成体组织中存在着能够自我更新、有多种分化潜能的细胞称成体干细胞。成体干细胞对器官的发育、自稳态维持有至关重要的作用，还有可能是癌症发生的细胞靶点。成体干细胞领域的挑战是：1）许多器官成体干细胞的身份属性并不清楚；2）成体干细胞一旦离开了体内的微环境信号，在体外不能维持干细胞的特性（干性），并且干细胞的数量难以在体外扩增，使得相关的分子机制研究难以进行。针对这些挑战和机遇，实验室的近期目标一是发现成体干细胞的身份属性，尤其是干细胞表面的特异标记分子，能够富集并分离得到活体的干细胞；目标二是发现成体干细胞的微环境因子，使得成体干细胞在体外能够长期培养和扩增，并保持干性。

        实验室主要以小鼠乳腺为组织模型，运用原代干细胞培养、基因操纵等体外实验，结合干细胞移植、构建转基因及基因敲除小鼠、损伤修复、谱系示踪等体内实验手段，研究成体干细胞的属性及调控机制。实验室近期的研究方向包括：
1) 发现各器官中成体干细胞的身份属性，包括乳腺、卵巢、血管、胰腺等；
2) 通过对比各成体干细胞，阐明干细胞“干性”的分子组成；
3) 发现成体干细胞新的微环境因子，阐明其调控干细胞的分子机理；
4) 研究干细胞关键调控分子在再生医学、癌症治疗中的调控变化。

         实验室的长远目标是阐明干细胞的分子调控机理，为癌症治疗和再生医学提供新的策略。

2001-01--2005-10   Simon Fraser University   博士

博士研究生

博士学位

发育生物学

   

（1） 中青年科技创新领军人才奖, , 部委级, 2017
（2） 中国科学院上海分院第五届“杰出青年科技创新人才”, 院级, 2016
（3） 2015-2016年度上海市三八红旗集体称号, , 省级, 2016
（4） 上海市优秀学术带头人, , 省级, 2016
（5） 巾帼文明岗, , 省级, 2016
（6） 优秀导师奖, 研究所（学校）, 2015
（7） 中国细胞生物学学会干细胞分会青年研究员奖, , 其他, 2015
（8） 中国细胞生物学学会青年研究员奖, 其他, 2015
（9） 上海市三八红旗集体称号, , 省级, 2015
（10） The Bienz- Waterman Award for best female presenter, 其他, 2014

[1] 曾艺, 王代松. TNBC划分和治疗的方法和组合物. CN: CN111656194A, 2020-09-11.
[2] 曾艺, 王代松. 三阴性乳腺癌标记物及其在诊断和治疗中的应用. CN: CN105349618B, 2020-01-24.
[3] Zeng, Yi, Wang, Daisong. Biomarker and Therapeutic Target for Triple Negative Breast Cancer. CN: US20190045758(A1), 2019-02-14.
[4] 曾艺, 王代松. 治疗三阴性乳腺癌的单克隆抗体. 中国: CN106267187A, 2017-01-04.
[5] 曾艺, 蔡车国. 一种体外扩增乳腺干细胞并维持其干细胞特性的方法及其应用. 中国: CN104974981A, 2015-10-14.

   

