比较免疫学；鱼类免疫学

071004-水生生物学

鱼类免疫学，比较免疫学，感染免疫学

2001-09--2005-01   中国科学院水生生物研究所   博士研究生
1998-09--2001-06   华中农业大学   硕士研究生

研究生

博士

   

2015-01~现在, 中国科学院水生生物研究所, 研究员
2009-04~2010-03,英国阿伯丁大学生命科学院, 访问学者
2008-06~2008-11,英国阿伯丁大学生命科学院, Honorary Research Fellow
2007-08~2015-01,中国科学院水生生物研究所, 副研究员
2005-02~2007-07,中国科学院水生生物研究所, 助理研究员

水产动物病害防控与免疫学

   

（1） 湖北省优秀博士论文, , 省级, 2006

[1] 昌鸣先, 方红, 武小曼, 杨媛媛. 一种抗菌蛋白、核苷酸、表达载体、抗菌产品及其应用. CN: CN114736282A, 2022-07-12.
[2] 昌鸣先, 武小曼, 曹璐. 核酸分子、表达载体及应用、抗菌药物和方法. CN: CN110195059A, 2019-09-03.
[3] 昌鸣先, 曹璐, 武小曼. 一种转录因子的核酸、蛋白质及其应用. CN: CN108690128A, 2018-10-23.
[4] 昌鸣先, 武小曼, 谢海侠, 李楠, 聂品. 一种抗菌蛋白及分离的核酸、抗菌药物和应用. CN: CN107540735A, 2018-01-05.

   

