like, a novel bHLH-PAS transcription factor family member, and Its role under hypoxia stress in the pacific oyster Crassostrea gigas, Plos One, 2016, 通讯作者
(10) Coverage recommendation for genotyping analysis of highly heterologous species using next-generation sequencing technology, Scientific Reports, 2016, 通讯作者
(11) A high-density snp genetic linkage map and qtl analysis of growth-related traits in a hybrid family of oysters (Crassostrea gigas x Crassostrea angulata) using genotyping-by-sequencing, G3-Genes Genomes Genetics, 2016, 通讯作者
(12) Effect of chronic temperature exposure on the immunity of abalone, Haliotis discus hannai, Aquaculture Research, 2016, 通讯作者
(13) Molecular Characterization and Functional Analysis of a Putative Octopamine/Tyramine Receptor during the Developmental Stages of the Pacific Oyster, Crassostrea gigas, Plos One, 2016, 通讯作者
(14) High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans, Scientific Reports, 2016, 通讯作者
(15) Pacific abalone farming in china: recent innovations and challenges, Journal of Shellfish Research, 2016, 通讯作者
(16) Potential of abalone shells as vectors for exotic oyster species in the abalone farming practice in China, Journal of Shellfish Research, 2016, 通讯作者
(17) Expression Characterization of Stress Genes Under High and Low Temperature Stresses in the Pacific Oyster, Crassostrea gigas, Marine Biotechnology, 2016, 通讯作者
(18) Molecular Basis for Adaptation of Oysters to Stressful Marine Intertidal Environments, Annual Review of Animal Biosciences, 2016, 第 1 作者
(19) RestrictionDigest: A powerful Perl module for simulating genomic restriction digests, Electronic Journal of Biotechnology, 2016, 通讯作者
(20) Characterization and functional analysis of two inhibitor of apoptosis genes in Zhikong scallop Chlamys farreri, Developmental and Comparative Immunology, 2016, 通讯作者
(21) Characterization of Oyster Voltage-Dependent Anion Channel 2 (VDAC2) Suggests Its Involvement in Apoptosis and Host Defense, Plos One, 2016, 通讯作者
(22) Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster, Fish & Shellfish Immunology, 2016, 通讯作者
(23) A bibliometric analysis of oyster research from 1991 to 2014, Aquaculture International, 2016, 通讯作者
(24) Genome-wide and single-base resolution DNA methylomes of the Pacific oyster Crassostrea gigas provide insight into the evolution of invertebrate CpG methylation, Bmc Genomics, 2015, 通讯作者
(25) Discovery and validation of genic single nucleotide polymorphisms in the Pacific oyster Crassostrea gigas, Molecular Ecology Resources, 2015, 通讯作者
(26) Characterization of a novel inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense, Developmental and Comparative Immunology, 2015, 通讯作者
(27) Identification and functional characterization of two Bcl-2 family protein genes in Zhikong scallop Chlamys farreri, Fish and Shellfish Immunology, 2015, 通讯作者
(28) Comparative analysis of oyster (Crassostrea gigas) immune responses under challenge by different Vibrio strains and conditions, Molluscan Research, 2015, 通讯作者
(29) Massive expansion and functional divergence of innate immune genes in a protostome, Scientific Reports, 2015, 通讯作者
(30) Structural characterization and expression analysis of a novel cysteine protease inhibitor from Haliotis discus hannai Ino, Fish Shellfish Immunology, 2015, 通讯作者
(31) Yield trait improvement of bay scallops following complete diallel crosses between different scallop stocks, Chinese Journal of Oceanology and Limnology, 2014, 通讯作者
(32) Transcriptome Analysis Reveals a Rich Gene Set Related to Innate Immunity in the Eastern Oyster (Crassostrea virginica), Marine Biotechnology, 2014, 通讯作者
(33) Phylogeny of forkhead genes in three spiralians and their expression in Pacific oyster Crassostrea gigas, Chinese Journal of Oceanology and Limnology, 2014, 通讯作者
(34) Identification of Conserved and Novel MicroRNAs in the Pacific Oyster Crassostrea gigas by Deep Sequencing, Plos One, 2014, 通讯作者
