基本信息
张先恩  男  博导  中国科学院生物物理研究所
电子邮件: zhangxe@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

研究领域

微生物学,分析病原微生物学

招生信息

   
招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
利用生物大分子识别功能和自组装原理,构建纳米生物传感体系
生物化学与分子生物学

教育背景

1991-09--1994-07   中国科学院微生物研究所   理学博士
1982-09--1985-07   中国科学院武汉病毒研究所   理学硕士
1979-09--1982-07   湖北大学   理学学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2013-05~现在, 中国科学院生物物理研究所, 研究员
2002-01~2013-04,科技部基础研究司, 司长
1999-01~2002-01,中国科学院武汉分院, 党组书记,副院长
1996-09~1996-11,英国伦敦帝国理工大学生化系, 高级访问学者
1994-06~1994-12,英国伦敦帝国理工大学生化系, 高级访问学者
1993-01~现在, 中国科学院武汉病毒研究所, 研究员
1993-01~1993-12,美国夏威夷大学, 高级访问学者
1992-01~1999-01,中国科学院武汉病毒研究所, 副所长,学术委员会主任
1989-01~1993-01,中国科学院武汉病毒研究所, 副研究员
1986-01~1987-01,加拿大阿伯达研究院生物工程系, 访问学者
1985-07~1988-12,中国科学院武汉病毒研究所, 实研,助研,课题组长
社会兼职
2014-09-01-今,亚洲生物技术协会,纳米生物技术、生物传感与生物芯片分会共会长,
2011-01-01-2016-12-31,伦敦纳米中心国际顾问委员会, 委员
2010-05-31-今,Biosensors &Bioelectronics, 编委
2009-06-30-2012-10-01,中国生物物理学会, 副理事长
2008-10-01-2016-10-01,中国微生物学会, 副理事长
2008-05-01-2018-04-30,世界生物传感学术大会(两年一度), 组委会中国代表
2003-05-01-今,Biocatalysis & Biotransformation, 编委

教授课程

生命科学导论
“重要生物体系的结构与功能”前沿讲座

专利与奖励

   
奖励信息
(1) 生物传感新原理研究, 一等奖, 省级, 2015
(2) 荣誉科学博士学位, 其他, 2015
(3) 中国科技部首批国家跨世纪人才第一、二层次人选, , 部委级, 1996
(4) 中科院有突出贡献的中青年专家, , 院级, 1994
(5) 中国科学院科技进步奖, 三等奖, 院级, 1989
(6) 首届中科院青年科学家奖, , 院级, 1989
专利成果
( 1 ) 一种高活力葡萄糖氧化酶的编码基因及制备方法和应用, 发明, 2010, 第 2 作者, 专利号: ZL 2007 1 0052783.8
( 2 ) 一种利用生物芯片检测二恶英类化学物质的方法, 发明, 2010, 第 2 作者, 专利号: ZL 2005 1 0019330.6
( 3 ) 单链抗体A1-甲基对硫磷水解酶融合蛋白及其制备方法, 发明, 2008, 第 2 作者, 专利号: ZL 2005 1 0020017.4
( 4 ) 一种检测二恶英的单链抗体方法, 发明, 2007, 第 1 作者, 专利号: ZL 2005 1 0019329.3
( 5 ) 一种高通量监测环境中二恶英类化学物质的方法, 发明, 2007, 第 2 作者, 专利号: ZL 2005 1 0018969.2
( 6 ) 一种纳米分子生物传感器及制备方法和用途, 发明, 2009, 第 3 作者, 专利号: 200910063483.9
( 7 ) 一种葡萄糖氧化酶的编码基因及制备方法和应用, 发明, 2010, 第 2 作者, 专利号: ZL 2007 1 0052784.2
( 8 ) 噬菌体免疫PCR检测病原的方法, 发明, 2008, 第 1 作者, 专利号: ZL 2006 1 0018858.6
( 9 ) 一种枯草芽孢杆菌脂肪酶及制备方法和应用, 发明, 2010, 第 1 作者, 专利号: 201010187107.3
( 10 ) 一种枯草芽孢杆菌脂肪酶及制备方法和应用, 发明, 2010, 第 1 作者, 专利号: 201010187108.8
( 11 ) 结核分枝杆菌吡嗪酰胺耐药性检测的方法, 发明, 2010, 第 5 作者, 专利号: 201010285041.1
( 12 ) 一种定量检测炭疽芽孢的磁性免疫层析试纸条及制备方法, 发明, 2011, 第 1 作者, 专利号: 201110151215.X
( 13 ) 一种结核分枝杆菌全蛋白质芯片及应用, 发明, 2014, 第 1 作者, 专利号: 201410095163.2
( 14 ) 一组结核分枝杆菌蛋白及其编码基因与应用, 发明, 2014, 第 1 作者, 专利号: 201410594400.X

