基本信息

张天宇  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: zhang_tianyu@gibh.ac.cn
通信地址: 广东省广州市黄埔区科学城开源大道190号A207
邮政编码: 510530

研究领域

1. 致病菌的后基因组学研究。

2. 抗致病菌药物研发,药物作用机制与耐药机制的研究。

3. 致病菌的快速诊断和药敏检测研究。

4.  细菌与宿主相互作用,疫苗的开发。

招生信息

接受申请-审核制博士生报考咨询
招生专业
071010-生物化学与分子生物学
招生方向
细菌性传染病相关机理研究

教育背景

2005-09--2010-08   美国约翰霍普金斯大学医学院   博士后
2002-08--2005-07   中国医学科学院暨中国协和医科大学   博士
1999-09--2002-07   首都师范大学生命科学学院   硕士
1995-09--1999-07   首都师范大学生命科学学院   学士
学位
博士
出国学习工作

2005-10 ~ 2010-08:美国约翰 霍普金斯大学医学院(The Johns Hopkins University, School of Medicine), 博士后。
2014-05:澳大利亚 CSIRO短期访问。

学历
博士

工作经历

2016-09 ~ 现在:中国科学院大学,教授

2012-02 ~ 现在:中国科学院广州生物医药与健康研究院,呼吸疾病国家重点实验室,结核病研究室联合主任。 

2011-01 ~ 现在:中国科学院广州生物医药与健康研究院,呼吸疾病国家重点实验室,研究员。 
2010-09 ~ 现在:中国科学院广州生物医药与健康研究院,研究员。中国科学技术大学兼职教授,安徽大学兼职教授。

社会兼职
2018-06-18-今,国家科学技术奖励评审专家, 评审专家
2018-06-18-今,教育部学位中心学位论文评审专家, 评审专家
2018-06-18-今,广东省自然科学基金及平台项目评审专家, 评审专家
2018-06-18-今,四川省、河北省科学基金评审专家, 评审专家
2018-06-18-今,广州市、东莞市、佛山市基金评审专家, 评审专家
2018-06-01-今,四川省科技奖励评审专家, 评审专家
2017-04-11-今,广东省防痨协会常务理事, 常务理事
2017-01-01-今,《遗传》杂志第十届编委, 编委
2016-01-01-今,卫生部重大传染病专项评审专家, 评审专家
2015-10-06-今,Frontiers in Microbiology 期刊编委, 编委
2015-10-06-今,Frontiers in Public Health 期刊编委, 编委
2015-10-06-今,Frontiers in Medicine编委, 编委
2015-09-01-今,广东省自然科学基金及平台项目评审专家, 评审专家
2014-01-01-今,国家科学技术奖励评审专家, 评审专家
2011-09-01-今,中国科技大学教授, 无
2011-09-01-今,安徽大学教授,

专利与奖励

专利:

美国专利:

Eric Nuermberger, Tianyu Zhang, Jacques Grosset.Autoluminescent mycobacterial reporter strains2011, patent number: (61/367,475).

PCT:

[1] 陆小云,汤健,丁克,张天宇,涂正超,伍甜,万军庭,曹元元。吡唑并[1,5-a]吡啶类化合物及其应用,2015,PCT (CN2015/086852)。

[2] 张天宇,刘志永。一种可投送自主发光元件的分枝杆菌噬菌体及其应用,2016,PCT(CN2016/081202)

[3] 张天宇,刘洋。一种吡啶类化合物的新用途(2018),专利申请号:PCT(CN2018/077992)。(申请提交日:2018-03-05)。

中国专利:
[1] 张天宇,杨峰,刘佳。整合质粒pOPHI及无抗性筛选标记的自主发光分枝杆菌(2012), 专利号:ZL 201210183007.2。授权证书号:1296049, 授权公告日:2013-10-30。
[2] 张天宇,杨峰,邹文英。一种用于高效构建无抗性标记重组分枝杆菌的抗性表达盒(2013),专利号:ZL 201310386264.0。授权证书号:1799902, 授权公告日:2015-09-23。
[3] 朱强,张天宇,刘兰英,鲁明辉,毛婷婷,黄金波。吲哚[3,2-c]喹啉类化合物或其药学上可接受的盐及其制备方法和应用(2013),ZL 201310385431.X。授权证书号:2017232, 授权公告日:2016-04-06。

