治疗神经退行性疾病的生物技术药物研发。

   

081703-生物化工
085238-生物工程

生物技术药物

2001-09--2004-07   北京大学医学部   博士
1998-09--2001-07   中国药科大学   硕士
1994-09--1998-07   南京大学&中国药科大学   学士

   

2012-12~现在, 中国科学院过程工程研究所, 副研究员
2010-04~2012-12,清华大学, 药学院
2005-12~2009-12,美国国立卫生研究院 （NIH）, 博士后

   

（ 1 ） 嵌合抗原受体修饰的神经胶质细胞及其用途, 发明专利, 2023, 第 4 作者, 专利号: CN117004632A

（ 2 ） 靶向淀粉样蛋白的修饰抗体及其用途, 发明专利, 2023, 第 3 作者, 专利号: CN116854815A

（ 3 ） 一种具有寡聚体特异性的核磁造影剂及其制备方法与应用, 发明专利, 2019, 第 3 作者, 专利号: CN109364270A

（ 4 ） 一种多肽及其应用, 发明专利, 2017, 第 2 作者, 专利号: CN106810603A

（ 5 ） 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用, 专利授权, 2017, 第 2 作者, 专利号: CN106800590A

   

（1） Fc effector of anti-A beta antibody induces synapse loss and cognitive deficits in Alzheimer's disease-like mouse model, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第 2 作者  通讯作者
（2） 胶质细胞介导的神经突触修剪在阿尔茨海默病中的作用, Synaptic pruning mediated by glia in Alzheimer���s disease, 药学学报, 2021, 第 2 作者
（3） Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer���s disease, JOURNALOFNEUROINFLAMMATION, 2021, 第 7 作者  通讯作者
（4） The immunodominant and neutralization linear epitopes for SARS-CoV-2, CELL REPORTS, 2021, 第 16 作者
（5） A Conditionally Releasable "Do not Eat Me" CD47 Signal Facilitates Microglia-Targeted Drug Delivery for the Treatment of Alzheimer's Disease, ADVANCED FUNCTIONAL MATERIALS, 2020, 第 4 作者
（6） Vaccines targeting the primary amino acid sequence and conformational epitope of A�� had distinct effects on neuropathology and cognitive deficits in EAE/AD mice, Br J Pharmacol, 2020, 第 1 作者
（7） Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein, FOOD & FUNCTION, 2020, 第 5 作者  通讯作者
（8） Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with A beta Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer's Disease, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 第 6 作者  通讯作者
（9） ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases, BRAIN RESEARCH, 2019, 第 6 作者  通讯作者
（10） Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of parkinson's disease, NEUROBIOLOGY OF DISEASE, 2019, 第 4 作者
（11） Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy, CURRENT ALZHEIMER RESEARCH, 2019, 第 7 作者  通讯作者
（12） Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia, ALZHEIMERS RESEARCH & THERAPY, 2018, 第 4 作者
（13） Resveratrol alleviates motor and cognitive deficits and neuropathology in the a53t-synuclein mouse model of parkinson's disease, FOOD & FUNCTION, 2018, 第 2 作者
（14） Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers, INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 第 2 作者
（15） Therapeutic vaccine against IL-1�� improved glucose control in a mouse model of type 2 diabetes, LIFE SCIENCES, 2018, 第 2 作者
（16） An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS, INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 第 4 作者  通讯作者
（17） 小胶质细胞对阿尔兹海默病发生发展的影响作用, The role of microglia in Alzheimer's disease, 过程工程学报, 2018, 
（18） Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway, BRAIN RESEARCH, 2018, 第 2 作者
（19） Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice, CURRENT ALZHEIMER RESEARCH, 2018, 第 3 作者
（20） MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice, JOURNAL OF MATERIALS CHEMISTRY B, 2017, 第 4 作者
（21） Interleukin-1��-Targeted Vaccine Improves Glucose Control and ��-Cell Function in a Diabetic KK-A y Mouse Model, PLOS ONE, 2016, 第 3 作者
（22） Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin, NEUROPHARMACOLOGY, 2016, 第 7 作者
（23） A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses, SCIENTIFIC REPORTS, 2016, 第 7 作者  通讯作者
（24） Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress, FOOD & FUNCTION, 2015, 第 1 作者  通讯作者
（25） Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation, BEHAVIOURAL BRAIN RESEARCH, 2014, 第 3 作者
（26） Activated Scavenger Receptor A Promotes Glial Internalization of A beta, PLOS ONE, 2014, 第 6 作者  通讯作者
（27） Pan-Amyloid Oligomer Specific scFv Antibody Attenuates Memory Deficits and Brain Amyloid Burden in Mice with Alzheimer's Disease, CURRENT ALZHEIMER RESEARCH, 2014, 第 8 作者  通讯作者
（28） Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease, FREE RADICAL BIOLOGY AND MEDICINE, 2014, 第 5 作者
（29） 抗淀粉样蛋白寡聚体单链抗体融合蛋白在真核细胞中表达的初步研究, 安徽农业大学学报, 2013, 第 4 作者
（30） A Peptide Binding to the beta-Site of APP Improves Spatial Memory and Attenuates A beta Burden in Alzheimer's Disease Transgenic Mice, PLOS ONE, 2012, 第 9 作者  通讯作者

（ 1 ） 药物研究中的分子识别 （第2版）, 北京大学医学出版社, 2015-08, 第 4 作者

   

（ 1 ） 寡聚体特异性抗原表位疫苗, 主持, 国家级, 2014-01--2016-12
（ 2 ） 纳微颗粒作为2型糖尿病疫苗佐剂的研究, 主持, 国家级, 2014-01--2016-12
（ 3 ） 治疗2型糖尿病的新型多肽及其动物实验研究, 主持, 国家级, 2015-01--2017-12
（ 4 ） 寡聚体特异性抗原表位疫苗, 主持, 省级, 2014-01--2017-06