出版信息

   
发表论文
[1] Tang, Jingya, Zhang, Guimin, Li, Feng, Zeng, Rongyu, Song, Jin, Abbas, Ghulam, Cui, Mengmeng, Zhang, Wei, Zhang, XianEn, Wang, DianBing. Two-Dimensional Protein Nanoarray as a Carrier of Sensing Elements for Gold-Based Immunosensing Systems. ANALYTICAL CHEMISTRY. 2022, [2] Cui, Mengmeng, Abbas, Ghulam, Wang, Dianbing, Liu, Qian, Gong, Rui, Li, Min, Zhang, XianEn. Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells. SCIENCE CHINA-LIFE SCIENCES. 2022, 65(6): 1259-1262, http://dx.doi.org/10.1007/s11427-021-2049-6.
[3] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Zhang, XianEn. Single-Particle Tracking Reveals the Interplay between HIV-1 Reverse Transcription and Uncoating. ANALYTICAL CHEMISTRY[J]. 2022, 94(5): 2648-2654, http://dx.doi.org/10.1021/acs.analchem.1c05199.
[4] Gong, Rui, Wang, Dianbing, Abbas, Ghulam, Li, Shimin, Liu, Qian, Cui, Mengmeng, Zhang, XianEn. A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(3): 540-549, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000697090200002.
[5] Ti Fang, Chaoqun Li, Ao Liang, Hui Zhang, Fan Zhang, XianEn Zhang, YiYu Yang, Feng Li. Probing cell membrane integrity using a histone-targeting protein nanocage displaying precisely positioned fluorophores. Nano Research. 2022, 1-11, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438879/.
[6] Chen Chen, Juan Zhou, Dong Men, Xian-En Zhang. Promoter-regulated in vivo asymmetric self-assembly strategy to synthesize heterogeneous nanoparticles for signal amplification. NANOSCALE[J]. 2022, [7] Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, XianEn Zhang, Zongqiang Cui, Michael S Diamond. T-Cell Immunoglobulin and Mucin Domain 1 (TIM-1) Is a Functional Entry Factor for Tick-Borne Encephalitis Virus. mBio[J]. 2022, 13(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787471/.
[8] Cao, Shanshan, Zhang, Qing, Song, Liu, Xiao, Mingzhong, Chen, Yexing, Wang, Dianbing, Li, Min, Hu, Jinchao, Lin, Lin, Zheng, Ying, Zhou, Kun, Ye, Shujian, Zhou, Juan, Zhou, Ya Na, Cui, Jing, Wang, Jingzhi, Sun, Jing, Tao, Junxiu, Chen, Zhou, Chen, Rong, Zhou, Peng, Shi, Zhengli, Wei, Sheng, Zhao, Linhua, Wang, Hui, Tong, Xiaoling, Li, Xiaodong, Men, Dong, Hou, Baidong, Zhang, XianEn. Dysregulation of Innate and Adaptive Immune Responses in Asymptomatic SARS-CoV-2 Infection with Delayed Viral Clearance. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2022, 18(12): 4648-4657, http://dx.doi.org/10.7150/ijbs.72963.
[9] Mao, Guobin, Wu, Guoqiang, Chen, Minghai, Yan, Chuang, Tang, Jingya, Ma, Yingxin, Zhang, XianEn. Synthesis of Dual-Emitting CdZnSe/Mn:ZnS Quantum Dots for Sensing the pH Change in Live Cells. ANALYTICAL CHEMISTRY[J]. 2022, 94(18): 6665-6671, http://dx.doi.org/10.1021/acs.analchem.1c04811.
[10] Ruimin Gao, Huan Tan, Shanshan Li, Shaojie Ma, Yufu Tang, Kaiming Zhang, Zhiping Zhang, Quli Fan, Jun Yang, XianEn Zhang, Feng Li. A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability. Proceedings of the National Academy of Sciences of the United States of America[J]. 2022, 119(5): [11] Zhou, Juan, Men, Dong, Zhang, XianEn. Progress in wearable sweat sensors and their applications. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2022, 50(2): 87-96, http://dx.doi.org/10.1016/j.cjac.2021.11.004.
[12] Li, Shimin, Wang, Dianbing, Ghulam, Abbas, Li, Xia, Li, Min, Li, Qin, Ma, Yingxin, Wang, Lei, Wu, Hangshen, Cui, Zongqiang, Zhang, XianEn. Tracking the Replication-Competent Zika Virus with Tetracysteine-Tagged Capsid Protein in Living Cells. JOURNAL OF VIROLOGY[J]. 2022, 96(7): http://dx.doi.org/10.1128/jvi.01846-21.
[13] Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, JIawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui. Self-Assembling Nanovaccine Confers Complete Protection Against Zika Virus Without Causing Antibody-Dependent Enhancement. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: 905431-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124840/.
[14] Song, Jin, Li, Yiwei, Ke, Dingkun, Wang, Dianbing, Zhang, XianEn. In situ graphene-modified carbon microelectrode array biosensor for biofilm impedance analysis. ELECTROCHIMICA ACTA[J]. 2022, 403: http://dx.doi.org/10.1016/j.electacta.2021.139570.
[15] Huang, Lin, Zhou, Mengyang, Abbas, Ghulam, Li, Chao, Cui, Mengmeng, Zhang, XianEn, Wang, DianBing. A Cancer Cell Membrane-Derived Biomimetic Nanocarrier for Synergistic Photothermal/Gene Therapy by Efficient Delivery of CRISPR/Cas9 and Gold Nanorods. ADVANCED HEALTHCARE MATERIALS. 2022, http://dx.doi.org/10.1002/adhm.202201038.
[16] Hou, Yu, Wang, Dianbing, Lu, Song, Guo, Dongge, Li, Min, Cui, Mengmeng, Zhang, XianEn. Optogenetic Control of Background Fluorescence Reduction for CRISPR-Based Genome Imaging. ANALYTICAL CHEMISTRY[J]. 2022, 94(24): 8724-8731, http://dx.doi.org/10.1021/acs.analchem.2c01113.
[17] Ma, Yingxin, Mao, Guobin, Yang, Weishan, Wu, Guoqiang, Li, Guoqiang, Li, Xiaoying, Lin, Xin, Lu, Junnan, Zhao, Shijun, Zhao, Wei, Dai, Junbiao, Zhang, XianEn. Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system. SCIENCE CHINA-LIFE SCIENCES. 2022, 65: 1-4, http://dx.doi.org/10.1007/s11427-022-2114-8.
[18] Xiayi Feng, Ding Gao, Yipeng Jing, Junchao Qian, Zongqiang Cui, Juan Zhou, Xian-En Zhang, Dong Men. Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway. Acs Applied Materials & Interfaces[J]. 2022, [19] Zheng, Yang, Zhang, Qing, Ali, Ashaq, Li, Ke, Shao, Nan, Zhou, Xiaoli, Ye, Zhiqin, Chen, Xiaomin, Cao, Shanshan, Cui, Jing, Zhou, Juan, Wang, Dianbing, Hou, Baidong, Li, Min, Cui, Mengmeng, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Yang, Qinfang, li, Yong, Wang, Hui, Lei, Yake, Yu, Bo, Cheng, Yegang, Tong, Xiaolin, Men, Dong, Zhang, XianEn. Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months. VIROLOGICA SINICA[J]. 2021, 36(5): 869-878, http://dx.doi.org/10.1007/s12250-021-00360-4.
