基本信息
张天宇  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: zhang_tianyu@gibh.ac.cn
通信地址: 广东省广州市黄埔区科学城开源大道190号A207
邮政编码: 510530

研究领域

方向一:建立新型新药筛选评价模型及药物作用机理研究。

方向二:开发快速临床诊断活菌感染技术及其药物敏感性检测技术。

方向三:新型治疗性疫苗、新生物疗法的开发。

方向四:致病菌诊治相关的合成生物学研究。

方向五:相关科研仪器设备的研发。



招生信息

接受申请-审核制博士生报考咨询
招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
开发快速临床诊断活菌感染技术及其药物敏感性检测技术
新型治疗性疫苗、新生物疗法的开发,致病菌诊治相关的合成生物学研究

教育背景

2002-08--2005-07   中国医学科学院暨中国协和医科大学   博士
1999-09--2002-07   首都师范大学生命科学学院   硕士
1995-09--1999-07   首都师范大学生命科学学院   学士
学位
博士
出国学习工作

2005-10 ~ 2010-08:美国约翰 霍普金斯大学医学院(The Johns Hopkins University, School of Medicine), 博士后。
2014-05:澳大利亚 CSIRO短期访问。

学历
博士

工作经历


2024.04-现在 广州医科大学-中国科学院广州生物医药与健康研究院联合生命科学学院,杰出导师

2022.03-现在  中国科学院广州生物医药与健康研究院广东省生物医药计算重点实验室,研究员

2021.08-现在 中华人民共和国科学技术部中国-新西兰生物医药与健康“一带一路”联合实验室,研究员

2021.06-现在 中国医学科学院医药生物技术研究所,客座教授

2021.06-现在 国家药品监督管理局体外诊断试剂质量研究与评价重点实验室,研究员

2021.05-现在 中国科学院广州生物医药与健康研究院感染与免疫中心副主任

2019.12-现在 广东省科技厅粤港澳呼吸系统传染病联合实验室,研究员

2018.08-现在 呼吸疾病全国重点实验室,结核病研究学组组长

2018.01-现在 中国科学院广州生物医药与健康研究院 分枝杆菌疾病诊疗新技术与产品研发重点培育方向带头人

2017.09-现在 广州市胸科医院客座教授

2016.09-现在 中国科学院大学存济医学院教授

2012.01-现在 呼吸疾病全国重点实验室,结核病研究室联合主任

2011.01-现在 呼吸疾病全国重点实验室,研究员

2010.09-现在 安徽大学教授

2010.09-现在 中国科学技术大学生命科学与医学部教授

2010.09-现在 中国科学院广州生物医药与健康研究院,感染与免疫中心,研究员




社会兼职
2019-12-31-今,期刊“Current Chinese Science”, 联合主编
2019-05-31-今,波兰国家科学中心国际基金, 评审人
2019-05-31-今,爱尔兰研究学会国际基金, 评审人
2019-05-31-今,国家重大科技计划项目, 评审专家
2019-05-31-今,国家重点研发计划项目, 评审专家
2019-05-31-今,中组部“****”青年项目, 评审专家
2019-05-31-今,“挑战杯”全国大学生课外学术科技作品竞赛终审决赛, 评委
2019-05-30-今,特阿拉伯阿卜杜拉国王国际医学研究中心国际基金, 评审人
2018-12-31-今,中科院国际合作项目, 评审专家
2018-06-17-今,国家科学技术奖励评审专家, 评审专家
2018-06-17-今,教育部学位中心学位论文评审专家, 评审专家
2018-06-17-今,广东省自然科学基金及平台项目评审专家, 评审专家
2018-06-17-今,四川省、河北省科学基金评审专家, 评审专家
2018-06-17-今,广州市、东莞市、佛山市基金评审专家, 评审专家
2018-05-31-今,四川省科技奖励评审专家, 评审专家
2017-04-10-今,广东省防痨协会常务理事, 常务理事
2016-12-31-今,《遗传》杂志第十届编委, 编委
2015-12-31-今,卫生部重大传染病专项评审专家, 评审专家
2015-10-05-今,Frontiers in Microbiology 期刊编委, 编委
2015-10-05-今,Frontiers in Public Health 期刊编委, 编委
2015-10-05-今,Frontiers in Medicine编委, 编委
2015-08-31-今,广东省自然科学基金及平台项目评审专家, 评审专家
2013-12-31-今,国家科学技术奖励评审专家, 评审专家
2011-08-31-今,安徽大学, 教授
2011-08-30-今,中国科技大学, 教授

专利与奖励

专利:

PCT

[1] 陆小云,汤健,丁克,张天宇,涂正超,伍甜,万军庭,曹元元。吡唑并[1,5-a]吡啶类化合物及其应用,2015PCT (CN2015/086852)美国授权专利号 US 10,155,756 B2 {申请提交日:2015-08-13专利授权日期2018-12-18}

[2] 张天宇,刘志永。一种可投送自主发光元件的分枝杆菌噬菌体及其应用,2016PCTCN2016/081202{申请提交日:2016-05-06}

[3] 张天宇刘洋。一种吡啶类化合物的新用途2018PCTCN2018/077992)。{申请提交日:2018-03-05}

[4] 张天宇王邦兴,朱丽叶斯.恩迪朗古.穆格文鲁,奇瓦拉.李雾,刘志永。一种重组耐药BCG菌株的构建方法及其应用,2021PCTCN2021/076989{(申请提交日:2021-02-20}

