基本信息

杨琛  女  博导  中国科学院分子植物科学卓越创新中心
电子邮件: cyang@cemps.ac.cn
通信地址: 上海枫林路300号
课题组网站:

研究领域

课题组致力于细胞代谢网络运转及调控机制的定量研究,实现其人工设计与系统优化。主要研究兴趣包括:

  1. 开发代谢流量分析与代谢组学分析技术;

  2. 定量研究细胞代谢网络运转机制,揭示各种分子机制对代谢流量的调节与控制;

  3. 开展光能自养微生物以及菌群的合成生物学研究。

围绕研究目标,利用我们在微生物学、生物工程、生物化学、计算生物学上的学科交叉优势,建立了代谢流量分析、代谢组学分析、比较基因组学、代谢网络建模等关键技术。其中,代谢流量(Metabolic flux)分析,即解析活体状态下的代谢反应速率,以表征基因、蛋白质、代谢物之间各种相互作用导致的代谢网络的动态行为和最终功能;它对于全面理解与认识生物体的物质与能量代谢过程,从而操纵生物体的生命活动,具有重要的意义。

招生信息

   
招生专业
071005-微生物学
081703-生物化工
招生方向
微生物代谢工程和比较基因组学

教育背景

1997-09--2001-09   日本九州工业大学   获得博士学位
1994-09--1997-08   浙江大学   获得硕士学位
1990-09--1994-08   浙江大学   获得学士学位

工作经历

   
工作简历
2008-07~现在, 中国科学院上海生命科学研究院植物生理生态研究所, 研究员
2004-05~2008-07,美国Burnham医学研究所, 博士后
2001-10~2004-04,日本庆应大学,先端生命科学研究所, 博士后