[20] Zhou, Xiaoli, Zhou, YaNa, Ali, Ashaq, Liang, Cuiqin, Ye, Zhiqin, Chen, Xiaomin, Zhang, Qing, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Luo, Jihong, Li, Wei, Zhou, Kun, Cao, Shanshan, Zhang, Xiaowei, Li, XiaoDong, Zhang, XianEn, Cui, Zongqiang, Men, Dong. Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.701295.
[21] Zhu, Weiwei, Fang, Ti, Zhang, Wenjing, Liang, Ao, Zhang, Hui, Zhang, ZhiPing, Zhang, XianEn, Li, Feng. A ROS scavenging protein nanocage for in vitro and in vivo antioxidant treatment. NANOSCALE[J]. 2021, 13(8): 4634-4643, http://dx.doi.org/10.1039/d0nr08878a.
[22] Zhang, Yuwei, Zhou, Juan, Zhang, Yuchen, Liu, Tiangang, Lu, Xiaoyun, Men, Dong, Zhang, XianEn. Auxiliary Module Promotes the Synthesis of Carboxysomes in E. coli to Achieve High-Efficiency CO2 Assimilation. ACS SYNTHETIC BIOLOGY[J]. 2021, 10(4): 707-715, http://dx.doi.org/10.1021/acssynbio.0c00436.
[23] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Cui, Zongqiang, Zhang, XianEn, Huang, Weiren. CRISPR-dCas9-Guided and Telomerase-Responsive Nanosystem for Precise Anti-Cancer Drug Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(7): 7890-7896, http://dx.doi.org/10.1021/acsami.0c19217.
[24] Shi, Hongmei, Li, Ting, Xu, Jintian, Yu, Jifang, Yang, Shanshan, Zhang, XianEn, Tao, Shengce, Gu, Jing, Deng, JiaoYu. MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.682205.
[25] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Chen, Minghai, Qin, Fujun, Zheng, Luping, Zhang, XianEn. Dual-Fluorescence Labeling Pseudovirus for Real-Time Imaging of Single SARS-CoV-2 Entry in Respiratory Epithelial Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(21): 24477-24486, http://dx.doi.org/10.1021/acsami.1c03897.
[26] Lu, Song, Wang, Dianbing, Hou, Yu, Guo, Dongge, Deng, Yulin, Zhang, XianEn. Illuminating single genomic loci in live cells by reducing nuclear background fluorescence. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(5): 667-677, http://dx.doi.org/10.1007/s11427-020-1794-2.
[27] Yang, Yong, Wang, Xi, Du, RongHui, Zhang, Wei, Si, HaoRui, Zhu, Yan, Shen, XuRui, Li, Qian, Li, Bei, Men, Dong, Zhou, Yana, Wang, Hui, Tong, Xiaolin, Zhang, Xianen, Shi, ZhengLi, Zhou, Peng. Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses. EMERGING MICROBES & INFECTIONS[J]. 2021, 10(1): 905-912, http://dx.doi.org/10.1080/22221751.2021.1919032.
[28] Li, Xia, Wang, Dianbing, Cui, Zongqiang, Li, Qin, Li, Min, Ma, Yingxin, Hu, Qinxue, Zhou, Yikai, Zhang, XianEn. HIV-1 viral cores enter the nucleus collectively through the nuclear endocytosis-like pathway. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(1): 66-76, http://lib.cqvip.com/Qikan/Article/Detail?id=7103797648.
[29] Chen, Xiaohua, Zhou, Juan, Chen, Chen, Hou, Baidong, Ali, Ashaq, Li, Feng, Hua, Zhaolin, Wu, Yingtao, Yang, Qin, Chen, Min, Zhang, Rong, Huang, Qianchuan, Ding, Jinya, Zhang, XianEn, Men, Dong. Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients. VIROLOGICA SINICA. 2021, 36(5): 1093-1096, http://dx.doi.org/10.1007/s12250-021-00425-4.
[30] Esmaeili, Chakavak, Song, Jin, Li, Yuliang, Mao, Lanqun, Liu, Huibiao, Wu, Fei, Chen, Yanhuan, Liu, Chenli, Zhang, XianEn. Synthesis and Application of Graphdiyne Oxide-Polyurethane Nanocomposite Yield a Highly Sensitive Non-Enzyme Glucose Sensor. JOURNAL OF THE ELECTROCHEMICAL SOCIETY[J]. 2021, 168(7): http://dx.doi.org/10.1149/1945-7111/ac139c.
[31] Chen, Minghai, Zhang, XianEn. Construction and applications of SARS-CoV-2 pseudoviruses: a mini review. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESnull. 2021, 17(6): 1574-1580, http://dx.doi.org/10.7150/ijbs.59184.
[32] Zhang, Wenjing, Jia, Qingyan, Teng, Yibo, Yang, Mengsi, Zhang, Hui, Zhang, XianEn, Wang, Pengfei, Ge, Jiechao, Cao, Sheng, Li, Feng. An Ultrastable Virus-Like Particle with a Carbon Dot Core and Expanded Sequence Plasticity. SMALL[J]. 2021, 17(35): http://dx.doi.org/10.1002/smll.202101717.
[33] Ali, Ashaq, Noman, Muhammad, Guo, Yong, Liu, Xu, Zhang, Rong, Zhou, Juan, Zheng, Yang, Zhang, XianEn, Qi, Yong, Chen, Xiaohua, Men, Dong. Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality. SCIENTIFIC REPORTS[J]. 2021, 11(1): http://dx.doi.org/10.1038/s41598-021-85426-9.
[34] Li, Wei, Liu, Ji, Liu, Yuanyuan, Li, Qin, Yin, Wen, Wanderi, Kevin K, Zhang, Xiaowei, Zhang, Zhiping, Zhang, XianEn, Cui, Zongqiang. HIV-1 Uses Dynamic Podosomes for Entry into Macrophages. JOURNAL OF VIROLOGY[J]. 2021, 95(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000647441000001.
[35] Chen, Minghai, Yan, Chuang, Qin, Fujun, Zheng, Luping, Zhang, XianEn. The intraviral protein-protein interaction of SARS-CoV-2 reveals the key role of N protein in virus-like particle assembly. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2021, 17(14): 3889-3897, http://dx.doi.org/10.7150/ijbs.64977.
[36] Chen, Minghai, Yan, Chuang, Ma, Yingxin, Zhang, XianEn. A tandem near-infrared fluorescence complementation system with enhanced fluorescence for imaging protein-protein interactions in vivo. BIOMATERIALS[J]. 2021, 268: http://dx.doi.org/10.1016/j.biomaterials.2020.120544.
[37] Zhang, Jianlin, Li, Shimin, Xie, Ni, Nie, Guohui, Tang, Aifa, Zhang, XianEn, Liang, Minmin, Yan, Xiyun. A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity. SCIENCE CHINA-LIFE SCIENCES. 2021, 64(8): 1375-1378, http://dx.doi.org/10.1007/s11427-020-1865-2.
[38] Zhang, Juan, Zhang, Wenjing, Yang, Mengsi, Zhu, Weiwei, Li, Ming, Liang, Ao, Zhang, Hui, Fang, Ti, Zhang, XianEn, Li, Feng. Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis. NANOSCALE[J]. 2021, 13(26): 11334-11342, http://dx.doi.org/10.1039/d1nr01619a.