[1] Li, Peng Wei, Zhang, Jie, Chang, Ming Xian. Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus. REVIEWS IN AQUACULTURE. 2023, http://dx.doi.org/10.1111/raq.12844.
[2] Song, Yun Jie, Zhang, Jie, Xu, Zhen, Nie, Pin, Chang, Ming Xian. Liver X Receptor LXRα Promotes Grass Carp Reovirus Infection by Attenuating IRF3-CBP Interaction and Inhibiting RLR Antiviral Signaling. JOURNAL OF IMMUNOLOGY[J]. 2023, 211(6): 1006-1019, https://journals.aai.org/jimmunol/article/211/6/1006/265825.
[3] Song, Yun Jie, Zhang, Jie, Xiao, Jun, Feng, Hao, Xu, Zhen, Nie, Pin, Chang, Ming Xian. Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral Replication. MICROBIOLOGY SPECTRUM[J]. 2023, 11(4): http://dx.doi.org/10.1128/spectrum.01287-23.
[4] Zhang, Jie, Chang, Ming Xian. TBK1 Isoform Inhibits Grass Carp Reovirus Infection by Targeting the Degradation of Viral Nonstructural Proteins NS80 and NS38. JOURNAL OF IMMUNOLOGY[J]. 2023, 210(2): 191-203, [5] Chang, Ming Xian. Emerging mechanisms and functions of inflammasome complexes in teleost fish. FRONTIERS IN IMMUNOLOGY[J]. 2023, 14: http://dx.doi.org/10.3389/fimmu.2023.1065181.
[6] Yang, Yuan Yuan, Zheng, Si Yao, Fang, Hong, Wu, Xiao Man, Zhang, Jie, Chang, Ming Xian. Immunoprotective Effects of Two Histone H2A Variants in the Grass Carp Against Flavobacterium columnare Infection. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: [7] Fan Xiong, Lu Cao, Jing Xiong, Ya Fang Wu, Wen Shu Huang, Ming Xian Chang. Time-resolved and multi-tissue RNAseq provides new insights on the immune responses of European eels following infection with Aeromonas hydrophila. WATER BIOLOGY AND SECURITY[J]. 2022, 1(1): http://dx.doi.org/10.1016/j.watbs.2021.100003.
[8] Jie Zhang, Pengwei Li, Riye Lu, Songying Ouyang, Ming Xian Chang. Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459132/.
[9] Cao, Lu, Fang, Hong, Yan, Dong, Wu, Xiao Man, Zhang, Jie, Chang, Ming Xian. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. COMMUNICATIONS BIOLOGY[J]. 2022, 5(1): http://dx.doi.org/10.1038/s42003-022-03856-1.
[10] Fang, Hong, Yang, Yuan Yuan, Wu, Xiao Man, Zheng, Si Yao, Song, Yun Jie, Zhang, Jie, Chang, Ming Xian. Effects and Molecular Regulation Mechanisms of Salinity Stress on the Health and Disease Resistance of Grass Carp. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000813216700001.
[11] Zhang, Jie, Wu, Xiao Man, Fang, Qin, Bi, Yong Hong, Nie, Pin, Chang, Ming Xian. Grass Carp Reovirus Nonstructural Proteins Avoid Host Antiviral Immune Response by Targeting the RLR Signaling Pathway. JOURNAL OF IMMUNOLOGY[J]. 2022, 208(3): 707-719, http://dx.doi.org/10.4049/jimmunol.2100723.
[12] Lu Cao, Hong Fang, Dong Yan, Xiao Man Wu, Jie Zhang, Ming Xian Chang. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. COMMUNICATIONS BIOLOGY[J]. 2022, 5(1): 1-19, https://doaj.org/article/d7244aa2ff73418180e39b2aeeafad07.
[13] Li, Pengwei, Chang, Mingxian. Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(14): http://dx.doi.org/10.3390/ijms22147688.
[14] 昌鸣先. The zebrafish antiapoptotic protein BIRC2 (cIAP1) promotes Edwardsiella piscicida infection by inhibiting caspases and accumulating p53 in a p53 transcription-dependent and -independent manner. Front Immunol[J]. 2021, [15] 昌鸣先. 鱼类和哺乳类Bcl-2家族蛋白的研究进展. 水生生物学报. 2021, [16] Chang, Ming Xian. The negative regulation of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) signaling pathway in fish. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2021, 119: http://dx.doi.org/10.1016/j.dci.2021.104038.
