基本信息
张丽娟  女  博导  中国科学院深圳先进技术研究院
电子邮件: lj.zhang@siat.ac.cn
通信地址: 中国科学院深圳先进技术研究院
邮政编码: 518055

研究领域

使用包括DTI, MRS, RS-fMRI, SWI, CESST 等功能磁共振和定量磁共振技术, 从结构, 功能, 代谢等方面深入探讨大脑发育, 衰老, 肿瘤, 缺血, 退行性改变等生理及病理机制.

招生信息

模式识别与智能系统

生物医学工程

生物化学与分子生物学

影像医学与核医学

磁共振成像

神经科学

教育背景

1995-07--1998-07   中国解放军总医院研究生院   硕士
1990-07--1995-07   哈尔滨医科大学   医学学士

工作经历

2013-10~今, 中国科学院深圳先进技术研究院, 研究员
2010-10~2013-10,中国科学院深圳先进技术研究院, 副研究员
2010-01~2010-10,Mount Sinai Medical College, 助理教授
2007-09~2009-12,Weill Cornell Medical College, 助理研究员
2002-01~2007-08,Weill Cornell Medical College, 博士后
1998-08~2002-01,南方医院, 放射科执业医师

教授课程

医学影像学基础

专利与奖励


专利成果
[1] 张丽娟, 邹超, 周洋, 蔡思琦. 一种基于肌酸化学交换饱和转移成像的测温方法及装置. 202110540092.2, 2022-05-18.

[2] 周诗辉, 张丽娟, 史彩云, 邹超. 磁化率加权图谱的构建方法和装置. CN202210215371.6, 2022-03-07.

[3] 周诗辉, 张丽娟, 史彩云, 蔡思琦, 邹超. 血管反应性的评价方法、装置、电子设备及存储介质. CN202111248385.X, 2021-10-26.

[4] 张丽娟, 蔡思琦, 孟锐, 姜春香, 隆晓菁. 脑胶质瘤术前分级方法、装置、设备及存储介质. CN: CN108710890A, 2018-10-26.

[5] 史彩云, 谢国喜, 张丽娟, 张晓勇, 刘新, 郑海荣. 动态磁共振图像成像方法和系统. CN: CN104248437B, 2017-04-12.

[6] 周武, 张丽娟, 梁长虹, 黄美萍, 庄建. 一种CT影像体表提取方法及系统. CN: CN106127750A, 2016-11-16.

[7] 周武, 张丽娟, 梁长虹, 黄美萍, 庄建. 一种外科手术中CT影像体表人工标记自动提取方法. CN: CN106127753A, 2016-11-16.

[8] 史彩云, 谢国喜, 张晓咏, 张丽娟, 刘新. 脑功能磁共振成像方法和系统. CN: CN104323776B, 2016-11-16.

[9] 周武, 张丽娟, 梁长虹, 黄美萍, 庄建. 一种X光图像中人工圆形标记的自动检测和定位方法. CN: CN106097362A, 2016-11-09.

[10] 隆晓菁, 张丽娟, 姜春香, 刘新, 郑海荣. 一种用于脑部MRI图像分类的图像处理方法. CN: CN105701499A, 2016-06-22.

[11] 周武, 程文强, 李鹏, 张丽娟. 一种医学影像中腹部骨骼分割方法及系统. CN: CN105701795A, 2016-06-22.

[12] 隆晓菁, 张丽娟, 姜春香, 安一硕, 刘新, 郑海荣. 医学图像分类方法和系统. CN: CN104573742A, 2015-04-29.

[13] 周武, 张丽娟, 谢耀钦. 基于梯度直方图分布匹配确定三维旋转量的方法和系统. CN: CN104537640A, 2015-04-22.

[14] 周武, 张丽娟, 谢耀钦. 三维图像配准方法和系统. CN: CN104537638A, 2015-04-22.

[15] 史彩云, 张丽娟, 谢国喜, 张晓咏, 刘新. 一种磁共振大脑血氧水平测量方法. CN: CN104490393A, 2015-04-08.

