Xian-En Zhang

Telephone: 8610-64888148
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China 

Postcode: 100101

Research Areas


Pathogenic biology


Sept 1991-Jul 1995, Institute of Microbiology, Chinese Academy of Sciences, Doctor of science degree

Sept 1982-Jul 1985, Wuhan Institute of Virology, Chinese Academy of Sciences, Master of science degree

Sept 1979-Jul 1982, Hubei University, BS degree


Work Experience

Jul 1985-Dec 1988,Wuhan Institute of Virology, Chinese Academy of Sciences, Research Assistant

Jan 1989-Jan 1993, Wuhan Institute of Virology, Chinese Academy of Sciences,  Associate Research Fellow

Jan 1993-present, Wuhan Institute of Virology, Chinese Academy of Sciences, Research Fellow

May 2013-present, Institute of Biophysics, Chinese  Academy of Sciences, Research Fellow


Research Assistant 


Research Assistant 


Research Assistant 

Honors & Distinctions

Honorary doctor of science degree from University of Alberta in 2015


(1) Sensing of biomolecular interactions using fluorescence complementing systems in living cells, Biosensors and Bioelectronics, 2016
(2) Three-Fragment Fluorescence Complementation Coupled with Photoactivated Localization Microscopy for Nanoscale Imaging of Ternary Complexes, ACS nano, 2016
(3) Real-Time Imaging of Single HIV-1 Disassembly with Multicolor Viral Particles, ACS Nano, 2016
(4) An automated approach for global identification of sRNA-encoding regions in RNA-Seq data from Mycobacterium tuberculosis, Acta Biochim Biophys Sin, 2016
(5) Self-Assembly of Ferritin Nanoparticles into an Enzyme Nanocomposite with Tunable Size for Ultrasensitive Immunoassay, ACS nano, 2015
(6) Novel near-infrared BiFC systems from a bacterial phytochrome for imaging protein interactions and drug evaluation under physiological conditions., Biomaterials, 2015
(7) Sensing of biomolecular interactions using fluorescence complementing systems in living cells, Biosensors and Bioelectronics, 2015
(8) A S-layer Protein of Bacillus anthracis as a Building Block for Functional Protein Arrays by in vitro Self-assembly, small, 2015
(9) Mycobacterium tuberculosis proteome microarray for global studies of protein function and immunogenicity. , Cell reports , 2014
(10) Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. , Nature genetics , 2013
(11) 2. MutL associates with Escherichia coli RecA and inhibits its ATPase activity, Archives of Biochemistry and Biophysics, 2012
(12) The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage, Nucleic Acid Research, 2011
(13) A Sir2-like protein participates in mycobacterial NHEJ,  Plos One, 2011
(14) A simplified method for reconstituting active E.coli DNA polymerase III, Protein and cell, 2011
(15) Crystal structure of DNA polymerase III beta sliding clamp from Mycobacterium tuberculosis, Biophysical Research Communication, 2011
(16) Crystal structure of YdaL, a stand-alone small MutS-related protein from E.coli, Journal of Structural Biology, 2011
(17) MutS-mediated enrichment of mutated DNA produced by directed evolution in vitro, World Journal of Microbiology and Biotechnology, 2011
(18) Quantitative Proteomic Analysis of Tumor Reversion in Multiple Myeloma Cells, J Proteome Res, 2011
(19) Proteomics: addressing the challenges of multiple myeloma, Acta Biochim Biophys Sin (Shanghai), 2011
(20) Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for inactivation of anti-tuberculosis drugs, Molecular Microbiology, 2011
(21) Proteomic analysis of multiple myeloma: Current status and future perspectives. Proteomics Clin, Appl, 2011
(22) Quantum dot-aptamer nanoprobes for recognizing and labeling influenza A virus particles., Nanoscale, 2011
(23) DNA probe functionalized QCM biosensor based on gold nanoparticle amplification for Bacillus anthracis detection., Biosens Bioelectron, 2011
(24) Colorimetric detection of melamine in complex matrices based on cysteamine-modified gold nanoparticles., Analyst, 2011
(25) New regulatory mechanisms for the intracellular localization and trafficking of influenza A virus NS1 protein revealed by comparative analysis of A/PR/8/34 and A/Sydney/5/97., J Gen Virol, 2010
(26) Integration of a fluorescent molecular biosensor into self-assembled protein nanowires: a large sensitivity enhancement., Angew Chem Int Ed Engl, 2010
(27) Biochemical characterization and mutational improvement of a thermophilic esterase from Sulfolobus solfataricus P2., Biotechnol Lett, 2010
(28) CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY., Mol Microbiol, 2010
(29) Functional analyses of Escherichia coli MutS-beta clamp interaction in vitro and in vivo., Curr Microbiol, 2010
(30) An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing., Biosens Bioelectron, 2010
(31) Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation., Small, 2010
(32) Mutations found in the pncA gene of Mycobacterium tuberculosis in clinical pyrazinamide-resistant isolates from a local region of China., J Int Med Res, 2009
(33) Detection of B. anthracis spores and vegetative cells with the same monoclonal antibodies., PLoS One, 2009
(34) Construction of bifunctional phage display for biological analysis and immunoassay., Anal Biochem, 2009
(35) Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci., Virology., 2009
(36) Seeding-induced self-assembling protein nanowires dramatically increase the sensitivity of immunoassays., Nano Lett, 2009
(37) Imaging Viral Behaviors in Mammalian Cells with Self-Assembled Capsid-Quantum-Dot Hybrid Particles., Small, 2009
(38) Development of a universal phosphorylated peptide-binding protein for simultaneous assay of kinases., Biosens Bioelectron, 2009
(39) The tegument protein UL94 of human cytomegalovirus as a binding partner for tegument protein pp28 identified by intracellular imaging., Virology, 2009
(40) Label-free detection of B. anthracis spores using a surface plasmon resonance biosensor., Analyst., 2009
(41) On-chip ligation of multiplexing probe-pairs for identifying point mutations out of dense SNP loci., Biosens Bioelectron, 2009
(42) Imaging and characterizing influenza A virus mRNA transport in living cells., Nucleic Acids Res., 2008
(43) Application of methyl parathion hydrolase (MPH) as a labeling enzyme., Anal Bioanal Chem, 2008
(44) Escherichia coli mismatch repair protein MutL interacts with the clamp loader subunits of DNA polymerase III., Mutat Res., 2008