[17] Zhitao Qi, Dong Yan, Lu Cao, Yang Xu, Mingxian Chang. Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: [18] Wu, Xiaoman, Xiong, Fan, Fang, Hong, Zhang, Jie, Chang, Mingxian. Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. ANTIBIOTICS-BASEL[J]. 2021, 10(7): http://dx.doi.org/10.3390/antibiotics10070861.
[19] Chang, Ming Xian, Xiong, Fan, Wu, Xiao Man, Hu, Yi Wei. The expanding and function of NLRC3 or NLRC3-like in teleost fish: Recent advances and novel insights. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2021, 114: http://dx.doi.org/10.1016/j.dci.2020.103859.
[20] Xiao Man Wu, Hong Fang, Jie Zhang, Yong Hong Bi, Ming Xian Chang. Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: [21] Xiaoman Wu, Fan Xiong, Hong Fang, Jie Zhang, Mingxian Chang. Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. ANTIBIOTICS[J]. 2021, 10(861): https://doaj.org/article/3de5fd17f869424facca15157fa77b67.
[22] Xiong, Fan, Cao, Lu, Wu, Xiao Man, Chang, Ming Xian. The function of zebrafish gpbar1 in antiviral response and lipid metabolism. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2021, 116: http://dx.doi.org/10.1016/j.dci.2020.103955.
[23] Chang, Ming Xian, Xiong, Fan. Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions. MOLECULES[J]. 2020, 25(22): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696511/.
[24] 武小曼, 方红, 聂品, 昌鸣先. 鱼类组蛋白核苷酸的多态性及其在杀鱼爱德华氏菌感染中的作用. 水产学报[J]. 2020, 44(9): 1525-1538, http://lib.cqvip.com/Qikan/Article/Detail?id=7102864359.
[25] Xiong, Fan, Xiong, Jing, Wu, Ya Fang, Cao, Lu, Huang, Wen Shu, Chang, Ming Xian. Time-resolved RNA-seq provided a new understanding of intestinal immune response of European eel (Anguilla anguilla) following infection with Aeromonas hydrophila. FISH & SHELLFISH IMMUNOLOGY[J]. 2020, 105: 297-309, http://dx.doi.org/10.1016/j.fsi.2020.06.059.
[26] Zhang, Jie, Wu, Xiao Man, Hu, Yi Wei, Chang, Ming Xian. A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3. FRONTIERS IN IMMUNOLOGY[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554342/.
[27] Nabi, Ghulam, McLaughlin, Richard W, Khan, Suliman, Hao, Yujiang, Chang, Ming Xian. Pneumonia in endangered aquatic mammals and the need for developing low-coverage vaccination for their management and conservation. ANIMAL HEALTH RESEARCH REVIEWSnull. 2020, 21(2): 122-130, http://dx.doi.org/10.1017/S1466252320000158.
[28] Fang, Hong, Wu, Xiao Man, Hu, Yi Wei, Song, Yun Jie, Zhang, Jie, Chang, Ming Xian. NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2020, 112: http://dx.doi.org/10.1016/j.dci.2020.103769.
[29] Wu, Xiao Man, Zhang, Jie, Li, Peng Wei, Hu, Yi Wei, Cao, Lu, Ouyang, Songying, Bi, Yong Hong, Nie, Pin, Chang, Ming Xian. NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. JOURNAL OF IMMUNOLOGY[J]. 2020, 204(8): 2216-2231, https://www.webofscience.com/wos/woscc/full-record/WOS:000525420100019.
[30] Wu, Xiao Man, Cao, Lu, Hu, Yi Wei, Chang, Ming Xian. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 94(1): 355-372, http://dx.doi.org/10.1016/j.fsi.2019.09.040.
[31] Zhen, Xiangkai, Zhou, Huan, Ding, Wei, Zhou, Biao, Xu, Xiaolong, Perulija, Vanja, Chen, ChunJung, Chang, MingXian, Choudhary, Muhammad Iqbal, Ouyang, Songying. Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages. PROTEIN & CELL[J]. 2019, 10(2): 131-136, http://lib.cqvip.com/Qikan/Article/Detail?id=7001589025.