[16] 姜春香, 张丽娟, 隆晓菁, 刘新, 郑海荣. 大脑异常参数的提取方法和系统. CN: CN104346530A, 2015-02-11.

[17] 史彩云, 谢国喜, 张丽娟, 刘新, 郑海荣. 功能磁共振成像方法和装置. CN: CN104337517A, 2015-02-11.

[18] 隆晓菁, 张丽娟, 姜春香, 刘新, 郑海荣. 用于脑部医学图像分类的图像预处理方法和系统. CN: CN104281856A, 2015-01-14.

[19] 丁玉琼, 黄文慧, 钟耀祖, 张丽娟, 刘新, 郑海荣. 磁共振弹性成像精确度检测方法. CN: CN102920457A, 2013-02-13.

[20] 钟耀祖, 朱燕杰, 刘新, 郑海荣, 张丽娟. 磁共振弹性成像三维可视化方法及系统. CN: CN102631196A, 2012-08-15.

[21] 隆晓菁, 潮毅, 邱本胜, 张丽娟, 刘新, 郑海荣. 图像分析方法和系统. CN: CN102521832A, 2012-06-27.

[22] 张丽娟, 黄文慧, 钟耀祖, 刘新, 郑海荣. 基于弹性成像的图像处理方法及系统. CN: CN102521823A, 2012-06-27.

[23] 郑海荣, 张丽娟, 刘新, 钟耀祖, 黄文慧, 曾成志, 蔡葳蕤. 激励装置及其系统. CN: CN202198595U, 2012-04-25.

