基本信息
朱顺义  男  博导  中国科学院动物研究所
电子邮件: zhusy@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院5号
邮政编码: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
多肽生物学及进化
多肽新分子设计

教育背景

1997-09--2001-04   武汉大学   博士

工作经历

   
工作简历
2001-10~2004-04,Leuven University, 博士后
1997-09~2001-04,武汉大学, 博士
社会兼职
2017-01-01-今,Scientific reports, 编委
2015-12-01-今,Journal of Biochemistry and Molecular Biology Research, 编委
2015-10-01-今,昆虫学报, 编委
2010-01-01-今,Bioinformatics & Biology Insights 编委,
2010-01-01-今,The Open Toxinology Journal , 编委

教授课程

进化生态学:分子、化学和行为适应机制

专利与奖励

   
奖励信息
(1) 东亚钳蝎的毒素组学研究, 一等奖, 省级, 2005
专利成果
( 1 ) 一种抗菌肽及其制备方法和应用, 2015, 第 1 作者, 专利号: ZL201210160509.3

出版信息

   
发表论文
(1) Did cis- and trans-defensins derive from a common ancestor?, Immunogenetics, 2019, 通讯作者
(2) Scorpion toxins: positive selection at a distal site modulates functional evolution at a bioactive site, Mol Biol Evol, 2019, 通讯作者
(3) Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Dev Comp Immunol, 2018, 通讯作者
(4) Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion, FEMS Microbiol Lett, 2018, 通讯作者
(5) Receptor variability-driven evolution of snake toxins, Zool Res, 2018, 通讯作者
(6) Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins, Amino Acids, 2018, 通讯作者
(7) Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin, Toxins, 2018, 通讯作者
(8) Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs, Front Microbiol, 2018, 通讯作者
(9) Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, Developmental and Comparative Immunology, 2018, 通讯作者
(10) Target-driven positive selection at hot spots of scorpion toxins uncovers their potential in design of insecticides, Mol Biol Evol, 2016, 通讯作者
(11) Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin, FASEB J, 2016, 通讯作者
(12) Target-driven evolution of scorpion toxins, Sci Rep, 2015, 通讯作者
(13) Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter, Biochem Pharmacol, 2015, 通讯作者
(14) An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity, ACS Chem Biol, 2014, 通讯作者
(15) Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene, Nat Commun, 2014, 第 1 作者
(16) Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function, Mol Biol Evol, 2014, 第 1 作者
(17) Dermatophytic defensin with antiinfective potential, Proc Natl Acad Sci USA , 2012, 通讯作者
(18) Evolutionary Diversification of Mesobuthus α-Scorpion Toxins Affecting Sodium Channels, Mol Cell Proteomics , 2012, 通讯作者
(19) Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin, J Med Chem , 2011, 通讯作者
(20) DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, Biochemical Phamacol , 2011, 通讯作者
(21) Molecular diversity and functional evolution of scorpion potassium channel toxins, Mol Cell Proteomics , 2011, 通讯作者
(22) Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels, Biochem Pharmacol , 2011, 通讯作者
(23) Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides, FASEB J, 2009, 通讯作者
(24) A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides, FASEB J, 2009, 通讯作者
(25) Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor, Trends Microbiol , 2008, 通讯作者
发表著作
Evolution of Venomous Animals and Their Toxins, Springer Science+Business Media Dordrecht, 2016-06, 第 3 作者

科研活动

   
科研项目
( 1 ) 动物神经毒素起源的实验室模拟, 主持, 国家级, 2008-01--2011-12
( 2 ) 寄主-寄生蜂间免疫抑制交互作用的分子机制, 主持, 国家级, 2007-07--2009-12
( 3 ) 应用进化基因组学研究免疫系统发育的关键分子, 主持, 国家级, 2010-01--2015-12
( 4 ) 基于一种新的蝎毒素支架的抗感染分子设计, 主持, 国家级, 2016-01--2019-12
( 5 ) 孢子霉素的工程化改造, 主持, 国家级, 2019-01--2022-12
参与会议
(1)Antimicrobial peptides in scorpion venom   国家自然科学基金委国际合作与交流项目会议   2016-01-12
(2)A multigene family of Caenorhabditis remanei-specific antifungal peptides with therapeutic potential    中比双边合作项目   高斌   2012-05-25