(35) Use of high-resolution melting analysis for detecting hybrids between the oysters Crassostrea sikamea and C-angulata reveals bidirectional gametic compatibility, Journal of Molluscan Studies, 2014, 通讯作者
(36) Aragonite shells are more ancient than calcite ones in bivalves: new evidence based on omics, Molecular Biology Reports, 2014, 通讯作者
(37) A new identification method for five species of oysters in genus Crassostrea from China based on high-resolution melting analysis, Chinese Journal of Oceanology and Limnology, 2014, 通讯作者
(38) Genome-wide survey and analysis of microsatellites in the Pacific oyster genome: abundance, distribution, and potential for marker development, Chinese Journal of Oceanology and Limnology, 2014, 通讯作者
(39) Identification two novel nacrein-like proteins involved in the shell formation of the Pacific oyster Crassostrea gigas, Molecular Biology Reports, 2014, 通讯作者
(40) Identification and Functional Characterization of Two Executioner Caspases in Crassostrea gigas, Plos One, 2014, 通讯作者
(41) Alternative splicing and immune response of Crassostrea gigas tumor necrosis factor receptor-associated factor 3, Molecular Biology Reports, 2014, 通讯作者
(42) SNP Identification by Transcriptome Sequencing and Candidate Gene-Based Association Analysis for Heat Tolerance in the Bay Scallop Argopecten irradians, Plos One, 2014, 通讯作者
(43) Identification and characterization of a novel phage-type like lysozyme from Manila clam, Ruditapes philippinarum, Developmental and Comparative Immunology, 2014, 通讯作者
(44) Heritability of larval and juvenile growth for two stocks of Manila clam Ruditapes philippinarum, Aquaculture Research, 2014, 第 4 作者
(45) Transcriptome analysis reveals a rich gene set related to innate immunity in the Eastern oyster (Crassostrea virginica), Marine Biotechnology, 2014, 通讯作者
(46) Validation of housekeeping genes as internal controls for studying gene expression during Pacific oyster development by quantitative real time PCR, Fish and Shellfish Immunology, 2013, 通讯作者
(47) Molecular cloning, characterization, and expression of two myeloid differentiation factor 88 (Myd88) in Pacific oyster, Crassostrea gigas, Journal of the World Aquaculture Society, 2013, 通讯作者
(48) Evolution and functional analysis of the Pif97 gene of the Pacific oyster Crassostrea gigas, Current Zoology, 2013, 通讯作者
(49) Oyster shell proteins originate from multiple organs and their probable transport pathway to the shell formation front, Plos One, 2013, 通讯作者
(50) Using microsatellites to assess genetic variation in a selective breeding program of Chinese bay scallop (Argopecten irradians irradians), Israeli Journal of Aquaculture-Bamidgeh, 2013, 通讯作者
(51) Fosmid library construction and end sequences analysis of the Pacific oyster, Crassostrea gigas, Molluscan Research, 2013, 通讯作者
(52) Crosses between two subspecies of bay scallop Argopecten irradians and heterosis for yield traits at harvest, Aquaculture Research , 2011, 通讯作者
(53) Cloning, genomic structure, and expression analysis of peroxiredoxin V from bay scallop Argopecten irradians, Fish and Shellfish Immunology , 2011, 通讯作者
(54) Novel polymorphisms in myostatin gene and their association with growth traits in a variety of bay scallop Argopecten irradians, Animal Genetics, 2011, 通讯作者
(55) A Crassostrea gigas Toll-like receptor and comparative analysis of TLR pathway in invertebrates., Fish and Shellfish Immunology , 2011, 通讯作者
(56) Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system, Developmental and Comparative Immunology, 2011, 通讯作者
(57) Crassostrea angulata bindin gene and the divergence of fucose-binding lectin repeats among three species of Crassostrea., Marine Biotechnology, 2011, 通讯作者
(58) Development and Linkage Analysis of 104 New Microsatellite Markers for Bay Scallop (Argopecten irradians)., Marine Biotechnology, 2011, 通讯作者
(59) Effects of salinity on larvae of the oysters Crassostrea ariakensis, C. sikamea and the hybrid cross., Marine Biology Research, 2011, 通讯作者