发表论文


发表论文
(1) Cerebrovascular Dysregulation in Patients with Glioma Assessed with Time-shifted BOLD fMRI., Radiology, 2022, 通讯作者
(2) Prediction of Microvascular Invasion of Hepatocellular Carcinoma Based on Contrast-Enhanced MR and 3D Convolutional Neural Networks, FRONTIERS IN ONCOLOGY, 2021, 第 4 作者
(3) Hemisphere-Specific Functional Remodeling and Its Relevance to Tumor Malignancy of Cerebral Glioma Based on Resting-State Functional Network Analysis, FRONTIERS IN NEUROSCIENCE, 2021, 通讯作者
(4) High spatial resolution BOLD fMRI using simultaneous multislice excitation with echo-shifting gradient echo at 7 Tesla, MAGNETIC RESONANCE IMAGING, 2020, 第11作者
(5) SUPER-RESOLUTION AND SELF-ATTENTION WITH GENERATIVE ADVERSARIAL NETWORK FOR IMPROVING MALIGNANCY CHARACTERIZATION OF HEPATOCELLULAR CARCINOMA, 2020 IEEE 17TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2020), 2020, 第 3 作者
(6) EVALUATION OF BRAIN TUMOR IN SMALL ANIMALS USING PLANE WAVE-BASED POWER DOPPLER IMAGING, ULTRASOUND IN MEDICINE AND BIOLOGY, 2019, 第 10 作者
(7) Grading of hepatocellular carcinoma based on diffusion weighted images with multiple b-values using convolutional neural networks, MEDICAL PHYSICS, 2019, 第 4 作者
(8) Ischemic Stroke in Pontine and Corona Radiata: Location Specific Impairment of Neural Network Investigated With Resting State fMRI, FRONTIERS IN NEUROLOGY, 2019, 通讯作者
(9) High Spatial Resolution BOLD fMRI Using Simultaneous Multislice Excitation with Echo-Shifting Gradient Echo at 7 Tesla, MagneticResonanceImaging, 2018, 第 9 作者
(10) Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry, Behavioural Neurology, 2018, 通讯作者
(11) MALIGNANCY CHARACTERIZATION OF HEPATOCELLULAR CARCINOMA USING HYBRID TEXTURE AND DEEP FEATURES, 2017 24TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP), 2017, 第 2 作者
(12) Prediction and classification of Alzheimer disease based on quantification of MRI deformation., PLOS ONE, 2017, 通讯作者
(13) Malignancy Characterization of Hepatocellular Carcinomas Based on Texture Analysis of Contrast-Enhanced MR Images, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2017, 通讯作者
(14) 年龄对大脑结构偏侧性的影响研究, Age Effect on Structural Hemispheric Asymmetry Revealed by Multivariate Model, Journal of Integration Technology, 2016, 第 2 作者
(15) Diurnal Variations in Neural Activity of Healthy Human Brain Decoded with Resting-State Blood Oxygen Level Dependent fMRI, FRONTIERS IN HUMAN NEUROSCIENCE, 2016, 通讯作者
(16) Noncontrast MRA of pedal arteries in type II diabetes: effect of disease load on vessel visibility., ACADEMIC RADIOLOGY, 2015, 第 1 作者
(17) High resolution three dimensional intracranial arterial wall imaging at 3 T using T1 weighted SPACE, MAGNETIC RESONANCE IMAGING, 2015, 第 4 作者
(18) High spatiotemporal resolution fMRI using partial separability model, BIO-MEDICAL MATERIALS AND ENGINEERING, 2015, 第 6 作者
(19) Fluctuation amplitude and local synchronization of brain activity in the ultra-low frequency band: An fMRI investigation of continuous feedback of finger force, BRAIN RESEARCH, 2015, 第 2 作者
(20) Discerning Mild Cognitive Impairment and Alzheimer Disease from Normal Aging: Morphologic Characterization Based on Univariate and Multivariate Models, ACADEMIC RADIOLOGY, 2014, 通讯作者
(21) Diurnal Microstructural variations of Healthy Adult Brain revealed by Diffusion tensor imaging., PLOS one, 2014, 通讯作者
