Hong Tang, PhD, Prof.

Telephone: 021-54923001
Fax: 021-63843571
Address: Institut Pasteur of Shanghai, Chinese Academy of Sciences

Research Areas

My laboratory studies innate immune response to pathogen infections. We aim at determination of new regulatory genes involved in type I interferon signaling pathway and the conserved anti-macriobial peptides pathway in Drosophila. We also study how innate inflammatory response to acute viral infections is regulated by adaptive cells. We have been able to identify both host factors and viral proteins that determine the innate signaling, and the new viral strategies to evade the innate immunity. We have also discovered that T cells possess innate cell-like function that is required for the either initiation or inhibition of innate inflammation. The work has been published in Nature Medicine, Nature Immunology, Cell Research, PNAS and J Immunology.


1988: Bachelor of Science, Department of Biochemistry, Nanjing University, China

1996: Doctor of Philosophy, Department of Molecular Genetics and Molecular Micreobiology, Rutgers University and Robert Wood Johnson Medical School, NJ

Professional experience

1996-1999: Postdoctoral Fellow of Irvington Institute for Medical Science Foundation

2000: Senior Scientist, Dupont Pharmaceutical Co., PA

2001-2004---The Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences

Professor, Director

2005-2011:The Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences Professor, Director

2009-2012:  The Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics Professor, Head

2012-2016:  Wuhan Institute of Virology, Chinese Academy of Sciences  Professor, Deputy Director General

2016----:  Institut Pasteur of Shanghai, Chinese Academy of Sciences ,Institute director

Selected Publications

1. Weng C, Li Y, Xu D, Shi Y, Tang H (2005) Specific cleavage of Mcl-1 by caspase-3 in TRAIL-induced apoptosis in Jurkat leukemia T cells. J Biol Chem, 280:(11) 10491–10500.

2. Perry AK, Chen G, Zheng DH, Tang H and Cheng G (2005) The host type I interferon response to viral and bacterial infections. Cell Res, 15(6):407-422.

3. Zheng Y, Yamaguchi H, Tian C, Lee M, Tang H, Wang H and Chen Q (2005) Arsenic trioxide (As2O3) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene, 24(20):3339-47.

4. Qin X and Tang H (2006) Differential regulation of chromatin structure of the murine 3’ IgH enhancer and IgG2b germline promoter in response to lipopolysaccharide and CD40 signaling. Mol Immunol 43:1211–20.

5. Chen J, Chen L, Wang G and Tang H (2007) Cholesterol-dependent and independent CD40 internalization and signaling activation in cardiovascular endothelial cells. Arterioscler Thromb Vasc Biol, 27:2005-2013.

6. Kim K, Zhao J, Auh S, Yang X, Du P, Tang H*, and Fu Y* (2007) Adaptive immune cells temper initial innate responses. Nature Med 13(10):1248-1252 (*co-correspondence).

7. Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N and Xie T (2007) Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. Cell Stem Cell, 1:458-469.

8. Zhao J, Kim KD, Yang X, Auh S, Fu YX* and Tang H* (2008) Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A 105(21):7528-33 (*co-correspondence).

9. Zheng D, Chen G, Guo B, Cheng G* and Tang H* (2008) PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production. Cell Res, 18:1105–13 (*co-correspondence).

10. Deng W, Shi M, Han M, Zhong J, Li Z, Li W, Hu Y, Yan L, Wang J, He Y, Tang H, Deubel V, Luo X, Ning Q, Sun B (2008) Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1. J Biol Chem. 283(51):35590-7.

11. Zhao J, Yang X, Kim KD, Auh S, Fu YX* and Tang H* (2009) Do adaptive immune cells suppress or activate innate immunity? Trends Immunol. 30(1):8-12 (*co-correspondence).

12. Li X, Yang X, Xu Y, Jiang X, Li X, Nan F, Tang H. (2009) Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res. 19(6):669-71.

13. Yu J, Pan L, Qin X, Chen H, Xu Y, Chen Y, Tang H. (2010) MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes. J Biol Chem, 285(11):8454–8462.

14. Mi Z, Fu J, Xiong Y and Tang H. (2010) SUMOylation of RIG-I positively regulates the type I interferon signaling. Protein Cell, 1(3):275-283.

15. Tang H and Fu Y (2010) A new role for T cells in dampening innate inflammatory responses. Sci China Life Sci, 53(2):190-4.

16. Jiang J, Tang H. (2010) Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein. Protein Cell, 1(12):1106-17.

17. Fu J, Xiong Y, Xu Y, Cheng G and Tang H. (2011) MDA5 is SUMOylated by PIAS2β in the upregulation of Type I interferon signaling. Mol Immunol. 48(4):415-22 (Epub 2010 Dec 14).

18. Da Q, Yang X, Xu Y, Gao G, Cheng G, Tang H. (2011) TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I. J Immunol. 186(5):3023-30 (Epub 2011 Jan 26).

19. Wang G, Chen G, Zheng D, Cheng G, Tang H (2011) PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway. PLoS ONE 6(2): e17192. doi:10.1371/journal.pone.0017192.

20. Wang X, Pan L, Wang S, Zhou J, McDowell W, Park J, Haug J, Staehling K, Tang H, Xie T. (2011) Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation. PLoS Genet. Dec;7(12):e1002426. Epub 2011 Dec 22.

21. Zhang X, Angkasekwinai P, Dong C and Tang H (2011) Structure and function of interleukin-17 family cytokines. Protein Cell, 2(1):26-40.

22. Upadhyay V, Poroyko V, Kim T, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H & Fu YX (2012) Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol 13(10):947-53.

23. X Wang, P Ying, F Diao, Q Wang, D Ye, C Jiang, N Shen, N Xu, W-B Chen, S Lai, S Jiang, X Miao, J Feng, W Tao, N Zhao, B Yao, Z Xu, H Sun, J Li, J Sha, X Huang, Q Shi, H Tang, X Gao and C Li (2013) Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. J Exp Med, 210(8):1559-74.

24. Yu J, He X, Chen YG, Hao Y, Yang S, Wang L, Pan L*, Tang H*. Myotubularin-related Protein 4 (MTMR4) Attenuates BMP/Dpp Signaling by Dephosphorylation of Smad Proteins. J Biol Chem. 288(1):79-88, 2013. (*co-correspondence)

25. A Wu, C Su, D Wang, Y Peng, M Liu, S Hua, T Li, G Gao, H Tang, J Chen, X Liu, Y Shu, D Peng, T Jiang (2013). Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China. Cell Host & Microbe, 14:1-7.

26. F Ma, J Feng, C Zhang, Y Li, G Qi, H Li, Y Wu, Y Fu, Y Zhao, H Chen, J Du*, H Tang* (2014) The Requirement of CD8+ T Cells to Initiate and Augment Acute Cardiac Inflammatory Response to High Blood Pressure. J Immunol (in press). (*co-correspondence)

Research Interests

Infection and immunity,
inflammation and inflammatory response,