主要研究方向包括人与非人灵长类大脑进化及脑疾病的遗传机制研究；非人灵长类天然动物模型的筛选及脑疾病动物模型的构建等。

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学术型硕士研究生

旨在培养全面发展，爱国守法，具有社会责任感，在本学科内掌握坚实的基础理论和系统的专门知识，具有从事科学研究、教学、管理或独立担负专门技术工作能力、富有创新精神、创新能力的高层次学术型专门人才。

071006-神经生物学

大脑进化，脑疾病的遗传机制

2008-09--2014-12   中国科学院昆明动物研究所   博士学位

博士

   

2019-06~现在, 中国科学院深圳先进技术研究院脑认知与脑疾病研究所, 副研究员
2017-05~2019-06,南方科技大学, 博士后
2015-01~2017-04,中国科学院昆明动物研究所, 助理研究员

   

[1] 王虹, Miao Li, Lixin Yang. A novel rat model of Dravet syndrome recapitulates clinical hallmarks. Neurobiology of Disease[J]. 2023, [2] Zhuang, Mengru, Geng, Xiaoqi, Han, Peng, Che, Pengfei, Liang, Fanghao, Liu, Chao, Yang, Lixin, Yu, Jun, Zhang, Zhuxia, Dong, Wei, Ji, ShengJian. YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory. MOLECULAR PSYCHIATRY. 2023, http://dx.doi.org/10.1038/s41380-023-01953-z.
[3] Niu, Fugui, Che, Pengfei, Yang, Zhuoxuan, Zhang, Jian, Yang, Lixin, Zhuang, Mengru, Ou, Xijun, Ji, ShengJian. m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs. ISCIENCE[J]. 2022, 25(9): http://dx.doi.org/10.1016/j.isci.2022.104908.
[4] Niu, Fugui, Han, Peng, Zhang, Jian, She, Yuanchu, Yang, Lixin, Yu, Jun, Zhuang, Mengru, Tang, Kezhen, Shi, Yuwei, Yang, Baisheng, Liu, Chunqiao, Peng, Bo, Ji, ShengJ, Mason, Carol A. The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. ELIFE[J]. 2022, 11: http://dx.doi.org/10.7554/eLife.75827.
[5] Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han,, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen,, Sheng-Jian Ji. The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.. 2021, [6] Hu, Yu, Li, Jiamin, Zhu, Yuyuan, Li, Mengqi, Lin, Jianbang, Yang, Lixin, Wang, Chuan, Lu, Zhonghua. Development and characterization of an Otp conditional loss of function allele. GENESIS[J]. 2020, 58(9): [7] Hao Li, LingYan Su, Lixin Yang, Min Li, Qianjin Liu, Zhenhui Li, Yan Hu, Hongwei Li, Shihao Wu, Wenchao Wang, Yingzhou Hu, Zhengbo Wang, Joshua D Rizak, Baihui Huang, Min Xu, Jing Wu, LongBao Lv, Christoph W Turck, Yong Yin, YongGang Yao, Bing Su, Xintian Hu. A cynomolgus monkey with naturally occurring Parkinson's disease. NATIONAL SCIENCE REVIEW. 2020, 8(3): [8] Qi, Xuebin, Zhang, Qu, He, Yaoxi, Yang, Lixin, Zhang, Xiaoming, Shi, Peng, Yang, Linping, Liu, Zhengheng, Zhang, Fuheng, Liu, Fengyun, Liu, Shiming, Wu, Tianyi, Cui, Chaoying, Ouzhuluobu, Bai, Caijuan, Baimakangzhuo, Han, Jianlin, Zhao, Shengguo, Liang, Chunnian, Su, Bing. The Transcriptomic Landscape of Yaks Reveals Molecular Pathways for High Altitude Adaptation. GENOME BIOLOGY AND EVOLUTION[J]. 2019, 11(1): 72-85, https://www.webofscience.com/wos/woscc/full-record/WOS:000462712200007.
[9] Lixin Yang, Yandong Yang, Jiamiao Yuan, Yan Sun, Jiapei Dai, Bing Su. Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing. CEREBRAL CORTEX (NEW YORK, NY). 2018, 29(2): 838-851, 

   

（ 1 ） SHANK3自闭症动物模型跨物种转录组解析, 主持, 国家级, 2020-12--2023-12