基本信息
姚醒蕾  女  硕导  中国科学院生态环境研究中心
电子邮件: xlyao@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码:

招生信息

   
招生专业
077601-环境科学
071009-细胞生物学
100702-药剂学
招生方向
环境毒理学
干细胞毒理学
环境污染物的健康效应评估

教育背景

2007-04--2010-03   日本大阪大学   药学博士学位
2005-04--2007-03   日本大阪大学   药学硕士学位
2000-09--2004-06   兰州大学   生物技术学士学位
2000-09--2004-06   兰州大学   计算机科学与技术双学士学位

工作经历

   
工作简历
2014-12~现在, 中国科学院生态环境研究中心, 副研究员
2014-07~2014-11,中国科学院生态环境研究中心, 助理研究员
2012-09~2014-07,北京协和医学院, 博士后
2010-05~2012-07,浙江大学, 博士后

教授课程

干细胞毒理学

出版信息

   
发表论文
[1] Wang, Yuanyuan, Wang, Fengbang, Chen, Zihan, Song, Maoyong, Yao, Xinglei, Jiang, Guibin. In situ High-Throughput Single-Cell Analysis Reveals the Crosstalk between Nanoparticle-Induced Cell Responses. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2021, 55(8): 5136-5142, http://dx.doi.org/10.1021/acs.est.0c08424.
[2] Lu, Zhenhua, Meng, Lingbing, Sun, Zhen, Shi, Xiaolei, Shao, Weiwei, Zheng, Yangyang, Yao, Xinglei, Song, Jinghai. Differentially Expressed Genes and Enriched Signaling Pathways in the Adipose Tissue of Obese People. FRONTIERS IN GENETICS[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175074/.
[3] Zhang, Wenjuan, Li, Aijing, Pan, Yu, Wang, Fengbang, Li, Ming, Liang, Yong, Yao, Xinglei, Song, Jinghai, Song, Maoyong, Jiang, Guibin. Tetrabromobisphenol A induces THR beta-mediated inflammation and uterine injury in mice at environmentally relevant exposure concentrations. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 407: https://www.webofscience.com/wos/woscc/full-record/WOS:000613429700009.
[4] Pang, Shaochen, Gao, Yue, Li, Aijing, Yao, Xinglei, Qu, Guangbo, Hu, Ligang, Liang, Yong, Song, Maoyong, Jiang, Guibin. Tetrabromobisphenol A Perturbs Erythropoiesis and Impairs Blood Circulation in Zebrafish Embryos. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 54(20): 12998-13007, https://www.webofscience.com/wos/woscc/full-record/WOS:000584422500021.
[5] Yao, Xinglei, Cao, Dong, Wang, Fengbang, Zhang, Wenjuan, Ma, Chunyan, Song, Maoyong. An overview of omics approaches to characterize the effect of perfluoroalkyl substances in environmental health. TRAC-TRENDS IN ANALYTICAL CHEMISTRYnull. 2019, 121: http://dx.doi.org/10.1016/j.trac.2018.12.021.
[6] Ma, Chunyan, Yang, Chenggong, Wang, Bin, Chen, Cheng, Wang, Fengbang, Yao, Xinglei, Song, Maoyong. Effects of H2O on HCHO and CO oxidation at room-temperature catalyzed by MCo2O4 (M = Mn, Ce and Cu) materials. APPLIED CATALYSIS B-ENVIRONMENTAL[J]. 2019, 254: 76-85, http://dx.doi.org/10.1016/j.apcatb.2019.04.085.
[7] Fengbang Wang, Yuanyuan Wang, Guangbo Qu, Xinglei Yao, Chunyan Ma, Maoyong Song, Hailin Wang, Guibin Jiang. Ultralong AgNWs-induced toxicity in A549 cells and the important roles of ROS and autophagy. Ecotoxicology and Environmental Safety. 2019, 186: http://dx.doi.org/10.1016/j.ecoenv.2019.109742.
[8] Li, Xueyan, Li, Aijing, Zhang, Wenjuan, Liu, Xiaowei, Liang, Yong, Yao, Xinglei, Song, Maoyong. A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2019, 186: [9] Wang, Fengbang, Wang, Yuanyuan, Yao, Xinglei, Ma, Chunyan, Yin, Yongguang, Song, Maoyong. Length and diameter-dependent phagocytosis and cytotoxicity of long silver nanowires in macrophages. CHEMOSPHERE[J]. 2019, 237: http://dx.doi.org/10.1016/j.chemosphere.2019.124565.
