基本信息
肖富辉  男  硕导  中国科学院昆明动物研究所
电子邮件: xiaofuhui@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区茨坝街道龙欣路17号
邮政编码: 650201

招生信息

   
招生专业
071007-遗传学
招生方向
疾病基因组学

教育背景

2010-09--2016-06   中国科学院昆明动物研究所   博士

工作经历

   
工作简历
2019-01~现在, 中国科学院昆明动物研究所, 副研究员
2016-07~2018-12,中国科学院昆明动物研究所, 助理研究员

出版信息

   
发表论文
[1] Wang, Hao-Tian, Xiao, Fu-Hui, Gao, Zong-Liang, Guo, Li-Yun, Yang, Li-Qin, Li, Gong-Hua, Kong, Qing-Peng. Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging. Aging Cell[J]. 2024, 第 2 作者  通讯作者  https://onlinelibrary.wiley.com/doi/10.1111/acel.14163.
[2] Xiao, Fu-Hui, Wang, Hao-Tian, Chen, Xiao-Qiong, Ge, Ming-Xia, Yan, Dongjing, Yang, Xing-Li, Yang, Li-Qin, Lin, Rong, Guo, Rong-Hui, Zhang, Wen, Tang, Nelson, He, Yonghan, Zhou, Jumin, Cai, Wang-Wei, Kong, Qing-Peng. Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging. National Science Review[J]. 2023, 第 1 作者10(6): https://doi.org/10.1093/nsr/nwad067.
[3] Wang, Hao-Tian, Zhao, Long, Yang, Li-Qin, Ge, Ming-Xia, Yang, Xing-Li, Gao, Zong-Liang, Cun, Yu-Peng, Xiao, Fu-Hui, Kong, Qing-Peng. Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity. Aging Cell[J]. 2023, 第 8 作者  通讯作者  23(1): http://dx.doi.org/10.1111/acel.13916.
[4] Li, GongHua, Han, Feifei, Xiao, FuHui, Gu, KangSuYun, Shen, Qiu, Xu, Weihong, Li, WenXing, Wang, YanLi, Liang, Bin, Huang, JingFei, Xiao, Wenzhong, Kong, QingPeng. System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity. Aging Cell[J]. 2022, 第 3 作者21(4): http://dx.doi.org/10.1111/acel.13595.
[5] Xiao, Fu-Hui, Yu, Qin, Deng, Zhili, Yang, Ke, Ye, Yunshuang, Ge, Mingxia, Yan, Dongjing, Wang, Haotian, Chen, Xiaoxiong, Yang, Liqin, Yang, Binyu, Lin, Rong, Zhang, Wen, Yang, Xingli, Dong, Lei, He, Yonghan, Zhou, Jumin, Cai, Wangwei, Li, Ji, Kong, Qingpeng. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity. Science Advances[J]. 2022, 第 1 作者8(17): https://www.science.org/doi/10.1126/sciadv.abf2017.
[6] Chen, Xiao-Qiong, Zhang, Fan, Xiao, Fu-Hui, Peng, Yu. Deciphering the nexus between the tumor immune microenvironment and DNA methylation in subgrouping estrogen receptor-positive breast cancer. Breast Cancer[J]. 2021, 第 3 作者  通讯作者  28(6): 1252-1260, http://dx.doi.org/10.1007/s12282-021-01262-9.
[7] Wang, Hao-Tian, Xiao, Fu-Hui, Li, Gong-Hua, Kong, Qing-Peng. Identification of DNA N-6-methyladenine sites by integration of sequence features. EPIGENETICS & CHROMATIN[J]. 2020, 第 2 作者13(1): http://dx.doi.org/10.1186/s13072-020-00330-2.
[8] Chen, Xiao-Qiong, Zhang, Fan, Su, Qi-Chen, Zeng, Chi, Xiao, Fu-Hui, Peng, Yu. Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype. Clinical Epigenetics[J]. 2020, 第 5 作者  通讯作者  12(1): http://dx.doi.org/10.1186/s13148-020-0811-1.
[9] Xia, Wang-Xiao, Yu, Qin, Li, Gong-Hua, Liu, Yao-Wen, Xiao, FuHui, Yang, Li-Qin, Rahman, Zia Ur, Wang, Hao-Tian, Kong, Qing-Peng. Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA. PEERJ[J]. 2019, 第 5 作者7: https://doaj.org/article/76f0ef2fac0d45c789e4382ebe731230.
[10] Xiao, Fu-Hui, Wang, Hao-Tian, Kong, Qing-Peng. Dynamic DNA Methylation During Aging: A "Prophet" of Age-Related Outcomes. Frontiers in Genetics[J]. 2019, 第 1 作者10: https://doaj.org/article/1b57ee339e224498bc9de9e41a8ae48b.
[11] Xiao, Fu-Hui, Chen, Xiao-Qiong, He, Yong-Han, Kong, Qing-Peng. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. CLINICAL EPIGENETICS[J]. 2018, 第 1 作者10(1): https://doaj.org/article/822c60a451f54c71b8bbeabd320dcb85.