[32] Chen, MingYue, Luo, Yi, Xu, JiangPing, Chang, MingXian, Liu, JingXia. Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. FRONTIERS IN IMMUNOLOGY[J]. 2019, 10(1): https://doaj.org/article/9fa587a2a75c4acf84664ea87fb7b4c8.
[33] Zhang, Chang, Zhang, Qin, Wang, Junya, Tian, Jiayin, Song, Yunjie, Xie, Haixia, Chang, Mingxian, Nie, Pin, Gao, Qian, Zou, Jun. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 94: 685-696, http://dx.doi.org/10.1016/j.fsi.2019.09.051.
[34] Zhang, Jie, Guo, Hong, Zhang, Fuxian, Chen, Qingxiu, Chang, Mingxian, Fang, Qin. NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A. VIROLOGY[J]. 2019, 529: 216-225, http://dx.doi.org/10.1016/j.virol.2019.01.029.
[35] Cao, Lu, Wu, Xiao Man, Nie, Pin, Chang, Ming Xian. The negative regulation of piscine CD44c in viral and bacterial infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2019, 96: 135-143, http://dx.doi.org/10.1016/j.dci.2019.03.005.
[36] Rahman K, Khan SU, Fahad S, Chang MX, Abbas A, Khan WU, Rahman L, Haq ZU, Nabi G, Khan D. Nano-biotechnology: a new approach to treat and prevent malaria. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2019, 14: 1401-1410, https://doaj.org/article/34d6a741946041e6af4161e40b69b706.
[37] Wu, Xiao Man, Cao, Lu, Nie, Pin, Chang, Ming Xian. Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2019, 101: 103455-, http://dx.doi.org/10.1016/j.dci.2019.103455.
[38] Jiang, Xinyu, Gao, Jingduo, Xue, Yujie, Qin, Yuting, Li, Xia, Sun, Zhaosheng, Xie, Haixia, Chang, Mingxian, Nie, Pin, Zou, Jun, Gao, Qian. Identification and expression analysis of IL-4/13 receptors in grass carp Ctenopharyngodon idella. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 87: 254-264, http://dx.doi.org/10.1016/j.fsi.2019.01.009.
[39] Bo Zhang, Weiwei Ye, Yangmiao Ye, Huan Zhou, Abdullah FUHSaeed, Jing Chen, Jinying Lin, Vanja Perculija, Qi Chen, ChunJung Chen, MingXian Chang, Muhammad lqbal Choudhary, Songying Ouyang. Structural insights into Cas13b-guided CRISPR RNA maturation and recognition. 细胞研究:英文版. 2018, 28(12): 1198-1201, http://lib.cqvip.com/Qikan/Article/Detail?id=6100228440.
[40] Zhang, Bo, Ye, Weiwei, Ye, Yangmiao, Zhou, Huan, Saeed, Abdullah F U H, Chen, Jing, Lin, Jinying, Perculija, Vanja, Chen, Qi, Chen, ChunJung, Chang, MingXian, Choudhary, Muhammad Iqbal, Ouyang, Songying. Structural insights into Cas13b-guided CRISPR RNA maturation and recognition. CELL RESEARCH[J]. 2018, 28(12): 1198-1201, http://lib.cqvip.com/Qikan/Article/Detail?id=6100228440.
[41] Wu, Xiao Man, Chen, Wen Qin, Hu, Yi Wei, Cao, Lu, Nie, Pin, Chang, Ming Xian. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. FRONTIERS IN IMMUNOLOGY[J]. 2018, 9(1): http://202.127.146.157/handle/2RYDP1HH/4900.
[42] Hu, Yi Wei, Zhang, Jie, Wu, Xiao Man, Cao, Lu, Nie, Pin, Chang, Ming Xian. TanK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. FRONTIERS IN IMMUNOLOGY[J]. 2018, 9(1): http://202.127.146.157/handle/2RYDP1HH/4620.
[43] 任诗思, 齐志涛, 昌鸣先. 大鲵短型肽聚糖识别蛋白PGRP-S的克隆及其功能研究. 水生生物学报[J]. 2018, 42(3): 473-479, http://lib.cqvip.com/Qikan/Article/Detail?id=675090225.
[44] Cao, Lu, Wu, Xiao Man, Hu, Yi Wei, Xue, Na Na, Nie, Pin, Chang, Ming Xian. The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2018, 84(1): 153-163, http://dx.doi.org/10.1016/j.dci.2018.02.013.