[5] 蒋析文,张天宇,刘悦,卢智黎,蔡晓吟。细菌检测系统及细菌检测方法2021PCTCN2021/106638)。{申请发文日2021-07-16} 

国际专利

[1] Eric Nuermberger, Tianyu Zhang, Jacques Grosset.Autoluminescent mycobacterial reporter strains2011, patent number: (美国专利61/367,475).{申请提交日:2011-03-03}

[2] 陆小云,汤健,丁克,张天宇,涂正超,伍甜,万军庭,曹元元。吡唑并[1,5-a]吡啶类化合物及其应用美国授权证书号US010155756B2{TB47专利,授权公告日:2018-12-18}

[3] 张天宇,刘志永。一种可投送自主发光元件的分枝杆菌噬菌体及其应用。2018,(美国专利:US16/1242522018-09-07[专利已授权US16/124252 ,授权通知是在2021.04.12证书是8月份拿到]日本专利:特愿2018-5472642018-09-06[专利已授权JP2018-547264,授权通知是在2020.12.01]巴西专利:BR 11 2018 068165 22018-09-10[巴西专利商标局在巴西公报号2583公告,一种可投送自主发光元件的分枝杆菌噬菌体及其应用 BR 112018068165-22020-07-07授权]印尼专利:P002018076562018-09-272021106日已授权,授权号:P00201807656菲律宾专利:PH120185019112018-09-07[专利已授权PH12018501911,授权通知是在2023.11.30]南非专利:ZA201805977[ (2018-09-062019515日已授权,2019626日在南非专利公报中刊登授权公告,授权号:ZA 201805977 B)]

[4] 张天宇,王邦兴,朱丽叶斯.恩迪朗古.穆格文鲁,奇瓦拉.李雾,刘志永。一种重组耐药BCG菌株的构建方法及其应用,进入美国,2022US 2022/0387575 A1公开日期,2022.12.08;尚未授权

 中国专利{45项,其中41项发明专利(22项已授权)、其中2项是实用新型专利2项已授权)、2项是外观设计专利2项已授权}

[1] 张天宇。整合质粒pOPHI及无抗性筛选标记的自主发光分枝杆菌2012, 专利号:ZL 201210183007.2授权证书号:1296049{申请提交日:2012-06-05授权公告日:2013-10-30} 

[2] 张天宇,杨峰,邹文英。一种用于高效构建无抗性标记重组分枝杆菌的抗性表达盒,2013,专利号:ZL 201310386264.0授权证书号:1799902{申请提交日:2013-08-30授权公告日:2015-09-23} 

[3] 朱强,张天宇,刘兰英,鲁明辉,毛婷婷,黄金波。吲哚[3,2-c]喹啉类化合物或其药学上可接受的盐及其制备方法和应用2013,专利号:ZL 201310385431.X授权证书号:2017232 {申请提交日:2013-08-30授权公告日:2016-04-06}

[4] 丁克,陆小云,张天宇,汤健,鲁明辉,李宇鹏,张章,梁镇兴,钱政江。N-4-三氟甲基苯基水杨酰胺衍生物的制备方法和应用,2014专利号:ZL201410073672.5授权证书号:3399514{申请提交日:2014-03-03中国授权公告日:2019-6-4}

[5] 陆小云,汤健,丁克,张天宇,涂正超,伍甜,万军庭,曹元元。吡唑并[1,5-a]吡啶类化合物及其应用,2014,专利号:ZL 201410562805.5 [优先权专利号更改为ZL 201510460751.6]中国授权证书号:2859327{申请提交日:2014-10-21中国授权公告日:2018-3-27}

[6] 张天宇,曹元元,伍甜,谭守勇,谭耀驹,蔡杏珊,刘春平。构建无选择标记的自主发光脓肿分枝杆菌的方法及建立相应体外高通量筛药模型,2015,专利号:ZL 201510104936.3授权证书号:3024757{申请提交日:2015-03-10授权公告日:2018-08-07} 

[7] 张天宇,刘志永。一种可投送自主发光元件的分枝杆菌噬菌体及其应用2016专利号:ZL 201610127984.9授权证书3366525 {申请提交日:2016-03-08授权公告日:2019-05-07}

[8] 鞠建华,马俊英,张天宇,刘志永。一种海洋链霉菌及其环肽化合物在制备抗结核分枝杆菌药物中的应用,2016,专利号:ZL 201610806737.1授权证书3541055 {申请提交日:2016-09-06授权公告日:2019-09-27}

[9] 张天宇,摩西·M·恩扎瑞,王邦兴,刘志永,韩轶,刘燕,刘洋。一种检测结核分枝杆菌耐药性的DNA标记物及其应用2016专利号:ZL201610564946.X{(申请提交日:2016-07-15) 授权证书3508930 (授权公告日:2019-08-27)}

[10] 涂正超,朱强,张天宇,黄金波,徐晓冰,万军庭,黎敏科,李登科,周亚丽,刘志永,王邦兴,米琦.托特雷拉。吲哚-2--3-螺噻嗪酮或噻唑酮化合物及其应用,2016专利申请号:ZL201610657161.7 {(申请提交日:2016-8-11)}授权证书号4070612授权公告号107722044 B (授权公告日:2020-11-03)

[11] 张天宇, 马格文如.朱丽俄斯,刘燕,王邦兴,曹元元,黄少波,玛卡芬.盖乐, 张洋,郭锦涛,柴然吉比.筹多拉瑞,刘洋。一种硫链丝菌素-庆大霉素抗性基因体系及含有其的抗性表达盒和重组质粒,2016专利申请号:201610902985.6{(申请提交日:2016-10-18}