[4] 丁克,陆小云,张天宇,汤健,鲁明辉,李宇鹏,张章,梁镇兴,钱政江。N-4-三氟甲基苯基水杨酰胺衍生物的制备方法和应用(2014),专利申请号:201410073672.5。

[5] 陆小云,汤健,丁克,张天宇,涂正超,伍甜,万军庭,曹元元。吡唑并[1,5-a]吡啶类化合物及其应用(2014),专利申请号:201410562805.5 [优先权专利号更改为2015104607516]。

[6] 张天宇,曹元元,伍甜,谭守勇,谭耀驹,蔡杏珊,刘春平。构建无选择标记的自主发光脓肿分枝杆菌的方法及建立相应体外高通量筛药模型(2015),专利申请号:ZL 201510104936.3。(2018.06.01已授权)

[7] 张天宇,刘志永。一种可投送自主发光元件的分枝杆菌噬菌体及其应用(2016),专利申请号:201610127984.9[抗结核候选药怡莱霉素申请了专利(201610885104.4)及发表了高水平的论文(Nat. Commun., 2017, 8, 391),研究成果发表以后受到了国家新华网、科技日报、国家自然科学基金委等国家级媒体的报道,并被收录国家自然科学基金委资助成果一书及入选“中国海洋与湖沼学会“2017年十大科技进展”]

[8] 鞠建华,马俊英,张天宇,刘志永。一种海洋链霉菌及其环肽化合物在制备抗结核分枝杆菌药物中的应用(2016),专利申请号:201610255638.9。

[9] 张天宇,摩西·M·恩扎瑞,王邦兴,刘志永,韩轶,刘燕,刘洋。一种检测结核分支杆菌耐药性的DNA标记物及其应用(2016),专利申请号:201610564946.X

[10] 涂正超(475345840 (美国护照),朱强,张天宇,黄金波,徐晓冰,万军庭,黎敏科,李登科,周亚丽,刘志永,王邦兴,米琦.托特雷拉。吲哚-2-酮-3-螺噻嗪酮或噻唑酮化合物及其应用(2016),专利申请号:2016106571617 (申请提交日:2016-8-11)

[11] 张天宇, 马格文如.朱丽俄斯,刘燕,王邦兴,曹元元,黄少波,玛卡芬.盖乐, 张洋,郭锦涛,柴然吉比.筹多拉瑞,刘洋。一种硫链丝菌素-庆大霉素抗性基因体系及含有其的抗性表达盒和重组质粒(2016),专利申请号:201610902985.6(申请提交日:2016-10-18,发文序号:2016101801161450)(公告日:专利申请公布和进入实质审查日:2017-05-17)

[12] 张天宇,刘洋,谭守勇,刘健雄,李昕洁,王邦兴,周佩佩,蔡杏珊,郭玲敏,刘燕,刘志永,唐运祥,高亚敏,姜火凤。吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的药物组合物(2017),专利申请号:201710240224.3。(申请提交日:2017-04-13)

[13] 王子厚,张天宇,马领弟,陈昌红。蜡梅属植物抗结核杆菌的用途(2017),专利申请号:201710392913.6。(申请提交日:2017-05-27)

[14] 鄢明,张天宇,张妞妞,刘志永,钱露,唐运祥,程亚娟,张学景。间二取代苯酚化合物及其制备方法与抗结核菌应用(2017),专利申请号:201711310722.7。(申请提交日:2017-12-11)。

[15] 罗有福,张天宇。新型小分子化合物、制备方法及在制备抗耐药结核分枝杆菌等分枝杆菌药物方面的用途(2018),专利申请号:201810003576.1。(申请提交日:2018-01-04)。

[16] 张天宇,刘洋。一种吡啶类化合物的新用途(2018),专利申请号:201810106538.9。(申请提交日:2018-02-02)。

[17] 张天宇,刘燕,孙彩军,潘恩祥,王邦兴,郭灵敏,陈凌,刘志永。一种艾滋病疫苗及其制备方法(2018),专利申请号:201810359440.4。(申请提交日:2018-04-20)。