[1] Wang, Jingqiang, Liu, Chunye, He, Lingli, Xie, Zhiyao, Bai, Lanyue, Yu, Wentao, Wang, Zuoyun, Lu, Yi, Gao, Dong, Fu, Junfen, Zhang, Lei, Zeng, Yi Arial. Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair. ELIFE[J]. 2022, 11: http://dx.doi.org/10.7554/eLife.75449.
[2] Liu, Chunye, Lin, Changdong, Wang, Daisong, Wang, Jingqiang, Tao, Yu, Li, Yue, Chen, Xinyi, Bai, Lanyue, Jia, Yingying, Chen, Jianfeng, Zeng, Yi Arial. Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells. CELL REPORTS[J]. 2022, 38(12): http://dx.doi.org/10.1016/j.celrep.2022.110548.
[3] Wang, Jingqiang, Wang, Daisong, Chen, Xinyi, Yuan, Shubo, Bai, Lanyue, Liu, Chunye, Zeng, Yi Arial. Isolation of mouse pancreatic islet Procr(+) progenitors and long-term expansion of islet organoids in vitro. NATURE PROTOCOLS[J]. 2022, 17(5): 1359-1384, http://dx.doi.org/10.1038/s41596-022-00683-w.
[4] Rosenthal, Christina Karlsson, Zeng, Yi Arial. Stem cells and art: an interview with Yi Arial Zeng on the promising future of the stem cell field. COMMUNICATIONS BIOLOGY[J]. 2021, 4(1): [5] Chen, Shiyang, Zheng, Yajuan, Ran, Xiaojuan, Du, Hui, Feng, Hua, Yang, Lei, Wen, Yating, Lin, Changdong, Wang, Shihui, Huang, Mengwen, Yan, Zhanjun, Wu, Dianqing, Wang, Hongyan, Ge, Gaoxiang, Zeng, An, Zeng, Yi Arial, Chen, Jianfeng. Integrin alpha E beta 7(+) T cells direct intestinal stem cell fate decisions via adhesion signaling. CELL RESEARCH. 2021, [6] Wang, Jingqiang, Song, Wenqian, Yang, Ruikai, Li, Chao, Wu, Ting, Dong, Xiao Bing, Zhou, Bin, Guo, Xizhi, Chen, Jianfeng, Liu, Zhiyong, Yu, Qing Cissy, Li, Wen, Fu, Junfen, Zeng, Yi Arial. Endothelial Wnts control mammary epithelial patterning via fibroblast signaling. CELL REPORTS[J]. 2021, 34(13): https://doaj.org/article/a772f8aabbaa4f5bb55f9a098bde359d.
[7] Wu, Ting, Wang, Yinghua, Xiao, Tianxiong, Ai, Yirui, Li, Jinsong, Zeng, Yi Arial, Yu, Qing Cissy. Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium. BMC BIOTECHNOLOGY[J]. 2021, 21(1): http://dx.doi.org/10.1186/s12896-021-00703-9.
[8] Jingqiang Wang, Kun Chu, Yinghua Wang, Jinsong Li, Junfen Fu, Yi Arial Zeng, Wen Li. Procr-expressing granulosa cells are highly proliferative and are important for follicle development. iScience. 2021, 24(2): [9] Wu, Ningbo, Sun, Hongxiang, Zhao, Xiaoyun, Zhang, Yao, Tan, Jianmei, Qi, Yuanyuan, Wang, Qun, Ng, Melissa, Liu, Zhaoyuan, He, Lingjuan, Niu, Xiaoyin, Chen, Lei, Liu, Zhiduo, Li, HuaBing, Zeng, Yi Arial, Roulis, Manolis, Liu, Dou, Cheng, Jinke, Zhou, Bin, Ng, Lai Guan, Zou, Duowu, Ye, Youqiong, Flavell, Richard A, Ginhoux, Florent, Su, Bing. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. NATURE[J]. 2021, 592(7855): 606-+, http://dx.doi.org/10.1038/s41586-021-03283-y.
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[17] Ajun Geng, Ting Wu, Cheguo Cai, Wenqian Song, Jiqiu Wang, Qing Cissy Yu, Yi Arial Zeng. A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling. eLife[J]. 2020, 9: https://doaj.org/article/883c1bd595d149bc98a3257182d6e5d9.
[18] Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng, Jianfeng Chen. A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis. BMC Biology[J]. 2020, 18(1): 1-15, http://dx.doi.org/10.1186/s12915-020-00784-6.
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（ 1 ） 中科院“****”, 主持, 部委级, 2010-08--2013-09
（ 2 ） 蛋白C受体对乳腺干细胞的作用及机制, 主持, 国家级, 2016-01--2020-12
（ 3 ） 乳腺干细胞微环境信号及其受激素调控机制的研究, 主持, 国家级, 2014-01--2017-12
（ 4 ） 乳腺干细胞自我更新的调控机制, 主持, 国家级, 2012-01--2015-12
（ 5 ） 单倍体干细胞的应用研究, 主持, 国家级, 2014-01--2018-08
（ 6 ） 建立应用于糖尿病治疗的胰腺成体干细胞体外培养体系, 主持, 部委级, 2016-01--2018-12
（ 7 ） 乳腺干细胞的信号调控及其与微环境的相互作用, 主持, 部委级, 2011-01--2015-12
（ 8 ） 乳腺干细胞的调控机理, 主持, 国家级, 2017-01--2020-12
（ 9 ） EPCR调节特定骨髓微环境对骨髓造血干细胞的归巢与维持, 主持, 国家级, 2017-01--2019-12
（ 10 ） 蛋白C受体对乳腺干细胞的作用及机制, 主持, 省级, 2017-05--2020-04
（ 11 ） 细胞可塑性和病变发生的干性因子, 主持, 部委级, 2017-01--2018-12
（ 12 ） 三阴性乳腺癌的靶治疗研究, 主持, 部委级, 2017-01--2018-12