[12] 张天宇,刘洋,谭守勇,刘健雄,李昕洁,王邦兴,周佩佩,蔡杏珊,郭玲敏,刘燕,刘志永,唐运祥,高亚敏,姜火凤。吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的药物组合物,2017专利号:ZL201710240224.3{(申请提交日:2017-04-13)授权证书4333946 (授权公告日:2021-3-30)}

[13] 王子厚,张天宇,马领弟,陈昌红。蜡梅属植物抗结核杆菌的用途,2017专利申请号:ZL201710392913.6{(申请提交日:2017-05-27)}授权证书号3131726授权公告号107137438 B (授权公告日:2018-11-02)

[14] 鄢明,张天宇,张妞妞,刘志永,钱露,唐运祥,程亚娟,张学景。间二取代苯酚化合物及其制备方法与抗结核菌应用,2017专利ZL201711310722.7{(申请提交日:2017-12-11)。授权证书3761703 (授权公告日:2020-04-17)}}

[15] 罗有福,张天宇。新型小分子化合物、制备方法及在制备抗耐药结核分枝杆菌等分枝杆菌药物方面的用途,2018专利申请号:ZL201810003576.1。(申请提交日:2018-01-04授权证书号:5664421(授权公告日:2022-12-27)

[16] 张天宇,刘洋。一种吡啶类化合物的新用途,2018,专利号:ZL201810106538.9{申请发文日2018-02-02}授权证书4187932 (授权公告日:2021-1-5 )

[17] 张天宇,刘燕,孙彩军,潘恩祥,王邦兴,郭玲敏,陈凌,刘志永。一种艾滋病疫苗及其制备方法2018专利申请号:201810359440.4{(申请提交日:2018-04-20}

[18] 罗有福,张天宇。嘧啶类小分子化合物及在制备抗分枝杆菌药物中的用途2018专利申请号:201810574690.X{(申请提交日:2018-06-06)。} 

[19] 朱天骄,高亚敏,孙春晓,张天宇,李德海,顾谦群,车茜。一种抗结核聚酮类化合物及其制备方法和用途2018专利申请号:ZL201810978010.0{(申请提交日:2018-08-27授权证书4928367(授权公告日:2022-02-11)}

[20] 张天宇,王帅,高亚敏,蔡晓吟,卢智黎。一种自主发光的铜绿假单胞菌及其构建方法和应用,2018专利申请号:201811351568.2{(申请提交日:2018-11-13}

[21] 张天宇,高亚敏,王帅,郭玲敏,卢智黎,蔡晓吟,方翠婷 。一种自主发光的鲍曼不动杆菌及其构建方法和应用,2019,专利号:ZL201910051035.0{申请提交日:2019-01-24授权证书5425981(通知授权日:2022-08-03授权公告日:2022-09-02)}

[22] 马俊英,孙长利,刘志永,张天宇,鞠建华。 环肽类抗生素及其制备方法和在制备抗结核药物中的应用2019专利申请号:ZL201910099287.0{(申请提交日:2019-01-31授权证书号4047037 (授权公告日:2020-10-23)}

[23] 潘力、付威威、尹焕才、张天宇、周哲、陈名利、刘敏、朱海龙。基于光电倍增管的微弱光检测装置,2019,专利申请号:201910107713.0{(申请提交日:2019-02-012019-7-18日进入实质审查}【发明新型】

[24] 潘力、付威威、尹焕才、张天宇、周哲、陈名利、刘敏、朱海龙。基于光电倍增管的微弱光检测装置,2019,专利号:ZL201920178543.0{(申请提交日:2019-02-01授权证书10111604(授权公告日:2020-03-06)}【实用新型】

[25] 鞠建华、张天宇、孙长利、刘志永、马俊英。海洋环肽化合物及其在制备抗结核分枝杆菌药物中的应用,2019专利申请号:ZL201911149125.X{(申请提交日:2019-11-21授权证书号5013871  (授权公告日:2022-03-22)} 

[26] 潘宇骏,钱庆,尹焕才,张天宇,杨任兵,陈名利,卢智黎,程文播,王继帅,王磊。基于ARP的临床检测结核分支杆菌自动化检测平台,2019,专利申请号:201910780865.7{(申请发文日:2019-08-22),2021-9-26发明人变更成功

[27]  宋旭,刘丹,赵永云,李为民,张天宇,曾凡亚,缪辉,李佳,李晓杰,李灵。新型冠状病毒疫苗及其制备方法和应用2020,专利申请号:202010119149.7{(申请提交日:2020-02-26}

[28] 张天宇,王邦兴,朱丽叶斯.恩迪朗古.穆格文鲁,奇瓦拉.李雾,刘志永。一种重组耐药BCG菌株的构建方法及其应用,2020,专利申请号:ZL202010134454.3{(申请提交日:2020-03-02授权证书4979727(授权公告日:2022-03-08} 

[29] 鞠建华李骏刘志永马俊英张天宇一种怡莱霉素F及其衍生物在制备抗结核分枝杆菌药物中的应用,2020,专利申请号:ZL202010402848.2{申请发文日2020-05-13授权证书号4779806  (授权公告日:2021-11-9)}

[30] 张天宇余崴,迟瓦剌.李雾。 一种基于吡唑并[1,5-a]吡啶类化合物的治疗结核分枝杆菌感染的药物组合物2020,专利申请号:ZL202010988049.8{申请发文日2020-09-19授权证书号4952714  (授权公告日:2022-2-2)}