[39] Gao, Ruimin, Zhang, XianEn, Li, Feng. Generation and characterization of self-assembled protein nanocages based on beta-carboxysomes in Escherichia coli. ACTA BIOCHIMICA ET BIOPHYSICA SINICA[J]. 2021, 53(7): 943-949, http://dx.doi.org/10.1093/abbs/gmab064.
[40] Zheng, Luping, Ma, Yingxin, Chen, Minghai, Wu, Guoqiang, Yan, Chuang, Zhang, XianEn. SARS-CoV-2 spike protein receptor-binding domain N-glycans facilitate viral internalization in respiratory epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 579: 69-75, http://dx.doi.org/10.1016/j.bbrc.2021.09.053.
[41] Chen, Minghai, Li, Siting, Li, Wei, Zhang, ZhiPing, Zhang, Xiaowei, Zhang, XianEn, Ge, Feng, Cui, Zongqiang. Nanoscale Imaging of RNA-Protein Interactions with a Photoactivatable Trimolecular Fluorescence Complementation System. ACS CHEMICAL BIOLOGY[J]. 2021, 16(6): 1003-1010, http://dx.doi.org/10.1021/acschembio.0c00945.
[42] Singh, Netrapal, Huang, Lin, Wang, DianBing, Shao, Nan, Zhang, XianEn. Simultaneous Detection of a Cluster of Differentiation Markers on Leukemia-Derived Exosomes by Multiplex Immuno-Polymerase Chain Reaction via Capillary Electrophoresis Analysis. ANALYTICAL CHEMISTRY[J]. 2020, 92(15): 10569-10577, [43] Li, Yiwei, Zhou, Juan, Song, Jin, Liang, Xiaosheng, Zhang, Zhiping, Men, Dong, Wang, Dianbing, Zhang, XianEn. Chemical nature of electrochemical activation of carbon electrodes (vol 144, 111534, 2019). BIOSENSORS & BIOELECTRONICSnull. 2020, 149: https://www.webofscience.com/wos/woscc/full-record/WOS:000504514100013.
[44] Xu, Chengchen, Zhu, Weiwei, Mao, Hanjing, Zhang, Wenjing, Yin, GenQuan, Zhang, XianEn, Li, Feng. Switch from Polymorphic to Homogenous Self-Assembly of Virus-Like Particles of Simian Virus 40 through Double-Cysteine Substitution. SMALL[J]. 2020, 16(45): https://www.webofscience.com/wos/woscc/full-record/WOS:000578249300001.
[45] Song, Jin, Li, Yiwei, Yin, Fang, Zhang, Zhitao, Ke, Dingkun, Wang, Dianbing, Yuan, Qipeng, Zhang, XianEn. Enhanced Electrochemical Impedance Spectroscopy Analysis of Microbial Biofilms on an Electrochemically In Situ Generated Graphene Interface. ACS SENSORS[J]. 2020, 5(6): 1795-1803, http://dx.doi.org/10.1021/acssensors.0c00570.
[46] Zhang, XianEn. Nanobiology-Symphony of bioscience and nanoscience. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(8): 1099-1102, http://lib.cqvip.com/Qikan/Article/Detail?id=7102433148.
[47] Feng, Wei, Newbigging, Ashley M, Le, Connie, Pang, Bo, Peng, Hanyong, Cao, Yiren, Wu, Jinjun, Abbas, Ghulam, Song, Jin, Wang, DianBing, Cui, Mengmeng, Tao, Jeffrey, Tyrrell, D Lorne, Zhang, XianEn, Zhang, Hongquan, Le, X Chris. Molecular Diagnosis of COVID-19: Challenges and Research Needs. ANALYTICAL CHEMISTRY[J]. 2020, 92(15): 10196-10209, http://dx.doi.org/10.1021/acs.analchem.0c02060.
[48] Sha Wei, Dianbing Wang, Hua Li, Lijun Bi, Jiaoyu Deng, Guofeng Zhu, Jibin Zhang, Chuanyou Li, Min Li, Yuan Fang, Guimin Zhang, Jian Chen, Shengce Tao, XianEn Zhang. Fatty acylCoA synthetase FadD13 regulates proinflammatory cytokine secretion dependent on the NF‐κB signalling pathway by binding to eEF1A1. Cellular Microbiology. 2019, 21(12): [49] Xi, Yan, Wang, Dianbing, Wang, Tingting, Huang, Lin, Zhang, XianEn. Quantitative profiling of CD13 on single acute myeloid leukemia cells by super-resolution imaging and its implication in targeted drug susceptibility assessment. NANOSCALE[J]. 2019, 11(4): 1737-1744, http://www.corc.org.cn/handle/1471x/2373182.
[50] DongGe Guo, DianBing Wang, Chong Liu, Song Lu, Yu Hou, XianEn Zhang. CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. BBA - Molecular Cell Research. 2019, 1866(12): http://dx.doi.org/10.1016/j.bbamcr.2019.07.013.
[51] Li, Lingling, Xu, Chengchen, Zhang, Wenjing, Secundo, Francesco, Li, Chunyan, Zhang, ZhiPing, Zhang, XianEn, Li, Feng. Cargo-Compatible Encapsulation in Virus-Based Nanoparticles. NANO LETTERS[J]. 2019, 19(4): 2700-2706, https://www.webofscience.com/wos/woscc/full-record/WOS:000464769100070.
[52] 黄琳, 王殿冰, 顾宁, 张先恩. 高效装载细胞内源蛋白工程化外泌体的构建. 生物工程学报[J]. 2019, 35(8): 1537-1545, http://lib.cqvip.com/Qikan/Article/Detail?id=7002704219.
[53] Huang, Lin, Gu, Ning, Zhang, XianEn, Wang, DianBing. Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells. ADVANCED FUNCTIONAL MATERIALS[J]. 2019, 29(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000459800400024.
[54] Yang, Fan, Zuo, Xiaolei, Fan, Chunhai, Zhang, XianEn. Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing. NATIONAL SCIENCE REVIEW[J]. 2018, 5(5): 740-755, http://dx.doi.org/10.1093/nsr/nwx134.
[55] Zhang, Wenjing, Zhang, XianEn, Li, Feng. Virus-Based Nanoparticles of Simian Virus 40 in the Field of Nanobiotechnology. BIOTECHNOLOGY JOURNAL[J]. 2018, 13(6): http://www.corc.org.cn/handle/1471x/2373262.
[56] Zhang, Z T, Wang, D B, Li, C Y, Deng, J Y, Zhang, J B, Bi, L J, Zhang, X E. Microbial sensor for drug susceptibility testing of Mycobacterium tuberculosis. JOURNAL OF APPLIED MICROBIOLOGY[J]. 2018, 124(1): 286-293, http://www.corc.org.cn/handle/1471x/2373357.
[57] Zhang, XianEn. Forty years of highly synchronous development in China's scientific research and economy. NATIONAL SCIENCE REVIEW. 2018, 5(6): 796-798, http://lib.cqvip.com/Qikan/Article/Detail?id=78658382504849564854484856.
[58] Yin, Wen, Li, Wei, Li, Qin, Qin, Chong, Zhang, Zhiping, Zhang, Xiaowei, Zhang, XianEn, Cui, Zongqiang. Structural Characterization and Analysis of Human Immunodeficiency Virus Encapsulating Quantum Dots. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2018, 18(7): 4487-4494, http://www.corc.org.cn/handle/1471x/2373339.