[45] Wang, Gai Ling, Wang, Ming Cheng, Zhang, Xiao Wen, Chang, Ming Xian, Xie, Hai Xia, Nie, Pin. Molecular cloning, biological effect, and tissue distribution of interleukin-8 protein in mandarin fish (Siniperca chuasti) upon Flavobacterium columnare infection. FISH & SHELLFISH IMMUNOLOGY[J]. 2017, 66(1): 112-119, http://dx.doi.org/10.1016/j.fsi.2017.05.016.
[46] Yi Wei Hu, Xiao Man Wu, Shi Si Ren, Lu Cao, Pin Nie, Ming Xian Chang. NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/06f4e46cccfd461ca82764b449a5b3aa.
[47] Wu, Xiao Man, Hu, Yi Wei, Xue, Na Na, Ren, Shi Si, Chen, Shan Nan, Nie, Pin, Chang, Ming Xian. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2017, 68(1): 58-68, http://dx.doi.org/10.1016/j.dci.2016.11.018.
[48] Chang, Ming Xian, Zhang, Jie. Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESnull. 2017, 18(7): https://doaj.org/article/67754e88ec6d45c4b6da0086c5210ef6.
[49] Qi, Zhitao, Ren, Shisi, Zhang, Qihuan, Zou, Jun, Xu, Qiaoqing, Wang, Zisheng, Qiao, Guo, Nie, Pin, Chang, Mingxian. Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus). ONCOTARGET[J]. 2017, 8(59): 99323-99335, http://dx.doi.org/10.18632/oncotarget.21470.
[50] Zhang Lin, Chen Wen Qin, Hu Yi Wei, Wu Xiao Man, Nie P, Chang Ming Xian. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. FISH AND SHELLFISH IMMUNOLOGY[J]. 2016, 54: 135-143, http://dx.doi.org/10.1016/j.fsi.2016.04.002.
[51] Zhang, Lin, Chen, Wen Qin, Hu, Yi Wei, Wu, Xiao Man, Nie, P, Chang, Ming Xian. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. FISH & SHELLFISH IMMUNOLOGY[J]. 2016, 54: 135-143, http://dx.doi.org/10.1016/j.fsi.2016.04.002.
[52] Peng Fei Zou, Ming Xian Chang, Ying Li, Na Na Xue, Jun Hua Li, Shan Nan Chen, Pin Nie. NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS. FISH AND SHELLFISH IMMUNOLOGY. 2016, 55: 173-185, http://dx.doi.org/10.1016/j.fsi.2016.05.031.
[53] Zou, Peng Fei, Chang, Ming Xian, Li, Ying, Xue, Na Na, Li, Jun Hua, Chen, Shan Nan, Nie, Pin. NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-kappa B, and also MDA5, RIG-I and MAVS. FISH & SHELLFISH IMMUNOLOGY[J]. 2016, 55(1): 173-185, http://ir.ihb.ac.cn/handle/342005/34652, http://www.irgrid.ac.cn/handle/1471x/6853845, http://ir.ihb.ac.cn/handle/342005/34653, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000381537000017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[54] Xu, Qiaoqing, Jiang, Yousheng, Wangkahart, Eakapol, Zou, Jun, Chang, Mingxian, Yang, Daiqin, Secombes, Chris J, Nie, Pin, Wang, Tiehui. Sequence and Expression Analysis of Interferon Regulatory Factor 10 (IRF10) in Three Diverse Teleost Fish Reveals Its Role in Antiviral Defense. PLOS ONE[J]. 2016, 11(1): https://doaj.org/article/0759b1f6835541dca8e718bf3f189540.
[55] Peng Fei Zou, Ming Xian Chang, Ying Li, Shu Huan Zhang, Jian Ping Fu, Shan Nan Chen, Pin Nie. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. FISH AND SHELLFISH IMMUNOLOGY. 2015, 43(1): 13-24, http://dx.doi.org/10.1016/j.fsi.2014.12.001.
[56] Fan, Yuding, Chang, Ming Xian, Ma, Jie, LaPatra, Scott E, Hu, Yi Wei, Huang, Lili, Nie, Pin, Zeng, Lingbing. Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus. VETERINARY RESEARCH[J]. 2015, 46(1): http://www.irgrid.ac.cn/handle/1471x/1012148.
[57] Chen, Wen Qin, Hu, Yi Wei, Zou, Peng Fei, Ren, Shi Si, Nie, Pin, Chang, Ming Xian. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2015, 49(1): 19-30, http://dx.doi.org/10.1016/j.dci.2014.10.017.