[31] 张天宇,田茜溶,高亚敏,王帅,余崴,方翠婷,张静然。一种无抗性标记自主发光肺炎克雷伯菌的构建方法及应用,2020,专利申请号:202011246711.9 (新改后的)。{(申请发文日:2020-11-10}

[32] 洪斌,武临专,张天宇,侍媛媛,刘志永,胡晓敏,任卫聪,布哈里• 优素福,田茜溶,李星星。创新霉素及其衍生物在抑制结核分枝杆菌中的应用,2021,专利申请号:202110601165.4{(申请发文日:2021-05-31}

[33] 蒋析文,张天宇,刘悦,卢智黎,蔡晓吟。细菌检测系统及细菌检测方法,2021,专利申请号:202110763013.4{(申请发文日:2021-07-07}暂未授权

[34] 蒋析文,张天宇,刘悦,卢智黎,蔡晓吟。细菌检测系统,2021,专利申请号:ZL202121528518.4{(申请发文日:2021-07-07授权证书15417694(授权公告日:2022-01-07}【实用新型】

[35] 蒋析文,张天宇,刘悦,卢智黎,蔡晓吟。分枝杆菌自动化检测装置,2021,专利申请号:ZL202130423816.6202130423816.6:自动化检测装置)。{(申请发文日:2021-07-07),授权证书10111604授权公告日:2021-11-05}【外观专利】

[36] 蒋析文,张天宇,刘悦,卢智黎,蔡晓吟。自动化药敏检测装置的外壳 2021,专利申请号:ZL202130423799.6{(申请发文日:2021-07-07),授权证书6973154授权公告2021-11-19}【外观专利】

[37] 张天宇, 孙彩军,方翠婷。一种重组的耻垢分枝杆菌、疫苗及其应用2021,专利申请号:202111148605.1{申请发文日2021-09-29}

[38] 张天宇, 高亚敏,方翠婷,何静,曾三山,韩星丽。阿西维辛在制备抗结核分枝杆菌的药物中的应用,2023,专利申请号:202310025379.0{(申请发文日:2023-01-09}

[39] 张天宇,田茜溶,高亚敏,余崴,巨亚男,曾三山,朱雨婷,丁洁,方香娥。富马酸卢帕他定在制备抑制分枝杆菌药物中的应用,2023,申请专利号:202310121229.X{申请发文日:2023-02-16}

[40] 曾嘉张天宇鄢明田茜溶彭瑞君沙阿拉姆布哈里尤瑟夫何静田国宝N-杂芳基-5-氯水杨酰胺类化合物及其制备方法与抗结核菌应用2023,申请专利号:202310311746.3{申请发文日:2023-03-28} 

[41] 张妞妞, 张天宇,梁力洪,刘志永,罗海条,周异欢,吴康杰2-吡啶酮并噻吩化合物及其制备方法、用途及抗结核药物2023,申请专利号:202311115329.8{申请发文日:2023-08-31}

[42] 张天宇高亚敏方翠婷何静田茜溶张晗。偶氮丝氨酸在制备抗分枝菌的药物中的应用2023,申请专利号:202311135741.6{申请发文日:2023-09-05}

[43] 张天宇余崴巨亚男韩星丽田茜溶李永国丁洁。一种用于治疗结核分枝杆菌感染的药物组合物及其应用,2023,申请专利号:202311163265.9{申请发文日:2023-09-08}

[44] 徐亚萍侯廷军车金鑫李丹陆扬杨柳胡雪萍董晓武张天宇。一种用于结核分枝杆菌DprE1酶抑制剂的化合物、组合物及其应用,2023,申请专利号:202310124680.7{申请发文日:2023-2-16}

[45] 洪斌,侍媛媛,解云英,逯媛,李怡宏,范佳会,李星星,孙红敏,王丽非,张天宇,韩星丽,朱雨婷一组 sansanmycin 衍生物及其应用。申请专利号:202311335796.1{申请发文日:2023-10-16} 


奖励:

1. 中国科学院广州教育基地2023年度“广州教育基地优秀研究生导师”

2. 广州市黄埔区开发区创新创业领军人才【穗埔人才领字[2022]1号 】

3. “基于自发光技术的新型抗菌药物活体筛选系统的研制”项目获得中国发明协会2021年度发明创业奖创新奖二等奖(医药卫生)【国科奖社证字第0123号】

4. 中国科学院大学教育基金会2021年臻溪生命科学优秀教育工作者

5. 广州市黄埔区“杰出人才”

6. 中国科学院广州分院2017-2021年优秀共产党员

7. 中国产学研合作促进会“2020年产学研合作创新奖(个人)”【国科奖社证字第0191号】

8. 国家“万人计划科技创新领军人才”中组函字[2020]81号

9. 科技部“创新人才推进计划中青年科技创新领军人才”2019RA2099 

10. 广州市“优秀专家”2019

11. 广州市黄埔区“优秀人才”(2019)

12. 广东省第五届专利奖 “优秀奖”(2018)

13. 广东特支计划“科技创新领军人才”2016TX03R095

14. 中国科学院“****”A类(2012)