(60) The first identification of molluscan Ecsit in the Pacific oyster, Crassostrea gigas, and its expression against bacterial challenge., Aquaculture Research, 2011, 通讯作者
(61) Tropomyosin is a nice marker gene for phylogenetic analysis of molluscs., Molecular Biology Reports, 2011, 通讯作者
(62) Genomic DNA extraction from in vivo sampled tissue of Pacific oyster, Crassostrea gigas, The Israeli Journal of Aquaculture-Bamidgeh, 2011, 通讯作者
(63) Classification of a common cupped oyster from southern China, Journal of Shellfish Research , 2010, 第 4 作者
(64) Crassostrea angulata bindin gene and the divergence of fucose-binding lectin repeats among three species of Crassostrea, Marine Biotechnology online, 2010, 通讯作者
(65) 长牡蛎(Crassostrea gigas)17个EST-SNP标记的开发, 海洋与湖沼, 2010, 通讯作者
(66) 皱纹盘鲍表型性状与肌肉重的相关与通径分析, 海洋科学, 2010, 通讯作者
(67) Molecular characterization of a mollusk chicken type lysozyme gene from Haliotis discus hannai lno and the antimicrobial activity of its recombinant protein, Fish and Shellfish Immunology, 2010, 通讯作者
(68) Divergent selection and realized heritability for growth in the Japanese scallop, Patinopecten yessoensis Jay, Aquaculture Research, 2010, 通讯作者
(69) Heterosis and combining ability: a diallel cross of three geographically isolated populations of Pacific abalone Haliotis discus hannai Ino, Chinese Journal of Oceanology and Limnology, 2010, 通讯作者
(70) Polymorphism of the superoxide dismutase gene family in the bay scallop (Argopecten irradians) and its association with resistance/susceptibility to Vibrio anguillarum , Developmental and Comparative Immunology, 2010, 通讯作者
(71) Intracellular copper/zinc superoxide dismutase from bay scallop Argopecten irradians: its gene structure, mRNA expression and recombinant protein, Fish and Shellfish Immunology , 2009, 通讯作者
(72) Cloning and characterization of manganese superoxide dismutase (MnSOD) from bay scallop Argopecten irradians, Fish and Shellfish Immunology , 2009, 通讯作者
(73) Laboratory hybridization between Crassostrea ariakensis and C. Sikamea, Journal of Shellfish Research, 2009, 通讯作者
(74) The manganese superoxide dismutase gene in bay scallop Argopecten irradians: Cloning, 3D modelling and mRNA expression, Fish and Shellfish Immunology , 2008, 通讯作者
(75) Inbreeding depression for various traits in two cultured populations of the American bay scallop, Argopecten irradians irradians Lamarck (1819) introduced into China, Journal of Experimental Marine Biology and Ecology, 2008, 通讯作者
(76) Cloning and expression analysis of a HSP70 gene from Pacific abalone, Haliotis discus hannai, Fish and Shellfish Immunology , 2007, 通讯作者
(77) Cloning and expression analysis of a HSP70 gene from Pacific abalone (Haliotis discus hannai), Fish and Shellfish Immunology , 2007, 通讯作者
(78) A new three-phase culture method for Manila clam, Ruditapes philippinarum, farming in northern China,  Aquaculture, 2006, 第 1 作者
(79) Abalone mariculture in China, Journal of Shellfish Research, 2004, 第 1 作者
(80) Different responses to selection in two stocks of the bay scallop, Argopecten irradians irradians Lamarck (1819) , Journal of Experimental Marine Biology and Ecology , 2004, 通讯作者
(81) Triploid induction in Pacific abalone Haliotis discus hannai Ino by 6-dimethylaminopurine and the performance of triploid juveniles, Journal of Shellfish Research, 1998, 第 1 作者
发表著作
( 1 ) 海湾扇贝养殖遗传学, Aquaculture Genetics in Bay Scallop, 科学出版社, 2009-09, 第 1 作者
( 2 ) 蛤仔养殖学, Manila Clam Aquaculture, 科学出版社, 2010-10, 第 1 作者

科研活动

   
科研项目
( 1 ) 养殖贝类重要经济性状的分析解析与设计育种基础研究, 负责人, 国家任务, 2010-01--2014-12
( 2 ) 国家产业技术体系(贝类体系), 负责人, 国家任务, 2011-01--2015-12
( 3 ) 中国近海牡蛎种类分布及系统演化, 负责人, 国家任务, 2008-01--2011-12
( 4 ) 重要养殖贝类比较基因组学研究, 负责人, 中国科学院计划, 2010-01--2012-12
( 5 ) 牡蛎基因组后续研究, 参与, 中国科学院计划, 2016-01--2018-12
( 6 ) 国家贝类产业技术体系, 负责人, 国家任务, 2017-01--2020-12
( 7 ) 基于全基因组关联分析的牡蛎生长与营养品质性状的遗传解析, 负责人, 国家任务, 2016-06--2020-12