[12] Xiao, Fu-Hui, Chen, Xiao-Qiong, Yu, Qin, Ye, Yunshuang, Liu, Yao-Wen, Yan, Dongjing, Yang, Li-Qin, Chen, Guijun, Lin, Rong, Yang, Liping, Liao, Xiaoping, Zhang, Wen, Zhang, Wei, Tang, Nelson-Leung-Sang, Wang, XiaoFan, Zhou, Jumin, Cai, Wang-Wei, He, Yong-Han, Kong, Qing-Peng. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. GENOME RESEARCH[J]. 2018, 第 1 作者28(11): 1601-1610, https://www.webofscience.com/wos/woscc/full-record/WOS:000448950400001.
[13] Wang, Xiao-Xiong, Xiao, Fu-Hui, Li, Qi-Gang, Liu, Jia, He, Yong-Han, Kong, Qing-Peng. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway. ONCOTARGET[J]. 2017, 第 2 作者8(7): 11868-11876, http://www.irgrid.ac.cn/handle/1471x/1151618.
[14] He, Yong-Han, Pu, Shao-Yan, Li, Wen, Chen, Xiao-Qiong, Xiao, Fu-Hui, Yan, Dong-Jing, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Yang, Xing-Li, Ge, Ming-Xia, Cai, Wang-Wei, Kong, Qing-Peng. DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY. ARCHIVES OF BIOLOGICAL SCIENCES[J]. 2016, 第 5 作者68(3): 533-540, https://www.webofscience.com/wos/woscc/full-record/WOS:000384908900007.
[15] He, YongHan, Chen, XiaoQiong, Yan, DongJing, Xiao, FuHui, Lin, Rong, Liao, XiaoPing, Liu, YaoWen, Pu, ShaoYan, Yu, Qin, Sun, HongPeng, Jiang, JianJun, Cai, WangWei, Kong, QingPeng. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. NEUROBIOLOGY OF AGING[J]. 2016, 第 4 作者47(X): 218.e11-218.e18, http://dx.doi.org/10.1016/j.neurobiolaging.2016.07.026.
[16] Xiao, Fu-Hui, Kong, Qing-Peng, Perry, Benjamin, He, Yong-Han. Progress on the role of DNA methylation in aging and longevity. BRIEFINGS IN FUNCTIONAL GENOMICS[J]. 2016, 第 1 作者15(6): 454-459, https://www.webofscience.com/wos/woscc/full-record/WOS:000392717700007.
[17] He, Yong-Han, Pu, Shao-Yan, Xiao, Fu-Hui, Chen, Xiao-Qiong, Yan, Dong-Jing, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Yu, Qin, Yang, Li-Qin, Yang, Xing-Li, Ge, Ming-Xia, Li, Ying, Jiang, Jian-Jun, Cai, Wang-Wei, Kong, Qing-Peng. Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families. SCIENTIFIC REPORTS[J]. 2016, 第 3 作者6(X): https://www.webofscience.com/wos/woscc/full-record/WOS:000370783700002.
[18] Xiao, Fu-Hui, He, Yong-Han, Li, Qi-Gang, Wu, Huan, Luo, Long-Hai, Kong, Qing-Peng. A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes. PLOS ONE[J]. 2015, 第 1 作者10(3): http://159.226.149.42:8080:8088/handle/152453/8328.
[19] He, Yong-Han, Chen, Xiao-Qiong, Yan, Dong-Jing, Xiao, Fu-Hui, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Cai, Wang-Wei, Kong, Qing-Peng. Thyroid Function Decreases with Age and May Contribute to Longevity in Chinese Centenarians' Families. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY[J]. 2015, 第 4 作者63(7): 1474-1476, https://www.webofscience.com/wos/woscc/full-record/WOS:000358254200033.
[20] Liu Li-Na, Wang Cheng-Ye, Lu Xiang, Xiao Fu-Hui, Wang Hua-Wei, Yang LiQin, Xu Liang-You, Kong Qing-Peng. The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population. SCIENCE CHINA-LIFE SCIENCES[J]. 2014, 第 4 作者57(10): 1024-1027, http://159.226.149.42:8080:8088/handle/152453/8157.
[21] 刘立娜, 王成业, 逯翔, 肖富辉, 王华伟, 杨利琴, 徐良友, 孔庆鹏. 中国汉族人群长寿老人TERT基因MNS16A长度多态研究. 中国科学:生命科学 ,[J]. 2014, 第 4 作者44(11): 1168-1172, http://www.irgrid.ac.cn/handle/1471x/1151594.

科研活动

   
科研项目
( 1 ) 转录因子ETS1调控核糖体功能促进寿命延长的作用机制研究, 负责人, 国家任务, 2021-01--2024-12
( 2 ) 长寿人群特异低表达基因LEF1延缓干细胞衰老的作用与机制研究, 负责人, 国家任务, 2018-01--2020-12
( 3 ) 利用转录组测序技术挖掘长寿老人的健康保护因子, 负责人, 中国科学院计划, 2017-01--2019-12
( 4 ) LEF1基因低表达延缓干细胞衰老促进长寿的作用与机制研究, 负责人, 地方任务, 2018-06--2021-05
( 5 ) 抑制核糖体功能促进健康长寿的时间选择和功能机制研究, 负责人, 地方任务, 2022-06--2025-05
( 6 ) 不同年龄核糖体功能降低对健康衰老的影响和功能机制研究, 负责人, 中国科学院计划, 2022-01--2024-12
( 7 ) 云南省高层次科技人才及创新团队选拔专项——中青年学术和技术带头人后备人才, 负责人, 地方任务, 2023-01--2027-12
参与会议
(1)Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians   第七届中国衰老与抗衰老学术大会   2019-10-19