(22) Diurnal Microstructural Variations in Healthy Adult Brain Revealed by Diffusion Tensor Imaging, PLOS ONE, 2014, 通讯作者
(23) A Novel Technique for Prealignment in Multimodality Medical Image Registration, BIOMED RESEARCH INTERNATIONAL, 2014, 通讯作者
(24) A novel technique for prealignment in multimodality medical imaging registration, Biomed Research International, 2014, 通讯作者
(25) Distinct Laterality Alterations Distinguish Mild Cognitive Impairment and Alzheimer's Disease From Healthy Aging: Statistical Parametric Mapping With High Resolution MRI, HUMAN BRAIN MAPPING, 2013, 通讯作者
(26) Lung Cancer Associated With Cystic Airspaces, AMERICAN JOURNAL OF ROENTGENOLOGY, 2012, 第 3 作者
(27) Healthy Aging: An Automatic Analysis of Global and Regional Morphological Alterations of Human Brain, ACADEMIC RADIOLOGY, 2012, 通讯作者
(28) Correlation of Volume Transfer Coefficient K trans with Histopathologic Grades of Gliomas, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2012, 第 2 作者
(29) Internal Growth of Non-solid Nodules: Radiologic-Pathologic Correlation., Radiology, 2012, 第 1 作者
(30) Transmural Heterogeneity of Left Ventricular Myocardium Remodeling in Postinfarct Porcine Model Revealed by MR Diffusion Tensor Imaging, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2011, 第 2 作者
(31) Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics, MICRO & NANO LETTERS, 2011, 第 9 作者
(32) CT- and computer-based features of small hamartomas, CLINICAL IMAGING, 2011, 第 6 作者
(33) Variations in Vascular Distribution in Small Lung Cancer., Lung Cancer, 2010, 第 1 作者
(34) Zone of Transition: A Potential Source of Error in Tumor Volume Estimation, RADIOLOGY, 2010, 第 1 作者
(35) Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications, LUNG CANCER, 2009, 第 8 作者
(36) The Use of Genetic Markers to Identify Lung Cancer in Fine Needle Aspiration Samples, CLINICAL CANCER RESEARCH, 2008, 第 5 作者
(37) Diffusion changes in patients with systemic lupus erythematosus, MAGNETIC RESONANCE IMAGING, 2007, 第 1 作者
(38) Distribution of microstructural damage in the brains of professional boxers: A diffusion MRI study, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2006, 第 3 作者
(39) Diffusion anisotropy changes in the brains of professional boxers, AMERICAN JOURNAL OF NEURORADIOLOGY, 2006, 
(40) Creatine in HD is safe, tolerable, elevates brain NAA, and reduces serum 8OH2’dG., Neurology, 2006, 通讯作者
(41) The MR Quantitation of Volume and Diffusion changes in the Developing Brain., AJNR, 2005, 第 1 作者
(42) Increased diffusion in the brain of professional boxers: A preclinical sign of traumatic brain injury?, AMERICAN JOURNAL OF NEURORADIOLOGY, 2003, 
(43) FLAIR signature of Amyotrophic Lateral Sclerosis, JMRI, 2003, 第 1 作者
(44) Discerning mild cognitive impairment and Alzheimer disease from normal aging: morphologic characterization based on univaritate and multivariate models, 
(45) Distinct Laterality Alterations Distinguish Mild Cognitive Impairment and Alzheimer's Disease From Healthy Aging: Statistical Parametric Mapping With High Resolution MRI, HUMAN BRAIN MAPPING, 
发表著作
(1) 临床磁共振神经影像:弥散,灌注及波谱, Clinical MR Neuroimaging:Diffusion, Perfusion and Spectroscopy, Cambridge University Press, 2004-07, 第 5 作者
(2) 磁共振功能成像临床应用, Clinical Application of Functional MRI, 人民军医出版社, 2012-06, 第 5 作者