[18] 罗有福张天宇。嘧啶类小分子化合物及在制备抗分枝杆菌药物中的用途(2018),专利申请号201810574690.X。(申请提交日:2018-06-06)。


奖励:

1. 广东省第五届专利奖 优秀奖(2018

2. 广东特支计划“科技创新领军人才”(2016)

3. 中国科学院****A类(2012

合作情况

    以呼吸疾病国家重点实验室为纽带,与广州市呼吸疾病研究所,广州市胸科医院,广东省检验检疫局有紧密合作。其中呼吸疾病国家重点实验室与广东省检验检疫局国家生物安全检测重点实验室共建有生物安全3级(BSL-3,即P3)实验室,可开展生物安全三级动物。与广州市胸科医院共建有"结核病研究室" ,致力于转化医学的研究。
    与中国科技大学,安徽大学共同培养学生。
    与复旦大学,中山大学,四川大学,中国医学科学院,武汉大学,中科院微生物研究所,中科院生物物理研究所,中科院武汉病毒所,深圳大学,广东工业大学,西南大学等有合作/紧密联系。
    与美国约翰霍普金斯大学,纽约州立大学石溪分校,香港中文大学,澳大利亚莫纳什大学和CSIRO有紧密合作。

指导学生

已指导学生

宫钰  硕士研究生  071010-生物化学与分子生物学  

现指导学生

刘燕  硕士研究生  085238-生物工程  

高亚敏  硕士研究生  085238-生物工程  

王帅  博士研究生  100102-免疫学  

何雪莹  硕士研究生  085238-生物工程  

郭玲敏  硕士研究生  085238-生物工程  

蔡晓吟  硕士研究生  085238-生物工程  

出版信息

   
发表的主要论文
[1] Xue-ping Hu, Liu Yang, Xin Chai, Yi-xuan Lei, Md Shah Alam, Lu Liu, Chao Shen, De-jun Jiang, Zhe Wang, Zhi-yong Liu, Lei Xu, Kang-lin Wan, Tian-yu Zhang, Yue-lan Yin, Dan Li, Dong-sheng Cao, Ting-jun Hou. Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening. Acta Pharmacol Sin[J]. 2022, online-, [2] Le Shang, Guobao Li, Qiao Lin, Min Ou, Juan Liang, Guohui Xiao, Zhaoqin Wang, Sheng Cui, Tianyu Zhang, Lei Liu, Guoliang Zhang. Crystal structure of the cytokinin-producing enzyme "lonely guy" (LOG) from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications[J]. 2022, accepted-, [3] Zafran Khan, Daniya Ualiyeva, Obed B. Amissah, Sanjeep Sapkota, H.M. Adnan Hameed, Tianyu Zhang. Insight into novel anti-tuberculosis vaccines by using immunoinformatics approaches. Front Microbiol[J]. 2022, 13: 866873-, [4] Galina I. Buravchenko, Dmitry A. Maslov, Md Shah Alam, Natalia E. Grammatikova, Svetlana G. Frolova, Aleksey A. Vatlin, Xirong Tian, Ivan V. Ivanov, Olga B. Bekker, Maxim A. Kryakvin, Olga A. Dontsova, Valery N. Danilenko, Tianyu Zhang, Andrey E. Shchekotikhin. 2-acyl-3-trifluoromethylquinoxaline 1,4-dioxides as po-tential antimicrobial agents. Pharmaceuticals[J]. 2022, Online-, [5] Juan He, Cong Li, Wei Hu, Chungen Li, Xin Xu, Song Liu, Jing Sui, Tianyu Zhang, Qingxiang Sun, Youfu Luo. Identification of selective mtb DHFR inhibitors by virtual screening and experimental approaches. Chem Biol Drug Des[J]. 2022, online-, [6] Wei Yu, Buhari Yusuf, Shuai Wang, Xirong Tian, H. M. Adnan Hameed, Zhili Lu, Gift Chiwala, Md Shah Alam, Gregory M. Cook, Dmitry A. Maslov, Nanshan Zhong, Tianyu Zhang. Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis. Antimicrob Agents Chemother[J]. 2021, 65(10): e00706-21-, [7] Sheng Zeng, Jingran Zhang, Mingwei Sun, Xiaofei Zhang, Gregory M. Cook, Tianyu Zhang. Nitric oxide-dependent electron transport chain inhibition by the cytochrome bc1 inhibitor and pretomanid combination kills Mycobacterium tuberculosis. Antimicrob Agents Chemother[J]. 2021, 65(9): e00956-21-, [8] 张天宇, 尹焕才. 基于自发光技术的新型抗菌药物活体筛选系统. 中国科学院院刊[J]. 2021, [9] Tian, Xirong, Gao, Yamin, Wang, Shuai, Hameed, H M Adnan, Yu, Wei, Fang, Cuiting, Zhang, Jingran, Tan, Yaoju, Cao, Zhizhong, Guan, Ping, Hu, Jinxing, Liu, Jianxiong, Zhong, Nanshan, Zhang, Tianyu. Rapid visualized assessment of drug efficacy in live mice with a selectable marker-free autoluminescent Klebsiella pneumoniae. BIOSENSORS & BIOELECTRONICS[J]. 2021, 177: http://dx.doi.org/10.1016/j.bios.2020.112919.
