1、核糖体生物学：蛋白质在核糖体上的生物合成过程的机理 

2、癌症与核糖体的关系：癌症发生、恶化、转移过程中的疾病模型、诊断、治疗

   

蛋白质翻译过程与肿瘤发生
核糖体，翻译调控
干细胞的分化

071010-生物化学与分子生物学
071008-发育生物学
071009-细胞生物学

   

 1995/09－1999/06，南开大学，生命科学院生物系，本科
 2001/10－2003/04，德国柏林自由大学，化学院，硕士
 2003/05－2006/02，德国马-普学会分子遗传研究所/柏林自由大学化学院，博士 
 2006/03- ， 德国马-普学会分子遗传研究所，博士后
 

   

2006年-今 中国科学院生物物理研究所研究员，RNA平台首席技术专家
2007年-今 中国科学院生物物理研究所，创新课题组长，博士生导师，中国科学院研究生院教授 (教授课程：结构生物学导论)
2014年-今 中国科学院大学岗位教授 （教授课程：分子生物学）

中国生物物理学会会员，脂代谢与生物能学分会委员
中国细胞生物学会会员
国家自然科学基金评审专家
北京市科委评审专家
教育部学位中心评审专家

发现生命奥秘
科研论文写作-2班
科研论文写作
生物化学与分子生物学实验
结构生物学导论
结构生物学

 分子生物学
 膜生物学

专利：
     EF4蛋白编码基因沉默在癌症治疗方面的应用
     线粒体蛋白质翻译因子Guf1在雄性不育研究中的应用
     Use of LepA for improving the accuracy of protein synthesis in vitro
奖励：
      线粒体中的蛋白质翻译调控 优秀青年

   

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科研项目：
1. 膜蛋白与蛋白质复合体的功能与结构研究：蛋白质翻译、折叠与降解    973项目  
2. 蛋白质翻译过程中的重要因子LepA 功能研究    国家自然科学基金委  
3. 蛋白质翻译起始和延伸过程中关键蛋白质复合物研究    中国科学院知识创新工程重要方向项目 
4 .The function of the mitochondrial translation factor in the diabetes pathogenesis       中国科学院国际合作项目 
5 .翻译延长因子EF-G的转运功能与核糖体解聚功能研究     国家自然科学基金委 
6. 蛋白质的生成、修饰与质量控制     973项目 
7. EF4(LepA)蛋白的分子伴侣活性及其与翻译过程的内在关系     国家自然科学基金项目” 
8. 线粒体功能障碍致早期心衰机制及干预策略研究    973项目 
9. 线粒体中的蛋白质翻译调控     国家自然科学基金委 
10. 线粒体翻译因子EF4蛋白在癌症和代谢疾病中的分子诊断     浙江省卫生厅 

近期参与会议：
    2015/02/22-27 高登会议之第一届翻译调控与疾病大会，美国 文图拉，大会邀请报告（Feb. 22-27th, 2015, Ventura, USA “1st Gordon Research Conference of Translation Machinery in Health & Disease”）
    2014/08/3-7 第十八届国际生物物理大会，澳大利亚 布里斯班，大会邀请报告（Aug. 3-7th, 2014, Brisbane, Australia “18th International Biophysics Congress”）
    2013/06/16-21 第十届亚洲线粒体大会，韩国 首尔，大会邀请报告（Nov. 4-6th, 2013, Seoul, Korea “10th Conference of the Asian Society of Mitochondrial Research and Medicine”）
    2013/07/9-12国际核糖体大会，美国 加州 纳帕谷，大会邀请报告 (July 9-12th 2013, California, US “Ribosomes Conference 2013”)
    2013/06/16-21 国际核酸酶与人类疾病相关酶大会，中国 香港，大会邀请报告 (Jun 16-21st 2013, HongKong “International Conference on Nucleic Acid Enzymes and Enzymes in Human Diseases”)

刘光桥 博士研究生 071010-生物化学与分子生物学

张德玖 博士研究生 071010-生物化学与分子生物学 

曹鑫涛   博士研究生 071010-生物化学与分子生物学 

徐本锦  博士研究生 071010-生物化学与分子生物学