电子邮件： zhangqingbo@scsio.ac.cn
通信地址： 广州市海珠区新港西路164号
邮政编码： 510301
研究领域
海洋微生物来源新药源分子和新功能酶的发现。
（1）海洋新药源分子的发现：采用随机筛选和基因组挖掘相结合的方法发现海洋微生物来源新药源分子，并提高其产量。
（2）海洋新功能酶的发现：揭示海洋微生物合成天然产物的新机制，发掘具有绿色催化功能的酶。
教育背景
工作经历
2022-01--至今, 中国科学院南海海洋研究所, 项目研究员
2024-05--2025-05, 德国马克斯·普朗克陆地微生物研究所, 访问学者
2017-01--2021-12, 中国科学院南海海洋研究所, 副研究员
2013-07--2016-12, 中国科学院南海海洋研究所, 助理研究员
2008-07--2010-08, 广东省微生物研究所, 研究助理
获得荣誉
（1）中国科学院院长优秀奖，2013年
（2）广州市“珠江科技新星”，2016年
（3）中国科学院南海海洋研究所“南海新星”，2019年
出版信息
发表论文：
# (co-first author), *
(corresponding author)
23. Ziyi Yang, Lili Sun, Zhuangjie Fang, Yuchan Chen, Weimin Zhang, Yiguang Zhub, Changsheng Zhang* and Qingbo Zhang.* Genome mining guided discovery of new pentangular polyketides from the marine rare actinomycete Actinoalloteichus hymeniacidonis DSM 45092. Journal of Asian Natural Products Research, 2026, accept (DOI: 10.1080/10286020.2026.2647386).
22. Wenzheng Wei,# Xiaodong Jiang,# Yiguang Zhu, Wenjun Zhang, Chunfang Yang, Qingbo Zhang,* and Changsheng Zhang.* Targeted Inactivation of an α/β Hydrolase Gene Enables Discovery of Heterodimeric Nenestatins. Marine Drugs, 2026, 24 (3): 103.
21. Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang*, Changsheng Zhang,* and Yiguang Zhu.* Discovery, bioactivity and biosynthesis of spirooxindole alkaloids. Natural Product Reports, 2026, DOI: 10.1039/d5np00046g.
20. Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351.
19. Bin Tan#, LipingZhang#, Qingbo Zhang#, Siqiang Chen, Weiliang Xiong, Yiguang Zhu*, Changsheng Zhang*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, 2023, 62 (27):
e202302043.
18. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang,* Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979-985.
17. Ziqian Cheng,# Qingbo Zhang,# Jing Peng,# Xiaoyang Zhao, Liang Ma, Changsheng Zhang*, Yiguang Zhu*. Genomics-Driven discovery of benzoxazole alkaloids from the marine-derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821.
16. Bin Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, (12): 1478–1484.
15. Bin Tan, Qingbo Zhang,* Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84.
14. Bin Tan, Qingbo Zhang,* Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103.
13. Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal macrolides kongjuemycins from coral-associated rare actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487.
12. Xiaodong Jiang,# Zhuangjie Fang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of a new asymmetric dimer nenestatin B and implications of dimerizing enzyme in a deep sea Actinomycete. Organic & Biomolecular Chemistry, 2021,19 (19): 4243-4247.
11. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, and Changsheng Zhang*. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194.
10. Yiguang Zhu,# Qingbo Zhang,# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,* and Changsheng Zhang*. Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069.
9. Zhuangjie Fang,# Xiaodong Jiang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130.
8. Bin Tan,# Qingbo Zhang,# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides. ACS Chemical Biology, 2020, 15 (3): 766-773.
7. Bin Tan,# Siqiang Chen,# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang and Changsheng Zhang*. Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066.
6. Ruidong Chen,# Qingbo Zhang,# Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, Changsheng Zhang*. Genome mining and activation of a silent PKS/NRPS gene cluster direct the production of totopotensamides. Organic Letters, 2017, 19(20): 5697-5700.
5. Qingbo Zhang,# Huixian Li,# Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, ShuMing Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu,* and Changsheng Zhang*. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science, 2017, 8(7): 5067-5077.
4. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Si Zhang, Weimin Zhang & Changsheng Zhang*. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039. The Journal of Antibiotics, 2013, 66 (1): 31-36.
3. Qingbo Zhang,# Huixian Li,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis. Organic Letters, 2012, 14 (24): 6142–6145.
2. Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán,* Changsheng Zhang*. N–N-coupled indolosesquiterpene atropo-diastereomers from a marine-derived actinomycete. European Journal of Organic Chemistry, 2012, 2012 (27): 5256-5262.
1. Huixian Li,# Qingbo Zhang,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, and Changsheng Zhang*. Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. Journal of the American Chemical Society, 2012, 134 (21): 8996-9005.