合作情况

  以呼吸疾病国家重点实验室为纽带,与广州市呼吸疾病研究所,广州市胸科医院,广东省检验检疫局有紧密合作。其中呼吸疾病国家重点实验室与广东省检验检疫局国家生物安全检测重点实验室共建有生物安全3级(BSL-3,即P3)实验室,可开展生物安全三级动物。与广州市胸科医院共建有"结核病研究室" ,致力于转化医学的研究。
  与中国科技大学,安徽大学共同培养学生。
  与复旦大学,中山大学,四川大学,中国医学科学院,武汉大学,中科院微生物研究所,中科院生物物理研究所,中科院武汉病毒所,深圳大学,广东工业大学,西南大学等有合作/紧密联系。
  与美国约翰霍普金斯大学,纽约州立大学石溪分校,香港中文大学,澳大利亚莫纳什大学和CSIRO有紧密合作。

指导学生

已指导学生

宫钰  硕士研究生  071010-生物化学与分子生物学  

刘燕  硕士研究生  085238-生物工程  

高亚敏  硕士研究生  085238-生物工程  

王帅  博士研究生  100102-免疫学  

何雪莹  硕士研究生  085238-生物工程  

郭玲敏  硕士研究生  085238-生物工程  

蔡晓吟  硕士研究生  085238-生物工程  

余崴  博士研究生  100102-免疫学  

高亚敏  博士研究生  100102-免疫学  

韩星丽  硕士研究生  100102-免疫学  

现指导学生

方翠婷  博士研究生  100103-病原生物学  

田茜溶  博士研究生  100103-病原生物学  

方香娥  硕士研究生  086000-生物与医药  

曾三山  硕士研究生  086000-生物与医药  

李瑞强  博士研究生  071010-生物化学与分子生物学  

陆子文  硕士研究生  100103-病原生物学  

马万里  硕士研究生  071010-生物化学与分子生物学  

张小凡  博士研究生  100102-免疫学  

李春宇  硕士研究生  100102-免疫学  

杨汝豪  硕士研究生  086000-生物与医药  

隆李花  硕士研究生  086000-生物与医药  

出版信息

   
发表的主要论文
(1) Novel derivatives of quinoxaline-2-carboxylic acid 1,4-dioxides as antimycobacterial agents: mechanistic studies and therapeutic potential, Pharmaceuticals, 2024, 通讯作者
(2) Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay, Journal of Thoracic Disease, 2024, 通讯作者
(3) Bactericidal and Sterilizing Efficacy of Sudapyridine-Clofazimine-TB47 Combined with Linezolid, and/or Pyrazinamide in a Murine Model of Tuberculosis, Antimicrob Agents Chemother, 2024, 通讯作者
(4) Synthesis and Biological Evaluation of 2-(Tetrazol-5-yl)sulfonylacetamides as Inhibitors of Mycobacterium tuberculosis, Bioorganic & Medicinal Chemistry Letters, 2024, 通讯作者
(5) EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin, mLife, 2024, 通讯作者
(6) Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis, Frontiers in Medicine, 2024, 通讯作者
(7) Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity, ACS Synthetic Biology, 2024, 第 10 作者
(8) 3-Methoxy-2-phenylimidazo[1,2-b]pyridazines Highly Active Against Mycobacterium tuberculosis and Mycobacterium marinum, European Journal of Medicinal Chemistry, 2024, 通讯作者
(9) Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir, Nature Microbiology, 2024, 其他(合作组作者)
(10) Indole propionic acid is an effective substrate for tryptophanyl-tRNA synthetase in Mycobacterium tuberculosis, ACS Infectious Diseases, 2024, 通讯作者
(11) Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in Mycobacteria, Microbiology Spectrum, 2024, 通讯作者
(12) Iterative Methylation Leads to 3-Methylchuangxinmycin Production in Actinoplanes tsinanensis CPCC 200056, JOURNAL OF NATURAL PRODUCTS, 2023, 第 13 作者
(13) A recombinant Mycobacterium smegmatis-based surface display system for developing the T cell-based COVID-19 vaccine, HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2023, 通讯作者
(14) Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023, 通讯作者
(15) Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis, JOURNAL OF MEDICINAL CHEMISTRY, 2023, 通讯作者
(16) Expanding the Chemical Diversity of Grisechelins via Heterologous Expression, Journal of Natural Products, 2023, 第 7 作者
(17) Discovery of N-(1-(6-oxo-1,6-dihydropyrimidine)-pyrazole) acetamide derivatives as novel noncovalent DprE1 inhibitors against Mycobacterium tuberculosis, Journal of Medicinal Chemistry, 2023, 第 8 作者
(18) Expanding structural diversity of 5′-aminouridine moiety of sansanmycin via mutational biosynthesis, Frontiers in Bioengineering and Biotechnology, 2023, 第 9 作者
(19) Azetidines kill multidrug resistant Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly, Journal of Medicinal Chemistry, 2023, 其他(合作组作者)
(20) Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening, Acta Pharmacol Sin, 2022, 第 13 作者
(21) Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 第 10 作者
(22) Crystal structure of the cytokinin-producing enzyme "lonely guy" (LOG) from Mycobacterium tuberculosis, Biochemical and Biophysical Research Communications, 2022, 第 9 作者
(23) Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus, MICROBIOLOGY SPECTRUM, 2022, 通讯作者
(24) Insight into novel anti-tuberculosis vaccines by using immunoinformatics approaches, Front Microbiol, 2022, 通讯作者
(25) 2-acyl-3-trifluoromethylquinoxaline 1,4-dioxides as po-tential antimicrobial agents, Pharmaceuticals, 2022, 第 13 作者
(26) Identification of selective mtb DHFR inhibitors by virtual screening and experimental approaches, Chem Biol Drug Des, 2022, 第 8 作者
(27) Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 第 10 作者
(28) Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest Hospital, China, INFECTION AND DRUG RESISTANCE, 2022, 通讯作者
(29) Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis, Antimicrob Agents Chemother, 2021, 通讯作者
(30) Nitric oxide-dependent electron transport chain inhibition by the cytochrome bc1 inhibitor and pretomanid combination kills Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2021, 通讯作者
(31) 基于自发光技术的新型抗菌药物活体筛选系统, 中国科学院院刊, 2021, 通讯作者
(32) Rapid visualized assessment of drug efficacy in live mice with a selectable marker-free autoluminescent Klebsiella pneumoniae, BIOSENSORS & BIOELECTRONICS, 2021, 通讯作者