[59] Wang, Jigang, Fang, Ti, Li, Ming, Zhang, Wenjing, Zhang, ZhiPing, Zhang, XianEn, Li, Feng. Intracellular delivery of peptide drugs using viral nanoparticles of bacteriophage P22: covalent loading and cleavable release. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(22): 3716-3726, http://www.corc.org.cn/handle/1471x/2373260.
[60] Huang, Lin, Wang, DianBing, Singh, Netrapal, Yang, Fang, Gu, Ning, Zhang, XianEn. A dual-signal amplification platform for sensitive fluorescence biosensing of leukemia-derived exosomes. NANOSCALE[J]. 2018, 10(43): 20289-20295, http://ir.siat.ac.cn:8080/handle/172644/14886.
[61] 张先恩. 2018合成生物学专辑序言. 中国科学院院刊. 2018, [62] Hua Li, Sha Wei, Yuan Fang, Min Li, Xia Li, Zhe Li, Jibin Zhang, Guofeng Zhu, Chuanyou Li, Lijun Bi, Guimin Zhang, Dianbing Wang, Xian-En Zhang. Quantitative proteomic analysis of host responses triggered by Mycobacterium tuberculosis infection in human macrophage cells. 生物化学与生物物理学报:英文版[J]. 2017, 49(9): 835-844, http://lib.cqvip.com/Qikan/Article/Detail?id=673691543.
[63] 张先恩. 生物传感发展50年及展望. 中国科学院院刊[J]. 2017, 32(12): 1271-1280, http://lib.cqvip.com/Qikan/Article/Detail?id=674385466.
[64] Fayyadh, Thaer Kadhim, Ma, Fuying, Qin, Chong, Zhang, Xiaowei, Li, Wei, Zhang, XianEn, Zhang, Zhiping, Cui, Zongqiang. Simultaneous detection of multiple viruses in their co-infected cells using multicolour imaging with self-assembled quantum dot probes. MICROCHIMICA ACTA[J]. 2017, 184(8): 2815-2824, http://202.127.146.157/handle/2RYDP1HH/4309.
[65] Ma, Yingxin, Wang, Mingxiu, Li, Wei, Zhang, Zhiping, Zhang, Xiaowei, Wu, Guoqiang, Tan, Tianwei, Cui, Zongqiang, Zhang, XianEn. Live Visualization of HIV-1 Proviral DNA Using a Dual-Color-Labeled CRISPR System. ANALYTICAL CHEMISTRY[J]. 2017, 89(23): 12896-12901, http://202.127.146.157/handle/2RYDP1HH/4452.
[66] 张先恩. 2017合成生物学专刊序言. 生物工程学报[J]. 2017, 33(3): 311-314, [67] Li, Qin, Li, Wei, Yin, Wen, Guo, Jia, Zhang, ZhiPing, Zeng, Dejun, Zhang, Xiaowei, Wu, Yuntao, Zhang, XianEn, Cui, Zongqiang. Single-Particle Tracking of Human Immunodeficiency Virus Type 1 Productive Entry into Human Primary Macrophages. ACS NANO[J]. 2017, 11(4): 3890-3903, http://www.corc.org.cn/handle/1471x/2373406.
[68] 王殿冰, 崔宗强, 张先恩. 分子生物传感器与细胞内分子影像. 中国科学院院刊[J]. 2017, 32(12): 1303-1312, http://lib.cqvip.com/Qikan/Article/Detail?id=674385469.
[69] Li Kun, Wang Xude, Yang ShanShan, Gu Jing, Deng JiaoYu, Zhang XianEn. Anti-folates potentiate bactericidal effects of other antimicrobial agents.. The Journal of antibiotics. 2017, [70] 张先恩. 科技强国植根于深厚的基础研究. 2017, http://www.chinaxiv.org/abs/201706.00297.
[71] Yingxin Ma, Mingxiu Wang, Wei Li, Zhiping Zhang, Xiaowei Zhang, Tianwei Tan, XianEn Zhang, Zongqiang Cui. Live cell imaging of single genomic loci with quantum dot-labeled TALEs. NATURE COMMUNICATIONS[J]. 2017, 8(1): http://www.corc.org.cn/handle/1471x/2373403.
[72] Chen, Minghai, Liu, Sanying, Li, Wei, Zhang, Zhiping, Zhang, Xiaowei, Zhang, XianEn, Cui, Zongqiang. Three-Fragment Fluorescence Complementation Coupled with Photoactivated Localization Microscopy for Nanoscale Imaging of Ternary Complexes. ACS NANO[J]. 2016, 10(9): 8482-8490, http://www.corc.org.cn/handle/1471x/2375027.
[73] Men, Dong, Zhou, Juan, Li, Wei, Leng, Yan, Chen, Xinwen, Tao, Shengce, Zhang, XianEn. Fluorescent Protein Nanowire-Mediated Protein Microarrays for Multiplexed and Highly Sensitive Pathogen Detection. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(27): 17472-17477, https://www.webofscience.com/wos/woscc/full-record/WOS:000379794100055.
[74] Ma, Yingxin, Cui, Zongqiang, He, Zhike, Li, Wei, Zhang, Zhiping, Zhang, Xiaowei, Zhang, XianEn, Tan, Tianwei. Delaying Photobleaching of a Light-Switch Complex for Real-Time Imaging of Single Viral Particle Uncoating. ANALYTICAL CHEMISTRY[J]. 2016, 88(21): 10675-10679, https://www.webofscience.com/wos/woscc/full-record/WOS:000386991200049.
[75] Ma, Yingxin, He, Zhike, Tan, Tianwei, Li, Wei, Zhang, Zhiping, Song, Shuang, Zhang, Xiaowei, Hu, Qinxue, Zhou, Peng, Wu, Yuntao, Zhang, XianEn, Cui, Zongqiang. Real-Time Imaging of Single HIV-1 Disassembly with Multicolor Viral Particles. ACS NANO[J]. 2016, 10(6): 6273-6282, https://www.webofscience.com/wos/woscc/full-record/WOS:000378973700076.
[76] Wang, Ting, Zheng, Zhenhua, Zhang, XianEn, Wang, Hanzhong. Quantum dot-fluorescence in situ hybridisation for Ectromelia virus detection based on biotin-streptavidin interactions. TALANTA[J]. 2016, 158: 179-184, http://www.corc.org.cn/handle/1471x/2374715.
[77] Zhang, XianEn, Cui, Zongqiang, Wang, Dianbing. Sensing of biomolecular interactions using fluorescence complementing systems in living cells. BIOSENSORS & BIOELECTRONICS[J]. 2016, 76: 243-250, http://dx.doi.org/10.1016/j.bios.2015.07.069.
[78] Zhang Xianen. Sensing of biomolecular interactions using fluorescence complementing systems in living cells. Biosensors and Bioelectronics. 2016, [79] Li, ZhaoYang, Zhang, ZhiPing, Bi, LiJun, Cui, ZongQiang, Deng, JiaoYu, Wang, DianBing, Zhang, XianEn. Mutagenesis of mNeptune Red-Shifts Emission Spectrum to 681-685 nm. PLOS ONE[J]. 2016, 11(4): https://doaj.org/article/37dbcbf3fc8c4b7885fa13ce60c6acdd.
[80] Ming Wang, Joy Fleming, Zihui Li, Chuanyou Li, Hongtai Zhang, Yunxin Xue, Maoshan Chen, Zongde Zhang, Xian-En zhang, Lijun Bi. An automated approach for global identification of sRNA-encoding regions in RNA-Seq data from Mycobacterium tuberculosis. 生物化学与生物物理学报:英文版[J]. 2016, 544-553, http://lib.cqvip.com/Qikan/Article/Detail?id=669809101.
[81] Sun, Xianxun, Li, Wei, Zhang, Xiaowei, Qi, Mi, Zhang, Zhiping, Zhang, XianEn, Cui, Zongqiang. In Vivo Targeting and Imaging of Atherosclerosis Using Multifunctional Virus-Like Particles of Simian Virus 40. NANO LETTERS[J]. 2016, 16(10): 6164-6171, http://www.corc.org.cn/handle/1471x/2374899.