[10] Dong, Hengzhi, Yao, Xinglei, Liu, Shuyu, Yin, Nuoya, Faiola, Francesco. Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2018, 164: 448-454, http://ir.rcees.ac.cn/handle/311016/41000.
[11] Li, Hongling, Zhu, Li, Chen, Huimin, Li, Tangping, Han, Qin, Wang, Shihua, Yao, Xinglei, Feng, Hongli, Fan, Linyuan, Gao, Shaorong, Boyd, Richard, Cao, Xu, Zhu, Ping, Li, Jing, Keating, Armand, Su, Xiaodong, Zhao, Robert Chunhua. Generation of Functional Hepatocytes from Human Adipose-Derived MYC+ KLF4(+) GMNN(+) Stem Cells Analyzed by Single-Cell RNA-Seq Profiling. STEM CELLS TRANSLATIONAL MEDICINE[J]. 2018, 7(11): 792-805, https://www.webofscience.com/wos/woscc/full-record/WOS:000449756700006.
[12] Wan L, Yao X, Faiola F, Liu B, Zhang T, Tabata Y, Mizuguchi H, Nakagawa S, Gao JQ, Zhao RC. Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2016, 11: 6763-6769, https://doaj.org/article/0a70645c3ae4409cac1c88baec1f3fd8.
[13] Xinglei Yao, Nuoya Yin, Francesco Faiola. Stem cell toxicology:a powerful tool to assess pollution effects on human health. 国家科学评论:英文版. 2016, 430-450, http://lib.cqvip.com/Qikan/Article/Detail?id=78658382504849544852484952.
[14] Yin, Nuoya, Yao, Xinglei, Zhou, Qunfang, Faiola, Francesco, Jiang, Guibin. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2015, 458(2): 405-410, http://ir.rcees.ac.cn/handle/311016/32696.
[15] Yin Nuoya, Yao Xinglei, Qin Zhanfen, Wang YuanLiang, Faiola Francesco. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA[J]. 2015, 36(1): 181-187, http://dx.doi.org/10.1016/j.jes.2015.06.004.
[16] Faiola, Francesco, Yin, Nuoya, Yao, Xinglei, Jiang, Guibin. The Rise of Stem Cell Toxicology. ENVIRONMENTAL SCIENCE & TECHNOLOGYnull. 2015, 49(10): 5847-5848, http://ir.rcees.ac.cn/handle/311016/32686.
[17] Yao, Xinglei, Zhou, Na, Wan, Li, Su, Xiaodong, Sun, Zhao, Mizuguchi, Hiroyuki, Yoshioka, Yasuo, Nakagawa, Shinsaku, Zhao, Robert Chunhua, Gao, JianQing. Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2014, 447(3): 383-387, https://www.webofscience.com/wos/woscc/full-record/WOS:000336413900001.
[18] Yao, XingLei, Yoshioka, Yasuo, Ruan, GuiXin, Chen, YuZhe, Mizuguchi, Hiroyuki, Mukai, Yohei, Okada, Naoki, Gao, JianQing, Nakagawa, Shinsaku. Optimization and Internalization Mechanisms of PEGylated Adenovirus Vector with Targeting Peptide for Cancer Gene Therapy. BIOMACROMOLECULES[J]. 2012, 13(8): 2402-2409, https://www.webofscience.com/wos/woscc/full-record/WOS:000307422300022.
[19] Yao, Xinglei, Yoshioka, Yasuo, Morishige, Tomohiro, Eto, Yusuke, Narimatsu, Shogo, Kawai, Yasuaki, Mizuguchi, Hiroyuki, Gao, JianQing, Mukai, Yohei, Okada, Naoki, Nakagawa, Shinsaku. Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy. MOLECULAR THERAPY[J]. 2011, 19(9): 1619-1625, http://dx.doi.org/10.1038/mt.2011.112.

科研活动

   
科研项目
( 1 ) 新型持久性环境污染物对间充质干细胞自我更新和分化能力的影响机制, 主持, 国家级, 2016-01--2019-12
( 2 ) 典型污染物的环境暴露与健康危害机制 项目三, 参与, 部委级, 2014-07--2019-06