(33) Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans, Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans, ACTA PHARMACEUTICA SINICA B, 2021, 通讯作者
(34) The structure-based virtual screening of non-benzofuran inhibitors against M. tuberculosis Pks13-TE for anti-tuberculosis phenotypic discovery, NEW JOURNAL OF CHEMISTRY, 2021, 通讯作者
(35) Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities, FRONTIERS IN CHEMISTRY, 2021, 第 5 作者
(36) A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line tuberculosis regimen, Biomed Pharmacother, 2021, 通讯作者
(37) Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430, ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 第11作者
(38) Cas12a/gRNA-based platform for rapid and accurate identification of major Mycobacterium species, J Clin Microbiol, 2020, 第 1 作者
(39) Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units, JOURNAL OF NATURAL PRODUCTS, 2020, 第 5 作者
(40) Anti-tubercular ilamycins from marine-derived Streptomyces atratus SCSIO ZH16 ∆ilaR, J. Nat. Prod., 2020, 
(41) Comparative Analysis of Whole-Genome and Methylome Profiles of a Smooth and a Rough Mycobacterium abscessus Clinical Strain, G3: GENES, 2020, 通讯作者
(42) TB47 and clofazimine form a highly synergistic sterilizing block in a second-line regimen for tuberculosis in mice, BIOMEDICINE & PHARMACOTHERAPY, 2020, 通讯作者
(43) revalence and molecular characterization of amikacin resistance among Mycobacterium tuberculosis isolates from southern China, J Glob Antimicrob Resist, 2020, 通讯作者
(44) Cas12a/Guide RNA-Based Platform for Rapid and Accurate Identification of Major Mycobacterium Species, JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 第11作者
(45) CRISPR/Cas12a-based biosensing platform for precise and efficient screening of CRISPR/Cas9-induced biallelic mutants, TALANTA, 2020, 第11作者
(46) Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR, JOURNAL OF NATURAL PRODUCTS, 2020, 第 9 作者
(47) Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy, FRONTIERS IN PHARMACOLOGY, 2020, 第 6 作者
(48) Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China, INFECTION AND DRUG RESISTANCE, 2020, 通讯作者
(49) Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 通讯作者
(50) Pangenome Analysis of Mycobacterium tuberculosis Reveals Core-Drug Targets and Screening of Promising Lead Compounds for Drug Discovery, ANTIBIOTICS-BASEL, 2020, 第 5 作者
(51) Identification of Mycobacterium abscessus species and subspecies using the Cas12a/sgRNA-based nucleic acid detection platform, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2020, 第 10 作者
(52) 无需麻醉小动物活体发光快速检测系统, 中国科学院院刊, 2020, 第 1 作者
(53) Identification of Mycobacteriuim abscessus species and subspecies using the Cas12a/sgRNA-based nucleic acid detection platform, Eur J Clin Microbiol Infect Dis, 2020, 第 1 作者
(54) Rapid, serial, non-invasive quantification of Pseudomonas aeruginosa in live mice with a selectable marker-free autoluminescent strain, BIOSENSORS & BIOELECTRONICS, 2020, 通讯作者
(55) Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and may prevent the emergence of resistance for Mycobacterium ulcerans, Acta Pharm Sin B, 2020, 通讯作者
(56) Phenotypic and Genotypic Characterization of Streptomycin-Resistant Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China, MICROBIAL DRUG RESISTANCE, 2020, 通讯作者
(57) Prevalence and molecular characterization of amikacin resistance among Mycobacterium tuberculosis clinical isolates from southern China, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2020, 通讯作者
(58) Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain, ORGANIC LETTERS, 2019, 通讯作者
(59) Immunoinformatics-Aided Design and Evaluation of a Potential Multi-Epitope Vaccine against Klebsiella Pneumoniae, VACCINES, 2019, 第 7 作者
(60) Design, synthesis, and in vitro biological evaluation of novel benzimidazole tethered allylidenehydrazinylmethylthiazole derivatives as potent inhibitors of Mycobacterium tuberculosis, MEDCHEMCOMM, 2019, 通讯作者
(61) Pyrazolo1,5-apyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resistant tuberculosis, ACS INFECTIOUS DISEASES, 2019, 第 17 作者
(62) Discovery of napabucasin derivatives for the treatment of tuberculosis, MEDCHEMCOMM, 2019, 通讯作者
(63) Design, synthesis, and antitubercular activity of 3‐amidophenols with 5‐heteroatomic substitutions, ARCHIV DER PHARMAZIE, 2019, 通讯作者
(64) The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model, NATURE COMMUNICATIONS, 2019, 通讯作者
(65) Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster, ORGANIC LETTERS, 2019, 第 7 作者
(66) Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy, MOLECULES, 2019, 通讯作者
(67) One-Step Engineering of a Stable, Selectable Marker-Free Autoluminescent Acinetobacter baumannii for Rapid Continuous Assessment of Drug Activity, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 通讯作者
(68) Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase, CELL CHEMICAL BIOLOGY, 2019, 通讯作者