[82] Chen, Minghai, Li, Wei, Zhang, Zhiping, Liu, Sanying, Zhang, Xiaowei, Zhang, XianEn, Cui, Zongqiang. Novel near-infrared BiFC systems from a bacterial phytochrome for imaging protein interactions and drug evaluation under physiological conditions. BIOMATERIALS[J]. 2015, 48: 97-107, http://dx.doi.org/10.1016/j.biomaterials.2015.01.038.
[83] Men, Dong, Zhang, TingTing, Hou, LiWei, Zhou, Juan, Zhang, ZhiPing, Shi, YuanYuan, Zhang, JinLi, Cui, ZongQiang, Deng, JiaoYu, Wang, DianBing, Zhang, XianEn. Self-Assembly of Ferritin Nanoparticles into an Enzyme Nanocomposite with Tunable Size for Ultrasensitive Immunoassay. ACS NANO[J]. 2015, 9(11): 10852-10860, https://www.webofscience.com/wos/woscc/full-record/WOS:000365464800032.
[84] Wang, XuYing, Wang, DianBing, Zhang, ZhiPing, Bi, LiJun, Zhang, JiBin, Ding, Wei, Zhang, XianEn. A S-Layer Protein of Bacillus anthracis as a Building Block for Functional Protein Arrays by In Vitro Self-Assembly. SMALL[J]. 2015, 11(43): 5826-5832, https://www.webofscience.com/wos/woscc/full-record/WOS:000365847600013.
[85] Deng, Jiaoyu, Bi, Lijun, Zhou, Lin, Guo, Shujuan, Fleming, Joy, Jiang, Hewei, Zhou, Ying, Gu, Jia, Zhong, Qiu, Wang, Zongxiu, Liu, Zhonghui, Deng, Ruiping, Gao, Jing, Chen, Tao, Li, Wenjuan, Wang, Jingfang, Wang, Xude, Li, Haicheng, Ge, Feng, Zhu, Guofeng, Zhang, Hainan, Gu, Jing, Wu, Fanlin, Zhang, Zhiping, Wang, Dianbing, Hang, Haiying, Li, Yang, Cheng, Li, He, Xiang, Tao, Shengce, Zhang, XianEn. Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity. CELL REPORTS[J]. 2014, 9(6): 2317-2329, http://dx.doi.org/10.1016/j.celrep.2014.11.023.
[86] Zhang, Hongtai, Li, Dongfang, Zhao, Lili, Fleming, Joy, Lin, Nan, Wang, Ting, Liu, Zhangyi, Li, Chuanyou, Galwey, Nicholas, Deng, Jiaoyu, Zhou, Ying, Zhu, Yuanfang, Gao, Yunrong, Wang, Tong, Wang, Shihua, Huang, Yufen, Wang, Ming, Zhong, Qiu, Zhou, Lin, Chen, Tao, Zhou, Jie, Yang, Ruifu, Zhu, Guofeng, Hang, Haiying, Zhang, Jia, Li, Fabin, Wan, Kanglin, Wang, Jun, Zhang, XianEn, Bi, Lijun. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. NATURE GENETICS[J]. 2013, 45(10): 1255-U217, https://www.webofscience.com/wos/woscc/full-record/WOS:000324989600025.
[87] Zhang Xianen. 2. MutL associates with Escherichia coli RecA and inhibits its ATPase activity. Archives of Biochemistry and Biophysics. 2012, [88] 毕利军. Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for inactivation of anti-tuberculosis drugs. Molecular Microbiology. 2011, [89] 王大成. The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(19): 8488-8502, http://dx.doi.org/10.1093/nar/gkr553.
[90] Gui, WenJun, Lin, ShiQiang, Chen, YuanYuan, Zhang, XianEn, Bi, LiJun, Jiang, Tao. Crystal structure of DNA polymerase III beta sliding clamp from Mycobacterium tuberculosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2011, 405(2): 272-277, http://www.irgrid.ac.cn/handle/1471x/757424.
[91] Feng Ge, Shengce Tao, Lijun Bi, Zhiping Zhang, Xian'En Zhang. Proteomics: addressing the challenges of multiple myeloma. 生物化学与生物物理学报:英文版[J]. 2011, 43(2): 89-95, http://lib.cqvip.com/Qikan/Article/Detail?id=37251533.
[92] Zhang Xianen. Proteomic analysis of multiple myeloma: Current status and future perspectives. Proteomics Clin. Appl. 2011, [93] Lin, ShiQiang, Bi, LiJun, Zhang, XianEn. A simplified method for reconstituting active E. coli DNA polymerase III. PROTEIN & CELL[J]. 2011, 2(4): 303-307, http://www.corc.org.cn/handle/1471x/2375946.
[94] Cui, ZongQiang, Ren, Qian, Wei, HongPing, Chen, Ze, Deng, JiaoYu, Zhang, ZhiPing, Zhang, XianEn. Quantum dot-aptamer nanoprobes for recognizing and labeling influenza A virus particles. NANOSCALE[J]. 2011, 3(6): 2454-2457, http://www.corc.org.cn/handle/1471x/2375911.
[95] 毕利军. Crystal structure of YdaL, a stand-alone small MutS-related protein from E.coli. Journal of Structural Biology. 2011, [96] Zhong, Tianying, Zhou, Yafeng, Bi, Lijun, Zhang, XianEn. MutS-mediated enrichment of mutated DNA produced by directed evolution in vitro. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2011, 27(6): 1367-1372, http://www.irgrid.ac.cn/handle/1471x/757489.
[97] Ge, Feng, Zhang, Liang, Tao, ShengCe, Kitazato, Kaio, Zhang, ZhiPing, Zhang, XianEn, Bi, LiJun. Quantitative Proteomic Analysis of Tumor Reversion in Multiple Myeloma Cells. JOURNAL OF PROTEOME RESEARCH[J]. 2011, 10(2): 845-855, http://www.irgrid.ac.cn/handle/1471x/757285.
[98] Liang, Xiaosheng, Wei, Hongping, Cui, Zongqiang, Deng, Jiaoyu, Zhang, Zhiping, You, Xiangyu, Zhang, XianEn. Colorimetric detection of melamine in complex matrices based on cysteamine-modified gold nanoparticles. ANALYST[J]. 2011, 136(1): 179-183, http://www.corc.org.cn/handle/1471x/2375890.
[99] Zhongdao Li, Jikai Wen, Yaning Lin, Shihua Wang, Peng Xue, Zhiping Zhang, Ying Zhou, Xiao Wang, Li Sui, LiJun Bi, XianEn Zhang. Correction: A Sir2-Like Protein Participates in Mycobacterial NHEJ. PLoS ONE[J]. 2011, 6(7): https://doaj.org/article/3d2a198153ce4ebf821fff66e28cd4ed.
[100] Hao, RongZhang, Song, HongBin, Zuo, GuoMin, Yang, RuiFu, Wei, HongPing, Wang, DianBing, Cui, ZongQiang, Zhang, ZhiPing, Cheng, ZhenXing, Zhang, XianEn. DNA probe functionalized QCM biosensor based on gold nanoparticle amplification for Bacillus anthracis detection. BIOSENSORS & BIOELECTRONICS[J]. 2011, 26(8): 3398-3404, http://www.corc.org.cn/handle/1471x/2375973.
[101] Zhou, Ying, Li, Feng, Chen, Yuanyuan, Bi, Lijun, Zhang, XianEn. Functional Analyses of Escherichia coli MutS-beta Clamp Interaction In Vitro and In Vivo. CURRENT MICROBIOLOGY[J]. 2010, 60(6): 466-470, http://www.irgrid.ac.cn/handle/1471x/757232.