专利与奖励

2010.09.032015.11.2514ZL201310128943.8利用蓝藻生产异戊二烯    杨琛,高翔,刘邓,高方


出版信息

   
发表论文
[1] Nie, Xiaoqun, Xia, Liliang, Gao, Fang, Liu, Lixia, Yang, Yi, Chen, Yingying, Duan, Huangqi, Yao, Yaxian, Chen, Zhiwei, Lu, Shun, Wang, Ying, Yang, Chen. Serum Metabolite Biomarkers Predictive of Response to PD-1 Blockade Therapy in Non-Small Cell Lung Cancer. FRONTIERS IN MOLECULAR BIOSCIENCES[J]. 2021, 8: https://doaj.org/article/307b214561e1409d8efdb7a4edbc27ad.
[2] Wenyue Dong, Xiaoqun Nie, Hong Zhu, Qingyun Liu, Kunxiong Shi, Linlin You, Yu Zhang, Hongyan Fan, Bo Yan, Chen Niu, LiangDong Lyu, GuoPing Zhao, Chen Yang. Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence. Proceedings of the National Academy of Sciences of the United States of America[J]. 2021, 118(16): [3] Yang Chen. Succinate-GPR-91 receptor signaling is responsible for nonalcoholic steatohepatitis-associated fibrosis: effects of DHA supplementation.. Liver International. 2020, [4] Wang, Weishan, Li, Shanshan, Li, Zilong, Zhang, Jingyu, Fan, Keqiang, Tan, Gaoyi, Ai, Guomin, Lam, Sin Man, Shui, Guanghou, Yang, Zhiheng, Lu, Hongzhong, Jin, Pinjiao, Li, Yihong, Chen, Xiangyin, Xia, Xuekui, Liu, Xueting, Dannelly, H Kathleen, Yang, Chen, Yang, Yi, Zhang, Siliang, Alterovitz, Gil, Xiang, Wensheng, Zhang, Lixin. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. NATURE BIOTECHNOLOGY[J]. 2020, 38(1): 76-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000510337700016.
[5] Chen, Chen, He, Bingshu, Liu, Xingxun, Ma, Xiaoding, Liu, Yujie, Yao, HongYan, Zhang, Peng, Yin, Junliang, Wei, Xin, Koh, HeeJong, Yang, Chen, Xue, HongWei, Fang, Zhengwu, Qiao, Yongli. Pyrophosphate-fructose 6-phosphate 1-phosphotransferase (PFP1) regulates starch biosynthesis and seed development via heterotetramer formation in rice (Oryza sativa L.). PLANT BIOTECHNOLOGY JOURNAL[J]. 2020, 18(1): 83-95, https://www.webofscience.com/wos/woscc/full-record/WOS:000530370800012.
[6] Nie, Xiaoqun, Hua, Qiang, Xu, Ping, Yang, Chen. Biological insights into non-model microbial hosts through stable-isotope metabolic flux analysis. CURRENT OPINION IN BIOTECHNOLOGYnull. 2020, 64: 32-38, http://dx.doi.org/10.1016/j.copbio.2019.09.010.
[7] Yang, Bin, Nie, Xiaoqun, Xiao, Youli, Gu, Yang, Jiang, Weihong, Yang, Chen. Ferrous-Iron-Activated Transcriptional Factor AdhR Regulates Redox Homeostasis in Clostridium beijerinckii. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2020, 86(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000522978900018.
[8] Yang, Bin, Nie, Xiaoqun, Gu, Yang, Jiang, Weihong, Yang, Chen. Control of solvent production by sigma‐54 factor and the transcriptional activator AdhR in Clostridium beijerinckii. Microbial Biotechnology[J]. 2020, 13(2): 328-338, https://doaj.org/article/50ac545e749848e3914ea49c8457571b.
[9] , , , , , . Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism. The Journal of Biological Chemistry. 2019, 295(7): 2113-2124, http://dx.doi.org/10.1074/jbc.RA119.011752.
[10] Nie, Xiaoqun, Dong, Wenyue, Yang, Chen. Genomic reconstruction of sigma(54) regulons in Clostridiales. BMC GENOMICS[J]. 2019, 20: http://dx.doi.org/10.1186/s12864-019-5918-4.
[11] Zhang, Hao, Yang, Chen. Arginine and nitrogen mobilization in cyanobacteria. MOLECULAR MICROBIOLOGYnull. 2019, 111(4): 863-867, [12] Zhang, Hao, Liu, Yujie, Nie, Xiaoqun, Liu, Lixia, Hua, Qiang, Zhao, GuoPing, Yang, Chen. The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase. NATURE CHEMICAL BIOLOGY[J]. 2018, 14(6): 575-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000435445100014.
[13] Shao, Yangyang, Lu, Ning, Wu, Zhenfang, Cai, Chen, Wang, Shanshan, Zhang, LingLi, Zhou, Fan, Xiao, Shijun, Liu, Lin, Zeng, Xiaofei, Zheng, Huajun, Yang, Chen, Zhao, Zhihu, Zhao, Guoping, Zhou, JinQiu, Xue, Xiaoli, Qin, Zhongjun. Creating a functional single-chromosome yeast. NATURE[J]. 2018, 560(7718): 331-+, http://202.127.25.143/handle/331003/3385.
[14] Manman Zhang, Chao Gao, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma, Ping Xu. Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/410d386a718d45bba309100ab02c7216.