(69) A pyrazolo[1,5-a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resistant tuberculosis, ACS Infect Dis, 2019, 第 1 作者
(70) Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Ortho-dihydroxylated Cinnamic Acyl Chain, Organic Letters, 2019, 
(71) Discovery of meta-amido bromophenols as new antitubercular agents., CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 通讯作者
(72) Detection of Novel Mutations Associated with Independent and Cross-resistance to Isoniazid and Protionamide in Mycobacterium tuberculosis Clinical Isolates, Clin Microbiol Infect, 2019, 通讯作者
(73) Phenotypic and genotypic characterization of levofloxacin- and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China, JOURNAL OF THORACIC DISEASE, 2019, 通讯作者
(74) Identification of Pyrazolo[1,5-a]pyridine-3-carboxamide Diphenyl or Azadiaryl Derivatives as Drug Resistant Anti-tuberculosis Agents, ACS Med Chem Lett, 2019, 通讯作者
(75) Design and synthesis of novel benzoimidazole tethered allylidenehydrazinylmethylthiazole derivatives as potent inhibitors of Mycobacterium tuberculosis, MEDCHEMCOMM, 2019, 通讯作者
(76) Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, 通讯作者
(77) The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study, The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study, 生物医学与环境科学:英文版, 2018, 第 10 作者
(78) Mutation ethAW21R Confers Co-resistance to Protionamide and Ethionamide in both M. bovis BCG and M. tuberculosis H37Rv, Infect Drug Resist, 2018, 通讯作者
(79) Discovery of novel anti-tuberculosis agents with pyrrolo1,2-aquinoxaline-based scaffold, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 第 8 作者
(80) Copper-Catalyzed Direct C-H Bond Arylation of Benzoxazoles with Anilines, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 第 3 作者
(81) Detection of novel mutations associated with independent and cross-resistance to isoniazid and prothionamide in mycobacterium tuberculosis clinical isolates, CLINICAL MICROBIOLOGY AND INFECTION, 2018, 第 18 作者
(82) The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study, BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2018, 通讯作者
(83) 一种新型医用动态空气消毒机对MTB等病原微生物杀菌效果的研究, Study on the bactericidal effect using a new type of medical dynamic air disinfector on MTB and other pathogenic microorganisms, 中国防痨杂志, 2018, 第 3 作者
(84) Synthesis and biological activity evaluation of pyrrolo[1,2-a] quinoxaline compounds as potential novel antitubercular agents, Bioorg Med Chem Lett, 2018, 第 1 作者
(85) Discovery of novel anti-tuberculosis agents with pyrrolo1,2-aquinoxaline-based scaffold, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 第 8 作者
(86) Advances in the development of molecular genetic tools for Mycobacterium tuberculosis, JOURNAL OF GENETICS AND GENOMICS, 2018, 通讯作者
(87) Design and synthesis of novel pyrimidine derivatives as potent anti-tubercular agents, Eur J Med Chem, 2018, 通讯作者
(88) Design, synthesis and biological evaluation of novel pyrrole derivatives as potential ClpP1P2 inhibitor against Mycobacterium tuberculosis, BIOORGANIC CHEMISTRY, 2018, 通讯作者
(89) Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv, INFECTION AND DRUG RESISTANCE, 2018, 通讯作者
(90) Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents, MEDCHEMCOMM, 2018, 通讯作者
(91) Advances in the development of molecular genetic tools for Mycobacterium tuberculosis, Advances in the development of molecular genetic tools for Mycobacterium tuberculosis, 遗传学报:英文版, 2018, 其他(合作组作者)
(92) Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 通讯作者
(93) Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7, NATURAL PRODUCT RESEARCH, 2017, 第 8 作者
(94) Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01, NATURAL PRODUCT RESEARCH, 2017, 第 5 作者
(95) Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents, NATURE COMMUNICATIONS, 2017, 第 10 作者
(96) Drug resistance mechanisms and novel drug targets for tuberculosis therapy, JOURNAL OF GENETICS AND GENOMICS, 2017, 通讯作者
(97) A Cassette Containing Thiostrepton, Gentamicin Resistance Genes, and dif sequences Is Effective in Construction of Recombinant Mycobacteria, FRONTIERS IN MICROBIOLOGY, 2017, 通讯作者
(98) Deletion of sigB Causes Increased Sensitivity to para -Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 第 8 作者
(99) Pyrazolo1,5-apyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 6 作者
(100) Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant Mycobacterium tuberculosis, MEDCHEMCOMM, 2017, 第 4 作者
(101) 抗生物耐药性研究领域的机遇和挑战, 遗传, 2016, 第 1 作者
(102) Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 通讯作者
(103) The Influence of Pyrazinamide Monoresistance on Treatment Outcomes in Tuberculosis Patients from Southern China, J Tuberculosis Res, 2016, 通讯作者
(104) Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702, JOURNAL OF NATURAL PRODUCTS, 2016, 第 10 作者
(105) 抗生素耐药性研究领域的机遇和挑战, 遗传, 2016, 第 1 作者
(106) Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 第 5 作者