[58] Wang, Binliang, Wang, Xi, Hu, Yiwei, Chang, Mingxian, Bi, Yonghong, Hu, Zhengyu. The combined effects of UV-C radiation and H2O2 on Microcystis aeruginosa, a bloom-forming cyanobacterium. CHEMOSPHERE[J]. 2015, 141: 34-43, http://dx.doi.org/10.1016/j.chemosphere.2015.06.020.
[59] Zou, Peng Fei, Chang, Ming Xian, Li, Ying, Zhang, Shu Huan, Fu, Jian Ping, Chen, Shan Nan, Nie, Pin. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. FISH & SHELLFISH IMMUNOLOGY[J]. 2015, 43(1): 13-24, http://dx.doi.org/10.1016/j.fsi.2014.12.001.
[60] Zou, Peng Fei, Chang, Ming Xian, Xue, Na Na, Liu, Xue Qin, Li, Jun Hua, Fu, Jian Ping, Chen, Shan Nan, Nie, Pin. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. IMMUNOLOGY[J]. 2014, 141(2): 192-202, http://www.irgrid.ac.cn/handle/1471x/850901.
[61] Xu Qiaoqing, Yang Daiqin, Tuo Rui, Wan Jing, Chang Mingxian, Nie Pin. Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel (Monopterus albus). ZOOLOGICAL RESEARCH[J]. 2014, 35(5): 380-388,  https://explore.openaire.eu/search/publication?articleId=od_______267::bbad22f6464da3de9d97d5acfcaf573e.
[62] Hu, Yi Wei, Yu, Zhang Long, Xue, Na Na, Nie, Pin, Chang, Ming Xian. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2014, 46(2): 323-332, http://dx.doi.org/10.1016/j.dci.2014.05.007.
[63] Li, Jun Hua, Yu, Zhang Long, Xue, Na Na, Zou, Peng Fei, Hu, Jing Yu, Nie, P, Chang, Ming Xian. Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2014, 42(2): 244-255, http://dx.doi.org/10.1016/j.dci.2013.09.014.
[64] Yu, Zhang Long, Li, Jun Hua, Xue, Na Na, Nie, Pin, Chang, Ming Xian. Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2014, 47(2): 264-274, http://dx.doi.org/10.1016/j.dci.2014.08.006.
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[68] Chang, MingXian, Zou, Jun, Nie, Pin, Huang, Bei, Yu, Zhanglong, Collet, Bertrand, Secombes, Chris J. Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection. PLOS PATHOGENS[J]. 2013, 9(11): https://doaj.org/article/6cb48802b1d5448582bd6be4ef3ec3d9.
[69] Wang, Gailing, Li, Junhua, Zou, Pengfei, Xie, Haixia, Huang, Bei, Nie, Pin, Chang, Mingxian. Expression pattern, promoter activity and bactericidal property of beta-defensin from the mandarin fish Siniperca chuatsi. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 33(3): 522-531, http://dx.doi.org/10.1016/j.fsi.2012.06.003.
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[71] Zhang, Shu H, Zhu, Dan D, Chang, Ming X, Zhao, Qin P, Jiao, Ran, Huang, Bei, Fu, Jian P, Liu, Zhi X, Nie, P. Three goose-type lysozymes in the gastropod Oncomelania hupensis: cDNA sequences and lytic activity of recombinant proteins. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2012, 36(1): 241-246, http://dx.doi.org/10.1016/j.dci.2011.06.014.
[72] Guo, H Z, Zou, P F, Fu, J P, Guo, Z, Zhu, B K, Nie, P, Chang, M X. Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. FISH & SHELLFISH IMMUNOLOGY[J]. 2011, 30(2): 515-524, http://dx.doi.org/10.1016/j.fsi.2010.11.027.
[73] 昌鸣先. Expression and functional characterization of the RIG-1 like receptors MDA5 and LGP2 in rainbow trout Oncorhynchus mykiss. Journal of virology. 2011, [74] Chang, Mingxian, Wang, Tiehui, Nie, Pin, Zou, Jun, Secombes, Christopher J. Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. FISH & SHELLFISH IMMUNOLOGY[J]. 2011, 30(1): 118-127, http://dx.doi.org/10.1016/j.fsi.2010.09.014.