[15] Brunk, Elizabeth, Chang, Roger L, Xia, Jing, Hefzi, Hooman, Yurkovich, James T, Kim, Donghyuk, Buckmiller, Evan, Wang, Harris H, Cho, ByungKwan, Yang, Chen, Palsson, Bernhard O, Church, George M, Lewis, Nathan E. Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(43): 11096-11101, https://www.webofscience.com/wos/woscc/full-record/WOS:000448040500079.
[16] Yang, Yunpeng, Nie, Xiaoqun, Jiang, Yuqian, Yang, Chen, Gu, Yang, Jiang, Weihong. Metabolic regulation in solventogenic clostridia: regulators, mechanisms and engineering. BIOTECHNOLOGY ADVANCESnull. 2018, 36(4): 905-914, http://dx.doi.org/10.1016/j.biotechadv.2018.02.012.
[17] Lu-Men Chao, Yao-Qian Liu, Dian-Yang Chen, Xue-Yi Xue, Ying-Bo Mao, Xiao-Ya Chen. Arabidopsis Transcription Factors SPL1 and SPL12 Confer Plant Thermotolerance at Reproductive Stage. 分子植物:英文版. 2017, 10(5): 735-748, http://lib.cqvip.com/Qikan/Article/Detail?id=672324842.
[18] Nie, Xiaoqun, Yang, Bin, Zhang, Lei, Gu, Yang, Yang, Sheng, Jiang, Weihong, Yang, Chen. PTS regulation domain-containing transcriptional activator CelR and sigma factor sigma(54) control cellobiose utilization in Clostridium acetobutylicum. MOLECULAR MICROBIOLOGY[J]. 2016, 100(2): 289-302, http://dx.doi.org/10.1111/mmi.13316.
[19] Yang Chen, Gao Xiang, Jiang Yu, Sun Bingbing, Gao Fang, Yang Sheng. Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli. Metabolic Engineering[J]. 2016, [20] Tong, Jingfeng, Meng, Lu, Wang, Xinwei, Liu, Lixia, Lyu, Liangdong, Wang, Chuan, Li, Yang, Gao, Qian, Yang, Chen, Niu, Chen. The FBPase Encoding Gene glpX Is Required for Gluconeogenesis, Bacterial Proliferation and Division In Vivo of Mycobacterium marinum. PLOS ONE[J]. 2016, 11(5): https://doaj.org/article/5718e5e69cab46e4bc3f51229c38ce49.
[21] Gao, Xiang, Gao, Fang, Liu, Deng, Zhang, Hao, Nie, Xiaoqun, Yang, Chen. Engineering the methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2. ENERGY & ENVIRONMENTAL SCIENCE[J]. 2016, 9(4): 1400-1411, http://dx.doi.org/10.1039/c5ee03102h.
[22] Yang Chen. Metabolic flux ratio analysis and cell staining suggest the existence of C4 photosynthesis in Phaeodactylum tricornutum. Journal of Applied Microbiology. 2015, [23] Zhang, Lei, Nie, Xiaoqun, Ravcheev, Dmitry A, Rodionov, Dmitry A, Sheng, Jia, Gu, Yang, Yang, Sheng, Jiang, Weihong, Yang, Chen. Redox-Responsive Repressor Rex Modulates Alcohol Production and Oxidative Stress Tolerance in Clostridium acetobutylicum. JOURNAL OF BACTERIOLOGY[J]. 2014, 196(22): 3949-3963, https://www.webofscience.com/wos/woscc/full-record/WOS:000343930600014.
[24] Liu, DongFeng, Ai, GuoMin, Zheng, QingXiang, Liu, Chang, Jiang, ChengYing, Liu, LiXia, Zhang, Bo, Liu, YiMing, Yang, Chen, Liu, ShuangJiang. Metabolic flux responses to genetic modification for shikimic acid production by Bacillus subtilis strains. MICROBIAL CELL FACTORIES[J]. 2014, 13(1): 40-40, https://www.webofscience.com/wos/woscc/full-record/WOS:000334713200001.
[25] Deng Liu, Chen Yang. The Nitrogen-regulated Response Regulator NrrA Controls Cyanophycin Synthesis and Glycogen Catabolism in the Cyanobacterium Synechocystis sp. PCC 6803 *. The Journal of Biological Chemistry. 2013, 289(4): 2055-2071, [26] Tao, Yongzhen, Liu, Deng, Yan, Xing, Zhou, Zhihua, Lee, Jeong K, Yang, Chen. Network Identification and Flux Quantification of Glucose Metabolism in Rhodobacter sphaeroides under Photoheterotrophic H-2-Producing Conditions. JOURNAL OF BACTERIOLOGY[J]. 2012, 194(2): 274-283, http://dx.doi.org/10.1128/JB.05624-11.
[27] Leyn, Semen A, Gao, Fang, Yang, Chen, Rodionov, Dmitry A. N-Acetylgalactosamine Utilization Pathway and Regulon in Proteobacteria GENOMIC RECONSTRUCTION AND EXPERIMENTAL CHARACTERIZATION IN SHEWANELLA. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(33): 28047-28056, http://dx.doi.org/10.1074/jbc.M112.382333.

毕业去向

学生毕业时间去向现职
郑庆祥2013博福建漳州农业局福建漳州农业局
刘邓2013博美国华盛顿大学 博后美国华盛顿大学
张蕾2014博美国阿尔伯特爱因斯坦医学院 博后美国明尼苏达大学
高翔2016博美国芝加哥大学 博后中国科学院深圳先进技术研究院 副研究员
夏静2017博
聂小群2018博中科院上海植物生理生态研究所 博后中科院分子植物卓越中心 博后
张昊2019博宾夕法尼亚大学 博后宾夕法尼亚大学 博后
杨彬2020博
博后出站时间去向现职
陶用珍2012年Burnham医学研究所中科院上海营养与健康研究所
申铁2011年贵州师范大学贵州师范大学