(107) Identification of lysine acetylation in mycobacterium abscessus using lc-ms/ms after immunoprecipitation, JOURNALOFPROTEOMERESEARCH, 2016, 通讯作者
(108) 非一线抗结核药物耐药机制及耐药性诊断研究进展, Progress in resistance mechanisms and diagnosis of non-first line anti-TB drugs, 遗传, 2016, 第 9 作者
(109) Correlation between HFE gene polymorphisms and increased risk of coronary artery disease among patients with type 2 diabetes in Iran, TURKISH JOURNAL OF MEDICAL SCIENCES, 2016, 第 6 作者
(110) Pyrazinamide resistance in Mycobacterium tuberculosis : Review and update, ADVANCES IN MEDICAL SCIENCES, 2016, 第 8 作者
(111) Design, Synthesis, and Biological Evaluation of Pyrazolo1,5-apyridine-3-carboxamides as Novel Antitubercular Agents, ACS MEDICINAL CHEMISTRY LETTERS, 2015, 通讯作者
(112) Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce, PHYTOCHEMISTRY LETTERS, 2015, 第 6 作者
(113) Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis, PLANTA MEDICA, 2015, 第 7 作者
(114) Role of folP1 and folP2 Genes in the Action of Sulfamethoxazole and Trimethoprim Against Mycobacteria, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 通讯作者
(115) RELATIONSHIP BETWEEN PPARGC1A GENE POLYMORPHISMS WITH THE INCREASED RISK OF CORONARY ARTERY DISEASE AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS IN IRAN, ACTA ENDOCRINOLOGICA-BUCHAREST, 2015, 
(116) 吡嗪酰胺敏感性检测结果应该运用到对结核病治疗, 广东医学, 2015, 第 1 作者
(117) Role of folp1 and folp2 genes in the action of sulfamethoxazole and trimethoprim against mycobacteria., J MICROBIOL BIOTECHNOL, 2015, 
(118) 吡嗪酰胺敏感性检测在结核病治疗中的应用, 广东医学, 2015, 第 2 作者
(119) Engineering More Stable, Selectable Marker-Free Autoluminescent Mycobacteria by One Step, PLOS ONE, 2015, 通讯作者
(120) Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40, MOLECULES, 2015, 第 7 作者
(121) Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation, NATURAL PRODUCT RESEARCH, 2015, 第 4 作者
(122) Role of pncA and rpsA Gene Sequencing in Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates from Southern China, JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 通讯作者
(123) Pestalols A-E, New Alkenyl Phenol and Benzaldehyde Derivatives from Endophytic Fungus Pestalotiopsis sp. Acbc2 Isolated from the Chinese Mangrove Plant, Aegiceras corniculatum. J Antibiot, 2014, 第 1 作者
(124) Risk factors for hemoptysis in pulmonary tuberculosis patients from southern China: a retrospective study, J Tuberculosis Res, 2014, 通讯作者
(125) Efficient construction of unmarked recombinant mycobacteria using an improved system, JOURNAL OF MICROBIOLOGICAL METHODS, 2014, 通讯作者
(126) Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6, JOURNAL OF ANTIBIOTICS, 2014, 第 6 作者
(127) Pestalols A-E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum, JOURNAL OF ANTIBIOTICS, 2014, 第 5 作者
(128) Evolution of Influenza A H7N9 Virus with an Emphasis on Gene Constellation, JOURNAL OF GENETICS AND GENOMICS, 2014, 第 3 作者
(129) A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp ZSDS1-F3, NATURAL PRODUCT RESEARCH, 2014, 第 8 作者
(130) Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17, MEDCHEMCOMM, 2014, 第 9 作者
(131) Rapid, Serial, Non-invasive Assessment of Drug Efficacy in Mice with Autoluminescent Mycobacterium ulcerans Infection, PLOS NEGLECTED TROPICAL DISEASES, 2013, 通讯作者
(132) 利用自主发光结核分枝杆菌快速连续检测抗结核药物的细胞内活性, 实用医学杂志, 2013, 第 3 作者
(133) Cloning and characterization of human Golgi phosphoprotein 2 gene (GOLPH2/GP73/GOLM1) promoter, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 第 4 作者
(134) Autoluminescent Mycobacterium tuberculosis for Rapid, Real-Time, Non-Invasive Assessment of Drug and Vaccine Efficacy, PLOS ONE, 2012, 通讯作者
(135) Using Bioluminescence To Monitor Treatment Response in Real Time in Mice with Mycobacterium ulcerans Infection, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 第 1 作者
(136) Short-Course Chemotherapy with TMC207 and Rifapentine in a Murine Model of Latent Tuberculosis Infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 第 1 作者
(137) Short-course therapy with TMC-207 and rifapentine in a murine model of latent tuberculosis infection, Am J Respir Crit Care Med, 2011, 第 1 作者
(138) Rapid Assessment of Antibacterial Activity against Mycobacterium ulcerans by Using Recombinant Luminescent Strains ▿, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 第 1 作者
(139) Short-Course Therapy with Daily Rifapentine in a Murine Model of Latent Tuberculosis Infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 第 1 作者
(140) Disruption of the ste22 gene encoding a glycosyltransferase and its function in biosynthesis of ebosin in Streptomyces sp. 139, CURRENT MICROBIOLOGY, 2006, 
(141) Disruption of ste23 gene affects composition profile and bioactivity of exopolysaccharide produced by Streptomyces sp 139, LETTERSINAPPLIEDMICROBIOLOGY, 2006, 
(142) 链霉菌来源的UDP-葡萄糖-4-差向异构酶基因的克隆表达及酶性质研究, Cloning and expression of UDP-glucose-4-epimerase gene from Streptomyces and characteristics of the enzyme, 微生物学报, 2005, 第 1 作者
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