[10] Yamin Gao, HMAdnan Hameed, Yang Liu, Lingmin Guo, Cuiting Fang, Xirong Tian, Zhiyong Liu, Shuai Wang, Zhili Lu, Md Mahmudul Islam, Tianyu Zhang. Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans. ACTA PHARMACEUTICA SINICA B[J]. 2021, 11(3): 738-749, http://dx.doi.org/10.1016/j.apsb.2020.11.007.
[11] Zhao, Guode, Tian, Xirong, Wang, Jian, Cheng, Maosheng, Zhang, Tianyu, Wang, Zihou. The structure-based virtual screening of non-benzofuran inhibitors against M. tuberculosis Pks13-TE for anti-tuberculosis phenotypic discovery. NEW JOURNAL OF CHEMISTRY[J]. 2021, 45(3): 1286-1300, http://dx.doi.org/10.1039/d0nj03828h.
[12] Li, Jun, Liu, Zhiyong, Hong, Mingye, Sun, Changli, Zhang, Tianyu, Zhang, Hua, Ju, Jianhua, Ma, Junying. Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities. FRONTIERS IN CHEMISTRY[J]. 2021, 9: http://dx.doi.org/10.3389/fchem.2021.774555.
[13] Wang, Lu, Huang, Yanbing, Zhang, Liping, Liu, Zhiwen, Liu, Wei, Xu, Huixin, Zhang, Qingbo, Zhang, Haibo, Yan, Yan, Liu, Zhiyong, Zhang, Tianyu, Zhang, Wenjun, Zhang, Changsheng. Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(27): 6030-6037, http://dx.doi.org/10.1039/d1ob00869b.
[14] 张天宇. A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line tuberculosis regimen. Biomed Pharmacother[J]. 2021, 142: 112047-, [15] Tianyu Zhang. Cas12a/gRNA-based platform for rapid and accurate identification of major Mycobacterium species. J Clin Microbiol. 2020, [16] Yang, Zhijie, Sun, Changli, Liu, Zhiyong, Liu, Qing, Zhang, Tianyu, Ju, Jianhua, Ma, Junying. Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(5): 1666-1673, https://www.webofscience.com/wos/woscc/full-record/WOS:000537539300036.
[17] Yu, Wei, Chiwala, Gift, Gao, Yamin, Liu, Zhiyong, Sapkota, Sanjeep, Lu, Zhili, Guo, Lingmin, Khan, Shahzad Akbar, Zhong, Nanshan, Zhang, Tianyu. TB47 and clofazimine form a highly synergistic sterilizing block in a second-line regimen for tuberculosis in mice. BIOMEDICINE & PHARMACOTHERAPY[J]. 2020, 131: http://dx.doi.org/10.1016/j.biopha.2020.110782.
[18] Chiranjibi Chhotaray, Shuai Wang, Yaoju Tan, Amjad Ali, Muhammad Shehroz, Cuiting Fang, Yang Liu, Zhili Lu, Xingshan Cai, H M Adnan Hameed, Md Mahmudul Islam, Goverdhan Surineni, Shouyong Tan, Jianxiong Liu, Tianyu Zhang. Comparative Analysis of Whole-Genome and Methylome Profiles of a Smooth and a Rough Mycobacterium abscessus Clinical Strain. G3: Genes[J]. 2020, 10(1): 13-22, https://doaj.org/article/4af4c5e5d29744dca0678d6cd05de51f.