( 1 ) 基因分析和生物芯片技术, GENE ANALYSIS AND BIOCHIP TECHNIQUE, 湖北科学技术出版社, 2004-01, 第 3 作者
( 2 ) High Technology Decelopment Report, 高技术发展报告, 科学出版社, 2005-03, 第 3 作者
( 3 ) 生物传感器, Biosensor, 化学工业出版社, 2005-08, 第 1 作者
( 4 ) 国际科学技术奖概况, A Survey of International Prizes in Science and Technology, 科学出版社, 2009-09, 第 1 作者


Jan 2017, Physical Virology Gordon Research Conference

May 2016, Biosensors 2016



黄旭  博士研究生  071005-微生物学  

崔宗强  博士研究生  071005-微生物学  

董艳杰  博士研究生  071005-微生物学  

游璠  博士研究生  071005-微生物学  

贾艳侠  博士研究生  071005-微生物学  

佀静雪  博士研究生  071005-微生物学  

郭永超  博士研究生  071005-微生物学  

乔岩梅  博士研究生  071005-微生物学  

张华  博士研究生  071005-微生物学  

李永进  博士研究生  071005-微生物学  

谷晶  博士研究生  071005-微生物学  

毕利军  博士研究生  071005-微生物学  

杨薇  博士研究生  071005-微生物学  

祁岑  博士研究生  071005-微生物学  

罗明  博士研究生  071005-微生物学  

王婷娟  博士研究生  071005-微生物学  

李可  博士研究生  071005-微生物学  

李中道  博士研究生  071005-微生物学  

田文武  博士研究生  071005-微生物学  

李峰  博士研究生  071005-微生物学  

吴进军  博士研究生  071005-微生物学  

周盈  博士研究生  071005-微生物学  

尤祥宇  博士研究生  071005-微生物学  

钟天映  博士研究生  071011-生物物理学  

林世强  博士研究生  071011-生物物理学  

任茜  硕士研究生  071010-生物化学与分子生物学  

林秀萍  硕士研究生  071010-生物化学与分子生物学  

尹娟  硕士研究生  071005-微生物学  

王绪德  博士研究生  071010-生物化学与分子生物学  

李茹  博士研究生  071010-生物化学与分子生物学  

张敏  博士研究生  071010-生物化学与分子生物学  

刘雅兰  博士研究生  071010-生物化学与分子生物学  

韩昱  硕士研究生  071010-生物化学与分子生物学  

杨仁斌  博士研究生  071010-生物化学与分子生物学  

杨明章  博士研究生  071010-生物化学与分子生物学  

门冬  博士研究生  071010-生物化学与分子生物学  

李风云  博士研究生  071010-生物化学与分子生物学  

梁晓声  博士研究生  071010-生物化学与分子生物学  

程芳  博士研究生  071010-生物化学与分子生物学  

顾佳  硕士研究生  071010-生物化学与分子生物学  

曾德军  硕士研究生  071010-生物化学与分子生物学  

高丁  博士研究生  071010-生物化学与分子生物学  

李昭阳  博士研究生  071010-生物化学与分子生物学  

李坤  博士研究生  071005-微生物学  

李阿茜  博士研究生  071010-生物化学与分子生物学  

田博  硕士研究生  430139-生物工程  

赵亮  硕士研究生  071010-生物化学与分子生物学  

刘凤英  博士研究生  071005-微生物学  

张晓莉  博士研究生  071005-微生物学  

王霆  博士研究生  071005-微生物学  

王明  博士研究生  071010-生物化学与分子生物学  

郝倩  硕士研究生  071005-微生物学  

宋双  硕士研究生  071005-微生物学  

陈涛  博士研究生  071010-生物化学与分子生物学  

黄荔  博士研究生  071005-微生物学  

陈秀秀  硕士研究生  071005-微生物学  

孙曼銮  博士研究生  071005-微生物学  

李敏  硕士研究生  085238-生物工程  

刘冲  硕士研究生  071005-微生物学  


孙宪迅  博士研究生  071005-微生物学  

印文  博士研究生  071005-微生物学  

陈媛媛  博士研究生  071010-生物化学与分子生物学  

郭冬各  博士研究生  071005-微生物学  

王继刚  博士研究生  071005-微生物学  

侯宇  硕士研究生  071010-生物化学与分子生物学  

陈明海  博士研究生  071005-微生物学  

王婷婷  博士研究生  071010-生物化学与分子生物学  

周昆  硕士研究生  071010-生物化学与分子生物学  

曹姗姗  硕士研究生  071010-生物化学与分子生物学  

陈晨  博士研究生  071010-生物化学与分子生物学  

席艳  博士研究生  071010-生物化学与分子生物学  

银芳  硕士研究生  085238-生物工程  

李士敏  博士研究生  071010-生物化学与分子生物学  

李一苇  博士研究生  071010-生物化学与分子生物学  

张玉威  博士研究生  071010-生物化学与分子生物学