[102] Dong Men, Zhi-Ping Zhang, Yong-Chao Guo, Duan-Hao Zhu, Li-Jun Bi, Jiao-Yu Deng, Zong-Qiang Cui, Hong-Ping Wei, Xian-En Zhang. An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing. Biosensors and Bioelectronics. 2010, 26(4): 1137-1141, http://dx.doi.org/10.1016/j.bios.2010.07.103.
[103] Li, Ru, Gu, Jing, Chen, YuanYuan, Xiao, ChuanLe, Wang, LiWei, Zhang, ZhiPing, Bi, LiJun, Wei, HongPing, Wang, XuDe, Deng, JiaoYu, Zhang, XianEn. CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY. MOLECULAR MICROBIOLOGY[J]. 2010, 76(5): 1162-1174, http://www.irgrid.ac.cn/handle/1471x/757243.
[104] Han, Han, Cui, ZongQiang, Wang, Wei, Zhang, ZhiPing, Wei, HongPing, Zhou, YaFeng, Zhang, XianEn. New regulatory mechanisms for the intracellular localization and trafficking of influenza A virus NS1 protein revealed by comparative analysis of A/PR/8/34 and A/Sydney/5/97. JOURNAL OF GENERAL VIROLOGY[J]. 2010, 91: 2907-2917, http://www.corc.org.cn/handle/1471x/2375715.
[105] Li, Feng, Li, Ke, Cui, ZongQiang, Zhang, ZhiPing, Wei, HongPing, Gao, Ding, Deng, JiaoYu, Zhang, XianEn. Viral Coat Proteins as Flexible Nano-Building-Blocks for Nanoparticle Encapsulation. SMALL[J]. 2010, 6(20): 2301-2308, http://www.corc.org.cn/handle/1471x/2375720.
[106] Shang, YuShuan, Zhang, XianEn, Wang, XuDe, Guo, YongChao, Zhang, ZhiPing, Zhou, YaFeng. Biochemical characterization and mutational improvement of a thermophilic esterase from Sulfolobus solfataricus P2. BIOTECHNOLOGY LETTERS[J]. 2010, 32(8): 1151-1157, http://www.corc.org.cn/handle/1471x/2375767.
[107] Leng, Yan, Wei, HongPing, Zhang, Zhi Ping, Zhou, YaFeng, Deng, JiaoYu, Cui, ZongQiang, Men, Dong, You, XiangYu, Yu, ZiNiu, Luo, Ming, Zhang, XianEn. Integration of a Fluorescent Molecular Biosensor into Self-Assembled Protein Nanowires: A Large Sensitivity Enhancement. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2010, 49(40): 7243-7246, http://www.corc.org.cn/handle/1471x/2375760.
[108] Zhang Xianen. Construction of bifunctional phage display for biological analysis and immunoassay.. Anal Biochem.. 2010, [109] Wei Li, Lijun Bi, Wenhua Wang, Yongjin Li, Yafeng Zhou, Hongping Wei, Tao Jiang, Lin Bai, Yuanyuan Chen, Zhiping Zhang, Xinghua Yuan, Jianping Xiao, Xian-En Zhang. Development of a universal phosphorylated peptide-binding protein for simultaneous assay of kinases. Biosensors and Bioelectronics. 2009, 24(9): 2871-2877, http://dx.doi.org/10.1016/j.bios.2009.02.020.
[110] Zhang Xianen. Imaging Viral Behaviors in Mammalian Cells with Self-Assembled Capsid-Quantum-Dot Hybrid Particles.. Small. 2009, [111] Liu, Yalan, Cui, Zongqiang, Zhang, Zhiping, Wei, Hongping, Zhou, Yafeng, Wang, Mingli, Zhang, XianEn. The tegument protein UL94 of human cytomegalovirus as a binding partner for tegument protein pp28 identified by intracellular imaging. VIROLOGY[J]. 2009, 388(1): 68-77, http://www.corc.org.cn/handle/1471x/2375599.
[112] Cui, Zongqiang, Zhang, Ke, Zhang, Zhiping, Liu, Yalan, Zhou, Yafeng, Wei, Hongping, Zhang, XianEn. Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci. VIROLOGY[J]. 2009, 392(2): 169-177, http://www.corc.org.cn/handle/1471x/2375598.
[113] Zhang Xianen. On-chip ligation of multiplexing probe-pairs for identifying point mutations out of dense SNP loci.. Biosens Bioelectron. 2009, [114] Zhang, H, Bi, LJ, Li, CY, Sun, ZG, Deng, JY, Zhang, XE. Mutations Found in the pncA Gene of Mycobacterium tuberculosis in Clinical Pyrazinamide-resistant Isolates from a Local Region of China. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH[J]. 2009, 37(5): 1430-1435, http://dx.doi.org/10.1177/147323000903700517.
[115] Wang, DianBing, Bi, LiJun, Zhang, ZhiPing, Chen, YuanYuan, Yang, RuiFu, Wei, HongPing, Zhou, YaFeng, Zhang, XianEn. Label-free detection of B-anthracis spores using a surface plasmon resonance biosensor. ANALYST[J]. 2009, 134(4): 738-742, http://www.irgrid.ac.cn/handle/1471x/757888.
[116] Wang, DianBing, Yang, Ruifu, Zhang, ZhiPing, Bi, LiJun, You, XiangYu, Wei, HongPing, Zhou, YaFeng, Yu, Ziniu, Zhang, XianEn. Detection of B. anthracis Spores and Vegetative Cells with the Same Monoclonal Antibodies. PLOS ONE[J]. 2009, 4(11): http://www.corc.org.cn/handle/1471x/2375591.
[117] Men, Dong, Guo, YongChao, Zhang, ZhiPing, Wei, Hongping, Zhou, YaFeng, Cui, ZongQiang, Liang, XiaoSheng, Li, Ke, Leng, Yan, You, XiangYu, Zhang, XianEn. Seeding-Induced Self-assembling Protein Nanowires Dramatically Increase the Sensitivity of Immunoassays. NANO LETTERS[J]. 2009, 9(6): 2246-2250, http://www.corc.org.cn/handle/1471x/2375538.
[118] Li, Feng, Liu, Qin, Chen, YuanYuan, Yu, ZiNiu, Zhang, ZhiPing, Zhou, YaFeng, Deng, JiaoYu, Bi, LiJun, Zhang, XianEn. Escherichia coli mismatch repair protein MutL interacts with the clamp loader subunits of DNA polymerase III. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2008, 637(1-2): 101-110, http://dx.doi.org/10.1016/j.mrfmmm.2007.07.008.
[119] Wang, Wei, Cui, ZongQiang, Han, Han, Zhang, ZhiPing, Wei, HongPing, Zhou, YaFeng, Chen, Ze, Zhang, XianEn. Imaging and characterizing influenza A virus mRNA transport in living cells. NUCLEIC ACIDS RESEARCH[J]. 2008, 36(15): 4913-4928, http://www.corc.org.cn/handle/1471x/2375514.
[120] Yang, Wei, Zhou, YaFeng, Dai, HePing, Bi, LiJun, Zhang, ZhiPing, Zhang, XiaoHua, Leng, Yan, Zhang, XianEn. Application of methyl parathion hydrolase (MPH) as a labeling enzyme. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2008, 390(8): 2133-2140, http://www.irgrid.ac.cn/handle/1471x/757700.
发表著作
( 1 ) 基因分析和生物芯片技术, GENE ANALYSIS AND BIOCHIP TECHNIQUE, 湖北科学技术出版社, 2004-01, 第 3 作者
( 2 ) High Technology Decelopment Report, 高技术发展报告, 科学出版社, 2005-03, 第 3 作者
( 3 ) 生物传感器, Biosensor, 化学工业出版社, 2005-08, 第 1 作者
( 4 ) 国际科学技术奖概况, A Survey of International Prizes in Science and Technology, 科学出版社, 2009-09, 第 1 作者

