基本信息
程靓  男  博导  中国科学院化学研究所
电子邮件: chengl@iccas.ac.cn
通信地址: 海淀区中关村北一街2号
邮政编码: 100190

学习工作经历

  • 2000-2004年,北京师范大学化学系,学士

  • 2004-2009年,中国科学院化学研究所,博士

  • 2011-2014年,美国哥伦比亚大学,博士后

  • 2015年-至今,中国科学院化学研究所,研究员,博士生导师

招生信息

   
招生专业
0703Z1-化学生物学
070303-有机化学
071010-生物化学与分子生物学
招生方向
化学生物学
有机化学

教授课程

高等有机合成

研究兴趣与方向

RNA的化学生物学研究

  1. RNA修饰的化学调控与干预

  2. 化学小分子对RNA的选择性识别

代表论著

  1. Lan, L.;# Sun, Y. J.#, Liu, L.; Cheng, L.* "A Photo-Responsive Chemical Modulation of m6A RNA demethylase FTO", Chem. Commun. 2021, DOI: 10.1039/D1CC04091J.  

  2. Xie, L.-J.; Lin, C.-L.; Liu, L.; Cheng, L.* "A Chemical Labelling of N6-Formyl Adenosine (f6A) RNA", Chin. Chem. Lett. 2021, DOI: 10.1016/j.cclet.2021.09.028.  

  3. Sun, Y.-J.; Cheng, L.* "The Chemistry behind ThiC rearrangement", ChemBioChem, 2021, DOI: 10.1002/cbic.202100385 (Invited review).

  4. Lan, L.; Sun, Y.-J.; Jin, X.-Y.; Xie, L.-J.; Liu, L.; Cheng, L.* "A Light-controllable Chemical Modulation of m6A RNA Methylation", Angew. Chem. Int. Ed. 2021, 60, 18116-18121.  

  5. Sun, Y.-J.; Liu, L.; Cheng, L.* "Regioselective Synthesis and Anticancer Evaluation of H2O2-Activatable Nucleosides", Chem. Commun. 2020, 56, 6484-6487 (Insider front cover article).

  6. Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Artificial Deprenylation of N6‐isopentenyladenosine (i6A) RNA", Angew. Chem. Int. Ed. 2020, 59, 10645-10650.

  7. Xie, L.-J.; Liu, L.; Cheng, L.* "Modifying Methionine on Proteins", ChemBioChem, 2020, 21, 461-463 (Invited review).  

  8. Xie, L.-J.; Liu, L.; Cheng, L.* "Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases", Biochemistry, 2020, 59, 230-239 (Invited review, Future of Biochemistry: The Asia-Pacific Issue). 

  9. Wang, R. -L.; Lan, L.; Liu, L.; Cheng, L.* "Asymmetric Polymerase Chain Reaction and Loop-mediated Isothermal Amplification (AP-LAMP) for ultrasensitive detection of microRNAs", Chin. Chem. Lett. 2020, 31, 159-162.

  10. Wang, R.-L.#; Jin, X.-Y.#; Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.; Cheng, L.* "Visible-Light Facilitated Fluorescence "Switch-On" Labelling of 5-Formylpyrimidine RNA", Adv. Synth. Catal. 2019, 361, 5406-5411.

  11. Wang, C.; Zou, P.; Yang, C.; Liu, L.; Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.*; Chen, P. R.* "Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions", Sci. China Life Sci. 2019, 62, 1459-1471.

  12. Li, X.-D.#; Gao, Y.-T.#; Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.; Cheng, L.* "A NaI/H2O2 Mediated Sulfenylation and Selenylation of Unprotected Uracil and its Derivatives", Org. Lett. 2019, 21, 6643-6647.

  13. Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "A chemical photo-oxidation of 5-methyl cytidines", Adv. Synth. Catal. 2019, 361, 4685-4690. (VIP Article)

  14. Lan, L.; Wang, R. L.; Liu , L.; Cheng, L.* "A Label-free Colorimetric Detection of microRNA via G-Quadruplex-based Signal Quenching Strategy", Anal. Chim. Acta. 2019, 1079, 207-211.

  15. 程靓,兰玲,刘利,“一种基于G-四链体探针结构解旋的可视化识别microRNA的检测方法”,中国专利,申请号:201910514343.2,授权公告号:CN 110229872 B,申请日:2019年6月14日,授权日:2020年11月10日。

  16. 程靓,王瑞丽,刘利,"一种基于不对称PCR和LAMP循环扩增反应进行miRNA快速检测的方法",中国专利,申请号:201910179354X,授权公告号:CN 109706226 B,申请日:2019年3月11日,授权日:2021年6月15日。

  17. 程靓,李学东,刘利,“制备5-硫/硒修饰尿嘧啶衍生物的方法”,中国专利,申请号:2019100843077,授权公告号:CN 109651267 B,申请日:2019年1月29日,授权日:2020年5月19日。

  18. Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032.

  19. Li, X.-D.; Liu, L.; Cheng, L.* "Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs", Org. Biomol. Chem. 2018, 16, 9191-9196.

  20. Li, X.-D.; Chen, B.; Lan, L.; Wang, R.-L.; Luo, D.-Q.; Liu, L.; Cheng, L.* "Selective Recognition of HIV RNA by Dinuclear Metallic Ligands", Chin. Chem. Lett. 2018, 29, 1637-1640.

  21. Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation of N6-Methyl Adenines", Chem. Commun. 2017, 53, 10734-10737.

  22. 程靓,谢丽君,刘利,"N6‑甲基腺嘌呤的光化学脱甲基方法",中国专利,授权公告号:CN 106967068 B,申请日:2017年5月9日(授权日:2019年1月11日)。

  23. Cheng, L.; Charles, D.*; Breslow, R.* "Evidence for Tunneling in Base-catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions", Proc. Natl. Acad. Sci. USA 2015, 112, 4218-4220.

  24. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* "Deoxypolypeptides Bind and Cleave RNA", Proc. Natl. Acad. Sci. USA 2014, 111, 7920-7924.

  25. Cheng, L.; Abhilash, K. G.; Breslow, R.* "Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles", Proc. Natl. Acad. Sci. USA 2012, 109, 12884-12887.