（1）PROCR in mammary stem cells and beyond.   第五届国际乳腺癌干细胞高峰论坛暨第四届滨海国际医学论坛   2017-10-09
（2）Wnt Signaling in regulating mammary stem cell and breast cancer.   2017年“干细胞微环境研讨会”   2017-09-09
（3）Wnt Signaling in regulating mammary stem cell and breast cancer.   2017年“基因组学、干细胞、组织再生”学术研讨会   2017-08-29
（4）PROCR in Regulating Mammary Stem Cells and Beyond.   2017年GRC“Wnt Signaling”研讨会   2017-08-09
（5）Wnt Signaling in Regulating Mammary Stem Cell and Breast Cancer.   全球华人生物学家大会暨第十六届美洲华人生物科学学会学术研讨会   2017-07-01
（6）Wnt Signaling in Regulating Mammary Stem Cell and Breast Cancer   第21届研究生研讨会   2016-12-01
（7）PROCR in mammary stem cells and beyond   第五届国际乳腺癌干细胞高峰论坛暨第四届滨海国际医学论坛   2016-10-09
（8）Protein C Receptor Marks Mammary Stem Cells and Vascular Endothelial Stem Cells   第六届细胞结构与功能的信号基础研讨会   2016-08-22
（9）Procr Stem Cells in Mammary Development and Cander   2016年高登研究会-“成体内皮干细胞与组织微环境”   2016-08-11
（10）Protein C Receptor as A surface Marker for Mammary Stem Cells & Beyond   华人生物学家协会第十一届双年会   2016-07-30
（11）Protein C receptor as a surface marker stem cells and its implication in breast cancer    第29届国际乳腺癌研究协会大会   2015-10-17
（12）EMT is a shared theme of protein C receptor- positive adult stem cells   美国癌症研究协会大会   2015-10-11
（13）Rspo1 is a novel hormone mediator for mammary stem cell self renewal.   第29届国际乳腺癌研究协会大会    2014-09-15

已指导学生

喻华  博士研究生  071008-发育生物学  

刘纬  博士研究生  071008-发育生物学  

现指导学生

宋文倩  博士研究生  071008-发育生物学  

王代松  博士研究生  071008-发育生物学  

王经强  博士研究生  071008-发育生物学  

吴亭  博士研究生  071008-发育生物学  

耿阿俊  博士研究生  071008-发育生物学  

刘春业  硕士研究生  071008-发育生物学  

白蓝月  博士研究生  071008-发育生物学