科研活动

学术会员
1. International Society for Magnetic Resonance in Medicine (ISMRM) 
2.  Radiological Society of North America (RSNA) 
3.  Organization of Human Brain Mapping (OHBM)
学术服务
1.  国际会议文章审稿人: ISMRM, OHBM, 生物医学工程与信息学会 BMEI 
2. 期刊文章审稿人: Neuroimage, AJNR, Neuroradiology,Frontiers of Human Neuroscience
3. 项目评审:  国家自然科学基金面上、青年、优青项目,广东省自然科学基金,深圳市科技创新委员会项目评阅人.

科研项目
( 1 ) 缺血性脑卒中氧代偿机制研究, 负责人, 国家任务, 2014-01--2017-12
( 2 ) 磁共振热成像引导肝癌射频消融的关键问题研究, 参与, 国家任务, 2014-01--2017-12
( 3 ) 胶质瘤对脑功能影响的多模判定, 负责人, 国家任务, 2015-01--2019-08
( 4 ) 多核素同步一体化肿瘤分子成像仪器研制, 负责人, 国家任务, 2017-01--2021-12
( 5 ) 缺血性脑卒中静脉响应时空异质性研究, 负责人, 地方任务, 2019-09--2021-09
( 6 ) 基于脑血管自主调节的胶质瘤临床异质性层析, 负责人, 地方任务, 2021-01--2023-12
( 7 ) 大脑肌酸CEST温度成像技术与胶质瘤诊疗应用研究, 负责人, 国家任务, 2022-01--2024-12
参与会议
(1)Alte red Dynamic Functional Connectivity in Subjects with Cerebral Glioma   2021-05-15
(2)Alte red systeminc fluctuation of blood flow in brains with glioma: an investigation with temporal shift resting-state fMRI   2020-08-10
(3)Hemisphereic specification of remote effect of cerebral glioma on white matter connectivity   2019-05-11
(4)Quantitative texture feature to predict Microscopic portal vein invasion of Hepatocellular carcinoma with contrast-enhanced MR images   2017-05-19
(5)Functional diaschisis of ischemic stroke investigated with R2' quantification   OHBM   Lijuan Zhang, Xiaojing Long, Chunxiang Jiang, Li Yi, Xiaoma Liu   2016-06-25
(6)Texture analysis of hepatocellular carcinomas in Contrast-enhanced MR images for malignant differentiation   2016-05-09
(7)Detection of imaging biomarkers between MCI converters and nonconverters using three different methods.   Xiaojing Long   2015-06-13
(8)Remote effect of ischemic stroke investigated with fMRI   Lijuan Zhang   2015-05-30
(9)Global Effect of Focal Ischemic Stroke Revealed by Regional Homogeneity with BOLD fMRI.   32. Lijuan Zhang,Xiaojing Long,Yanjun Diao, Li Yi,Chunxiang Jian   2014-05-11
(10)Gender-Specific Anatomical Alterations of Hemispheric Asymmetry during Healthy Aging of Human Brain   26. Xiaojing Long, Chunxiang Jiang, Weiqi Liao, and Lijuan Zhang*   2013-04-19
(11)Mapping the diurnal alterations of oxygen extraction fraction in basal ganglia and thalami.    Lijuan Zhang, Chunxiang Jiang, Weiqi Liao, Xiaojing Long, Mengyue He   2012-06-09
(12)Non-Contrast MRA of Pedal Arteries in Type II Diabetes: Effect of Disease Load on Vessel Visibility   Lijuan Zhang, Na Zhang, Weiqi Liao, Xin Liu, Yang Liu, Dehe Weng, Renate Jerecic, Fei Feng, Zhaoyang Fan, and Debiao Li   2012-05-08
(13)Transmural Heterogeneity of Left Ventricular Myocardium Remodeling in Postinfarct Porcine Model Revealed by MR Diffusion Tensor Imaging.   13. Yin Wu, Li-Juan Zhang,Chao Zou, Hung-Fat Tse, Ed X. Wu.   2011-05-09
(14)Effects of Artery Input Function on Dynamic Contrast Enhanced MRI for Determining Grades of Gliomas.   12. N. Zhang1, L. Zhang1, X. Liu1, H. Zheng1, J. Carpenter2, and B. L. Hou   2011-05-09
(15)Diffusion changes in patients with systemic lupus erythematosus   6. Lijuan Zhang, Melanie Harrison, Linda A. Heier, Robert D. Zimmerman, Michael Lockshin, Aziz M. Ulug   2005-05-13
(16)Distribution of microstructural damage in the brains of professional boxers: a diffusion MRI study   7. M. Chappell, A.M.Ulu?, L. Zhang, M. Heitger, B. Jordan, R.D.Zimmerman, R.Watts   2005-05-13
(17)Diffusion anisotropy changes in the brains of the professional boxers.   Lijuan Zhang, Linda A. Heier, Robert D. Zimmerman, Berry Jordan, Aziz M. Ulu?.    2005-05-13
(18)Diffusion and MRS Study of Huntington1s Disease   5. Lijuan Zhang, Michael T. Lin, Flint Beal, Aziz M. Ulug   2004-05-14
(19) Quantitative Evidence of Localized Brain Damage in Professional Boxers Using Diffusion Tensor Imaging   4. BM Hentel, L Zhang, CE Johnson, BD Jordan, AM Ulug, RD Zimmerman   2003-10-24
(20)Diffusion and volume changes during brain development   2. Lijuan Zhang, Kathleen M. Thomas, Matthew C. Davidson, BJ Casey, Linda A. Heier, Aziz M. Ulug.    2003-07-11
(21)Quantitative diffusion tensor imaging evidence of brain damage in professional boxers.   8. Lijuan Zhang, Lisa D. Ravdin, Norman Relkin, Robert D. Zimmerman, Aziz M. Ulug   2003-07-11
(22)Use of FLAIR imaging in diagnosing Amyotrophic Lateral Sclerosis   3. Lijuan Zhang, Robert D. Zimmerman, Michael Lin, Michael Rubin, M. Flint Beal, Aziz M. Ulug.   2003-07-11
(23)Experimental study ofmyocardial perfusion with contrast enhanced fast MRI.    中放   1. Lijuan Zhang, Youquan Cai, Jukun Chen, Yuangui Gao.    1998-09-28

合作情况

天坛医院,复旦大学附属华山医院,北京大学深圳医院, 香港大学滨海医院

指导学生

已指导学生

蔡思琦  硕士研究生  085208-电子与通信工程  

孟锐  硕士研究生  071010-生物化学与分子生物学  

周诗辉  硕士研究生  085210-控制工程  

现指导学生

姜春香  博士研究生  071010-生物化学与分子生物学  

蔡思琦  博士研究生  081104-模式识别与智能系统  

蒲尧  硕士研究生  085400-电子信息