[19] 鞠建华. Anti-tubercular ilamycins from marine-derived Streptomyces atratus SCSIO ZH16 ∆ilaR. J. Nat. Prod.. 2020, [20] Xiao, Guohui, Liu, Shuyan, Liu, Houming, He, Xing, Zhang, Su, Liang, Zhihang, Guo, Huixin, Ou, Min, Zhou, Lin, Liu, Lei, Zhang, Tianyu, Zhang, Guoliang. CRISPR/Cas12a-based biosensing platform for precise and efficient screening of CRISPR/Cas9-induced biallelic mutants. TALANTA[J]. 2020, 210: http://dx.doi.org/10.1016/j.talanta.2019.120613.
[21] Tianyu Zhang. revalence and molecular characterization of amikacin resistance among Mycobacterium tuberculosis isolates from southern China. J Glob Antimicrob Resist. 2020, [22] Xiao, Guohui, He, Xing, Zhang, Su, Liu, Yaya, Liang, Zhihang, Liu, Houming, Zhang, Juanjuan, Ou, Min, Cai, Shuhao, Lai, Wenjie, Zhang, Tianyu, Ren, Lili, Zhang, Guoliang. Cas12a/Guide RNA-Based Platform for Rapid and Accurate Identification of Major Mycobacterium Species. JOURNAL OF CLINICAL MICROBIOLOGY[J]. 2020, 58(2): http://dx.doi.org/10.1128/JCM.01368-19.
[23] Sun, Changli, Liu, Zhiyong, Zhu, Xiangcheng, Fan, Zhiying, Huang, Xuanmei, Wu, Qiaoling, Zheng, Xiaohong, Qin, Xiangjing, Zhang, Tianyu, Zhang, Hua, Ju, Jianhua, Ma, Junying. Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(5): 1646-1657, https://www.webofscience.com/wos/woscc/full-record/WOS:000537539300034.
[24] Zhang, Pengfei, Li, Lijun, Sun, Huimin, Zhang, Yipeng, Zhang, Guoliang, Zhang, Tianyu, Zeng, Changchun. Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy. FRONTIERS IN PHARMACOLOGY[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556285/.
[25] Hameed, H M Adnan, Tan, Yaoju, Islam, Md Mahmudul, Lu, Zhili, Chhotaray, Chiranjibi, Wang, Shuai, Liu, Zhiyong, Fang, Cuiting, Tan, Shouyong, Yew, Wing Wai, Zhong, Nanshan, Liu, Jianxiong, Zhang, Tianyu. Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China. INFECTION AND DRUG RESISTANCE[J]. 2020, 13: 217-227, https://www.webofscience.com/wos/woscc/full-record/WOS:000510861600001.
[26] Liu, Yang, Tan, Yaoju, Islam, M Mahmudul, Cao, Yuanyuan, Lu, Xiaoyun, Zeng, Sheng, Hameed, H M Adnan, Zhou, Peipei, Cai, Xingshan, Wang, Shuai, Mugweru, Julius N, Zhang, Guoliang, Yin, Huancai, Liu, Jianxiong, Nuermberger, Eric, Zhang, Tianyu. Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2020, 64(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000516763200037.
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[89] 张天宇. 吡嗪酰胺敏感性检测结果应该运用到对结核病治疗. 广东医学. 2015, [90] Liu Z, Cao Y, Zhou Y, Guo J, Zhang T, Njire M, Xu Y, Julius M, Wang C, Wu T, Liu T, Wang B. Role of folp1 and folp2 genes in the action of sulfamethoxazole and trimethoprim against mycobacteria.. J microbiol biotechnol[J]. 2015, Vol.25 no.9: 1559-1567, http://www.corc.org.cn/handle/1471x/2156455.
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发表著作
( 1 ) 无, 无, 无, 2011-04, 第 1 作者