RNA表观遗传学特征、调控和功能。研发RNA化学修饰高通量测序和分析技术，系统研究RNA甲基化及其修饰酶，阐明其功能及遗传性状（表型）和组织器官再生机制，揭示其与疾病关联及干预​。

生化、分子、细胞、基因组学、生物信息学、计算等

0710Z1-基因组学
0710J3-生物信息学

RNA甲基化表观转录调控
多组学网络计算

1995-07--2000-07   中科院上海药物所及上海生物工程研究中心   博士
1991-09--1995-09   复旦大学   学士

生物化学与分子生物学实验
分子遗传学和表观遗传学
入学教育与交流
健康数据与基因组技术
表观遗传学
染色体结构与基因组稳定性
英文生物论文写作
干细胞研究进展系列讲座
基因组科学与信息

   

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[52] Gao, Min, Wei, Wei, Li, MingMing, Wu, YongSheng, Ba, Zhaoqing, Jin, KangXuan, Li, MiaoMiao, Liao, YouQi, Adhikari, Samir, Chong, Zechen, Zhang, Ting, Guo, CaiXia, Tang, Tieshan, Zhu, BingTao, Xu, XingZhi, Mailand, Niels, Yang, YunGui, Qi, Yijun, Danielsen, Jannie M Rendtlew. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Research[J]. 2014, 第 17 作者24(5): 532-541, https://www.webofscience.com/wos/woscc/full-record/WOS:000335914700003.
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[54] Tapias, Alicia, Zhou, ZhongWei, Shi, Yue, Chong, Zechen, Wang, Pei, Groth, Marco, Platzer, Matthias, Huttner, Wieland, Herceg, Zdenko, Yang, YunGui, Wang, ZhaoQi. Trrap-Dependent Histone Acetylation Specifically Regulates Cell-Cycle Gene Transcription to Control Neural Progenitor Fate Decisions. Cell Stem Cell[J]. 2014, 第 10 作者14(5): 632-643, http://dx.doi.org/10.1016/j.stem.2014.04.001.
[55] Zhao, Xu, Yang, Ying, Sun, BaoFa, Zhao, YongLiang, Yang, YunGui. FTO and Obesity: Mechanisms of Association. CURRENT DIABETES REPORTS[J]. 2014, 第 5 作者  通讯作者  14(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000334449100005.
[56] Niu, YaMei, Zhao, Xu, Wu, YongSheng, Li MingMing, Wang, XiuJie, Yang, YunGui. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2013, 第 6 作者11(1): 8-17, http://dx.doi.org/10.1016/j.gpb.2012.12.002.
[57] Zheng, Guanqun, Dahl, John Arne, Niu, Yamei, Fu, Ye, Klungland, Arne, Yang, YunGui, He, Chuan. Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases. RNA BIOLOGY. 2013, 第 6 作者10(6): 915-918, https://www.webofscience.com/wos/woscc/full-record/WOS:000327574000003.
[58] Yin, Ruichuan, Mao, ShiQing, Zhao, Bailin, Chong, Zechen, Yang, Ying, Zhao, Chao, Zhang, Dapeng, Huang, Hua, Gao, Juan, Li, Zheng, Jiao, Yan, Li, Cuiping, Liu, Shengquan, Wu, Danni, Gu, Weikuan, Yang, YunGui, Xu, GuoLiang, Wang, Hailin. Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals. JOURNALOFTHEAMERICANCHEMICALSOCIETY[J]. 2013, 第 16 作者135(28): 10396-10403, http://dx.doi.org/10.1021/ja4028346.
[59] Li, MingMing, Nilsen, Anja, Shi, Yue, Fusser, Markus, Ding, YueHe, Fu, Ye, Liu, Bo, Niu, Yamei, Wu, YongSheng, Huang, ChunMin, Olofsson, Maria, Jin, KangXuan, Lv, Ying, Xu, XingZhi, He, Chuan, Dong, MengQiu, Danielsen, Jannie M Rendtlew, Klungland, Arne, Yang, YunGui. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. NATURE COMMUNICATIONS[J]. 2013, 第 19 作者  通讯作者  4: 1832, https://www.webofscience.com/wos/woscc/full-record/WOS:000320589900028.
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（1） RNA甲基化表观转录组学, 浙江大学出版社, 2021-02, 第 1 作者