科研活动

   
科研项目
( 1 ) 结核分枝杆菌全蛋白质组芯片的构建及应用研究, 主持, 部委级, 2014-01--2016-12
( 2 ) 分析病原微生物学和生物传感, 主持, 部委级, 2013-05--2017-12
参与会议
(1)分子生物传感与细胞分子影像   参加第二届无标记技术国际研讨会   张先恩   2015-03-11
(2)中国合成生物学研究进展   冷泉港亚洲会议   张先恩   2014-12-02
(3)大会组委会中国代表   第二十四届世界生物传感大会   张先恩   2014-05-27

指导学生

已指导学生

黄旭  博士研究生  071005-微生物学  

崔宗强  博士研究生  071005-微生物学  

董艳杰  博士研究生  071005-微生物学  

游璠  博士研究生  071005-微生物学  

贾艳侠  博士研究生  071005-微生物学  

佀静雪  博士研究生  071005-微生物学  

郭永超  博士研究生  071005-微生物学  

乔岩梅  博士研究生  071005-微生物学  

张华  博士研究生  071005-微生物学  

李永进  博士研究生  071005-微生物学  

谷晶  博士研究生  071005-微生物学  

毕利军  博士研究生  071005-微生物学  

杨薇  博士研究生  071005-微生物学  

祁岑  博士研究生  071005-微生物学  

罗明  博士研究生  071005-微生物学  

王婷娟  博士研究生  071005-微生物学  

李可  博士研究生  071005-微生物学  

李中道  博士研究生  071005-微生物学  

田文武  博士研究生  071005-微生物学  

李峰  博士研究生  071005-微生物学  

吴进军  博士研究生  071005-微生物学  

周盈  博士研究生  071005-微生物学  

尤祥宇  博士研究生  071005-微生物学  

钟天映  博士研究生  071011-生物物理学  

林世强  博士研究生  071011-生物物理学  

任茜  硕士研究生  071010-生物化学与分子生物学  

林秀萍  硕士研究生  071010-生物化学与分子生物学  

尹娟  硕士研究生  071005-微生物学  

王绪德  博士研究生  071010-生物化学与分子生物学  

李茹  博士研究生  071010-生物化学与分子生物学  

张敏  博士研究生  071010-生物化学与分子生物学  

刘雅兰  博士研究生  071010-生物化学与分子生物学  

韩昱  硕士研究生  071010-生物化学与分子生物学  

杨仁斌  博士研究生  071010-生物化学与分子生物学  

杨明章  博士研究生  071010-生物化学与分子生物学  

门冬  博士研究生  071010-生物化学与分子生物学  

李风云  博士研究生  071010-生物化学与分子生物学  

梁晓声  博士研究生  071010-生物化学与分子生物学  

程芳  博士研究生  071010-生物化学与分子生物学  

顾佳  硕士研究生  071010-生物化学与分子生物学  

曾德军  硕士研究生  071010-生物化学与分子生物学  

高丁  博士研究生  071010-生物化学与分子生物学  

李昭阳  博士研究生  071010-生物化学与分子生物学  

李坤  博士研究生  071005-微生物学  

李阿茜  博士研究生  071010-生物化学与分子生物学  

田博  硕士研究生  430139-生物工程  

赵亮  硕士研究生  071010-生物化学与分子生物学  

刘凤英  博士研究生  071005-微生物学  

张晓莉  博士研究生  071005-微生物学  

王霆  博士研究生  071005-微生物学  

王明  博士研究生  071010-生物化学与分子生物学  

郝倩  硕士研究生  071005-微生物学  

宋双  硕士研究生  071005-微生物学  

陈涛  博士研究生  071010-生物化学与分子生物学  

黄荔  博士研究生  071005-微生物学  

陈秀秀  硕士研究生  071005-微生物学  

孙曼銮  博士研究生  071005-微生物学  

李敏  硕士研究生  085238-生物工程  

刘冲  硕士研究生  071005-微生物学  

现指导学生

孙宪迅  博士研究生  071005-微生物学  

印文  博士研究生  071005-微生物学  

陈媛媛  博士研究生  071010-生物化学与分子生物学  

郭冬各  博士研究生  071005-微生物学  

王继刚  博士研究生  071005-微生物学  

侯宇  硕士研究生  071010-生物化学与分子生物学  

陈明海  博士研究生  071005-微生物学  

王婷婷  博士研究生  071010-生物化学与分子生物学  

周昆  硕士研究生  071010-生物化学与分子生物学  

曹姗姗  硕士研究生  071010-生物化学与分子生物学  

陈晨  博士研究生  071010-生物化学与分子生物学  

席艳  博士研究生  071010-生物化学与分子生物学  

银芳  硕士研究生  085238-生物工程  

李士敏  博士研究生  071010-生物化学与分子生物学  

李一苇  博士研究生  071010-生物化学与分子生物学  

张玉威  博士研究生  071010-生物化学与分子生物学