[75] Wei, You Chuan, Pan, Ting Shuang, Chang, Ming Xian, Huang, Bei, Xu, Zhen, Luo, Ting Rong, Nie, P. Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY[J]. 2011, 141(3-4): 173-182, http://dx.doi.org/10.1016/j.vetimm.2011.02.016.
[76] 齐志涛, 张启焕, 王资生, 王爱民, 黄贝, 昌鸣先, 聂品. 非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析（英文）. 动物学研究[J]. 2011, http://www.irgrid.ac.cn/handle/1471x/291348.
[77] QI ZhiTao, ZHANG QiHuan, WANG ZiSheng, WANG AiMin, HUANG Bei, CHANG MingXian, NIE Pin. 非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析. 动物学研究[J]. 2011, 32(4): 371-378, http://lib.cqvip.com/Qikan/Article/Detail?id=38923472.
[78] Chang, Mingxian, Collet, Bertrand, Nie, Pin, Lester, Katherine, Campbell, Scott, Secombes, Christopher J, Zou, Jun. Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss). JOURNAL OF VIROLOGY[J]. 2011, 85(16): 8403-8412, http://dx.doi.org/10.1128/JVI.00445-10.
[79] 齐志涛, 张启焕, 王资生, 王爱民, 黄贝, 昌鸣先, 聂品. 非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析. 动物学研究[J]. 2011, 32(4): 371-378, http://lib.cqvip.com/Qikan/Article/Detail?id=38923472.
[80] 郭慧芝, 付建平, 昌鸣先, 郭政, 朱邦科, 聂品. 中华绒螯蟹铁蛋白基因的克隆及表达分析. 水产学报[J]. 2010, 725-732, http://lib.cqvip.com/Qikan/Article/Detail?id=34288801.
[81] 许巧情, 昌鸣先, 肖凡书, 李楠, 聂品. 草鱼干扰素调节因子5的表达研究. 水生生物学报[J]. 2010, 34(6): 1206-1210, http://lib.cqvip.com/Qikan/Article/Detail?id=36156883.
[82] 齐志涛, 高谦, 黄贝, 昌鸣先, 聂品. 非洲爪蟾短型肽聚糖识别蛋白基因的克隆与鉴定. 水生生物学报[J]. 2010, 34(5): 922-926, http://lib.cqvip.com/Qikan/Article/Detail?id=35353477.
[83] Zou, Jun, Chang, Mingxian, Nie, Pin, Secombes, Chris J. Origin and evolution of the RIG-I like RNA helicase gene family. BMC EVOLUTIONARY BIOLOGY[J]. 2009, 9(1): 85-85, https://doaj.org/article/b501e9249e0a48718cc4e207450967d5.
[84] Wei, Lili, Sun, Baojian, Chang, MingXian, Liu, Yi, Nie, Pin. Effects of cyanobacterial toxin microcystin-LR on the transcription levels of immune-related genes in grass carp Ctenopharyngodon idella. ENVIRONMENTAL BIOLOGY OF FISHES[J]. 2009, 85(3): 231-238, http://dx.doi.org/10.1007/s10641-009-9488-1.
[85] 高原, 昌鸣先, 聂品. 鳜肿瘤坏死因子相关的凋亡诱导配体Trail基因的原核表达. 水生生物学报[J]. 2009, 33(4): 762-766, http://lib.cqvip.com/Qikan/Article/Detail?id=30970544.
[86] Chang, Mingxian, Nie, Pin, Collet, Bertrand, Secombes, Christopher J, Zou, Jun. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. IMMUNOGENETICS[J]. 2009, 61(4): 315-325, http://dx.doi.org/10.1007/s00251-009-0366-y.
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（ 1 ） 鱼类模式识别受体在信号传导通路及免疫反应中的作用, 主持, 国家级, 2009-01--2012-12
（ 2 ） 淡水池塘集约化养殖的基础科学问题研究, 参与, 国家级, 2009-01--2013-12
（ 3 ） 草鱼肽聚糖识别蛋白不同剪接异构体在抗菌及炎症反应中的作用, 主持, 国家级, 2012-01--2015-12
（ 4 ） 斑马鱼胞内模式识别受体NLRC5在抗感染中的作用及其机制, 主持, 国家级, 2014-01--2017-12
（ 5 ） 斑马鱼CD44在胸腺T细胞发育以及免疫调节中的作用及其机制, 主持, 国家级, 2017-01--2020-12
（ 6 ） 鱼类组蛋白H2A基因的核苷酸多态性及其在病原感染中的作 用, 主持, 国家级, 2019-01--2022-12

（1）鱼类NOD1/RIP2信号在幼鱼发育以及免疫反应中的调控作用及其机制   2018年鱼类分子免疫学前沿论坛   2018-10-15
（2）鱼类NLR和RLR受体的相互调控对免疫反应的影响   2018水生动物免疫学研讨会   2018-06-13
（3）鱼类模式识别受体在信号传导通路以及免疫反应中的作用   中国水产学会鱼病专业委员会学术讨论会   2013-11-05
（4）Activation of intracellular antiviral immune responses by antibacterial pattern recognition receptor NOD1   第一届鱼贝免疫学国际会议   2013-06-25

已指导学生

薛娜娜  硕士研究生  430139-生物工程  

余章龙  硕士研究生  071004-水生生物学  

任诗思  硕士研究生  071004-水生生物学  

胡祎玮  博士研究生  071004-水生生物学  

现指导学生

武小曼  博士研究生  090801-水产养殖  

方红  硕士研究生  071004-水生生物学  

李鹏伟  博士研究生  090801-水产养殖  

曹璐  博士研究生  071004-水生生物学