已指导学生

黄春敏  硕士研究生  071010-生物化学与分子生物学  

徐倩  硕士研究生  071010-生物化学与分子生物学  

周东平  硕士研究生  071022-基因组学  

王文岭  硕士研究生  071022-基因组学  

高敏  博士研究生  071022-基因组学  

廖友琦  硕士研究生  071010-生物化学与分子生物学  

李明明  博士研究生  071010-生物化学与分子生物学  

赵旭  博士研究生  071010-生物化学与分子生物学  

金康宣  硕士研究生  071022-基因组学  

杨莹  博士研究生  071022-基因组学  

史悦  博士研究生  071022-基因组学  

吕英  硕士研究生  071010-生物化学与分子生物学  

肖文  博士研究生  071010-生物化学与分子生物学  

平晓丽  博士研究生  071010-生物化学与分子生物学  

李苗苗  硕士研究生  071010-生物化学与分子生物学  

马海丽  硕士研究生  071010-生物化学与分子生物学  

郝亚娟  博士研究生  071010-生物化学与分子生物学  

王文佳  硕士研究生  071010-生物化学与分子生物学  

祝芹  硕士研究生  071010-生物化学与分子生物学  

杨鑫  博士研究生  0710Z1-基因组学  

孙慧颖  硕士研究生  0710Z1-基因组学  

王兴  硕士研究生  071010-生物化学与分子生物学  

于佳丽  硕士研究生  071010-生物化学与分子生物学  

闫克强  硕士研究生  071010-生物化学与分子生物学  

韩亚男  硕士研究生  0710J3-生物信息学  

现指导学生

陈宇晟  博士研究生  071010-生物化学与分子生物学  

李昂  博士研究生  071010-生物化学与分子生物学  

时博阳  博士研究生  071010-生物化学与分子生物学  

张益畅  硕士研究生  0710J3-生物信息学  

鞠林芳  硕士研究生  071010-生物化学与分子生物学  

葛新阳  硕士研究生  071010-生物化学与分子生物学  

韩悦  博士研究生  0710Z1-基因组学  

张清杨  博士研究生  071010-生物化学与分子生物学  

李若琳  硕士研究生  071010-生物化学与分子生物学  

周佳熠  博士研究生  0710Z1-基因组学  

梁承志  硕士研究生  071010-生物化学与分子生物学  

姚欢  博士研究生  0710Z1-基因组学  

刘倩兰  博士研究生  0710Z1-基因组学  

杨文兰  博士研究生  071010-生物化学与分子生物学  

陈静  硕士研究生  085238-生物工程  

2008-11--至今 中科院北京基因组研究所研究员，博士生导师

2005-11--2008-11 英国癌症研究署，博士后，导师：Tomas Lindhal教授/英国皇家科学院院士、2015诺贝尔化学奖得主

2000-09--2005-11 法国世界卫生组织国际癌症研究署，博士后/Staff Scientist，导师：汪兆琦教授/欧洲科学院院士

1、中以NSFC-ISF合作研究项目，解析神经发育疾病基因MeCP2和LIS1相互作用的分子机制，3161101005，2017/01-2019/12，在研，主持；

2、国家“杰出青年”科学基金，基因表达调控与表观遗传学，31625016，2017/01-2022/12，在研，主持；

3、国家重点研发计划精准医学研究重点专项，表观基因组学检测技术研发与临床应用，2016YFC0900300，2016/07-2018/12，在研，主持；

4、国家自然科学基金重点项目，RNA m6A修饰甲基转移酶复合物及其表观调控因子鉴定和作用机制研究，2015/01-2019/12，在研，主持；

5、国家自然科学基金面上项目，RNA表观遗传新机制调控DNA双链断裂修复分子机理研究，2014/01-2017/12，在研，主持；

6、国家自然科学基金重大研究计划(集成项目)，DNA与RNA甲基化表观修饰对单倍体干细胞多能性与发育能力影响的机制研究，2014/01-2018/12，在研，参加；

7、科技部 973，中国人前列腺癌的表观遗传特征及调控机制，2012/01-2016/09，已结题，骨干；

8、科技部 973，组蛋白甲基化对肺癌发生发展的作用及其机制，2011/01-2015/12，已结题，主持；

9、国家自然科学基金面上项目，ALKBH4加双氧酶介导的细胞分裂重要功能因子去甲基化机制研究，2011/01-2013/12，已结题，主持；

10、国家自然科学基金面上项目，DNA损伤检验点和DNA双链断裂修复途径的相互协调维持基因组稳定性的分子机理的研究，2009/01-2011/12，已结题，主持；

11、中科院“****”人才项目,科研启动经费，2008/11-2013/12，已结题，主持。

2012 获中国科学院大学-BHPB 导师科研奖

2013 获中国科学院青年科学家国际合作奖

2013 获中国科学院朱李月华优秀教师奖

2014 中国科学院“****”终期评估优秀获得者

2015中国科学院特聘研究员

2016国家“杰出青年”科学基金获得者

2016 科技部创新人才推进计划-中青年科技创新领军人才

2017中组部国家“万人计划”科技创新领军人才

2017 Sanofi-Cell Research优秀研究文章奖

2017年度中国生命科学领域十大进展

2018中国科学院优秀导师奖

2018第三届中国科协优秀科技论文

课题组于2008年11月成立，系统研究表观转录组调控与RNA甲基化功能机理，在拓展RNA甲基化表观转录组调控的前沿新领域合作研究中，取得了系列原创性发现，包括鉴定人源RNA m6A的修饰甲基转移酶复合物 METTL3/METTL14/WTAP和m6A去甲基化酶ALKBH5/FTO （Nat Chem Biol, 2011; Mol Cell, 2013; Cell Res, 2014a），揭示非编码miRNA介导的m6A甲基化位点形成的选择性机制(Cell Stem Cell,2015)及其m6A修饰的外显子被保留现象（Cell Res, 2014b）等。发现了m6A的识别因子（reader）YTHDC1的的两个互作蛋白是mRNA剪接因子SRSF3和SRSF10 （Mol Cell，2016；RNA Biol, 2016）。揭示m5C调控mRNA出核的重要功能以及YTHDF3和YTHDF1在翻译过程中的协同调控作用机制（Cell Res, 2017a, 2017b）；，发现m6A通过YTHDF2介导notch1a mRNA的稳定性，维持内皮和造血细胞基因表达平衡，进而调控造血干细胞的命运决定（Nature, 2017；被评为2017中国生命科学十大研究进展）；阐明了m6A调控脑发育和记忆作用机制（PLos Biol, 2018; Cell Res, 2018a,b）。对m6A的甲基转移酶、结合蛋白和去甲基化酶的生物学功能，及m6A在可变剪接等RNA代谢过程的调控作用进行了系统综述（Cell Res, 2018c）。